Canadian Journal of Anesthesia-Journal Canadien D Anesthesie最新文献

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Organ donation after death determination by circulatory criteria: family members' experiences with withdrawal of life-sustaining measures in Canadian intensive care units. 根据循环标准确定死亡后的器官捐献:加拿大重症监护病房中停止维持生命措施的家庭成员经历。
IF 3.4 3区 医学
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie Pub Date : 2025-06-01 Epub Date: 2025-06-26 DOI: 10.1007/s12630-025-02978-4
Aimee J Sarti, Stephanie Sutherland, Maureen Meade, Matthew J Weiss, Sonny Dhanani, Ken M Lotherington, Angele Landriault, Brandi Vanderspank-Wright, Sabira Valiani, Sean Keenan, Andreas H Kramer, Stephen Beed, Joanne Brennan, Pierre Cardinal, Michaël Chassé, Peter Nickerson, Sam D Shemie
{"title":"Organ donation after death determination by circulatory criteria: family members' experiences with withdrawal of life-sustaining measures in Canadian intensive care units.","authors":"Aimee J Sarti, Stephanie Sutherland, Maureen Meade, Matthew J Weiss, Sonny Dhanani, Ken M Lotherington, Angele Landriault, Brandi Vanderspank-Wright, Sabira Valiani, Sean Keenan, Andreas H Kramer, Stephen Beed, Joanne Brennan, Pierre Cardinal, Michaël Chassé, Peter Nickerson, Sam D Shemie","doi":"10.1007/s12630-025-02978-4","DOIUrl":"10.1007/s12630-025-02978-4","url":null,"abstract":"<p><strong>Purpose: </strong>Donation after death determination by circulatory criteria (DCC) is an option currently available for imminently dying patients who do not meet neurologic criteria for death. When organ donation is not successful following withdrawal of life-sustaining measures (WLSM), family members may experience additional feelings of loss and bereavement. In this study, we sought to explore the lived experiences of family members who consented to donation after DCC, including families whose loved ones proceeded to donation and those for whom donation was not possible.</p><p><strong>Methods: </strong>We conducted a qualitative study using semi-structured interviews with family members whose loved ones agreed to donation after DCC and underwent WLSM in Canadian intensive care units. We recruited participants from all Canadian provinces with an organ donation organization (n = 10) and analyzed themes using a modified grounded theory approach.</p><p><strong>Results: </strong>Interviews with 79 family members of 78 potential donors with DCC revealed nine main themes as important in the context of WLSM in DCC: 1) early and repetitive communication, 2) predicting time of death (after WLSM), 3) invitation to witness WLSM, 4) family agency in donation after DCC (e.g., wishing they had been able to take some action and/or exert more control), 5) environment, 6) support, 7) honouring donor/meaning making, 8) guilt, and 9) triple loss (i.e., death, unsuccessful donation, and loss for recipients).</p><p><strong>Conclusion: </strong>In this qualitative study, we identified a range of experiences among family members in the context of WLSM in DCC. Among those, we found family involvement in the WLSM and the DCC process to be very important. Family member perspectives on organ donation are essential to guide practices that can support consistent, high-quality family-centred care in this context.</p>","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":"975-985"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceptions of health care providers involved in organ donation or transplantation on cardiac donation after death by circulatory criteria: a qualitative study. 根据循环标准,参与器官捐赠或移植的卫生保健提供者对死后心脏捐赠的看法:一项定性研究。
IF 3.4 3区 医学
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie Pub Date : 2025-06-01 Epub Date: 2025-07-02 DOI: 10.1007/s12630-025-02979-3
Kimia Honarmand, Ian Ball, Maureen O Meade, Aimee Sarti, Danielle LeBlanc, John Basmaji, Emilie P Belley-Côté, Michaël Chassé, Frédérick D'Aragon, Gordon Guyatt, Bram Rochwerg, Sam D Shemie, Robert Sibbald, Marat Slessarev, Mathew J Weiss, Jeanna Parsons Leigh
{"title":"Perceptions of health care providers involved in organ donation or transplantation on cardiac donation after death by circulatory criteria: a qualitative study.","authors":"Kimia Honarmand, Ian Ball, Maureen O Meade, Aimee Sarti, Danielle LeBlanc, John Basmaji, Emilie P Belley-Côté, Michaël Chassé, Frédérick D'Aragon, Gordon Guyatt, Bram Rochwerg, Sam D Shemie, Robert Sibbald, Marat Slessarev, Mathew J Weiss, Jeanna Parsons Leigh","doi":"10.1007/s12630-025-02979-3","DOIUrl":"10.1007/s12630-025-02979-3","url":null,"abstract":"<p><strong>Purpose: </strong>Cardiac donation after death determination by circulatory criteria (DCC) can be performed using either 1) direct procurement and perfusion of ex situ organs or 2) normothermic regional perfusion (NRP). Nevertheless, there are concerns regarding the acceptability and ethics of these procedures, particularly NRP in which the blood supply to the brain is surgically interrupted and circulation in the thorax and abdomen is restored prior to heart retrieval. We aimed to understand the perspectives on cardiac donation following DCC of Canadian clinicians who are involved in donation and transplantation.</p><p><strong>Methods: </strong>We performed a qualitative descriptive study of 75 clinicians to better understand the perspectives of physicians on cardiac DCC. We purposively sampled clinicians who care for organ donors (N = 51) and those who care for transplant recipients (N = 24) in Canada. We performed thematic analysis to generate themes describing participants' perspectives about cardiac DCC and its implementation in Canada.</p><p><strong>Results: </strong>We found that the broad support and interest to implement cardiac DCC among the cohort of clinicians interviewed was tempered by their anticipation that other clinicians, donor families, and the public would be less supportive. Donor clinicians were particularly concerned about potential erosion in public trust in the organ donation system as a whole. Participants identified opportunities to address anticipated challenges, including strategies for education and communication around cardiac DCC, staged/gradual introduction of cardiac DCC, and the option for stakeholders (clinicians, donor families, potential transplant recipients) to opt out of participation in cardiac DCC.</p><p><strong>Conclusions: </strong>In this qualitative study of clinicians involved in organ donation or transplantation across Canada, we found broad support for cardiac DCC. Nevertheless, we observed several challenges with the implementation of cardiac DCC, particularly concerns of nonsupport by other stakeholders. Participants also identified opportunities to address anticipated barriers.</p>","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":"986-999"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dexmedetomidine and acute kidney injury in patients with sepsis: a retrospective cohort study. 右美托咪定与脓毒症患者急性肾损伤:一项回顾性队列研究。
IF 3.4 3区 医学
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI: 10.1007/s12630-025-02977-5
Papawadee Chaengsuthiworawat, Tharin Thampongsa, Thanyalak Thamjamrassri, Chawika Pisitsak
{"title":"Dexmedetomidine and acute kidney injury in patients with sepsis: a retrospective cohort study.","authors":"Papawadee Chaengsuthiworawat, Tharin Thampongsa, Thanyalak Thamjamrassri, Chawika Pisitsak","doi":"10.1007/s12630-025-02977-5","DOIUrl":"10.1007/s12630-025-02977-5","url":null,"abstract":"<p><strong>Purpose: </strong>Acute kidney injury (AKI) is a common complication of sepsis. AKI is associated with increased morbidity and mortality. Studies show that dexmedetomidine has a protective effect against AKI. We sought to evaluate the association between dexmedetomidine administration and AKI in patients with sepsis.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 331 adult patients with sepsis. We divided patients into two groups: patients who received an infusion of dexmedetomidine of ≥ 0.2 µg·kg<sup>-1</sup>·hr<sup>-1</sup> for > 6 hr within 72 hr of sepsis diagnosis (the dexmedetomidine group; N = 73) and patients who did not receive a dexmedetomidine infusion (the nondexmedetomidine group; N = 258). The primary outcome was the incidence of AKI within seven days, defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria. We analyzed our results using multivariable logistic regression models including 1) the entire cohort (331 patients) or 2) a 1:1 propensity-score-matched cohort (73 patients per group).</p><p><strong>Results: </strong>Acute kidney injury was diagnosed in 190/331 (57.4%) patients. The incidence of AKI was not different between the dexmedetomidine group and the nondexmedetomidine group in both the entire cohort (54.8% vs 58.1%; P = 0.61) and the propensity-matched cohort (54.7% vs 63.0%; P = 0.31). Additionally, there were no significant differences between groups in the incidence of renal replacement therapy (10.9% vs 13.6%; P = 0.61) and 30-day mortality (32.8% vs 24.6%; P = 0.27). We observed a statistically significant interaction between patient age > 65 yr and reduced odds of developing AKI in patients who received dexmedetomidine (adjusted odds ratio, 0.25; 95% confidence interval, 0.07 to 0.90; P = 0.03).</p><p><strong>Conclusions: </strong>While there was no association between dexmedetomidine administration and AKI in our overall cohort of patients with sepsis, we observed reduced odds of developing AKI in older patients (aged > 65 yr) who received dexmedetomidine. Further research is needed to confirm that dexmedetomidine has a protective effect against AKI in this patient population.</p>","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":"966-974"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ambulatory total knee arthroplasty in a patient with cold agglutinin disease. 冷凝素病患者的动态全膝关节置换术。
IF 3.4 3区 医学
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie Pub Date : 2025-06-01 Epub Date: 2025-05-09 DOI: 10.1007/s12630-025-02961-z
Shikha Bansal
{"title":"Ambulatory total knee arthroplasty in a patient with cold agglutinin disease.","authors":"Shikha Bansal","doi":"10.1007/s12630-025-02961-z","DOIUrl":"10.1007/s12630-025-02961-z","url":null,"abstract":"<p><strong>Purpose: </strong>Cold agglutinin disease (CAD) is a rare autoimmune disease caused by high titres of cold-reacting autoantibodies that cause red blood cell agglutination and subsequent hemolysis at low temperatures. Trauma, surgery, and infection/inflammation exacerbate CAD. The present report describes the successful perioperative management of a patient with CAD who underwent outpatient total knee arthroplasty (TKA).</p><p><strong>Clinical features: </strong>A 70-yr-old female was diagnosed with CAD in 2016 with symptoms of pain and pallor in her fingertips, numbness and bluish discoloration of her tongue, and shortness of breath. She was treated with folic acid, rituximab, and bendamustine. After remaining symptom-free for 4 yrs and following consultation with hematology, she was scheduled to undergo TKA. She received a spinal anesthetic with chloroprocaine, intravenous sedation, antiemetic prophylaxis, and an adductor canal catheter for continuous perineural analgesia. Warming measures, including a warm (20 °C) operating room, warm intravenous fluids, warm irrigating fluids, warm surgical prepping solution, forced-air warming blankets, and avoidance of a thigh tourniquet, helped prevent hypothermia in the patient. The patient's perioperative course was uneventful, and she was discharged on the same day. She was followed up via a patient monitoring mobile application and advised to monitor herself for signs of CAD relapse. She had no concerns up to three months after surgery.</p><p><strong>Conclusion: </strong>The perioperative management of patients with CAD is challenging, and multidisciplinary collaboration and coordination between the anesthesiologist, surgeon, hematologist, and nurses, as well as adequate intraoperative precautions and postoperative instructions and monitoring, are essential to ensuring safe surgery and optimal patient outcomes.</p>","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":"1015-1020"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Umbilical analgesic concentrations after labour analgesia with programmed intermittent epidural bolus: a prospective observational study. 计划性间歇硬膜外灌注分娩镇痛后脐部镇痛浓度:一项前瞻性观察研究。
IF 3.4 3区 医学
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie Pub Date : 2025-06-01 Epub Date: 2025-06-10 DOI: 10.1007/s12630-025-02975-7
Arisa Ijuin, Masaki Sato, Nagayoshi Umehara, Shoichiro Amari, Jumpei Saito, Mayuko Abe, Wataru Matsunaga, Yoko Yamashita, Yasuyuki Suzuki, Kenichi Masui
{"title":"Umbilical analgesic concentrations after labour analgesia with programmed intermittent epidural bolus: a prospective observational study.","authors":"Arisa Ijuin, Masaki Sato, Nagayoshi Umehara, Shoichiro Amari, Jumpei Saito, Mayuko Abe, Wataru Matsunaga, Yoko Yamashita, Yasuyuki Suzuki, Kenichi Masui","doi":"10.1007/s12630-025-02975-7","DOIUrl":"10.1007/s12630-025-02975-7","url":null,"abstract":"<p><strong>Purpose: </strong>The umbilical analgesic concentrations after using programmed intermittent epidural bolus (PIEB) and patient-controlled epidural analgesia (PCEA) without continuous infusion are unknown. We aimed to characterize umbilical ropivacaine and fentanyl concentrations and examine their influence on neonatal conditions at delivery.</p><p><strong>Methods: </strong>We prospectively studied 50 parturients with singleton pregnancies who received combined spinal-epidural analgesia using PIEB (7 mL every 45 min) and PCEA (7 mL per bolus; lockout interval: 15 min) with 0.08% ropivacaine and 2 μg·mL<sup>-1</sup> fentanyl, with clinician-administered boluses as necessary. We evaluated the umbilical venous analgesic concentrations and neonatal characteristics.</p><p><strong>Results: </strong>The median [interquartile range (IQR)] hourly ropivacaine and fentanyl doses were 13 [11-15] mg·hr<sup>-1</sup> and 39 [30-50] µg·hr<sup>-1</sup>, respectively. The ropivacaine and fentanyl concentrations were 77 [56-98] ng·mL<sup>-1</sup> and 0.125 [0.125-0.20] ng·mL<sup>-1</sup> at delivery, respectively. The umbilical analgesic concentrations were correlated with the labour duration and total dose. In parturients given clinician-administered boluses within 1 hr before delivery, the ropivacaine and fentanyl concentrations were similar to those without (81 [54-104] vs 77 [54-96] ng·mL<sup>-1</sup> and 0.20 [0.125-0.20] vs 0.125 [0.05-0.20] ng·mL<sup>-1</sup>, respectively). The umbilical arterial pH was > 7.2 and the Apgar score at 5 min was ≥ 8 for all neonates. No neonates exhibited systemic local anesthetic toxicity. Respiratory support was required for 14 neonates.</p><p><strong>Conclusions: </strong>Umbilical analgesic concentrations at delivery were low after labour analgesia using a regimen of PIEB with PCEA for up to 19 hr. An intermittent bolus dosing regimen may contribute to a decrease in umbilical analgesic concentrations.</p>","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":"934-944"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical features and airway management experience in an infant with Arboleda-Tham syndrome. 1例婴幼儿Arboleda-Tham综合征的临床特点及气道管理体会。
IF 3.4 3区 医学
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie Pub Date : 2025-06-01 Epub Date: 2025-05-20 DOI: 10.1007/s12630-025-02966-8
Kumi Kataoka, Igor Luginbuehl
{"title":"Clinical features and airway management experience in an infant with Arboleda-Tham syndrome.","authors":"Kumi Kataoka, Igor Luginbuehl","doi":"10.1007/s12630-025-02966-8","DOIUrl":"10.1007/s12630-025-02966-8","url":null,"abstract":"","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":"1028-1029"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between general anesthesia combined with peripheral nerve blocks versus neuraxial anesthesia without nerve blocks for high-risk isolated distal deep venous thrombosis in patients undergoing knee arthroplasty: a historical cohort study. 膝关节置换术患者高危孤立远端深静脉血栓形成的全麻联合周围神经阻滞与不加神经阻滞的轴向麻醉的相关性:一项历史队列研究
IF 3.4 3区 医学
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie Pub Date : 2025-06-01 Epub Date: 2025-05-28 DOI: 10.1007/s12630-025-02957-9
Nanbo Luo, Li Luo, Lei Yang, Zhi Li, Qingmin Yu, Wenling Jian, Wei Sun, Pac-Soo Chen, Qian Chen, Daqing Ma, Qingsheng Xue, Yan Luo, Buwei Yu, Hao Wang, Zhiheng Liu
{"title":"Association between general anesthesia combined with peripheral nerve blocks versus neuraxial anesthesia without nerve blocks for high-risk isolated distal deep venous thrombosis in patients undergoing knee arthroplasty: a historical cohort study.","authors":"Nanbo Luo, Li Luo, Lei Yang, Zhi Li, Qingmin Yu, Wenling Jian, Wei Sun, Pac-Soo Chen, Qian Chen, Daqing Ma, Qingsheng Xue, Yan Luo, Buwei Yu, Hao Wang, Zhiheng Liu","doi":"10.1007/s12630-025-02957-9","DOIUrl":"10.1007/s12630-025-02957-9","url":null,"abstract":"<p><strong>Purpose: </strong>General anesthesia combined with peripheral nerve blocks has become a common anesthesia regimen for knee replacement surgery. Its association with high-risk isolated distal deep venous thrombosis (IDDVT) remains uncertain.</p><p><strong>Methods: </strong>In this cohort study, we obtained consecutive data from the electronic inpatient records of Shenzhen Second People's Hospital, including adults who underwent knee arthroplasty from 1 September 2019 to 31 August 2021. The primary outcome was the incidence of high-risk IDDVT. We compared the outcomes in patients who received general anesthesia combined with nerve blocks with those in patients who received neuraxial anesthesia without nerve blocks, using a multivariable regression model with inverse probability weighting according to the propensity score.</p><p><strong>Results: </strong>Of the 848 patients who underwent knee arthroplasty, 330 were excluded because they lacked thrombus testing or had received other types of anesthesia. Of the remaining 518 patients, 267/518 (52%) received general anesthesia combined with nerve blocks and 251/518 (48%) received neuraxial anesthesia with no nerve blocks. A total of 99 patients developed high-risk IDDVT. In the primary multivariable analysis with inverse probability weighting according to the propensity score, general anesthesia combined with nerve blocks was associated with a significantly reduced high-risk IDDVT compared with neuraxial anesthesia without nerve blocks (odds ratio, 0.50; 95% confidence interval, 0.31 to 0.81; P = 0.005). The results of multiple sensitivity analyses were similar between the two cohorts. E-value analysis suggested robustness to unmeasured confounding.</p><p><strong>Conclusions: </strong>Compared with neuraxial anesthesia without peripheral nerve blocks, general anesthesia combined with peripheral nerve blocks in patients undergoing knee arthroplasty was associated with a reduced incidence of high-risk IDDVT in our retrospective study. A large multicentre prospective clinical trial is needed to validate our findings.</p><p><strong>Study registration: </strong>ChiCTR.org.cn ( ChiCTR2200057006 ), first submitted 25 February 2022.</p>","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":"882-894"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large language models in perioperative medicine-applications and future prospects: a narrative review. 大语言模型在围手术期医学中的应用和未来前景:叙述性回顾。
IF 3.4 3区 医学
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI: 10.1007/s12630-025-02980-w
Arnaud Romeo Mbadjeu Hondjeu, Zi Ying Zhao, Luka Newton, Anass Ajenkar, Emily Hladkowicz, Karim Ladha, Duminda N Wijeysundera, Daniel I McIsaac
{"title":"Large language models in perioperative medicine-applications and future prospects: a narrative review.","authors":"Arnaud Romeo Mbadjeu Hondjeu, Zi Ying Zhao, Luka Newton, Anass Ajenkar, Emily Hladkowicz, Karim Ladha, Duminda N Wijeysundera, Daniel I McIsaac","doi":"10.1007/s12630-025-02980-w","DOIUrl":"10.1007/s12630-025-02980-w","url":null,"abstract":"<p><strong>Purpose: </strong>Large language models (LLMs) are a subset of artificial intelligence (AI) and linguistics designed to help computers understand and analyze human language. Clinical applications of LLMs have recently been recognised for their potential enhanced analytic capacity. Availability and performance of LLMs are expected to increase substantially over time with a significant impact on patient care and health care provider workflow. Despite increasing recognition of LLMs, insights on the utilities, associated benefits and limitations are scarce among perioperative clinicians. In this narrative review, we delve into the functionalities and prospects of existing LLMs and their clinical application in perioperative medicine. Furthermore, we summarize challenges and constraints that must be addressed to fully realize the potential of LLMs.</p><p><strong>Source: </strong>We searched MEDLINE, Google Scholar, and PubMed® databases for articles referencing LLMs in perioperative care.</p><p><strong>Principal findings: </strong>We found that in the perioperative setting (from surgical diagnosis to discharge postoperatively), LLMs have the potential to improve the efficiency and accuracy of health care delivery by extracting and summarizing clinical data, making recommendations on the basis of these findings, as well as addressing patient queries. Moreover, LLMs can be used for clinical decision-making support, surveillance tools, predictive modelling, and enhancement of medical research and education.</p><p><strong>Conclusions: </strong>The integration of LLMs into perioperative medicine presents a significant opportunity to enhance patient care, clinical decision-making, and operational efficiency. These models can streamline processes, provide personalized patient education, and offer robust decision support. Nevertheless, their clinical implementation requires addressing several key challenges, including managing hallucinations, ensuring data security, and mitigating inherent biases. If these challenges are met, LLMs can revolutionize perioperative practice, improving both patient outcomes and clinician workflow.</p>","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":"1000-1014"},"PeriodicalIF":3.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional outcomes among the survivors of veno-venous extracorporeal membrane oxygenation during the COVID-19 pandemic: a historical cohort study. COVID-19大流行期间静脉-静脉体外膜氧合幸存者的功能结局:一项历史队列研究
IF 3.4 3区 医学
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie Pub Date : 2025-05-29 DOI: 10.1007/s12630-025-02965-9
Eunicia Ursu, Ana Mikolić, Bobo Tong, Noah D Silverberg, Nishtha Parag, Denise Foster, Mypinder S Sekhon, William Panenka, Sonny Thiara, Donald E G Griesdale
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引用次数: 0
Resourcefulness in anesthesia: overcoming absurd limitations in pediatric induction in sub-Saharan Africa. 在麻醉足智多谋:克服荒谬的限制在儿科诱导在撒哈拉以南非洲。
IF 3.4 3区 医学
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie Pub Date : 2025-05-28 DOI: 10.1007/s12630-025-02968-6
Amina Omari, Sheidai Salim, Simon Ponthus, Lionel Dumont
{"title":"Resourcefulness in anesthesia: overcoming absurd limitations in pediatric induction in sub-Saharan Africa.","authors":"Amina Omari, Sheidai Salim, Simon Ponthus, Lionel Dumont","doi":"10.1007/s12630-025-02968-6","DOIUrl":"https://doi.org/10.1007/s12630-025-02968-6","url":null,"abstract":"","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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