Breast Journal最新文献

{"title":"Comparison of Characteristics of Breast Cancer Detected through Different Imaging Modalities in a Large Cohort of Hong Kong Chinese Women: Implication of Imaging Choice on Upcoming Local Screening Program.","authors":"Yik Shuen Chan,&nbsp;Wai Ka Hung,&nbsp;Lok Wa Yuen,&nbsp;Ho Yan Yolanda Chan,&nbsp;Chiu Wing Winnie Chu,&nbsp;Polly Suk Yee Cheung","doi":"10.1155/2022/3882936","DOIUrl":"https://doi.org/10.1155/2022/3882936","url":null,"abstract":"<p><strong>Background: </strong>We compared the clinico-radio-pathological characteristics of breast cancer detected through mammogram (MMG) and ultrasound (USG) and discuss the implication of the choice of imaging as the future direction of our recently launched local screening program.</p><p><strong>Methods: </strong>Retrospective study of 14613 Hong Kong Chinese female patients with histologically confirmed breast cancer registered in the Hong Kong Breast Cancer Registry between January 2006 and February 2020. Patients were classified into four groups based on the mode of breast cancer detection (detectable by both mammogram and ultrasound (MMG+/USG+), mammogram only (MMG+/USG-), ultrasound only (MMG-/USG+), or not detectable by either (MMG-/USG-). Characteristics of breast cancer detected were compared, including patient demographics, breast density on MMG, mode of presentation, tumour size, histological type, and staging. Types of mammographic abnormalities were also evaluated for MMG+ subgroups.</p><p><strong>Results: </strong>85% of the cancers were detectable by MMG, while USG detected an additional 9%. MMG+/USG+ cancers were larger, more advanced in stage, often of symptomatic presentation, and commonly manifested as mammographic mass. MMG+/USG- cancers were more likely of asymptomatic presentation, manifested as microcalcifications, and of earlier stage and to be ductal carcinoma in situ. MMG-/USG+ cancers were more likely seen in young patients and those with denser breasts and more likely of symptomatic presentation. MMG-/USG- cancers were often smaller and found in denser breasts.</p><p><strong>Conclusion: </strong>Mammogram has a good detection rate of cancers in our local population. It has superiority in detecting early cancers by detecting microcalcifications. Our current study agrees that ultrasound is one of the key adjunct tools of breast cancer detection.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9569198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farewell to The Breast Journal: A novel scientific publication led by a pathologist who moved beyond the microscope and faced the patients","authors":"Shahla Masood MD","doi":"10.1111/tbj.14304","DOIUrl":"10.1111/tbj.14304","url":null,"abstract":"","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39719011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower lymph node yield in axillary lymph node dissection specimens in breast cancer patients receiving neoadjuvant chemotherapy: Quality concern or treatment effect?","authors":"Junko Ozao-Choy MD, FACS,&nbsp;Ashkan Moazzez MD, MPH, FACS,&nbsp;Christine Dauphine MD, FACS","doi":"10.1111/tbj.14303","DOIUrl":"10.1111/tbj.14303","url":null,"abstract":"<p>Axillary lymph node dissection (ALND) specimens should have at least ten-lymph nodes for examination according to established guidelines. Nonetheless, recent evidence suggests that neoadjuvant chemotherapy (NAC) results in fewer nodes in the specimen. We sought to examine if NAC patients have lower lymph node yield from ALND specimens and whether the number of lymph nodes in the specimen is correlated with pathologic complete response (pCR). Using the National Cancer Database (NCDB), a study cohort of female patients with node-positive, non-metastatic invasive breast cancer diagnosed from 2012 to 2015 was identified. The axillary lymph node retrieval count was compared in NAC and non-NAC patients and then correlated with pCR. A multivariable analysis was performed to identify factors that were associated with less than ten-lymph nodes in the ALND pathologic specimen. Of 56,976 patients identified, 27,197 (48%) received neoadjuvant chemotherapy; 29,779 (52%) did not. NAC patients failed to meet the ten-lymph node minimum in the ALND specimen more often than non-NAC patients (35% vs. 27%, <i>p </i>&lt; 0.001). NAC patients with fewer than ten-lymph nodes were more likely to have a pCR than those with ten or more (22% vs. 16%, <i>p </i>&lt; 0.001). On multivariable analysis, pCR of the primary tumor and receptor status were found to be independent predictors of having fewer than ten-lymph nodes in the ALND specimen. Node-positive breast cancer patients that underwent NAC were more likely to not meet the ten-lymph node standard. However, NAC patients who did not meet the minimum were also more likely to have a pCR compared to NAC patients who did. This suggests lower lymph node yield may not truly be a marker of lower quality surgery but rather a potential marker of NAC treatment effect.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39814706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bloody nipple discharge in Carney complex: A case report","authors":"Julian K K Chan MBChB MRCP,&nbsp;Natalia Garibotto BMedSci(Hons) MBBS MRCS(Edin) FRACS,&nbsp;Deepthi Dissanayake MBBS FRANZCR,&nbsp;Benjamin F Dessauvagie BMedSci MBBS FRCPA,&nbsp;Anmol Rijhumal MBBCh FRCPA,&nbsp;Elizabeth J Wylie MBBS FRANZCR","doi":"10.1111/tbj.14302","DOIUrl":"10.1111/tbj.14302","url":null,"abstract":"<p>Carney complex (CNC) is an extremely rare, autosomal dominant genetic syndrome consisting of pigmented skin and mucosal changes with multiple endocrine and nonendocrine tumors, including the breast. Breast tumors are typically multiple and benign and are most commonly reported as myxoid fibroadenomas and/or intraductal papillomas. We present a young female patient with known CNC who presented with copious bloody nipple discharge with multiple breast lumps and discuss the breast imaging features regarding this complex and often underrecognized genetic condition.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39788115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superficial angiomyxoma of the breast in a 16-year-old girl without carney’s complex: A case report","authors":"Iram Dubin MD,&nbsp;Shabnam Mortazavi MD,&nbsp;Tiffany Yu MD,&nbsp;Irene R. Riahi MD,&nbsp;Jennifer L. Baker MD","doi":"10.1111/tbj.14301","DOIUrl":"10.1111/tbj.14301","url":null,"abstract":"<p>Superficial angiomyxoma (SA) is a rare benign soft-tissue tumor, arising sporadically or as the earliest manifestation of Carney's complex. When it arises sporadically, the breast is infrequently involved with only few cases reported in the literature. Key imaging findings include T2 signal hyperintensity on MRI and hypervascularity. In this study, we report the clinical, radiological, surgical, and histopathologic findings of a case of sporadic SA of the breast in a 16-year-old girl.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39690099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral breast necrotizing leukocytoclastic vasculitis: First case report","authors":"Hassan Baig MBChB, MSc, MRCS,&nbsp;Wen Ling Choong MBChB, BMSc, MSc, MBA, FRCS,&nbsp;Pei Ru Chew BSc (Hons.), MBBS, MRCS,&nbsp;Alessio Vinci MD, FRCS","doi":"10.1111/tbj.14300","DOIUrl":"10.1111/tbj.14300","url":null,"abstract":"<p>Leukocytoclastic vasculitis (LCV) is a very rare immune complex-mediated condition affecting the small vessels walls. We present the case of a 48-year-old woman with necrotizing bilateral breast LCV on treatment with glatiramer acetate for multiple sclerosis. Bilateral mastectomies and debridement of the anterior abdominal wall were required due to the rapidly evolving necrotizing process. Rapid assessment and a multidisciplinary approach are fundamental in treating this rare life-threatening condition.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39673028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of vitamin D replacement on pathological complete response (pCR) in breast cancer patients receiving neoadjuvant systemic chemotherapy (NAC)","authors":"Vahit Ozmen MD, FACS,&nbsp;Cetin Ordu MD,&nbsp;Ahmet Serkan Ilgun MD,&nbsp;Caglar Unal MD,&nbsp;Gursel Soybir MD,&nbsp;Zeynep Erdogan MD,&nbsp;Tuba Kayan Tapan MS,&nbsp;Fatma Aktepe MD,&nbsp;Gul Alco MD,&nbsp;Tomris Duymaz MS,&nbsp;Tolga Ozmen MD, FACS","doi":"10.1111/tbj.14299","DOIUrl":"10.1111/tbj.14299","url":null,"abstract":"1Department of General Surgery, Istanbul University Istanbul Faculty of Medicine, Capa, Istanbul, Turkey 2Department of Medical Oncology, Gayrettepe Florence Nightingale Hospital, Istanbul, Turkey 3Department of General Surgery, Demiroglu Bilim University, Istanbul, Turkey 4Department of Medical Oncology, Demiroglu Bilim University, Istanbul, Turkey 5Department of General Surgery, Sisli Memorial Hospital, Istanbul, Turkey 6Department of Physical Therapy Rehabilitation, Biruni University, Istanbul, Turkey 7Department of Nutrition and Dietetic, Demiroglu Bilim University, Istanbul, Turkey 8Department of Pathology, Sisli Memorial Hospital, Istanbul, Turkey 9Department of Radiation Oncology, Gayrettepe Florence Nightingale Hospital, Istanbul, Turkey 10Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Istanbul Bilgi University, Istanbul, Turkey 11Department of General Surgery, University of Miami, Miller School of Medicine/Jackson Memorial Hospital, Miami, Florida, USA","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39734438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The continued role of intraoperative assessment of the surgical margins in lumpectomy samples.","authors":"Shahla Masood","doi":"10.1111/tbj.14298","DOIUrl":"https://doi.org/10.1111/tbj.14298","url":null,"abstract":"Currently, breast conservation therapy that includes removal of the primary tumor of the breast by lumpectomy followed by adjunct radiation is a preferred treatment for majority of breast cancer patients.1,2 This practice, however, requires the ability to obtain negative lumpectomy margins to balance between optimal local control of the tumor and minimal tissue resection.3 Obtaining clear surgical margins are found to be important for local control as positive surgical margins increase local recurrence rate by at least twofold.4– 6 Studies have demonstrated that as positive surgical margins are associated with higher rate of local recurrence and the need for a second return to the operating room for the reexcision of positive margins, measures should be in place to avoid this process. In addition, it is critically important to follow the established national guidelines in respect to the accepted definition of an adequate margin. Based on 2014, and 2016 consensus statements offered by the Society of Surgical Oncology and the American Society of Radiation Oncology, adequate surgical margin is defined as no tumor at ink for invasive breast cancer and a 2mm tumorfree margin adequate for ductal carcinoma in situ.7,8 In order to avoid a second surgery and the associated cost and anxiety to breast cancer patients undergoing lumpectomy, it is important to consider providing an intraoperative assessment of surgical margins. This requires an accurate and costeffective rapid intraoperative technique that would evaluate surgical margins and allow for realtime reexcision to be perform if necessary.9,10 There are two alternatives to provide an intraoperative consultation. The most traditional approach has been the frozen section analysis. This approach has shown to minimize reoperation rates.11– 17 In a recent study reported by Racz et al.,18 the use of intraoperative frozen section pathologic evaluation of margins in patients undergoing lumpectomy has resulted in an extremely low reoperation rate of <2%. Similarly, in the study reported by Akrami et al.19 published in the current issue of The Breast Journal, the authors report the low rate of 2.3% positive surgical margins among 4843 patients enrolled in this study. The authors attribute the low rate of the positive margins in their study to the use of the intraoperative frozen section consultation in their practice. There is, however, a trend that has made the use of intraoperative consultation by frozen sectioning less frequent with dependence only on the final permanent section diagnosis of surgical margins. This may be the result of frozen sections being considered labor intensive, expensive and technically difficult to freeze and cut adipose tissue.20– 22","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39717868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information","authors":"","doi":"10.1111/tbj.13918","DOIUrl":"https://doi.org/10.1111/tbj.13918","url":null,"abstract":"","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43933246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axillary management based on American college of surgeons oncology group Z0011 criteria makes it possible to omit intraoperative diagnosis of sentinel lymph nodes in early breast cancer patients.","authors":"Nobuyoshi Kittaka,&nbsp;Satomi Nakajima,&nbsp;Takaaki Hatano,&nbsp;Yukiko Seto,&nbsp;Hiroki Kusama,&nbsp;Saki Matsui,&nbsp;Minako Nishio,&nbsp;Fumie Fujisawa,&nbsp;Keiichiro Honma,&nbsp;Takahiro Nakayama,&nbsp;Yasuhiro Tamaki","doi":"10.1111/tbj.14291","DOIUrl":"https://doi.org/10.1111/tbj.14291","url":null,"abstract":"<p><p>The ACOSOG Z0011 trial has resulted in the omission of axillary lymph node dissection (ALND) in early breast cancer patients with one or two metastatic sentinel lymph nodes (SLNs). There has been increasing interest in the necessity of intraoperative assessment of SLNs in patients treated based on the Z0011 criteria. We evaluated the utility of intraoperative assessment in these eligible patients. A total of 1396 patients were treated following the Z0011 criteria from April 2012 to December 2019. We examined the proportion and clinicopathological features of patients who underwent ALND due to three or more metastatic SLNs and the sensitivity of intraoperative assessment. Only 16 (1.1%) patients had three or more metastatic SLNs diagnosed by intraoperative assessment, and they immediately underwent ALND. Of the clinicopathological factors, high clinical tumor stage (p = 0.002) and high Ki-67 labeling index value (p = 0.056) were more likely to be associated with the presence of three or more metastatic SLNs. The major independent risk factor for three or more metastatic SLNs was high clinical tumor stage (OR 3.94 [95% CI 1.42-11.0]; p = 0.009). Intraoperative assessment had low sensitivity (70.5%) and a high false-negative rate (29.5%) in detecting SLN metastases. The main finding of our study was the small proportion of patients who required ALND due to three or more metastatic SLNs according to the Z0011 criteria. The Z0011 strategy enables intraoperative assessment of SLNs to be omitted in early breast cancer patients.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39444708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}