Breast Journal最新文献

{"title":"The Effect of Adjuvant Radiotherapy on One- and Two-Stage Prosthetic Breast Reconstruction and on Autologous Reconstruction: A Multicenter Italian Study among 18 Senonetwork Breast Centres","authors":"Andrea Vittorio Emanuele Lisa,&nbsp;Marzia Salgarello,&nbsp;Alessandra Huscher,&nbsp;Fabio Corsi,&nbsp;Daniele Piovani,&nbsp;Federica Rubbino,&nbsp;Stefania Andreoletti,&nbsp;Giovanni Papa,&nbsp;Francesco Klinger,&nbsp;Corrado Tinterri,&nbsp;Alberto Testori,&nbsp;Marta Scorsetti,&nbsp;Paolo Veronesi,&nbsp;Maria Cristina Leonardi,&nbsp;Mario Rietjens,&nbsp;Umberto Cortinovis,&nbsp;Valeria Summo,&nbsp;Emanuele Rampino Cordaro,&nbsp;Pier Camillo Parodi,&nbsp;Paolo Persichetti,&nbsp;Mauro Barone,&nbsp;Giorgio De Santis,&nbsp;Matteo Murolo,&nbsp;Michele Riccio,&nbsp;Angelica Aquinati,&nbsp;Francesco Cavaliere,&nbsp;Nicola Vaia,&nbsp;Giulia Pagura,&nbsp;Erica Dalla Venezia,&nbsp;Franco Bassetto,&nbsp;Vincenzo Vindigni,&nbsp;Luigi Ciuffreda,&nbsp;Maria Alessandra Bocchiotti,&nbsp;Alberto Sciarillo,&nbsp;Nadia Renzi,&nbsp;Graziano Meneghini,&nbsp;Tajna Kraljic,&nbsp;Andrea Loreti,&nbsp;Lucio Fortunato,&nbsp;Valentina Pino,&nbsp;Valeriano Vinci,&nbsp;Marco Klinger","doi":"10.1155/2023/6688466","DOIUrl":"10.1155/2023/6688466","url":null,"abstract":"<div>\u0000 <p><i>Purpose</i>. In modern breast cancer treatment, a growing role has been observed for breast reconstruction together with an increase in clinical indications for postmastectomy radiotherapy (PMRT). Choosing the optimum type of reconstructive technique is a clinical challenge. We therefore conducted a national multicenter study to analyze the impact of PMRT on breast reconstruction. <i>Methods</i>. We conducted a retrospective case-control multicenter study on women undergoing breast reconstruction. Data were collected from 18 Italian Breast Centres and stored in a cumulative database which included the following: autologous reconstruction, direct-to-implant (DTI), and tissue expander/immediate (TE/I). For all patients, we described complications and surgical endpoints to complications such as reconstruction failure, explant, change in type of reconstruction, and reintervention. <i>Results</i>. From 2001 to April 2020, 3116 patients were evaluated. The risk for any complication was significantly increased in patients receiving PMRT (aOR, 1.73; 95% CI, 1.33–2.24; <i>p</i> &lt; 0.001). PMRT was associated with a significant increase in the risk of capsular contracture in the DTI and TE/I groups (aOR, 2.24; 95% CI, 1.57–3.20; <i>p</i> &lt; 0.001). Comparing type of procedures, the risk of failure (aOR, 1.82; 95% CI, 1.06–3.12, <i>p</i> = 0.030), explant (aOR, 3.34; 95% CI, 3.85–7.83, <i>p</i> &lt; 0.001), and severe complications (aOR, 2.54; 95% CI, 1.88–3.43, <i>p</i> &lt; 0.001) were significantly higher in the group undergoing DTI reconstruction as compared to TE/I reconstruction. <i>Conclusion</i>. Our study confirms that autologous reconstruction is the procedure least impacted by PMRT, while DTI appears to be the most impacted by PMRT, when compared with TE/I which shows a lower rate of explant and reconstruction failure. The trial is registered with NCT04783818, and the date of registration is 1 March, 2021, retrospectively registered.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2023 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9949365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Lobular Neoplasia Diagnosed by Core Biopsy","authors":"Chinmay Jani,&nbsp;Margaret Lotz,&nbsp;Sarah Keates,&nbsp;Yasha Gupta,&nbsp;Alexander Walker,&nbsp;Omar Al Omari,&nbsp;Arshi Parvez,&nbsp;Dipesh Patel,&nbsp;Maria Gnata,&nbsp;John Perry,&nbsp;Leila Khorashadi,&nbsp;Lisa Weissmann,&nbsp;Susan E. Pories","doi":"10.1155/2023/8185446","DOIUrl":"10.1155/2023/8185446","url":null,"abstract":"<div>\u0000 <p>Lobular neoplasia (LN) involves proliferative changes within the breast lobules. LN is divided into lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH). LCIS can be further subdivided into three subtypes: classic LCIS, pleomorphic LCIS, and LCIS with necrosis (florid type). Because classic LCIS is now considered as a benign etiology, current guidelines recommend close follow-up with imaging versus surgical excision. The goal of our study was to determine if the diagnosis of classic LN on core needle biopsy (CNB) merits surgical excision. This is a retrospective, observational study conducted at Mount Auburn Hospital, Cambridge, MA, from May 17, 2017, through June 30, 2020. We reviewed the data of breast biopsies conducted at our hospital over this period and included patients who were diagnosed with classic LN (LCIS and/or ALH) and excluded patients having any other atypical lesions on CNB. All known cancer patients were excluded. Of the 2707 CNBs performed during the study period, we identified 68 women who were diagnosed with ALH or LCIS on CNB. CNB was performed for an abnormal mammogram in the majority of patients (60; 88%) while 7(10.3%) had an abnormal breast magnetic resonance imaging study (MRI), and 1 had an abnormal ultrasound (US). A total of 58 patients (85%) underwent excisional biopsy, of which 3 (5.2%) showed malignancy, including 2 cases of DCIS and 1 invasive carcinoma. In addition, there was 1 case (1.7%) with pleomorphic LCIS and 11 cases with ADH (15.5%). The management of LN found on core biopsy is evolving, with some advocating surgical excision and others recommending observation. Our data show a change in diagnosis with excisional biopsy in 13 (22.4%) of patients with 2 cases of DCIS, 1 invasive carcinoma, 1 pleomorphic LCIS, and 9 cases of ADH, diagnosed on excisional biopsy. While ALH and classic LCIS are considered benign, the choice of ongoing surveillance versus excisional biopsy should be made with shared decision making with the patient, with consideration of personal and family history, as well as patient preferences.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2023 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting of Ki-67 Expression Level Using Diffusion-Weighted and Synthetic Magnetic Resonance Imaging in Invasive Ductal Breast Cancer","authors":"Liying Zhang,&nbsp;Jisen Hao,&nbsp;Jia Guo,&nbsp;Xin Zhao,&nbsp;Xing Yin","doi":"10.1155/2023/6746326","DOIUrl":"10.1155/2023/6746326","url":null,"abstract":"<div>\u0000 <p><i>Objectives</i>. To investigate the association between quantitative parameters generated using synthetic magnetic resonance imaging (SyMRI) and diffusion-weighted imaging (DWI) and Ki-67 expression level in patients with invasive ductal breast cancer (IDC). <i>Method</i>. We retrospectively reviewed the records of patients with IDC who underwent SyMRI and DWI before treatment. Precontrast and postcontrast relaxation times (T1, longitudinal; T2, transverse), proton density (PD) parameters, and apparent diffusion coefficient (ADC) values were measured in breast lesions. Univariate and multivariate regression analyses were performed to screen for statistically significant variables to differentiate the high (≥30%) and low (&lt;30%) Ki-67 expression groups. Their performance was evaluated by receiver operating characteristic (ROC) curve analysis. <i>Results</i>. We analyzed 97 patients. Multivariate regression analysis revealed that the high Ki-67 expression group (<i>n</i> = 57) had significantly higher parameters generated using SyMRI (pre-T1, <i>p</i> = 0.001) and lower ADC values (<i>p</i> = 0.036) compared with the low Ki-67 expression group (<i>n</i> = 40). Pre-T1 showed the best diagnostic performance for predicting the Ki-67 expression level in patients with invasive ductal breast cancer (areas under the ROC curve (AUC), 0.711; 95% confidence interval (CI), 0.609–0.813). <i>Conclusions</i>. Pre-T1 could be used to predict the pretreatment Ki-67 expression level in invasive ductal breast cancer.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2023 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10098409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9323177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MYL5 as a Novel Prognostic Marker is Associated with Immune Infiltrating in Breast Cancer: A Preliminary Study","authors":"Minghe Lv","doi":"10.1155/2023/9508632","DOIUrl":"10.1155/2023/9508632","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Myosin light chain plays a vital regulatory function in a large-scale cellular physiological procedure, however, the role of myosin light chain 5 (MYL5) in breast cancer has not been reported. In this study, we aimed to elucidate the effects of MYL5 on clinical prognosis and immune cell infiltration, and further explore the potential mechanism in breast cancer patients. <i>Methods</i>. In this study, we first explored the expression pattern and prognostic value of MYL5 in breast cancer across multiple databases, including Oncomine, TCGA, GTEx, GEPIA2, PrognoScan, and Kaplan–Meier Plotter. The correlations of MYL5 expression with immune cell infiltration and associational gene markers in breast cancer were analyzed by using the TIMER, TIMER2.0, and TISIDB databases. The enrichment and prognosis analysis of MYL5-related genes were implemented by using LinkOmics datasets. <i>Results</i>. We found that there was a low expression of MYL5 in breast cancer than in corresponding normal tissue by analyzing the data from Oncomine and TCGA datasets. Furthermore, research showed the prognosis of the MYL5 high-expression group was better than the low-expression group in breast cancer patients. Furthermore, MYL5 expression is markedly related to the tumor-infiltrating immune cells (TIICs), including cancer-associated fibroblast, B cell, CD8⁺ T cell, CD4⁺ T cell, macrophage, neutrophil, and dendritic cell, and related to immune molecules as well as the associated gene markers of TIICs. <i>Conclusion</i>. MYL5 can serve as a prognostic signature in breast cancer and is associated with immune infiltration. This study first offers a relatively comprehensive understanding of the oncogenic roles of MYL5 for breast cancer.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2023 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10800474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Oncologic Safety of Sentinel Lymph Node Biopsy in Patients with Node-Positive Breast Cancer with Complete Response to Neoadjuvant Chemotherapy: A Single-Center Experience","authors":"Ismail Can Tercan,&nbsp;Baha Zengel,&nbsp;Ozlem Ozdemir,&nbsp;Demet Cavdar,&nbsp;Funda Tasli,&nbsp;Zehra Hilal Adibelli,&nbsp;Murat Karatas,&nbsp;Cenk Simsek,&nbsp;Isabel Raika Durusoy,&nbsp;Adam Uslu","doi":"10.1155/2023/4549033","DOIUrl":"10.1155/2023/4549033","url":null,"abstract":"<div>\u0000 <p><i>Objective</i>. To evaluate the efficiency and safety of sentinel lymph node biopsy (SLNB) in patients with breast cancer with complete response to neoadjuvant chemotherapy (NAC). <i>Methods</i>. Ninety-two consecutive (T1-4 and N1-2) patients with breast cancer who had pathologic and/or clinical and radiologic axillary lymph node involvement were included. All patients received NAC. Patients with a clinical and radiologic complete response in the axilla after NAC underwent SLNB. Pathologic complete response (ypCR) was defined as the absence of residual invasive and in situ cancer, and near-complete response (ypNCR) represented in situ and/or ≤ 1 mm residual tumor in the breast and/or presence of malignant cell clusters (≤0.2 mm) and/or micrometastases (≤2.0 mm) in the axillary lymph nodes (ALN) (ypTis/T1mi, ypN0i+/pN1mi). <i>Results</i>. The mean age of the 92 patients was 49.6 ± 10.3 years and the mean follow-up was 34.0 ± 17.8 months. With respect to breast tumors, 23 (25.0%) patients had complete and 14 (15.2%) had a near-complete response to NAC. Complete response in ALN was obtained in 39 (42.4%) patients and near-complete in six (6.5%) patients. The overall survival of the 33 patients who achieved ypCR and ypNCR was 100% and the remaining 59 patients with partial or no response to NAC was 83.1% at a mean follow-up of 34 months (<i>p</i> = 0.063). <i>Conclusions</i>. In this study, no event developed in cases with ypCR and ypNCR in the breast and axilla. The persistence of the same results in long-termfollow-ups may enable the use of ypNCR as a positive prognostic marker in addition to ypCR.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2023 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10699581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contralateral Prophylactic Mastectomy among Women with Pathogenic Variants in BRCA1/2: Overall Survival, Racial, and Ethnic Differences","authors":"Sukh Makhnoon,&nbsp;Angelica M. Gutierrez Barrera,&nbsp;Roland Bassett,&nbsp;Aimaz Afrough,&nbsp;Isabelle Bedrosian,&nbsp;Banu K. Arun","doi":"10.1155/2022/1447545","DOIUrl":"10.1155/2022/1447545","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Patients with unilateral breast cancer carrying pathogenic variants in <i>BRCA1/2</i> have the option to undergo contralateral prophylactic mastectomy (CPM). However, differences in CPM use and survival outcomes following CPM are poorly understood in this high-risk population, in part due to a lack of data from contemporary clinical cohorts. The objective of this study was to evaluate post-CPM overall survival (OS) and related racial/ethnic differences in a contemporary clinical cohort. <i>Methods</i>. We retrospectively reviewed the medical records of women with a personal history of unilateral breast cancer carrying pathogenic variants in <i>BRCA1/2</i> who were diagnosed between 1996 and 2012. Genetic test results, self-reported demographic characteristics, and clinical factors were abstracted from electronic medical records. <i>Results</i>. Of 144 BRCA-positive patients, the majority were White (79.2%, <i>n</i> = 114). Overall, 56.1% (<i>n</i> = 81) of all <i>BRCA1/2</i> carriers chose to undergo CPM, with no racial/ethnic difference in CPM election (<i>p</i> = 0.78). Of 81 patients who underwent CPM, there is strong evidence of a difference in survival between the racial/ethnic groups, with White patients having the highest OS compared to non-White patients (<i>p</i> = 0.001). Of the 63 patients who did not undergo CPM, there is no racial/ethnic difference in overall survival (<i>p</i> = 0.61). In multivariable cox regression, adjusted for demographic and clinical characteristics, OS was significantly lower among non-Whites than in Whites (HR = 0.39, <i>p</i> = 0.04). <i>Conclusions</i>. Evaluation of a contemporary clinical cohort of BRCA-positive women with unilateral breast cancer showed no racial/ethnic difference in CPM use, but there was a significant difference in post-CPM overall survival.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10581792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features and Prognosis Analysis of Hormone Receptor-Positive, HER2-Negative Breast Cancer with Differential Expression Levels of Estrogen and Progesterone Receptors: A 10-Year Retrospective Study","authors":"Jin Liu,&nbsp;Mingyu Gan,&nbsp;Zijing Lin,&nbsp;Qin Deng,&nbsp;Juan Deng,&nbsp;Bin Zeng,&nbsp;Yanling Shi,&nbsp;Jia Ming","doi":"10.1155/2022/5469163","DOIUrl":"10.1155/2022/5469163","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Estrogen and progesterone receptor status can predict breast cancer patient prognosis and treatment sensitivity, but research on low ER and PR levels and expression balance remains limited. <i>Methods</i>. From January 2010 to October 2016, 283 ER+/PR+/HER2-breast cancer patients who met the inclusion criteria were enrolled and divided into the H group (ER &gt; 10%, <i>N</i> = 261) and the <i>L</i> group (1% ≤ ER ≤ 10%, <i>N</i> = 22). Groups were further divided into the HH group (ER &gt; 10%/PR &gt; 20%, <i>N</i> = 201), the HL group (ER &gt; 10%/ER 1% ≤ PR ≤ 20% PR, <i>N</i> = 60), the LH group (1% ≤ ER ≤ 10%/PR &gt; 20%, <i>N</i> = 5), and the LL group (1% ≤ ER ≤ 10%/1% ≤ PR ≤ 20%, <i>N</i> = 17). The LH group was excluded due to its small size, leaving the clinical and prognostic characteristics of 2 large groups and 3 subgroups to be analyzed. <i>Results</i>. <i>L</i> group patients had significantly more stage <i>N</i>2 axillary lymph nodes than H group patients (31.8% vs. 9.2%, <i>P</i> = 0.007). Age (<i>P</i> = 0.011), menopause status (<i>P</i> = 0.001), and tumor size (<i>P</i> = 0.024) were significantly different in the HL vs. HH and LL groups. Five-year DFS (94.6% vs. 77.0%, <i>P</i> &lt; 0.001) and 5-year OS (97.2% vs. 85.8%, <i>P</i> = 0.001) rates significantly differed between HH and HL. No significant differences in 5-year DFS (77.0% vs. 81.9%, <i>P</i> = 0.564) or 5-year OS (85.8% vs. 87.8%, <i>P</i> = 0.729) rates were observed between HL and LL; the OS rates of HL and LL were similar. <i>Conclusion</i>. In the group of ER+/PR+/HER2-patients, there was no significant prognostic difference between ER-low positive and ER-high positive groups, but low PR expression was significantly associated with a worse prognosis. The role of ER and PR balance in breast cancer progression and individualized treatment requires further investigation.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10789973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserving Nipple Sensitivity after Breast Cancer Surgery: A Systematic Review and Meta-Analysis","authors":"Varsha Harish,&nbsp;Zoe K. Haffner,&nbsp;Jenna C. Bekeny,&nbsp;Adaah A. Sayyed,&nbsp;David H. Song,&nbsp;Kenneth L. Fan","doi":"10.1155/2022/9654741","DOIUrl":"10.1155/2022/9654741","url":null,"abstract":"<div>\u0000 <p><i>Purpose</i>. As breast-conserving procedures become increasingly safe and viable options for surgical management of breast cancer, efforts have focused on assessing and optimizing patient-reported outcome measures (PROMs), such as nipple sensation. This study aims to evaluate the current understanding of nipple-areolar complex (NAC) sensation outcomes in breast cancer patients undergoing breast cancer surgeries, namely, nipple-sparing mastectomies (NSM), skin-sparing mastectomies (SSM), and lumpectomies. <i>Methods</i>. Articles including terms related to “nipple,” “mastectomy,” “sensation,” and “patient-reported outcome” were queried from three databases according to PRISMA guidelines. Study characteristics, patient demographics, and surgical details were recorded. Outcomes of interest included objective nipple sensitivity testing and PROMs. <i>Results</i>. Of 888 manuscripts identified, 28 articles met the inclusion criteria. Twelve studies (<i>n</i> = 578 patients) used objective measures to evaluate sensitivity, such as monofilament testing. Sixteen studies (<i>n</i> = 1785 patients) assessed PROMs through validated or investigator-generated surveys. Three of the included studies reported NAC sensitivity in patients who received NSM with neurotization (<i>n</i> = 203 patients) through a variety of techniques that used various grafts to coapt a lateral intercostal nerve to the NAC nerve stumps. Results of investigator surveys showed that of 1565 patients without neurotization, nipple sensation was maintained in 29.0% (<i>n</i> = 453) of patients. Of 138 NSM patients without NAC neurotization, SWM testing showed an average loss of protective sensation in the nipple (average SWM score: 4.7) compared to normal or diminished sensation to light touch in nonoperated controls (average SWM score: 2.9, <i>n</i> = 195). Of patients who underwent NSM with neurotization, one study (<i>n</i> = 78) reported maintenance of NAC sensation in 100% of patients, while another study (<i>n</i> = 7) reported average diminished protective sensation in the nipple (average SWM score: 3.9). <i>Conclusion</i>. Our study has shown that objective and patient-reported results of nipple sensitivity support nipple-sparing techniques as a viable option for preserving NAC sensation, although patients can expect a decrease in sensation overall. Neurotization of the NAC during NSM shows promising results of improved postoperative nipple sensitivity, though additional studies are warranted to confirm this finding. Variations between study methodologies highlight the lack of standardization in sensory testing techniques when evaluating NAC sensation.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10343396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Physical Exercise, Quality of Life, Psychological Symptoms and Treatment Side Effects in Early Breast Cancer","authors":"Leena Vehmanen,&nbsp;Johanna Mattson,&nbsp;Evangelos Karademas,&nbsp;Albino J. Oliveira-Maia,&nbsp;Berta Sousa,&nbsp;Ruth Pat-Horenczyk,&nbsp;Ketti Mazzocco,&nbsp;Panagiotis Simos,&nbsp;Fátima Cardoso,&nbsp;Greta Pettini,&nbsp;Chiara Marzorati,&nbsp;Eleni Kolokotroni,&nbsp;Georgios Stamatakos,&nbsp;Diana Frasquilho,&nbsp;Paula Poikonen-Saksela","doi":"10.1155/2022/9921575","DOIUrl":"10.1155/2022/9921575","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Identifying and understanding modifiable factors for the well-being of cancer patients is critical in survivorship research. We studied variables associated with the exercise habits of breast cancer patients and investigated if the achievement of exercise recommendations was associated with enhanced quality of life and/or psychological well-being. <i>Material and Methods</i>. 311 women from Finland, Portugal, Israel, and Italy receiving adjuvant therapy for stage I–III breast cancer answered questions about sociodemographic factors and physical exercise. Quality of life was assessed by the EORTC C30 and BR23 questionnaires. Anxiety and depression were evaluated using the HADS scale. <i>Results</i>. At the beginning of adjuvant therapy and after twelve months, 32% and 26% of participants were physically inactive, 27% and 30% exercised between 30 and 150 minutes per week, while 41% and 45% exercised the recommended 150 minutes or more per week. Relative to other countries, Finnish participants were more likely to be active at baseline and at twelve months (89% vs. 50%, <i>p</i> &lt; 0.001 and 87% vs. 64%, <i>p</i> &lt; 0.001). Participants with stage I cancer were more likely to be active at twelve months than those with a higher stage (80% vs. 70%,<i>p</i> &lt; 0.05). The inactive participants reported more anxiety (<i>p</i> &lt; 0.05) and depression (<i>p</i> &lt; 0.001), lower global quality of life (<i>p</i> &lt; 0.001), and more side effects (<i>p</i> &lt; 0.05) than the others at twelve months. Accordingly, those who remained inactive or decreased their level of exercise from baseline to twelve months reported more anxiety (<i>p</i> &lt; 0.01) and depression (<i>p</i> &lt; 0.001), lower global quality of life (<i>p</i> &lt; 0.001), and more side effects (<i>p</i> &lt; 0.05) than those with the same or increased level of exercise. <i>Conclusion</i>. For women with early breast cancer, exercise was associated with a better quality of life, less depression and anxiety, and fewer adverse events of adjuvant therapy. Trial registration number: NCT05095675. Paula Poikonen-Saksela on behalf of Bounce consortium (https://www.bounce-project.eu/).</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10336653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Characteristics of Breast Cancer Detected through Different Imaging Modalities in a Large Cohort of Hong Kong Chinese Women: Implication of Imaging Choice on Upcoming Local Screening Program","authors":"Yik Shuen Chan,&nbsp;Wai Ka Hung,&nbsp;Lok Wa Yuen,&nbsp;Ho Yan Yolanda Chan,&nbsp;Chiu Wing Winnie Chu,&nbsp;Polly Suk Yee Cheung","doi":"10.1155/2022/3882936","DOIUrl":"10.1155/2022/3882936","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. We compared the clinico-radio-pathological characteristics of breast cancer detected through mammogram (MMG) and ultrasound (USG) and discuss the implication of the choice of imaging as the future direction of our recently launched local screening program. <i>Methods</i>. Retrospective study of 14613 Hong Kong Chinese female patients with histologically confirmed breast cancer registered in the Hong Kong Breast Cancer Registry between January 2006 and February 2020. Patients were classified into four groups based on the mode of breast cancer detection (detectable by both mammogram and ultrasound (MMG+/USG+), mammogram only (MMG+/USG−), ultrasound only (MMG−/USG+), or not detectable by either (MMG−/USG−). Characteristics of breast cancer detected were compared, including patient demographics, breast density on MMG, mode of presentation, tumour size, histological type, and staging. Types of mammographic abnormalities were also evaluated for MMG+ subgroups. <i>Results</i>. 85% of the cancers were detectable by MMG, while USG detected an additional 9%. MMG+/USG+ cancers were larger, more advanced in stage, often of symptomatic presentation, and commonly manifested as mammographic mass. MMG+/USG− cancers were more likely of asymptomatic presentation, manifested as microcalcifications, and of earlier stage and to be ductal carcinoma in situ. MMG−/USG+ cancers were more likely seen in young patients and those with denser breasts and more likely of symptomatic presentation. MMG−/USG− cancers were often smaller and found in denser breasts. <i>Conclusion</i>. Mammogram has a good detection rate of cancers in our local population. It has superiority in detecting early cancers by detecting microcalcifications. Our current study agrees that ultrasound is one of the key adjunct tools of breast cancer detection.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2022 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9569198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}