Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

{"title":"[Surgical treatment of secondary trigeminal neuralgia].","authors":"V M Dzhafarov, E N Rozhnova, V V Gosteva, S A Mamykina, S A Melchenko, A I Volkov, O V Boyko, I V Senko","doi":"10.17116/jnevro2024124111203","DOIUrl":"https://doi.org/10.17116/jnevro2024124111203","url":null,"abstract":"<p><strong>Objective: </strong>To present a case series analysis of surgical treatment of patients with secondary trigeminal neuralgia.</p><p><strong>Material and methods: </strong>The treatment of 8 patients with secondary trigeminal neuralgia who underwent surgery since 2021 was analyzed. All records, neuroimaging archive, and follow-up observations were reviewed.</p><p><strong>Results: </strong>There were 5 patients with trigeminal neuralgia associated with multiple sclerosis; with neurosarcoidosis (<i>n</i>=1); with tumor (<i>n</i>=1); with unspecified degenerative disease (<i>n</i>=1). The mean age was 61 years (from 48 to 73), the mean duration of disease was 7.2 years (from 5 to 13). Radiofrequency ablation (RF) was performed in 4 cases, balloon compression in 3 cases, tumor removal in 1 case. Relief of trigeminal neuralgia after surgery was observed in 7 patients, partial reduction in 1 patient. A complication was noted in a patient with neurosarcoidosis after RF with the appearance of dysesthesia, dry eye. The mean follow-up was 10 months (1 to 29). Pain recurrence occurred in 2 patients, one of them underwent the surgery twice.</p><p><strong>Conclusion: </strong>Surgical treatment of patients with secondary trigeminal neuralgia contributes to pain relief.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 11","pages":"203-209"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A comparative assessment of neurochemical and neurophysiological parameters of cardiac surgery patients who underwent different versions of multitasking cognitive training].","authors":"O A Trubnikova, I V Tarasova, T B Temnikova, D S Kupriyanova, I N Kukhareva, A S Sosnina, O L Barbarash","doi":"10.17116/jnevro202412412162","DOIUrl":"https://doi.org/10.17116/jnevro202412412162","url":null,"abstract":"<p><strong>Objective: </strong>To compare biomarkers of neurovascular unit (NVU) - S100β, NSE, BDNF and indicators of the brain electrical activity in patients who underwent coronary artery bypass grafting (CABG) depending on the use of different versions of multi-tasking cognitive training (CT).</p><p><strong>Material and methods: </strong>The study included 89 people, of whom 47 completed the CTI (postural and three cognitive tasks (counting backwards, verbal fluency and the open-ended task «Unusual use of an ordinary object») and 42 patients, who underwent CTII (visuomotor reaction and the same cognitive tasks) in the early postoperative CABG period. The patients of both groups underwent complex testing of psychomotor, executive functions, attention, short-term memory and EEG study in the perioperative period of CABG. Concentrations of NVU markers in peripheral blood serum were also analyzed.</p><p><strong>Results: </strong>The highest values of S100β protein concentration in both patients with CTI and CTII were observed on the 1^st-2^nd days after CABG, followed by a significant decrease on the 10^th-12^th days to preoperative values only in the CTII group. Also, during CTI, low concentrations of S100β and NSE protein were associated with higher indicators of cognitive status, such as short-term memory and general integral index. In patients with CTI, the concentration of BDNF on days 10-12 of CABG was significantly higher compared to patients with CTII, and its higher levels were associated with higher levels of attention. Only if the training was successful, the patients with CTI had greater preoperative levels of EEG alpha-1 and alpha-2 activity compared to patients with CTII.</p><p><strong>Conclusion: </strong>The version of multitasking CT using the postural motor component more actively triggered the processes of neuroplasticity due to the expression of BDNF and its success was due to the greater presence of alpha-activity in the preoperative period of CABG. Further research is needed to study the neurophysiological mechanisms of recovery of cognitive functions after cardiac surgery.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 12","pages":"62-68"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Features of primary and recurrent ischemic stroke in men aged 18-50 years].","authors":"N A Pizov, M V Bakucheva, O P Rechkina","doi":"10.17116/jnevro202412412265","DOIUrl":"https://doi.org/10.17116/jnevro202412412265","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the features of primary and recurrent stroke in men aged 18-50 years with atherothrombotic, lacunar, and cardioembolic subtypes.</p><p><strong>Material and methods: </strong>A total of 125 men with primary and recurrent stroke were included in the study. The main vascular risk factors and lifestyle-related risk factors were assessed. Neurological, neuroimaging, ultrasound and laboratory examinations were performed. Hemostasis parameters, lipid metabolism and endothelial function parameters were studied.</p><p><strong>Results: </strong>Among 125 men with ischemic stroke with a median age of 43 years, 104 (83.2%) patients had a primary stroke and 21 (16.8%) patients had a recurrent stroke. Recurrent stroke occurred more frequently in patients with the cardioembolic subtype (26.3%) and with almost equal frequency in patients with the atherothrombotic (13.3%) and lacunar (17.4%) subtypes. In the group as a whole, patients with primary and recurrent strokes did not differ in age (43.1±5.5 and 43.7±4.3 years, respectively). In a comparative analysis of patients with primary and recurrent stroke with different subtypes of stroke, significant differences in the main risk factors, indicators of lipid metabolism, hemostasis and endothelial function were obtained.</p><p><strong>Conclusion: </strong>The study in men, aged 18-50 years, with atherothrombotic, lacunar and cardioembolic subtypes revealed the features of risk factors, indicators of hemostasis system, lipid metabolism and endothelial function in primary and recurrent stroke.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 12. Vyp. 2","pages":"65-74"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Locked-in-syndrome].","authors":"L T Khasanova, D Kh Okhtova, K N Arkhagova, I A Lomakina, E A Koltsova","doi":"10.17116/jnevro202412412257","DOIUrl":"https://doi.org/10.17116/jnevro202412412257","url":null,"abstract":"<p><p>Locked-in syndrome is a rare neurological disorder. It is characterized by tetraparesis, paralysis of facial and masticatory muscles, anarthria and pseudobulbar syndrome with possible preservation of vertical movements of the eyeballs and blinking, as well as preservation of consciousness. A serious problem with the «locked-in person» syndrome is the inability of the patient to socialize, which causes him to experience no less suffering than from physical limitations. Modern comprehensive rehabilitation of patients, the maximum possible socialization, and the provision of electronic devices to maintain contact with the outside world increase the chances of improving the condition. The life expectancy of patients directly depends on the cause of the disease, concomitant somatic pathology, the quality of medical care, and proper support from loved ones. A case of a patient with locked-in syndrome, which developed as a result of cardioembolic ischemic stroke, is presented, and the dynamics of the condition against the background of rehabilitation measures is described.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 12. Vyp. 2","pages":"57-64"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cerebrolysin in the preventive therapy of dementia in elderly patients with mild cognitive impairment: a three-year prospective comparative study].","authors":"E V Ponomareva, L V Androsova, S A Krynskiy, S I Gavrilova","doi":"10.17116/jnevro202412409151","DOIUrl":"10.17116/jnevro202412409151","url":null,"abstract":"<p><strong>Objective: </strong>To study the efficacy and safety of long-term (3 years) course Cerebrolysin therapy in an open comparative study as a means potentially capable of slowing or preventing the transition of MCI into dementia, as well as to analyze the possibility of Cerebrolysin preventive effect predicting based on clinical and biological parameters.</p><p><strong>Material and methods: </strong>In total, 100 patients with aMCI were included in the study, randomly assigned to 2 groups: patients of group 1 (<i>n</i>=50) received annual course therapy with Cerebrolysin for 3 years (20 intravenous infusions of Cerebrolysin 20 ml in 100 ml of saline solution for 4 weeks). Group 2 patients underwent annual clinical examination, but did not receive therapy. All patients were monitored on an outpatient basis and were examined once a year. Clinical and psychopathological, psychometric, immunological, catamnestic, molecular genetic, and statistical methods were used.</p><p><strong>Results: </strong>A comparative three-year prospective study conducted in a group of aMCI patients treated with annual course therapy with Cerebrolysin and those who did not receive therapy showed a lower progression of cognitive deficits and a significantly lower conversion rate to dementia in patients who received annual courses for 3 years Cerebrolysin therapy compared with the comparison group.</p><p><strong>Conclusion: </strong>The data obtained indicate the presence of a disease-modifying effect in the annual course of Cerebrolysin and the possibility of using this drug in programs of dementia preventive therapy in people with a high risk of cognitive deficits progression and the dementia development in elderly patients with aMCI.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 9","pages":"51-59"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Stiff-person syndrome].","authors":"V V Zaharova, E A Ruina, E A Antipenko","doi":"10.17116/jnevro2024124061139","DOIUrl":"10.17116/jnevro2024124061139","url":null,"abstract":"<p><p>Stiff-person syndrome is a rare autoimmune disorder manifested by stiffness in the trunk and proximal limb muscles and painful muscle spasms in them. The disease is associated with the production of glutamate decarboxylase autoantibodies, an enzyme converting glutamate into gamma-aminobutyric acid. An increase of anti-GAD antibody serum levels above 10.000 IU/mL is specific for stiff-person syndrome. Our own clinical observation of a patient diagnosed with stiff-person syndrome is presented.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 6","pages":"139-144"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Possibilities of stimulating epileptic seizures using deep stereo-EEG electrodes in presurgical diagnosis in patients with drug-resistant epilepsy].","authors":"N O Ivin, E A Gordeyeva, N P Utyashev, A A Zuev","doi":"10.17116/jnevro20241240917","DOIUrl":"10.17116/jnevro20241240917","url":null,"abstract":"<p><p>Electrical stimulation mapping using depth stereo-EEG electrodes is an important method in the structure of presurgical diagnostics in patients with drug-resistant forms of epilepsy. Electrical stimulation mapping was first used in the 1960s and has been actively developed since then, but despite such a long history, a unified protocol for the use of this technique has not been developed and different approaches to stimulation mapping are used in different countries. Based on publications on the topic in PubMed and other available resources, we tried to briefly outline the current opinion on the significance of this technique, paying special attention to the methodological approaches of different schools to stimulation parameters when mapping epileptogenic zones, highlighting in a separate section approaches to stimulation of functionally significant zones Finally, we summarize data on the effectiveness of this method in the presurgical diagnostics of epilepsy.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 9","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The effect of ethylmethylhydroxypyridine succinate on the parameters of chronic neuroinflammation and plastic processes in the brain of old rats during course of dexamethasone administration].","authors":"O L Terekhina, Yu I Kirova","doi":"10.17116/jnevro2024124091115","DOIUrl":"10.17116/jnevro2024124091115","url":null,"abstract":"<p><strong>Objective: </strong>To study was to evaluate the potential modulatory impact of succinate/SUCNR1 signaling on the non-genomic immunosuppressive and gene-mediated inflammatory-degenerative effects of glucocorticoid receptor (GR) activation in the cerebral cortex (CC) of aging rats.</p><p><strong>Material and methods: </strong>Using Western blot analysis, we assessed the expression level of pro-inflammatory (TNF-α, IL-1β), anti-inflammatory cytokines (IL-10, TGF-β1), mitochondriogenesis markers (PGC-1α, NDUFV2, SDHA, cyt c1, COX2, ATP5A), angiogenesis marker VEGF, neurotrophin BDNF, GR, succinate receptor SUCNR1 in the CC of 18-month-old rats with isolated administration of the highly specific GR ligand dexamethasone (1 mg/kg, i.p., daily, 10 days) and its combined administration with the succinate-containing drug Mexidol (100 mg/kg, i.p., daily, 10 days).</p><p><strong>Results: </strong>Dexamethasone caused a decrease in the content of all detectable parameters in the CC of 18-month-old rats, including anti-inflammatory IL-10, TGF-β1, PGC-1α, VEGF, BDNF, which progressed by 10 days, amounting to 40-60%, which is consistent with the literature data on transrepression by GR of key pro-inflammatory (NFkB, AP1, STAT1), anti-inflammatory (PPARγ, ERRα), pro-anabolic transcription factors (estrogen, androgen receptors). The administration of Mexidol daily an hour after the injection of dexamethasone did not affect the dexamethasone-induced suppression of pro-inflammatory cytokines, but increased the expression levels of anti-inflammatory cytokines, protein markers of mitochondrio-, angio- and synaptogenesis.</p><p><strong>Conclusion: </strong>The study demonstrates for the first time the prospect and pathogenetic foundation of the combined use of dexamethasone and Mexidol in an aging body in order to minimize the activity of GC aimed at suppressing pro-anabolic programs and mechanisms for resolving inflammation.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 9","pages":"115-121"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Severe traumatic brain injury with damage to the posterior cranial fossa in a teenager].","authors":"V F Byankin, G S Zhdanovich, A V Livadarov, A S Popov","doi":"10.17116/jnevro2024124081113","DOIUrl":"10.17116/jnevro2024124081113","url":null,"abstract":"<p><p>In the presented clinical observation of complex therapy of severe combined trauma: severe brain contusion, subarachnoid hemorrhage, closed fracture of the occipital bone, closed compression fracture of Th_VI-Th_VIII vertebral bodies, contusion of the lungs and kidneys, blunt abdominal trauma and closed fracture of both bones of the right leg in lower third with displacement) in a teenager after an accident, the need for dynamic introscopic examination of the patient is shown for timely detection of abnormalities in the state of brain structures and correction of treatment up to surgical intervention. The effectiveness of the inclusion of Cytoflavin in complex treatment regimens was noted in the form of positive dynamics of the clinical and introscopic picture. The results obtained may serve as a basis for further research.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 8","pages":"113-117"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The effect of pregnancy on multiple sclerosis].","authors":"I V Zakroyshchikova, T O Simaniv, D O Zemlyanaya, A A Timofeeva, M N Zakharova","doi":"10.17116/jnevro202412407243","DOIUrl":"10.17116/jnevro202412407243","url":null,"abstract":"<p><p>Planning for pregnancy and possibility of disease modifying treatment (DMTs) is an important question in female patients of reproductive age who suffer from multiple sclerosis (MS). The frequency of refusals to plan pregnancy is 14%. This is due to numerous concerns about the course of pregnancy, its outcomes, as well as the possible effect of DMTs on the fetus and the probability of disease transmission to a child. The article discusses immunological reactions taking place in MS patients during pregnancy, which are protective in its nature. Data for all groups of DMTs regarding pregnancy planning, possible risks of their impact on fertility and teratogenicity is presented.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 7. Vyp. 2","pages":"43-49"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}