Canadian Journal of Anesthesia-Journal Canadien D Anesthesie最新文献

{"title":"Blood transfusion and acute kidney injury after cardiac surgery: a retrospective observational study.","authors":"Yuliya Boyko, Sebastian B Rasmussen, Justyna Bartoszko, Wilton A van Klei, Stuart McCluskey, Keyvan Karkouti, Hanne B Ravn","doi":"10.1007/s12630-025-03036-9","DOIUrl":"https://doi.org/10.1007/s12630-025-03036-9","url":null,"abstract":"<p><strong>Purpose: </strong>Cardiac surgery-associated acute kidney injury (AKI) is linked to poor outcomes. An observational study from Copenhagen, Denmark identified perioperative red blood cell (RBC) transfusion as a modifiable risk factor for AKI, with a dose-dependent relationship between the number of RBC units transfused and the occurrence and severity of AKI. We aimed to externally validate those findings in a larger population.</p><p><strong>Methods: </strong>We conducted a retrospective observational study of adult patients undergoing nonemergent on-pump cardiac surgery at Toronto General Hospital (Toronto, ON, Canada) between 2016 and 2021. Acute kidney injury was classified using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Data were analyzed using inverse probability weighted logistic regression.</p><p><strong>Results: </strong>Among 5,204 patients, 798 developed AKI, with 77% classified as stage 1, 11% as stage 2, and 12% as stage 3. Patients with AKI were older, had lower preoperative hemoglobin levels and estimated glomerular filtration rates, longer cardiopulmonary bypass duration, and lower intraoperative hemoglobin levels. Red blood cells were administered to 37% of patients, with 14% receiving plasma and 32% platelets. Only RBC transfusion, alone or combined with other blood products, was significantly associated with AKI. The transfusion of 1-2 RBC units increased the probability of stage 1 AKI by 4% and stage 2-3 AKI by 2% compared with patients not receiving RBCs. The risk was especially pronounced with the transfusion of > 2 units of RBCs, which raised the probability of stage 1 AKI by 12% and stage 2-3 AKI by 9%.</p><p><strong>Conclusions: </strong>This study confirms previous findings that RBC transfusion is associated with postoperative AKI in cardiac surgery patients. The association was strongest among patients who received > 2 units of RBCs. Prospective studies are needed to determine the optimal strategies for transfusion in these patients and evaluate potential alternatives.</p>","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An encounter of unusual pressure dynamics during thoracic epidural placement: a \"breathing\" syringe.","authors":"Priya Thappa, Ashutosh Kumar, Amardeep Kaur, Virendra K Arya","doi":"10.1007/s12630-025-03022-1","DOIUrl":"https://doi.org/10.1007/s12630-025-03022-1","url":null,"abstract":"","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Richard Chisholm, MD, FRCPC.","authors":"John Chisholm, Michael J Wong","doi":"10.1007/s12630-025-03023-0","DOIUrl":"https://doi.org/10.1007/s12630-025-03023-0","url":null,"abstract":"","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond misconduct: forging an ethical future in academia.","authors":"Britta S von Ungern-Sternberg, Karin Becke-Jakob","doi":"10.1007/s12630-025-03021-2","DOIUrl":"https://doi.org/10.1007/s12630-025-03021-2","url":null,"abstract":"","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric airway foreign body-a unique simulation scenario for anesthesiology and otolaryngology trainees.","authors":"Arnim Vlatten, Sally J Bird, Tim Brown, Liane Johnson","doi":"10.1007/s12630-025-02990-8","DOIUrl":"https://doi.org/10.1007/s12630-025-02990-8","url":null,"abstract":"","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video-based teaching of airway management for a resource-limited environment.","authors":"Julia Schuler, Linda Grüßer, Gereon Schälte, Talishi Shivolo, Peter Njuki, Alexander Reineke, Akutu Munyika","doi":"10.1007/s12630-025-03016-z","DOIUrl":"https://doi.org/10.1007/s12630-025-03016-z","url":null,"abstract":"","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Association between general anesthesia combined with peripheral nerve blocks versus neuraxial anesthesia without nerve blocks for high-risk isolated distal deep venous thrombosis in patients undergoing knee arthroplasty: a historical cohort study.","authors":"Nanbo Luo, Li Luo, Lei Yang, Zhi Li, Qingmin Yu, Wenling Jian, Wei Sun, Pac-Soo Chen, Qian Chen, Daqing Ma, Qingsheng Xue, Yan Luo, Buwei Yu, Hao Wang, Zhiheng Liu","doi":"10.1007/s12630-025-03012-3","DOIUrl":"https://doi.org/10.1007/s12630-025-03012-3","url":null,"abstract":"","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderate to deep sedation and ilioinguinal block for adolescent radiofrequency catheter ablation.","authors":"Lauren Coulombe, Joseph Atallah, Mancho Ng","doi":"10.1007/s12630-025-03018-x","DOIUrl":"https://doi.org/10.1007/s12630-025-03018-x","url":null,"abstract":"","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Representation of women as corresponding authors in Canadian academic anesthesiology.","authors":"Ekambir Saran, Amrit Brar, Connor T A Brenna","doi":"10.1007/s12630-025-03017-y","DOIUrl":"https://doi.org/10.1007/s12630-025-03017-y","url":null,"abstract":"","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of out-of-hospital mortality following injury in Canadian provinces and territories: a historical cohort study.","authors":"Alexandra Lapierre, Audace Nkeshimana, Natalie Yanchar, Barbara Haas, David C Evans, Markus Ziesman, Amanda W McFarlan, Éric Mercier, Jacynthe Lampron, Bourke Tillmann, Lynne Moore","doi":"10.1007/s12630-025-02964-w","DOIUrl":"10.1007/s12630-025-02964-w","url":null,"abstract":"<p><strong>Purpose: </strong>Trauma systems encompass injury prevention, prehospital care, acute care, rehabilitation, and community integration. The proportion of out-of-hospital injury deaths may indicate the effectiveness of trauma systems, particularly in prevention and prehospital care. In the absence of Canadian data, we aimed to estimate this proportion nationally and by province and analyze variations by age, sex, and year.</p><p><strong>Methods: </strong>We conducted a historical cohort study to analyze aggregate data on hospital discharges and mortality statistics covering injury-related deaths in Canadian provinces and territories from 2017 to 2020. We included deaths from all Canadian provinces and territories except Quebec, for which data on in-hospital deaths were unavailable. We calculated the proportions of out-of-hospital deaths with 95% confidence intervals. We used robust Poisson models to assess provincial variation, adjusting for age, sex, and year for Ontario, Alberta, and British Columbia (the volumes were too low in the other provinces). We conducted subgroup analyses for age group, sex, year, and injury mechanism.</p><p><strong>Results: </strong>Canada recorded 64,725 injury-related deaths between 2017 and 2020 (32.3% ≥ age 65 yr; 34.5% female), with 48% occurring outside of hospitals globally and 80% in < 65-yr-olds. Proportions of out-of-hospital deaths ranged from 30% in the Atlantic provinces to 58% in Saskatchewan. After adjusting for age, sex, and year, Alberta had a 13% higher risk of out-of-hospital mortality than Ontario (reference standard), while British Columbia had a 26% lower risk. Subgroup analyses revealed variations across age groups, sex, and years.</p><p><strong>Conclusions: </strong>Half of all injury deaths in Canada between 2017 and 2020 occured outside of hospitals. This proportion varied by province, possibly suggesting differences in the development and maturity of provincial trauma systems. Future studies should strive to identify modifiable determinants of these interprovincial variations to inform public health strategies.</p>","PeriodicalId":56145,"journal":{"name":"Canadian Journal of Anesthesia-Journal Canadien D Anesthesie","volume":" ","pages":"1130-1139"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}