Brain Impairment最新文献

Motor imagery-based brain-computer interface training for post-stroke upper limb dysfunction: systematic review and meta-analysis. 基于运动图像的脑机接口训练治疗脑卒中后上肢功能障碍：系统回顾和荟萃分析。

IF 1.5 4区医学

Brain Impairment Pub Date : 2026-09-24 DOI: 10.1071/IB25022

Zhen Yang, Shangang Zhang, Du Wang, Mengmei Guan, Linru Qiao

{"title":"Motor imagery-based brain-computer interface training for post-stroke upper limb dysfunction: systematic review and meta-analysis.","authors":"Zhen Yang, Shangang Zhang, Du Wang, Mengmei Guan, Linru Qiao","doi":"10.1071/IB25022","DOIUrl":"10.1071/IB25022","url":null,"abstract":"Background: Motor imagery-based brain-computer Interface (MI-BCI) utilises electroencephalographic signals from imagined limb movements for control commands, enabling real-time interaction with external devices. Clinical trials suggest its potential for upper limb recovery post-stroke. This study aims to systematically evaluate the effectiveness of MI-BCI on upper limb motor function in patients with post-stroke hemiplegia.Methods: A comprehensive search was conducted across PubMed, Cochrane Library, Web of Science and Embase through March 2026 for randomised controlled trials assessing MI-BCI effects on upper limb motor impairments post-stroke. A systematic review and meta-analysis were performed.Results: The analysis included 27 studies for systematic review, with meta-analyses encompassing 24 studies involving 846 participants. MI-BCI training showed statistically significant improvements in measures of isolated limb movement and fine motor control, specifically the Fugl-Meyer Assessment for Upper Extremity (s.m.d. 0.31, 95% CI: 0.18-0.45; I² = 17%) and the Wolf Motor Function Test (s.m.d. 0.45, 95% CI: 0.24-0.66; I² = 39%).Conclusions: MI-BCI training can improve upper limb motor function, particularly for isolated movements and fine motor control, in stroke patients. Its effects on complex functional activities, activities of daily living and spasticity were not significant in the current evidence. Due to heterogeneity in control conditions (including sham interventions) across studies, the current evidence does not support definitive conclusions regarding its superiority over standardised traditional rehabilitation.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":"27 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An experimental study of resilience and its effect on simulated persistent postconcussion symptoms. 弹性及其对模拟持续性脑震荡后症状影响的实验研究。

IF 1.5 4区医学

Brain Impairment Pub Date : 2026-09-24 DOI: 10.1071/IB26016

Olivia Beh, Gabrielle Cain, Karen A Sullivan

{"title":"An experimental study of resilience and its effect on simulated persistent postconcussion symptoms.","authors":"Olivia Beh, Gabrielle Cain, Karen A Sullivan","doi":"10.1071/IB26016","DOIUrl":"10.1071/IB26016","url":null,"abstract":"Background: Mild traumatic brain injury (mTBI) is a significant public health concern. Several factors contribute to symptom persistence, including potentially modifiable psychological factors. This study focused on resilience as a predictor of simulated persistent postconcussion symptoms (PPCS).Methods: Participants were randomly assigned to a mTBI vignette condition with (n = 96) or without resilience-activation (control, n = 95). PPCS was measured using the Rivermead Post-Concussion Symptoms Questionnaire. The potential for a moderated relationship was explored using a measure of emotional distress (Hospital Anxiety and Depression Scale).Results: Resilience, as measured by the Connor-Davidson Resilience Scale, was successfully manipulated via the vignette (resilience activation > controls). Hierarchical linear regression (N = 191) demonstrated a significant negative association between group and PPCS, with resilience significantly accounting for 3.27% of unique variance in PPCS. The interaction between predictor variables did not significantly contribute to the overall variance in PPCS.Conclusions: Findings are consistent with prior correlational studies of resilience and PPCS, with the present study also isolating a specific role for resilience as distinct from emotional distress. Psychological resilience appears to be a promising target for PPCS reduction.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":"27 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond word count: a pilot study of the verbal fluency task in chronic mild traumatic brain injury. 超越字数：慢性轻度创伤性脑损伤中语言流畅性任务的初步研究。

IF 1.5 4区医学

Brain Impairment Pub Date : 2026-09-24 DOI: 10.1071/IB26001

Warren C Brown, Anthony P Salvatore, Louise C Keegan, Jerry K Hoepner

{"title":"Beyond word count: a pilot study of the verbal fluency task in chronic mild traumatic brain injury.","authors":"Warren C Brown, Anthony P Salvatore, Louise C Keegan, Jerry K Hoepner","doi":"10.1071/IB26001","DOIUrl":"10.1071/IB26001","url":null,"abstract":"Background: To examine the clustering and switching behaviours, beyond total word count, as indicators of subtle executive dysfunction in individuals with and without a history of mild traumatic brain injury (mTBI), and to determine whether subcomponent analyses reveal cognitive inefficiencies overlooked by standard assessments.Methods: Thirty-five university students (mTBI = 9; controls = 26) aged 18-24 years completed phonemic (FAS) and semantic (animal naming) verbal fluency tasks. Total correct responses, mean cluster size and number of switches were analysed.Results: Compared with controls, individuals with mTBI produced fewer 'S' words (z = 2.66, P = 0.007, r = 0.45) and semantic switches (z = 2.45, P = 0.015, r = 0.41). Both groups were significantly different in semantic and phonemic clusters (mTBI: z = 2.22, P = 0.026, r = 0.74; controls: z = 3.51; P < 0.001, r = 0.69). No group differences were observed for phonemic switching. Findings indicate subtle reductions in cognitive flexibility and verbal productivity in individuals with chronic mTBI.Conclusions: Clustering and switching analyses in verbal fluency tasks may detect subtle, executive deficits in individuals with chronic mTBI that are not captured by total word count alone. These findings support the feasibility of subcomponent verbal fluency measures as sensitive tools for long-term mTBI assessment and monitoring.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":"27 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive portrait of the needs of caregivers of individuals living with a traumatic brain injury: a systematic mixed-methods review. 创伤性脑损伤患者护理人员需求的综合描述：一项系统的混合方法综述。

IF 1.5 4区医学

Brain Impairment Pub Date : 2026-09-24 DOI: 10.1071/IB25030

Pascale Simard, Rania Jribi, Mélanie Levasseur, Marie-Eve Lamontagne

{"title":"Comprehensive portrait of the needs of caregivers of individuals living with a traumatic brain injury: a systematic mixed-methods review.","authors":"Pascale Simard, Rania Jribi, Mélanie Levasseur, Marie-Eve Lamontagne","doi":"10.1071/IB25030","DOIUrl":"10.1071/IB25030","url":null,"abstract":"Background: Caring for an individual living with traumatic brain injury may place physical and emotional demands on caregivers, yet evidence on their specific needs remains fragmented. Synthesising this evidence is therefore essential to address this gap and to inform the development of targeted support strategies. The aim of this study was to appraise and synthesise the evidence the needs of caregivers of individuals living with moderate-to-severe traumatic brain injury.Methods: A mixed-methods systematic review was conducted in 2024 across MEDLINE, PsycINFO, CINAHL and Web of Science (PROSPERO #CRD42023432812) to locate primary studies published in English or French after 2000. Two reviewers conducted the screening. Quality appraisal was completed using the Mixed Methods Appraisal Tool. The Joanna Briggs Institute approach informed data extraction and synthesis.Results: Thirty-two studies were included, nearly half being qualitative. Most study participants were women. The main needs identified included information, mental health support, hope, financial assistance, education of the social network and peer support.Conclusion: Despite variations in quality assessment, findings guide the development of tailored interventions. Given the broad spectrum of needs identified, further studies are necessary to clarify and prioritise those needs to ensure support services are aligned with caregivers' priorities.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":"27 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148633062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with variability in recovery after mild traumatic brain injury among adults referred to outpatient concussion clinics. 与成人轻度创伤性脑损伤后恢复变异性相关的因素涉及门诊脑震荡诊所。

IF 1.5 4区医学

Brain Impairment Pub Date : 2026-09-24 DOI: 10.1071/IB26011

Deborah Snell, Jonathan Williman, Josh Faulkner, Noah D Silverberg, Alice Theadom, Lois Surgenor, Richard Siegert

{"title":"Factors associated with variability in recovery after mild traumatic brain injury among adults referred to outpatient concussion clinics.","authors":"Deborah Snell, Jonathan Williman, Josh Faulkner, Noah D Silverberg, Alice Theadom, Lois Surgenor, Richard Siegert","doi":"10.1071/IB26011","DOIUrl":"10.1071/IB26011","url":null,"abstract":"Background: To understand factors associated with symptom and disability recovery trajectories among adults referred to outpatient clinics after mild traumatic brain injury.Methods: Adults (n = 110; mean age 39 years, 36% men), were assessed at clinic intake (baseline mean 6.5 weeks), and monthly thereafter for 6 months. Validated questionnaires assessed distress, fear avoidance and catastrophising at baseline, and mild traumatic brain injury symptoms and disability. Using correlations and linear mixed modelling, we explored associations between demographic characteristics (age, gender), baseline psychological factors and recovery as a function of time.Results: The models predicted improvement in symptoms (R2 = 0.22) and disability (R2 = 0.37). After adjusting for baseline severity of symptoms and disability, higher distress was associated with slower recovery and greater variability for symptoms (P = 0.06) and disability (P < 0.01). Higher baseline catastrophising predicted less symptom improvement (P = 0.02). Those with higher fear avoidance behaviour at baseline showed greater variability in disability outcomes (P = 0.02), even when other psychological variables were accounted for.Conclusions: Participants showed improvements on average, in both symptoms and disability. Variability and rates of recovery were associated with distress, catastrophising and fear avoidance. Clinicians can target such psychological factors in treatment and anticipate recovery fluctuations, normalising these while maintaining cautiously optimistic messaging regarding expected good prognosis after mild traumatic brain injury.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":"27 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mild traumatic brain injury recovery: a qualitative study of noise sensitivity, vestibular issues and anxiety interactions. 轻度创伤性脑损伤恢复：噪声敏感性、前庭问题和焦虑相互作用的定性研究。

IF 1.5 4区医学

Brain Impairment Pub Date : 2026-09-24 DOI: 10.1071/IB25095

Rebekah Miller, Jennifer A Dunn, Greg A O'Beirne, Susan L Whitney, Deborah Snell

{"title":"Mild traumatic brain injury recovery: a qualitative study of noise sensitivity, vestibular issues and anxiety interactions.","authors":"Rebekah Miller, Jennifer A Dunn, Greg A O'Beirne, Susan L Whitney, Deborah Snell","doi":"10.1071/IB25095","DOIUrl":"10.1071/IB25095","url":null,"abstract":"Background: Mild traumatic brain injury (mTBI) is a common public health issue, and a substantial minority of individuals experience persistent symptoms that disrupt everyday functioning. Although vestibular symptoms, noise sensitivity and anxiety are each recognised following mTBI, little is known about how people make sense of these symptom experiences or perceive their interaction during recovery.Methods: This qualitative study explored the lived experiences of 14 adults recovering from mTBI, purposively sampled from a larger longitudinal cohort. Equal numbers had short (<6 months) or prolonged recovery. Semi-structured interviews were conducted 8-12 months post-injury and analysed using inductive thematic analysis informed by a critical realist framework.Results: Three themes were identified. 'Noise really hurts' described distressing sensitivity to layered or unexpected noise and strategies to seek quiet. 'Broken spirit level' captured vestibular disturbance, including balance, spatial orientation and visual difficulty. 'Amplified apprehension' reflected heightened anxiety, and avoidance of symptom-provoking activities. Although most participants reported one or more symptoms, a minority explicitly described perceived relationships between them. Noise sensitivity was particularly prominent among those with prolonged recovery.Conclusion: Symptom experiences following mTBI are context dependent and can meaningfully constrain participation. Greater clinical attention to vestibular symptoms, noise sensitivity, and anxiety/fear-avoidance may support more responsive assessment and rehabilitation following mTBI.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":"27 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The change in mental well-being over 1 year for people with neurological disabilities and complex needs after moving into individualised housing: an exploratory sequential mixed-methods study. 有神经障碍和复杂需求的人在搬进个性化住房后一年内心理健康的变化：一项探索性顺序混合方法研究。

IF 1.5 4区医学

Brain Impairment Pub Date : 2026-09-24 DOI: 10.1071/IB25032

Rebecca Rothman, Stacey Oliver, Jacinta Douglas, Kate D'Cruz, Di Winkler

{"title":"The change in mental well-being over 1 year for people with neurological disabilities and complex needs after moving into individualised housing: an exploratory sequential mixed-methods study.","authors":"Rebecca Rothman, Stacey Oliver, Jacinta Douglas, Kate D'Cruz, Di Winkler","doi":"10.1071/IB25032","DOIUrl":"10.1071/IB25032","url":null,"abstract":"Background: Although housing is a social determinant of health, little is known about the well-being of people with a neurological disability after moving into individualised housing from a range of previous living arrangements. This exploratory sequential mixed-methods study explored the change in well-being at 6 and 12 months post-move, addressing the need to better understand well-being trajectories among people with neurological disabilities transitioning to individualised housing.Methods: Sixteen participants with a neurological disability completed the Warwick-Edinburgh Mental Well-being Scale, and interviews at pre-move, and 6 and 12 months post-move. Paired samples t-test and reliable change index compared Warwick-Edinburgh Mental Well-being Scale scores. A qualitative collective-case study was conducted for three participants with clinically reliable changes of well-being at 12 months.Results: Well-being significantly increased at 6 months post-move (t(15) = 1.85, P = 0.04), with no significant improvements found at 12 months post-move. The Warwick-Edinburgh Mental Well-being Scale item of 'feeling useful' significantly increased at 6 months (t(15) = 3.78, P = 0.002) and 12 months post-move (t(15) = 2.42, P = 0.014). Case study analysis revealed an overarching pattern of having a secure base and three sub-patterns: doing more at home, pursuing new opportunities and developing stronger social connections.Conclusions: Findings support the transition to individualised housing with results indicating increased feelings of usefulness, an important aspect of well-being. The importance of having a secure base for improved well-being is also highlighted. Further research is needed to understand what sustains well-being in individualised housing.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":"27 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing frequencies: Boston Naming Test normative data for Australian young adults. 改变频率：波士顿命名测试对澳大利亚年轻人的规范性数据。

IF 1.5 4区医学

Brain Impairment Pub Date : 2026-09-24 DOI: 10.1071/IB25146

Chloe Sidwell, Annabel Hudson, Genevieve Rayner, Charles B Malpas, Fiore D'Aprano

{"title":"Changing frequencies: Boston Naming Test normative data for Australian young adults.","authors":"Chloe Sidwell, Annabel Hudson, Genevieve Rayner, Charles B Malpas, Fiore D'Aprano","doi":"10.1071/IB25146","DOIUrl":"10.1071/IB25146","url":null,"abstract":"Background: The Boston Naming Test (BNT) is a commonly used measure of visual confrontation naming, where performance is quantified relative to demographically representative normative data. Given that there are currently no BNT normative data for Australian young adults, the present study aimed to create normative data and determine item familiarity among this population.Methods: Participants were 73 Australian university students (mean age 20.04 years, range 18-34 years old, 73% assigned female at birth). Participants were sampled on the standard BNT-2 items 1-60 and three additional Australian items. Normative data were created for this sample, producing z, T and percentile scores for raw BNT scores. Additionally, the number of correct responses to each item was calculated as the index of item familiarity.Results: Mean BNT scores (mean 52.23/60, s.d. 4.44) were determined. At an item level, the current sample was uniquely unfamiliar with items 'yoke', 'trellis' and 'latch', and more familiar with items 'pretzel' and 'beaver' than normative samples from Australia and New Zealand.Conclusions: Normative BNT data were produced for Australian young adults, the unique performance of which highlights the importance of representative and iteratively updated BNT normative data for accurate clinical decision-making.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":"27 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Māori experiences of neuroimaging practice in Aotearoa: illuminating cultural needs and opportunities to support whānau Māori (Māori families). Māori奥特罗阿的神经影像学实践经验：阐明文化需求和支持whānau Māori （Māori家庭）的机会。

IF 1.5 4区医学

Brain Impairment Pub Date : 2026-09-24 DOI: 10.1071/IB25071

Ebony Komene, Monica Koia, Hinemoa Elder, Hone Morris, Corinne Bareham

{"title":"Māori experiences of neuroimaging practice in Aotearoa: illuminating cultural needs and opportunities to support whānau Māori (Māori families).","authors":"Ebony Komene, Monica Koia, Hinemoa Elder, Hone Morris, Corinne Bareham","doi":"10.1071/IB25071","DOIUrl":"10.1071/IB25071","url":null,"abstract":"Background: Culturally safe health care relies on partnering with Indigenous communities to determine and meet their care needs. For Māori, the head - and particularly the roro (brain) - is regarded as the most tapu (sacred) part of the body, yet there are currently no national-level guidelines for conducting neuroimaging in Aotearoa. Describing Māori experiences and their cultural considerations for neuroimaging practices offers opportunities to support culturally safe neuroimaging practice.Methods: A Māori-centred approach guided this study. Semi-structured uiuinga (interviews) with three Māori men (aged 20, 21 and 46 years), who had previously participated in an electroencephalography session, were co-led by Māori and non-Māori researchers.Results: Reflexive thematic analysis identified key themes across the neuroimaging journey, highlighting the importance of relational engagement, culturally grounded communication to support shared decision-making, and the integration of Māori values to enhance whānau confidence, agency and wellbeing. A second stage of collective data analysis, known as mahi ā-rōpū, involved participants, Māori language and tikanga (cultural) experts, and researchers informing the co-design of neuroimaging guidelines to enhance culturally safe practice in Aotearoa.Conclusion: The research offers insight into Māori experiences of neuroimaging, and shows how Indigenous perspectives can be meaningfully integrated to ensure healthcare practices align with Māori values. The guideline proposed is an iterative starting point to inform care design, supporting both whānau and professionals when undertaking neuroimaging in Aotearoa.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":"27 3","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between physical activity levels and stroke incidence in middle-aged and older populations: a cross-sectional and Mendelian randomisation study. 中老年人群体力活动水平与卒中发病率之间的关系：横断面和孟德尔随机化研究。

IF 1.5 4区医学

Brain Impairment Pub Date : 2026-06-26 DOI: 10.1071/IB24116

Fengjiao Zhang, Dan Zhao, Zhaoyin Su, Zhenxia Huang, Jing Zhang

{"title":"Association between physical activity levels and stroke incidence in middle-aged and older populations: a cross-sectional and Mendelian randomisation study.","authors":"Fengjiao Zhang, Dan Zhao, Zhaoyin Su, Zhenxia Huang, Jing Zhang","doi":"10.1071/IB24116","DOIUrl":"10.1071/IB24116","url":null,"abstract":"Background: In the middle-aged and older population, the association between different levels of physical activity and the risk of stroke remains unclear.Methods: Data were sourced from the China Health and Retirement Longitudinal Study. A cross-sectional analysis of risk factors for stroke incidence in the middle-aged and older population was conducted. Mendelian randomisation analyses, conducted using European population data, were utilised to assess causality between physical activity and the reduction of stroke risk.Results: A total of 1368 (7.05%) participants developed stroke among the 19,395 participants. The incidence of stroke was higher among participants aged ≥65 years (OR 1.049, 95% CI 1.043-1.055, P < 0.001), those married but separated (OR 2.004, 95% CI 1.091-3.683, P = 0.025) and widowed individuals (OR 1.669, 95% CI 1.452-1.919, P < 0.001). After adjusting for marital status and education level, being aged ≥ 65 years (OR 2.398, 95% CI 2.139-2.668, P < 0.001) was associated with an increased risk of stroke incidence. Being female (OR 0.834, 95% CI 0.746-0.933, P ＝ 0.001) was associated with a decreased risk of stroke incidence. Additionally, moderate-intensity physical activity (OR 0.755, 95% CI 0.652-0.874, P < 0.001) and high-intensity physical activity (OR 0.498, 95% CI 0.433-0.572, P < 0.001) were also associated with a reduced risk of stroke incidence. The Mendelian randomisation analyses, leveraging the inverse variance weighted method, unveiled substantial causal links between physical activity and stroke risk.Conclusion: Engaging in moderate physical activity could lower the risk of stroke. Additionally, being female, having higher levels of education and enjoying a satisfying family life may also contribute to reducing the risk of stroke incidence.","PeriodicalId":56329,"journal":{"name":"Brain Impairment","volume":"27 2","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0