Predicting of Ki-67 Expression Level Using Diffusion-Weighted and Synthetic Magnetic Resonance Imaging in Invasive Ductal Breast Cancer.

IF 1.9 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Breast Journal Pub Date : 2023-01-01 DOI:10.1155/2023/6746326

Liying Zhang, Jisen Hao, Jia Guo, Xin Zhao, Xing Yin

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引用次数: 1

Abstract

Objectives: To investigate the association between quantitative parameters generated using synthetic magnetic resonance imaging (SyMRI) and diffusion-weighted imaging (DWI) and Ki-67 expression level in patients with invasive ductal breast cancer (IDC).

Method: We retrospectively reviewed the records of patients with IDC who underwent SyMRI and DWI before treatment. Precontrast and postcontrast relaxation times (T1, longitudinal; T2, transverse), proton density (PD) parameters, and apparent diffusion coefficient (ADC) values were measured in breast lesions. Univariate and multivariate regression analyses were performed to screen for statistically significant variables to differentiate the high (≥30%) and low (<30%) Ki-67 expression groups. Their performance was evaluated by receiver operating characteristic (ROC) curve analysis.

Results: We analyzed 97 patients. Multivariate regression analysis revealed that the high Ki-67 expression group (n = 57) had significantly higher parameters generated using SyMRI (pre-T1, p=0.001) and lower ADC values (p=0.036) compared with the low Ki-67 expression group (n = 40). Pre-T1 showed the best diagnostic performance for predicting the Ki-67 expression level in patients with invasive ductal breast cancer (areas under the ROC curve (AUC), 0.711; 95% confidence interval (CI), 0.609-0.813).

Conclusions: Pre-T1 could be used to predict the pretreatment Ki-67 expression level in invasive ductal breast cancer.

Abstract Image

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扩散加权和合成磁共振成像预测浸润性导管乳腺癌中Ki-67表达水平。

目的:探讨合成磁共振成像(SyMRI)和弥散加权成像(DWI)产生的定量参数与浸润性导管性乳腺癌(IDC)患者Ki-67表达水平的关系。方法:回顾性分析治疗前行SyMRI和DWI检查的IDC患者资料。对比前后的松弛时间(T1，纵向;测量乳腺病变部位的T2(横截面)、质子密度(PD)参数和表观扩散系数(ADC)值。进行单因素和多因素回归分析，筛选具有统计学意义的变量，以区分高(≥30%)和低(结果:我们分析了97例患者。多因素回归分析显示，与Ki-67低表达组(n = 40)相比，Ki-67高表达组(n = 57)使用SyMRI生成的参数显著增加(t1前，p=0.001)， ADC值显著降低(p=0.036)。Pre-T1对浸润性导管性乳腺癌患者Ki-67表达水平的预测效果最好(ROC曲线下面积(AUC)， 0.711;95%置信区间(CI)， 0.609-0.813)。结论:Pre-T1可预测浸润性导管性乳腺癌预处理Ki-67表达水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast Journal 医学-妇产科学

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Breast Journal is the first comprehensive, multidisciplinary source devoted exclusively to all facets of research, diagnosis, and treatment of breast disease. The Breast Journal encompasses the latest news and technologies from the many medical specialties concerned with breast disease care in order to address the disease within the context of an integrated breast health care. This editorial philosophy recognizes the special social, sexual, and psychological considerations that distinguish cancer, and breast cancer in particular, from other serious diseases. Topics specifically within the scope of The Breast Journal include: Risk Factors Prevention Early Detection Diagnosis and Therapy Psychological Issues Quality of Life Biology of Breast Cancer.