Breast Journal最新文献

{"title":"Adolescent Girls’ Breast Self-Examination Practices in Eastern Region of Ghana","authors":"Stella Sagoe,&nbsp;Patricia Tsotsoo Clottey,&nbsp;Isaac Nyarko Kwakye,&nbsp;Emmanuel Lamptey,&nbsp;Sussana Sagoe,&nbsp;Thywill Amenuveve Degley,&nbsp;Ruth Nimota Nukpezah,&nbsp;Daniel Adom-Fynn","doi":"10.1155/tbj/5207043","DOIUrl":"10.1155/tbj/5207043","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Breast cancer incidence is rising globally, including in Ghana, making early detection vital. Breast self-examination (BSE) is key to reducing morbidity and mortality. This study assessed BSE practices among adolescent girls in Ghana’s Eastern Region to inform prevention efforts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional design was adopted, and the simple random sampling strategy was used to recruit 385 female students from Aburi Girls’ Senior High School. Data were collected using a structured questionnaire covering demographic information, BSE knowledge, and practices and were analyzed using SPSS Version 21. Descriptive statistics were used to summarize the data, while Pearson’s correlation assessed the association between knowledge and practice. Logistic regression was performed to determine the predictive effects of demographic variables on BSE practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants demonstrated moderate to high knowledge of BSE with mean scores ranging from 1.00 to 1.92, with strongest awareness of palpation techniques (mean = 1.92, SD = 0.272) but lower understanding of positional and visual inspection methods. Most respondents (67.3%) knew how to perform BSE, yet only 25.2% adhered to monthly timing guidelines. Hands (75%) and mirrors (25%) were commonly used, with 41.3% performing both palpation and observation. Knowledge and practice were positively correlated (<i>r</i> = 0.149, <i>p</i> = 0.003). Logistic regression identified age, educational level, knowing someone with breast cancer, and workshop attendance as significant predictors of BSE practice (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Educating adolescent girls on breast cancer and proper BSE practices is essential. Targeted interventions can strengthen knowledge and skills among young Ghanaian women, supporting early detection and broader prevention efforts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tyrer–Cuzick Lifetime Risk Is Not Associated With Non-BRCA1/2 Pathogenic Variants for Breast Carcinoma","authors":"Divya Rao,&nbsp;Chloe Wernecke,&nbsp;Lisa Baron,&nbsp;Steven Cai,&nbsp;Peter Beitsch,&nbsp;Rakesh Patel,&nbsp;Pat Whitworth,&nbsp;Barry Rosen,&nbsp;Nhan Nguyen Tran,&nbsp;Kevin Hughes,&nbsp;Paul L. Baron","doi":"10.1155/tbj/8670441","DOIUrl":"10.1155/tbj/8670441","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The Tyrer–Cuzick (TC) or IBIS risk calculator is a widely used tool to estimate the probability of developing breast cancer. The latest version incorporates various factors to assess the risk of breast cancer, including family history, personal history, breast density, and past medical history. The TC is commonly used to guide patients toward further diagnostic imaging, genetic testing, chemoprevention, or risk-reducing surgery. However, it is unclear whether the TC is associated with non-BRCA1/2 pathogenic variants (PVs) in breast cancer susceptibility genes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A population of 964 patients with TC was evaluated for 12 PVs and variants of unknown significance (VUS) using lab-agnostic genetic testing. Patients were enrolled from 2019 to 2022. Historical TC were used for the subgroup of patients who developed breast cancer after enrollment. TC scores were compared between the three patient cohorts that had BRCA gene mutations, non-BRCA PVs, and negative for PVs, using the Kruskal–Wallis test followed by pairwise comparison using DSCF adjustment for multiple comparisons. Data collection for patient cohorts occurred simultaneously and was only separated in analysis. Logistic regression was carried out to predict BRCA versus negative in a model with TC scores, as well as non-BRCA versus negative. Area under the receiver operating characteristic (ROC) curve (AUC) was calculated to assess model fit.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study found an average TC of 7.71%. A family history of cancer was noted in 78.30% of patients, and a personal history of cancer other than breast occurred in 20.74% of patients. The presence of PVs and VUS was evaluated, and 12.03% of patients were found to have a PV, with an average TC of 8.98%. The most common PVs were CHEK2, BRCA2, BRCA1, and BARD1. Out of those with PVs, 52% had non-BRCA1/2 PVs with an average TC of 5.47%. A total of 102 patients (10.58%) had a VUS, with an average TC of 8.29%. In further statistical analysis, TC were distributed significantly differently among the three groups, with differences observed between the BRCA group and negative group, as well as between BRCA and non-BRCA1/2 PVs group. A higher TC was also associated with BRCA1/BRCA2 variants compared to non-BRCA1/2 PVs.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;TC scores provide valuable information regarding the lifetime risk of an individual of developing breast cancer. However, the study found they were not associated with prediction of non-BRCA1/","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Characteristics of PAX7 and Its Prognostic Correlation in Breast Cancer","authors":"Bahatiguli Silafu,&nbsp;Jinxing Huang,&nbsp;Xierzhati Aizezi","doi":"10.1155/tbj/3060151","DOIUrl":"10.1155/tbj/3060151","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To conduct a thorough analysis of public databases to investigate the expression patterns of the PAX7 gene in breast cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We gathered gene expression data, clinical details, immunohistochemistry images, and genomic information from breast cancer patients through various public databases, such as TCGA, THPA, GEPIA, and cBioPortal. To analyze differential expression, we used the limma package. We assessed the relationship between PAX7 and clinical characteristics using chi-square tests and Fisher’s exact tests. For survival analysis, we employed Kaplan–Meier survival curves and Cox regression models to evaluate prognostic factors. Furthermore, we conducted functional clustering analysis to explore the roles of related genes. The MCPcounter and TIMER packages were utilized for analyzing immune infiltration, while statistical computations and visualizations were carried out using the R programming language and its associated packages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The expression levels of PAX7 in breast cancer tissues were significantly higher than normal tissues. Survival analyses showed that patients with high PAX7 expression had notably lower overall survival, disease-specific survival, and progression-free survival, establishing PAX7 as an independent prognostic factor. Assessments of immune infiltration demonstrated a significant relationship between PAX7 and the levels of Th2 cells, TReg, and TFH. Additionally, Clustering analysis of PAX7 genes showed enrichment in cell division, chromosome regions, and pathways like the cell cycle.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PAX7 was highly expressed in cancer tissues and had a notable impact on patient survival. Furthermore, it was identified as an independent prognostic factor, with related genes being enriched in various biological processes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12791159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information Needs and Preferences of Men With Breast Cancer: A Qualitative Analysis of Internet Forum Posts","authors":"Nicole Schemmel,&nbsp;Julia Lauberger,&nbsp;Julia Lühnen,&nbsp;Anke Steckelberg","doi":"10.1155/tbj/8821629","DOIUrl":"https://doi.org/10.1155/tbj/8821629","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Sex-/gender-specific health information for men with breast cancer is lacking. Health information supports patients in shared decision-making. When developing evidence-based health information, it is important to identify the patients’ information needs and preferences with regard to age, sex or gender, and other diversity aspects, including how the content is provided for the target group. However, studies show that sex/gender differences have rarely been considered. Our study investigates the information needs and preferences of cisgender men with breast cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A content-structuring, qualitative content analysis of forum posts was performed. Internet forums and posts were selected according to the following criteria: relevance of the topic, English or German language, and public availability without registration. A qualitative content analysis according to Kuckartz was conducted. The selected posts were coded using MAXQDA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1025 posts from three Internet forums were screened, and 96 posts were included for analysis—most of them from a German Internet forum. We identified seven main categories and 26 subcategories. Information needs and preferences are represented by the following main categories: “Epidemiology and general questions about the disease,” “Diagnostics,” “Therapy,” “Physician specialist services,” “Rehabilitation and lifestyle adaption,” and “Mental health.” Additionally, the “Preference for and access to current information” plays a role for the patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study provides new insights into the information needs and preferences of men with breast cancer, mainly from German-speaking countries. Providing accurate and reliable health information that meets patients’ needs and preferences is an ethical duty and has to be provided by healthcare systems. Such patient-centered and inclusive health care will empower patients to make informed decisions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/8821629","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145930982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Novel MRI Findings in Idiopathic Granulomatous Mastitis: Diagnostic Significance and Clinical Perspectives.","authors":"Fatih Işık, Mehmet Eren Öztürk, Fatih Alper","doi":"10.1155/tbj/8058328","DOIUrl":"10.1155/tbj/8058328","url":null,"abstract":"<p><strong>Objectives: </strong>Idiopathic granulomatous mastitis (IGM) is an uncommon, benign, chronic inflammatory breast disease that frequently mimics carcinoma both clinically and radiologically, posing diagnostic challenges. While classical imaging manifestations have been described, the full spectrum of MRI features remains incompletely characterized. This study aimed to identify and characterize novel MRI descriptors of histopathologically confirmed IGM and assess their reproducibility and potential clinical implications.</p><p><strong>Methods: </strong>In this retrospective single-center study, 45 consecutive women with biopsy-proven IGM were evaluated using 1.5 T breast MRI. Imaging protocols included T2-weighted fat-suppressed, T1-weighted, diffusion-weighted, and dynamic contrast-enhanced sequences. Two experienced radiologists, blinded to clinical and pathological data, independently reviewed all cases for classical and novel MRI features. Interobserver agreement was assessed using raw agreement and Cohen's κ statistics. Associations between imaging descriptors and clinical-demographic variables were tested with nonparametric methods.</p><p><strong>Results: </strong>The most common MRI pattern was a heterogeneously enhancing mass with concomitant nonmass enhancement (NME) (75.6%), followed by rim-enhancing microabscesses (62.2%) and isolated NME (48.9%). Four novel MRI features were identified: spherical transformation of mammary fat lobules (62.2%), disruption of fibroglandular tissue architecture (73.3%), ring-like enhancement with asymmetric wall morphology (46.6%), and nipple-areolar complex retraction (11.1%). Interobserver reproducibility was high (κ = 0.786-1.000; raw agreement > 90%). Novel descriptors, particularly spherical lobule transformation, fibroglandular disruption, and ring-like enhancement, were strongly associated with NME (all p < 0.001), but not with age or lesion laterality.</p><p><strong>Conclusion: </strong>These imaging descriptors may contribute to a better radiologic understanding of the morphological manifestations of IGM and may assist radiologists in recognizing imaging patterns associated with granulomatous inflammation. However, given the retrospective design and absence of a comparative cohort, these findings should be considered exploratory and hypothesis-generating.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":"e8058328"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Findings in Patients With Benign Adenomyoepithelioma: A Retrospective Analysis.","authors":"Pelin Seher Öztekin, Özge Özdemir, Selen Yakıştıran, Saygın Altıner, Serap Erel, Fatma Aslan Yay","doi":"10.1155/tbj/9666015","DOIUrl":"10.1155/tbj/9666015","url":null,"abstract":"<p><strong>Background and aim: </strong>Adenomyoepithelioma (AME) is a rare breast tumor characterized by the biphasic proliferation of epithelial and myoepithelial cells. Due to its rarity, data on its imaging characteristics-particularly magnetic resonance imaging (MRI) findings-remain limited. This study aimed to evaluate the radiological features of AME and assess the diagnostic contribution of multiparametric imaging.</p><p><strong>Methods: </strong>This retrospective study included 11 patients pathologically diagnosed with AME between 2013 and 2024 who underwent mammography, ultrasound (US), and MRI prior to diagnosis. Lesions were evaluated according to BI-RADS criteria: mammography (shape, margin, density, and calcifications); US (shape, margin, orientation, echogenicity, posterior features, vascularity, and elastography); and MRI (morphology, T2 signal intensity, ADC values, and enhancement kinetics).</p><p><strong>Results: </strong>The most common mammographic finding was an isodense oval or round mass with partially obscured margins (36.4%). No lesions demonstrated irregular shape or suspicious microcalcifications. On US, 90.9% of lesions were oval/round with circumscribed (45.5%) or indistinct (54.5%) margins. All lesions were hypoechoic and vascular; 71.4% exhibited soft elasticity on strain elastography. On MRI, 54.5% were hyperintense on T2 weighted images (T2WI) with circumscribed margins. ADC values ranged from 1.00 to 1.434 × 10^-3 mm²/s (mean 1.273 × 10^-3 mm²/s). Enhancement kinetics demonstrated Type I in 3/11, Type II in 3/11, and Type III in 5/11 lesions.</p><p><strong>Conclusion: </strong>Although AME often demonstrates benign morphological features, it is frequently categorized as BI-RADS 4 due to vascular and kinetic characteristics that raise suspicion for malignancy. Our findings suggest that relatively low ADC values further contribute to this suspicious imaging profile. However, the absence of suspicious microcalcifications, an oval or round shape, and hyperintensity on T2WI may aid in the differential diagnosis. Given the malignant potential of these lesions, wide local excision with negative margins is essential, and radiological findings play a crucial role in guiding the need for pathological confirmation.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":"e9666015"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Shoulder Mobility After Breast Reconstruction With a Lipofilled Latissimus Dorsi Mini-Flap: A Prospective Cohort Study.","authors":"Bruno Carvalho Carelli, Fabio Bagnoli, Eduardo de Melo Carvalho Rocha, José Francisco Rinaldi, Vilmar Marques de Oliveira","doi":"10.1155/tbj/5107548","DOIUrl":"https://doi.org/10.1155/tbj/5107548","url":null,"abstract":"<p><strong>Background: </strong>The lipofilled latissimus dorsi mini-flap (LDMF-L) broadens autologous breast-reconstruction options, yet its functional impact on the shoulder remains uncertain.</p><p><strong>Objective: </strong>To evaluate shoulder strength, range of motion (ROM) and patient-reported upper-limb function QuickDash 90 days after breast reconstruction with the LDMF-L.</p><p><strong>Methods: </strong>Prospective cohort of 20 patients operated on between November 2022 and November 2024.</p><p><strong>Inclusion: </strong>Breast cancer requiring immediate or delayed reconstruction with LDMF-L; exclusion: Implant use or major pre-existing limitation. Strength (Oxford scale), ROM (goniometry) and QuickDASH score were assessed preoperatively and at 90 days. Wilcoxon, Student's t-test, Mann-Whitney and McNemar tests were used appropriately (α = 0.05).</p><p><strong>Results: </strong>Mean age 54 ± 11.8 years; immediate/delayed reconstruction = 50/50%. Strength remained unchanged in 85% (p = 1.000). Active flexion and abduction showed significant reductions (p = 0.016 and 0.045), with no difference in rotations. QuickDASH increased from 8 ± 16 to 19 ± 24 (p = 0.008); nevertheless, 80% stayed within minimal/mild disability.</p><p><strong>Conclusions: </strong>The LDMF-L preserves strength and produces only mild early ROM decreases with limited functional impact, supporting its functional safety as an implant-free autologous option.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":"e5107548"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cohort Study on Cardiovascular Disease Mortality in Breast Cancer Patients With Different Subtypes.","authors":"Zhipeng Wang, Lihong Deng, Peng Wang, Yacong Zhang, Zhongyang Shen","doi":"10.1155/tbj/8076118","DOIUrl":"10.1155/tbj/8076118","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate cardiovascular disease (CVD) mortality among patients with different breast cancer (BC) subtypes to assess its implications for long-term survival.</p><p><strong>Patients and methods: </strong>In total, 423,758 BC patients were included in this study utilizing data from the Surveillance, Epidemiology, and End Results 17 Registries Database (2010-2020). Competing risk curves were utilized to assess whether the cumulative CVD mortality surpassed the cumulative BC mortality. Multivariate competing risk models were used to explore potential factors associated with CVD mortality. Standardized mortality ratios (SMRs) were calculated to investigate CVD mortality in comparison to the general population.</p><p><strong>Results: </strong>In total, 5863 BC patients died from CVD during follow-up time, accounting for 10.0% of all deaths (56,856). The number of deaths and the percentage of all deaths among patients died from CVD for luminal A, luminal B, HER-2 enriched, and triple-negative subtype were 4160 (12.2%), 615 (9.7%), 291 (7.7%), and 797 (6.2%), respectively. After 9 years, BC mortality remained over 10% higher than CVD mortality for luminal A and B subtypes, but the difference was under 10% for HER-2-enriched and triple-negative subtypes. HER-2-enriched and triple-negative BC patients aged 55-84 had higher CVD mortality compared to the general population. Triple-negative BC was independently associated with increased CVD mortality compared with luminal A (HR 1.103 [95% CI: 1.016-1.199]).</p><p><strong>Conclusions: </strong>Patients with the triple-negative subtype have a high risk of CVD mortality. This underscores the need for enhanced surveillance and targeted cardiovascular interventions for these patients to improve their long-term health outcomes.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":"e8076118"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrin Beta 4 Protein Expression Bimodally Predicts Sensitivity to CDK4/6 Inhibition and Resistance to Immunotherapy in Breast Cancer.","authors":"Zhi-Min Zhu, Lei Hu, Yan-Wen Ma, Qiong-Ni Zhu","doi":"10.1155/tbj/7668096","DOIUrl":"10.1155/tbj/7668096","url":null,"abstract":"<p><strong>Background: </strong>Integrin beta 4 (ITGB4) has been implicated in breast cancer progression, yet its clinical utility as a biomarker remains unclear due to inconsistent findings across studies. This discrepancy may stem from the failure to distinguish between RNA and protein levels.</p><p><strong>Methods: </strong>We performed an integrated multiomics analysis of ITGB4 across breast cancer subtypes using data from TCGA, CPTAC, METABRIC, and GEO cohorts. Key findings were functionally validated using CDK4/6 inhibition in luminal cells and via immunohistochemistry on triple-negative breast cancer (TNBC) tissue microarrays.</p><p><strong>Results: </strong>ITGB4 exhibited significant RNA-protein discordance across breast cancer subtypes. High ITGB4 protein expression predicted a favorable prognosis in ER-positive breast cancer (HR = 0.58, 95% CI: 0.39-0.86, p = 0.007) and enhanced sensitivity to CDK4/6 inhibitors. Conversely, high ITGB4 expression in TNBC correlated with immunotherapy resistance, characterized by elevated PD-L1/PD-L2 expression and reduced cytotoxic lymphocyte infiltration. Mechanistically, we identified the ESR1/miR-342-5p/UBE2E3 axis as a potential regulator of ITGB4 protein stability.</p><p><strong>Conclusion: </strong>ITGB4 protein expression serves as a bimodal biomarker in breast cancer, predicting CDK4/6 inhibitor sensitivity in luminal subtypes while indicating immunotherapy resistance in TNBC. ITGB4 protein thus represents a critical biomarker for guiding personalized therapy in precision oncology.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":"e7668096"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Sentinel Lymph Node Biopsy Decisions for Clinically Node-Negative Microinvasive DCIS.","authors":"Cien Huang, Priyanka Parmar, Noor Habboosh, Fardeen Bhimani, Yu Chen, David Entenberg, Maja Oktay, Anjuli Gupta, Jessica Pastoriza, Maureen McEvoy, Sheldon Feldman","doi":"10.1155/tbj/5479226","DOIUrl":"10.1155/tbj/5479226","url":null,"abstract":"<p><strong>Background: </strong>Ductal carcinoma in situ with microinvasion (DCISM), defined as invasion ≤ 1 mm, occurs in 5%-10% of DCIS cases. There is ongoing debate on whether DCISM should be managed as DCIS or as small invasive cancer. As treatments increasingly emphasize minimizing morbidity, efforts have focused on identifying low-risk patients who may safely forgo axillary surgery, including sentinel lymph node biopsy (SLNB). However, axillary management of DCISM remains unclear due to limited data. This study aims to identify preoperative predictors of upstaging to invasive carcinoma on final pathology to guide SLNB use.</p><p><strong>Methods: </strong>A retrospective chart review was conducted of women aged ≥ 19 years with confirmed or suspected DCISM on initial biopsy who were clinically node negative and treated at a tertiary center from 2013 to 2023. Fisher's exact test and Student's t-test were used for categorical and continuous variables, respectively. Univariate and multivariate analyses were performed to identify predictors of upstaging.</p><p><strong>Results: </strong>A total of 61 women with DCISM on initial biopsy were identified. Of these, 40.9% (25/61) were upstaged to invasive carcinoma on final pathology. Among upstaged patients, 95% (19/20) underwent SLNB at the time of surgery, and 12.5% (3/24) had positive lymph nodes. Time from biopsy to surgery did not differ significantly between groups (p = 0.12). Preoperative predictors of upstaging included palpable mass (OR 9.0, 95% CI 2.38-44.98, p = 0.003), mass on mammogram (OR 12.86, 95% CI 1.95-255.34, p = 0.02), and mass with calcifications (OR 13.34, 95% CI 1.30-255.08, p = 0.047).</p><p><strong>Conclusion: </strong>Clinically node-negative DCISM patients without a palpable or mammographic mass (with or without calcifications) had a low risk of upstaging and lymph node involvement, suggesting that they may safely forgo SLNB. Identifying preoperative variables can guide risk stratifications and de-escalation of axillary surgery. Larger prospective studies are needed to further inform guidelines for DCISM management in diverse populations.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":"e5479226"},"PeriodicalIF":2.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}