Breast Journal最新文献

{"title":"Clinical Features and Prognosis Analysis of Hormone Receptor-Positive, HER2-Negative Breast Cancer with Differential Expression Levels of Estrogen and Progesterone Receptors: A 10-Year Retrospective Study","authors":"Jin Liu,&nbsp;Mingyu Gan,&nbsp;Zijing Lin,&nbsp;Qin Deng,&nbsp;Juan Deng,&nbsp;Bin Zeng,&nbsp;Yanling Shi,&nbsp;Jia Ming","doi":"10.1155/2022/5469163","DOIUrl":"10.1155/2022/5469163","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Estrogen and progesterone receptor status can predict breast cancer patient prognosis and treatment sensitivity, but research on low ER and PR levels and expression balance remains limited. <i>Methods</i>. From January 2010 to October 2016, 283 ER+/PR+/HER2-breast cancer patients who met the inclusion criteria were enrolled and divided into the H group (ER &gt; 10%, <i>N</i> = 261) and the <i>L</i> group (1% ≤ ER ≤ 10%, <i>N</i> = 22). Groups were further divided into the HH group (ER &gt; 10%/PR &gt; 20%, <i>N</i> = 201), the HL group (ER &gt; 10%/ER 1% ≤ PR ≤ 20% PR, <i>N</i> = 60), the LH group (1% ≤ ER ≤ 10%/PR &gt; 20%, <i>N</i> = 5), and the LL group (1% ≤ ER ≤ 10%/1% ≤ PR ≤ 20%, <i>N</i> = 17). The LH group was excluded due to its small size, leaving the clinical and prognostic characteristics of 2 large groups and 3 subgroups to be analyzed. <i>Results</i>. <i>L</i> group patients had significantly more stage <i>N</i>2 axillary lymph nodes than H group patients (31.8% vs. 9.2%, <i>P</i> = 0.007). Age (<i>P</i> = 0.011), menopause status (<i>P</i> = 0.001), and tumor size (<i>P</i> = 0.024) were significantly different in the HL vs. HH and LL groups. Five-year DFS (94.6% vs. 77.0%, <i>P</i> &lt; 0.001) and 5-year OS (97.2% vs. 85.8%, <i>P</i> = 0.001) rates significantly differed between HH and HL. No significant differences in 5-year DFS (77.0% vs. 81.9%, <i>P</i> = 0.564) or 5-year OS (85.8% vs. 87.8%, <i>P</i> = 0.729) rates were observed between HL and LL; the OS rates of HL and LL were similar. <i>Conclusion</i>. In the group of ER+/PR+/HER2-patients, there was no significant prognostic difference between ER-low positive and ER-high positive groups, but low PR expression was significantly associated with a worse prognosis. The role of ER and PR balance in breast cancer progression and individualized treatment requires further investigation.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10789973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserving Nipple Sensitivity after Breast Cancer Surgery: A Systematic Review and Meta-Analysis","authors":"Varsha Harish,&nbsp;Zoe K. Haffner,&nbsp;Jenna C. Bekeny,&nbsp;Adaah A. Sayyed,&nbsp;David H. Song,&nbsp;Kenneth L. Fan","doi":"10.1155/2022/9654741","DOIUrl":"10.1155/2022/9654741","url":null,"abstract":"<div>\u0000 <p><i>Purpose</i>. As breast-conserving procedures become increasingly safe and viable options for surgical management of breast cancer, efforts have focused on assessing and optimizing patient-reported outcome measures (PROMs), such as nipple sensation. This study aims to evaluate the current understanding of nipple-areolar complex (NAC) sensation outcomes in breast cancer patients undergoing breast cancer surgeries, namely, nipple-sparing mastectomies (NSM), skin-sparing mastectomies (SSM), and lumpectomies. <i>Methods</i>. Articles including terms related to “nipple,” “mastectomy,” “sensation,” and “patient-reported outcome” were queried from three databases according to PRISMA guidelines. Study characteristics, patient demographics, and surgical details were recorded. Outcomes of interest included objective nipple sensitivity testing and PROMs. <i>Results</i>. Of 888 manuscripts identified, 28 articles met the inclusion criteria. Twelve studies (<i>n</i> = 578 patients) used objective measures to evaluate sensitivity, such as monofilament testing. Sixteen studies (<i>n</i> = 1785 patients) assessed PROMs through validated or investigator-generated surveys. Three of the included studies reported NAC sensitivity in patients who received NSM with neurotization (<i>n</i> = 203 patients) through a variety of techniques that used various grafts to coapt a lateral intercostal nerve to the NAC nerve stumps. Results of investigator surveys showed that of 1565 patients without neurotization, nipple sensation was maintained in 29.0% (<i>n</i> = 453) of patients. Of 138 NSM patients without NAC neurotization, SWM testing showed an average loss of protective sensation in the nipple (average SWM score: 4.7) compared to normal or diminished sensation to light touch in nonoperated controls (average SWM score: 2.9, <i>n</i> = 195). Of patients who underwent NSM with neurotization, one study (<i>n</i> = 78) reported maintenance of NAC sensation in 100% of patients, while another study (<i>n</i> = 7) reported average diminished protective sensation in the nipple (average SWM score: 3.9). <i>Conclusion</i>. Our study has shown that objective and patient-reported results of nipple sensitivity support nipple-sparing techniques as a viable option for preserving NAC sensation, although patients can expect a decrease in sensation overall. Neurotization of the NAC during NSM shows promising results of improved postoperative nipple sensitivity, though additional studies are warranted to confirm this finding. Variations between study methodologies highlight the lack of standardization in sensory testing techniques when evaluating NAC sensation.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10343396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Physical Exercise, Quality of Life, Psychological Symptoms and Treatment Side Effects in Early Breast Cancer","authors":"Leena Vehmanen,&nbsp;Johanna Mattson,&nbsp;Evangelos Karademas,&nbsp;Albino J. Oliveira-Maia,&nbsp;Berta Sousa,&nbsp;Ruth Pat-Horenczyk,&nbsp;Ketti Mazzocco,&nbsp;Panagiotis Simos,&nbsp;Fátima Cardoso,&nbsp;Greta Pettini,&nbsp;Chiara Marzorati,&nbsp;Eleni Kolokotroni,&nbsp;Georgios Stamatakos,&nbsp;Diana Frasquilho,&nbsp;Paula Poikonen-Saksela","doi":"10.1155/2022/9921575","DOIUrl":"10.1155/2022/9921575","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Identifying and understanding modifiable factors for the well-being of cancer patients is critical in survivorship research. We studied variables associated with the exercise habits of breast cancer patients and investigated if the achievement of exercise recommendations was associated with enhanced quality of life and/or psychological well-being. <i>Material and Methods</i>. 311 women from Finland, Portugal, Israel, and Italy receiving adjuvant therapy for stage I–III breast cancer answered questions about sociodemographic factors and physical exercise. Quality of life was assessed by the EORTC C30 and BR23 questionnaires. Anxiety and depression were evaluated using the HADS scale. <i>Results</i>. At the beginning of adjuvant therapy and after twelve months, 32% and 26% of participants were physically inactive, 27% and 30% exercised between 30 and 150 minutes per week, while 41% and 45% exercised the recommended 150 minutes or more per week. Relative to other countries, Finnish participants were more likely to be active at baseline and at twelve months (89% vs. 50%, <i>p</i> &lt; 0.001 and 87% vs. 64%, <i>p</i> &lt; 0.001). Participants with stage I cancer were more likely to be active at twelve months than those with a higher stage (80% vs. 70%,<i>p</i> &lt; 0.05). The inactive participants reported more anxiety (<i>p</i> &lt; 0.05) and depression (<i>p</i> &lt; 0.001), lower global quality of life (<i>p</i> &lt; 0.001), and more side effects (<i>p</i> &lt; 0.05) than the others at twelve months. Accordingly, those who remained inactive or decreased their level of exercise from baseline to twelve months reported more anxiety (<i>p</i> &lt; 0.01) and depression (<i>p</i> &lt; 0.001), lower global quality of life (<i>p</i> &lt; 0.001), and more side effects (<i>p</i> &lt; 0.05) than those with the same or increased level of exercise. <i>Conclusion</i>. For women with early breast cancer, exercise was associated with a better quality of life, less depression and anxiety, and fewer adverse events of adjuvant therapy. Trial registration number: NCT05095675. Paula Poikonen-Saksela on behalf of Bounce consortium (https://www.bounce-project.eu/).</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10336653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Characteristics of Breast Cancer Detected through Different Imaging Modalities in a Large Cohort of Hong Kong Chinese Women: Implication of Imaging Choice on Upcoming Local Screening Program","authors":"Yik Shuen Chan,&nbsp;Wai Ka Hung,&nbsp;Lok Wa Yuen,&nbsp;Ho Yan Yolanda Chan,&nbsp;Chiu Wing Winnie Chu,&nbsp;Polly Suk Yee Cheung","doi":"10.1155/2022/3882936","DOIUrl":"10.1155/2022/3882936","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. We compared the clinico-radio-pathological characteristics of breast cancer detected through mammogram (MMG) and ultrasound (USG) and discuss the implication of the choice of imaging as the future direction of our recently launched local screening program. <i>Methods</i>. Retrospective study of 14613 Hong Kong Chinese female patients with histologically confirmed breast cancer registered in the Hong Kong Breast Cancer Registry between January 2006 and February 2020. Patients were classified into four groups based on the mode of breast cancer detection (detectable by both mammogram and ultrasound (MMG+/USG+), mammogram only (MMG+/USG−), ultrasound only (MMG−/USG+), or not detectable by either (MMG−/USG−). Characteristics of breast cancer detected were compared, including patient demographics, breast density on MMG, mode of presentation, tumour size, histological type, and staging. Types of mammographic abnormalities were also evaluated for MMG+ subgroups. <i>Results</i>. 85% of the cancers were detectable by MMG, while USG detected an additional 9%. MMG+/USG+ cancers were larger, more advanced in stage, often of symptomatic presentation, and commonly manifested as mammographic mass. MMG+/USG− cancers were more likely of asymptomatic presentation, manifested as microcalcifications, and of earlier stage and to be ductal carcinoma in situ. MMG−/USG+ cancers were more likely seen in young patients and those with denser breasts and more likely of symptomatic presentation. MMG−/USG− cancers were often smaller and found in denser breasts. <i>Conclusion</i>. Mammogram has a good detection rate of cancers in our local population. It has superiority in detecting early cancers by detecting microcalcifications. Our current study agrees that ultrasound is one of the key adjunct tools of breast cancer detection.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9569198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ductal Carcinoma In Situ (DCIS) Diagnosed by MRI-Guided Biopsy among BRCA1/BRCA2 Mutation Carriers","authors":"Renata Faermann,&nbsp;Eitan Friedman,&nbsp;Orit Kaidar-Person,&nbsp;Jonathan Weidenfeld,&nbsp;Malka Brodsky,&nbsp;Anat Shalmon,&nbsp;Osnat Halshtok Neiman,&nbsp;Michael Gotlieb,&nbsp;Yael Yagil,&nbsp;David Samoocha,&nbsp;Dana Madorsky Feldman,&nbsp;Miri Sklair-Levy","doi":"10.1155/2022/4317693","DOIUrl":"10.1155/2022/4317693","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. While <i>BRCA1/BRCA2</i> pathogenic sequence variants (PSVs) clearly confer an increased risk for invasive breast cancer, the extent to which these mutant alleles increase DCIS risk is less clear. <i>Objective</i>. To assess the rate of detection over a 5-year period, and MRI imaging features of pure noncalcified DCIS in a cohort of Israeli <i>BRCA1/BRCA2</i> PSV carriers attending a high-risk clinic from 2015 to 2020. <i>Materials and Methods</i>. All female <i>BRCA1/BRCA2</i> PSV-carriers followed at the Meirav High-risk clinic from 2015 to 2020 were eligible if they underwent semiannual breast imaging (MRI/mammography) and MRI-guided biopsy-proven pure DCIS. Clinical data, pathology information, and imaging characteristics were retrieved from the computerized archiving system. <i>Results</i>. 18/121 (15.2%) participating <i>BRCA1</i> PSV carriers and 8/81 (10.1%) <i>BRCA2</i> PSV-carriers who underwent MRI-guided biopsy were diagnosed with DCIS. The median age of <i>BRCA1</i> carriers and <i>BRCA2</i> carriers was 49.8 years and 60.6 years, respectively (<i>p</i> = 0.55). Negative estrogen-receptor tumors were diagnosed in 13/18 (72%) <i>BRCA1</i> and 2/8 (25%) <i>BRCA2</i> PSV carriers (<i>p</i> &lt; 0.05). Thirteen (13/18–72%) <i>BRCA1</i> carriers had intermediate to high-grade or high-grade DCIS compared with 4/8 (50%) of <i>BRCA2</i> carriers (<i>p</i> = 0.03). Over the 5-year study period, 29/1100 (2.6%) <i>BRCA1/BRCA2</i> PSV carriers were diagnosed with DCIS seen on MRI only. <i>Conclusion</i>. MRI-detected noncalcified DCIS is more frequent in <i>BRCA1</i> PSV carriers compared with <i>BRCA2</i> carriers, unlike the <i>BRCA2</i> predominance in mammography-detected calcified DCIS. <i>BRCA1</i>-related DCIS is diagnosed earlier, more likely to be estrogen receptor-negative and of higher grade compared with <i>BRCA2</i>-related DCIS. Future prospective studies should validate these results and assess the actual impact they might have on clinical management of <i>BRCA</i> PSV carriers.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10404786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Nipple- or Skin-Sparing Mastectomy and Immediate Breast Reconstruction with Endoscopic Harvesting of the Latissimus Dorsi Flap: A Preliminary Experience of an Innovative Technique","authors":"Yu Feng,&nbsp;Nan Wen,&nbsp;Faqing Liang,&nbsp;Jiao Zhou,&nbsp;Xiangquan Qin,&nbsp;Xinran Liu,&nbsp;Juan Li,&nbsp;Mengxue Qiu,&nbsp;Huanzuo Yang,&nbsp;Zhenggui Du","doi":"10.1155/2022/1373899","DOIUrl":"10.1155/2022/1373899","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Endoscopic nipple- or skin-sparing mastectomy (E-N/SSM) and endoscopic latissimus dorsi muscle flap (E-LDMF) harvest have been operational difficulties over decades. The aim of this study was to describe the preliminary outcomes of our novel surgical technique, which allows the performance of E-N/SSM and E-LDMF harvest for immediate breast reconstruction (IBR) through a single cosmetic axillary incision for breast cancer patients. <i>Methods</i>. This prospective study included 20 breast cancer patients who underwent E-N/SSM and E-LDMF harvesting through a single axillary incision in our hospital from September 2020 to June 2022. The outcomes were statistically calculated, including patient characteristics, operative data, complication rate, hospital length of stay and costs, and patient-reported outcomes. <i>Results</i>. A total of 20 breast cancer patients underwent our sufficiently mature novel endoscopy technique. The mean LD flap harvest time was 96.5 ± 25.3 min, the mean operation time was 262.6 ± 54.4 min, and the average length of LDMF was 26.9 ± 3.1. During the median follow-up time of 7.5 months, 4 patients developed donor-site seroma. One of them was also complicated by hypopigmentation of the nipple areola, and one of them suffered from breast cellulitis. No bleeding or flap necrosis happened. No tumor recurrence or metastasis was found until the last follow-up. In the BREAST-Q evaluation, although they gave a lower score beginning at 1-month post-operation than preoperatively (<i>P</i> &gt; 0.05, except for physical well-being: chest and physical well-being: back and shoulder, <i>P</i> &lt; 0.01), there was an uptrend at 3 months postoperatively. Because of the hidden and short incision, the mean score of the appearance scale of the SCAR-Q at 3 months post-operation was 74.2 ± 8.8. <i>Conclusions</i>. The novel endoscopy technique, which was first reported to perform lymph node surgery, N/SSM, and LDMF harvesting in an operation for breast cancer patients through a single axillary incision, is associated with a shorter surgery time, lower complication rates, and better patient-reported outcomes.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10412987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Useful Reduction Mammoplasty Technique in Oncoplastic Breast Surgery and Reconstruction","authors":"Jong Ho Lee,&nbsp;Jeong Yeop Ryu,&nbsp;Kang Young Choi,&nbsp;Jung Dug Yang,&nbsp;Ho Yun Chung,&nbsp;Byung Chae Cho,&nbsp;Byeongju Kang,&nbsp;Jeeyeon Lee,&nbsp;Ho Yong Park,&nbsp;Joon Seok Lee","doi":"10.1155/2022/2952322","DOIUrl":"10.1155/2022/2952322","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. A combination of the reduction mammoplasty technique and breast reconstruction allows surgeons to lift ptotic breasts through local flaps and skin reduction during surgery for breast cancer. This study presents a reliable course for the combination of partial and skin or nipple-sparing mastectomy with reduction-reconstruction surgery. <i>Methods</i>. Fifty-seven patients underwent a partial mastectomy before reduction mammoplasty of both breasts during the same time period between 2014 and 2021 at our institution and thirteen patients underwent skin or nipple-sparing mastectomy, breast reconstruction with an extended latissimus dorsi flap or silicone implant, and aesthetic reduction mammoplasty of the contralateral breast during the same time period. Additional photos were obtained preoperatively, immediately after the operation, and at one, three, six, and twelve months postoperatively. Patient satisfaction was evaluated preoperatively and postoperatively and postoperative complications were noted. <i>Results</i>. Among the patients who underwent a partial mastectomy, the mean age was 45.18 ± 11.05 years, the mean body mass index (BMI) was 26.74 ± 3.53 kg/m², and the mean preoperative right and left breast volumes were 663.85 (±28.12) cc and 664.34 (±37.13) cc, respectively, and the mean excised mass weight was 177.74 (±213.93) g. Among the patients who underwent a skin-sparing mastectomy, the mean age was 51.62 ± 8.96 years, the mean BMI was 26.91 ± 4.34 kg/m², and the mean preoperative right and left breast volumes were 624.17 (±98.52) cc and 562.31 (±80.81) cc, respectively, and the mean excised mass weight was 618.05 (±338.17) g. Four patients (5.3%) in the partial mastectomy group had fat necrosis. The mean patient satisfaction score was higher postoperatively in both groups. <i>Conclusion</i>. Patients with breast cancer and large and/or ptotic breasts can successfully undergo reduction mammoplasty for both breasts immediately following partial mastectomy and nipple or skin-sparing mastectomy.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10417446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer Epidemiology and Survival Analysis of Shenyang in Northeast China: A Population-Based Study from 2008 to 2017","authors":"Hongbo Su,&nbsp;Xun Li,&nbsp;Yi Lv,&nbsp;Xueshan Qiu","doi":"10.1155/2022/6168832","DOIUrl":"10.1155/2022/6168832","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. To investigate the status of breast cancer incidence, trends, and survival in women in urban Shenyang from 2008–2017 using large Cancer Registry data. <i>Methods</i>. Breast cancer incidence and mortality data were abstracted from the Shenyang Cancer Registry between 2008 and 2017. The crude and age-standardized incidence and mortality rates were calculated for each year. Average annual percentage changes (AAPC) were used to describe the change over time. <i>Results</i>. A total of 14,255 out of 18,782,956 women were diagnosed with breast cancer between 2008 and 2017 in urban Shenyang. The overall crude and age-standardized incidences were 75.89 and 43.42 per 100,000, respectively. The crude incidence increased from 61.93 per 100,000 in 2008 to 90.07 per 100,000 in 2017, with an AAPC of 5.10%. The crude mortality increased from 11.41 per 100,000 in 2008 to 17.29 per 100,000 in 2017, with an AAPC of 4.60. The highest age-specific incidence occurs in the 55–59 year age group at a rate of 140.67 per 100,000. During the study period, 2,710 women died from breast cancer. The overall crude and age-standardized mortality rates were 14.43 and 7.43 per 100,000, respectively. The highest age-specific mortality occurs at 80–84 years old at a rate of 57.57 per 100,000. The 3-year and 5-year survival rates for female breast cancer in urban Shenyang from 2008 to 2013 were 85.61% and 77.39%, respectively, and both declined with age. <i>Conclusion</i>. The incidence and mortality rates of breast cancer in Shenyang increased over time. Screening and control strategies should be enhanced, especially for perimenopausal females.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40448745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of the Pathological Perspective in the Management of the Invasive Lobular Carcinoma","authors":"Funda Tasli,&nbsp;Demet Cavdar,&nbsp;Sibel Demir Kececi,&nbsp;Baha Zengel,&nbsp;Zehra Hilal Adibelli,&nbsp;Gamze Dal,&nbsp;Irem Gonen,&nbsp;Ozden Oz,&nbsp;Cengiz Yilmaz,&nbsp;Ozlem Ozdemir,&nbsp;Hulya Mollamehmetoglu,&nbsp;Ismail Dilek,&nbsp;Enver Ilhan,&nbsp;Adam Uslu","doi":"10.1155/2022/2461242","DOIUrl":"10.1155/2022/2461242","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Invasive lobular carcinomas (ILC) account for 10–15% of all breast cancers and are the second most common histological form of breast cancer. They usually show a discohesive pattern of single cell infiltration, tend to be multifocal, and the tumor may not be accompanied by a stromal reaction. Because of these histological features, which are not common in other breast tumors, radiological detection of the tumor may be difficult, and its pathological evaluation in terms of size and spread is often problematic. The SSO-ASTRO guideline defines the negative surgical margin in breast-conserving surgeries as the absence of tumor detection on the ink. However, surgical margin assessment in invasive lobular carcinomas has not been much discussed from the pathological perspective. <i>Methods</i>. The study included 79 cases diagnosed with invasive lobular carcinoma by a Tru-cut biopsy where operated in our center between 2014 and 2021. Clinicopathological characteristics of the cases, results of an intraoperative frozen evaluation in cases that underwent conservative surgery, the necessity of re-excision and complementary mastectomy, and consistency in radiological and pathological response evaluation in cases receiving neoadjuvant treatment were questioned. <i>Results</i>. The tumor was multifocal in 37 (46.8%) cases and single tumor focus in 42 (53.2%) cases. When the entire patient population was evaluated, regardless of focality, mastectomy was performed in 27 patients (34.2%) and breast-conserving surgery (BCS) was performed in 52 patients (65.8%). Of the 52 patients who underwent BCS, 26 (50%) required an additional surgical procedure (cavity revision or completion mastectomy). There is a statistical relationship between tumor size and additional surgical intervention (<i>p</i> &lt; 0.05). BCS was performed in 7 of 12 patients who were operated on after neoadjuvant treatment, but all of them were reoperated with the same or a second session and turned to mastectomy. Neoadjuvant treatment and the need for reoperation were statistically significant (<i>p</i> &lt; 0.05). Additional surgical procedures were performed in 20 (44.4%) of 45 patients in BCS cases who did not receive neoadjuvant therapy. <i>Conclusions</i>. Diagnostic difficulties in the intraoperative frozen evaluation of invasive lobular carcinoma are due to the different histopathological patterns of the ILC. In our study, it was determined that large tumor size and neoadjuvant therapy increased the need for additional surgical procedures. It is thought that the pathological perspective is the determining factor in order to minimize the negative effects such as unsuccessful cosmesis, an additional surgical burden on the patient, and cost increase that may occur with additional surgical procedures; for this reason, new approaches should be discussed in the treatment planning of invasive lobular carcinoma cases.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33509945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacitracin for Injection Recall: Impact on Immediate Breast Implant Surgical Outcomes","authors":"Abigail R. Tirrell,&nbsp;Jenna C. Bekeny,&nbsp;Eshetu A. Tefera,&nbsp;David H. Song,&nbsp;Kenneth L. Fan","doi":"10.1155/2022/1389539","DOIUrl":"10.1155/2022/1389539","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Triple-antibiotic irrigation of breast implant pockets is a mainstay of infection prophylaxis in breast reconstruction and augmentation. The recall of bacitracin for injection due to risk of anaphylaxis and nephrotoxicity in January 2020, a staple component of the irrigation solution, has raised concern for worsened postoperative sequelae. This study aimed to investigate pre- and post-recall implant-based breast surgery to analyze the impact of bacitracin in irrigation solutions on infection rates. <i>Methods</i>. All implant-based breast reconstruction or augmentation surgeries from January 2019 to February 2021 were retrospectively reviewed. In a regression discontinuity study design, patients were divided into pre- and post-recall groups. Patient demographics, surgical details, and outcomes including infection rates were collected. Differences in complication rates were compared between groups and with surgical and patient factors. <i>Results</i>. 254 implants in 143 patients met inclusion criteria for this study, with 172 implants placed before recall and 82 placed after recall. Patients in each cohort did not differ in age, BMI, smoking status, or history of breast radiation or capsular contracture (<i>p</i> &gt; 0.05). All breast pockets were irrigated with antibiotic solution, most commonly bacitracin, cefazolin, gentamycin, and povidone-iodine before recall (116,67.4%) and cefazolin, gentamycin, and povidone-iodine after recall (59,72.0%). There was no difference in incidence of infection (6.4% vs. 8.5%, <i>p</i> = 0.551) or cellulitis (3.5% vs. 3.7%, <i>p</i> = 0.959) before and after recall. Implant infection was associated with smoking history (<i>p</i> &lt; 0.001) and increased surgical time (<i>p</i> = 0.003). <i>Conclusions</i>. Despite the recent recall of bacitracin from inclusion in breast pocket irrigation solutions, our study demonstrated no detrimental impact on immediate complication rates. This shift in irrigation protocols calls for additional investigations into optimizing antibiotic combinations in solution, as bacitracin is no longer a viable option, to improve surgical outcomes and long-term benefits.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40357969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}