Pediatrics and Neonatology最新文献

{"title":"Twenty years’ experience of midgut malrotation and volvulus in a tertiary center in northern Taiwan: A retrospective study","authors":"Wen-Yu Tseng ,&nbsp;Ming-Wei Lai ,&nbsp;Jin-Yao Lai ,&nbsp;Chien-Chang Chen ,&nbsp;Hsun-Chin Chao ,&nbsp;Jeng-Chang Chen ,&nbsp;Shih-Yen Chen ,&nbsp;Yung-Ching Ming ,&nbsp;Hung-Yu Yeh ,&nbsp;Hung-Hsiang Lai ,&nbsp;Sze-Ya Ting ,&nbsp;Pai-Jui Yeh","doi":"10.1016/j.pedneo.2023.11.009","DOIUrl":"10.1016/j.pedneo.2023.11.009","url":null,"abstract":"<div><h3>Background</h3><div>Early diagnosis and surgical intervention for midgut malrotation with bowel obstruction are crucial. We aimed to identify risk factors for adverse outcomes in infants with midgut malrotation and to develop a prediction model.</div></div><div><h3>Methods</h3><div>We reviewed the operation records of infants surgically diagnosed with midgut malrotation at Chang Gung Children's Medical Center between January 2000 and December 2020. Patients were classified into the poor-outcome group (PO) if they underwent bowel resection or experienced mortality; all others were categorized as the favorable-outcome group (FO). Data on demographics, initial presentations, laboratory results, radiographic or sonographic findings, maternal conditions, and outcomes were collected and analyzed. Fisher's exact test, the independent sample <em>t-</em>test, and the Mann-Whitney test were utilized for comparative analysis when suitable.</div></div><div><h3>Results</h3><div>The study included 103 infants. Eleven were in the PO group, and 92 were in the FO group. Initial presentations such as respiratory distress, poor activity, and shock status were notably more prevalent in the PO group. The INR, hemoglobin, HCO₃, base excess, and aspartate transaminase values showed significant variation between the two groups. Multivariate analysis identified that lower hemoglobin (OR 0.677, <em>p</em> = 0.043) and higher AST (OR 1.036, <em>p</em> = 0.044) were independent predictors of adverse outcomes. An AST/Hb ratio of &lt;3.78 demonstrated a high negative predictive value (98.6%) for an adverse outcome in midgut malrotation.</div></div><div><h3>Conclusions</h3><div>Prompt diagnosis and surgical treatment of midgut malrotation are vital to prevent bowel resection or mortality. The independent predicting factors for poor outcomes include low hemoglobin and elevated AST levels.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 7-11"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jordanian parental perception of screen time and its association with psychological distress: A cross-sectional design","authors":"Jehad Feras AlSamhori ,&nbsp;Ahmad A. Toubasi ,&nbsp;Dunia Z. Jaber ,&nbsp;Hadeel H. Ghanem ,&nbsp;Bayan I. Thainat ,&nbsp;Ahmad Feras AlSamhori ,&nbsp;Heba Kalbouneh","doi":"10.1016/j.pedneo.2023.11.010","DOIUrl":"10.1016/j.pedneo.2023.11.010","url":null,"abstract":"<div><h3>Background</h3><div>The excessive use of electronic devices among children is a global concern because of its negative impact on behavior. This cross-sectional study aimed to assess parents' awareness of their children's electronic device use and their perspective on how screen time affects behavior for 4–10-year-olds in Jordan.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted to assess parents' awareness of their children's electronic device usage. The study included 807 mothers and fathers from Jordan with at least one child aged 4 to 10. The data collection instrument consisted of a self-administered survey with 43 questions, including sociodemographic characteristics and the Strength and Difficulties Questionnaire. Descriptive analysis, categorical Chi-square test, Independent <em>t</em>-test, and Mann-Whitney <em>U</em> test were used for statistical analysis. The study followed ethical standards and principles.</div></div><div><h3>Results</h3><div>A survey of 807 parents in Jordan found that gaming and videos were the most common content watched by children, and 61.3% used devices alone. Only 37.1% of parents believed that device use could improve their children's psychological growth, while 72.7% and 65.9% believed it could impact negatively their children's mental and psychological growth, respectively. The Strengths and Difficulties Questionnaire showed that 51.4% of children were normal, while 25.3% were borderline and 23.3% were abnormal.</div></div><div><h3>Conclusion</h3><div>Children in the study used electronic devices excessively and this was linked to severe behavioral problems. Parents should follow AAP guidelines and spend more time with their children through non-electronic activities to improve their behavior.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 12-17"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and outcomes of vitamin D deficiency in very preterm infants","authors":"Hannah Cho ,&nbsp;Yoon Lee ,&nbsp;Saelin Oh ,&nbsp;Ju Sun Heo","doi":"10.1016/j.pedneo.2024.04.004","DOIUrl":"10.1016/j.pedneo.2024.04.004","url":null,"abstract":"<div><h3>Background</h3><div>Vitamin D is essential for bone health and immune system. Vitamin D deficiency (VDD) poses a high-risk to very preterm (VP) infants. This study aimed to evaluate the risk factors associated with VDD in VP infants and its potential clinical outcomes.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted on VP infants admitted to the neonatal intensive care unit of a specialized tertiary hospital in Seoul, Republic of Korea, between January 2018 and June 2022. Serum 25-hydroxyvitamin D (25(OH)D) levels and other biochemical parameters were measured between 4 and 6 weeks of age. VDD was defined as a serum 25(OH)D level &lt;20 ng/mL. Prenatal and postnatal risk factors and clinical outcomes were compared between the VDD and non-VDD groups.</div></div><div><h3>Results</h3><div>Of the 82 VP infants analyzed, 27 (32.9%) were diagnosed with VDD. The VDD group exhibited a significantly longer duration of parenteral nutrition (PN) compared to the non-VDD group (adjusted odds ratio [OR] = 1.12; 95% confidence interval [CI]: 1.008–1.245). Breast milk intake was lower in the VDD group than in the non-VDD group (adjusted OR = 0.976, 95% CI, 0.955–0.999). Notably, calcium levels were significantly lower in the VDD group, while parathyroid hormone levels were significantly higher, compared with the non-VDD group. Additionally, the rickets severity score was higher in the VDD group than in the non-VDD, although the difference was not statistically significant.</div></div><div><h3>Conclusions</h3><div>Prolonged PN duration and low breast milk intake significantly increased the risk of VDD in VP infants.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 31-36"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141055180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exome re-analysis increases the diagnostic yield of monogenic diseases in children","authors":"Atanu Kumar Dutta ,&nbsp;Niladri Sekhar Bhunia ,&nbsp;Rohit Bhowmik ,&nbsp;Nihar Ranjan Mishra ,&nbsp;Rimjhim Sonowal ,&nbsp;Nibedita Sarma ,&nbsp;Sumit Mukherjee ,&nbsp;Kalyan Goswami","doi":"10.1016/j.pedneo.2024.10.001","DOIUrl":"10.1016/j.pedneo.2024.10.001","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 81-82"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial","authors":"Mandana Kashaki ,&nbsp;Arash Mohazzab ,&nbsp;Mohammad Radgoudarzi ,&nbsp;Arash Bordbar ,&nbsp;Sama Dabbagh","doi":"10.1016/j.pedneo.2023.12.007","DOIUrl":"10.1016/j.pedneo.2023.12.007","url":null,"abstract":"<div><h3>Background</h3><div>Persistent Pulmonary Hypertension of the newborn (PPHN) is characterized by sustained elevated Pulmonary Artery Pressure (PAP). Drug resistance and the adverse effects of current therapeutic agents warrant investigation of other targeted therapies. Bosentan has shown benefits in affected neonates. However, trials reported the association with unwanted effects. Thus, in this study, we assess another agent in the same family, Macitentan. However, its efficacy in the treatment of PPHN is not yet reported. Hence, this study evaluated the effect of Macitentan compared to Bosentan in terms of efficacy and safety in the treatment of PPHN.</div></div><div><h3>Methods</h3><div>This randomized, double-blinded non-inferiority clinical trial was conducted in Shahid Akbar Abadi hospital, Tehran, Iran. Sixty clinically stable neonates with signs suggestive of PPHN were randomly allocated into two groups (n = 30 in each group) and they received either Bosentan 1 mg/kg/dose BD (twice daily) or Macitentan 1 mg/kg/dose BD simultaneously with sildenafil. The echocardiographic and laboratory indices of efficacy and safety were compared between groups. SPAP (systolic pulmonary artery pressure) was used to assess the non-inferiority of the Macitentan compared to the Bosentan in their respective doses used in the study.</div></div><div><h3>Results</h3><div>Participants’ mean (SD) age was 3.53 (1.21) days, and 55% were female. No mortality case occurred. SPAP was reduced in both Bosentan and Macitenan groups with the mean difference in SPAP of 9 (95% CI: 7.34–10.65) in Bosentan and SPAP mean difference of 14 (95% CI: 12.12–15.86) in Macitentan group. Categorical comparison of primary outcome improvement showed that Macitentan was superior to Bosentan with a 10% non-inferiority margin. Similar results were obtained in other echocardiographic indices. Also, no significant alterations were observed in laboratory safety parameters.</div></div><div><h3>Conclusion</h3><div>Macitentan 1 mg/kg/dose BD (twice daily) is non-inferior to Bosentan 1 mg/kg/dose BD in improving echo outcomes of PPHN and it was even more effective in improving some of these. Also, it is non-inferior to Bosentan in terms of safety.</div></div><div><h3>Trial registry number</h3><div>(IRCT20160120026115N9).</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 44-49"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141135276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological predictors of quality of life and the role of early markers in children with cerebral palsy: A multi-centric cross-sectional study","authors":"Shraddha Badgujar ,&nbsp;Jagannath Dixit ,&nbsp;Bina M. Kuril ,&nbsp;L.S. Deshmukh ,&nbsp;Prabha Khaire ,&nbsp;Varsha Vaidya ,&nbsp;Madhavi Shelke","doi":"10.1016/j.pedneo.2024.04.003","DOIUrl":"10.1016/j.pedneo.2024.04.003","url":null,"abstract":"<div><h3>Background</h3><div>More than 100 million children in the world have at least one type of disability. Among disabled children, approximately 25% of chronic disabilities are of neurological origin. Cerebral Palsy is the leading cause of chronic disability in children, making them not only physically and mentally handicapped but also socially aloof.</div></div><div><h3>Methods</h3><div>This study was conducted among 200 eligible participants from three centers with Child Guidance or Cerebral Palsy clinics in the outpatient department. All the participants were included in the analysis of the epidemiological profile and the role of early markers. Of these, 70 participants were assessed for quality of life according to the age criteria of a pre-tested Cerebral Palsy Quality of Life questionnaire (CP-QOL).</div></div><div><h3>Results</h3><div>Mean ± S.D. age in years was 3.7 ± 2.8. Birth history included 182 (39%) neonatal etiopathology, followed by 173 (38%) perinatal, and 106 (23%) antenatal causes. Mean ± S.D. birth weight was 2.3 ± 1.2 kg. The positive predictors of various domains of Quality of Life were an absence of any associated sensory, neurological, communication, or psychological disorder or disability. While, the negative predictors were decreasing functional capacity, involvement of number of limbs in increasing order, high therapeutic requirements, and dependency.</div></div><div><h3>Conclusion</h3><div>The association between early diagnosis of cerebral palsy and improved functional capacity, involvement of a lesser number of limbs, better quality of life, and absence of associated disabilities is established from the findings of our study.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 18-24"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141044940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival trends of extracorporeal membrane oxygenation support for pediatric emergency patients in regional and metropolitan areas in Japan","authors":"Noriyuki Kaku ,&nbsp;Wakato Matsuoka ,&nbsp;Kentaro Ide ,&nbsp;Takaaki Totoki ,&nbsp;Katsuki Hirai ,&nbsp;Soichi Mizuguchi ,&nbsp;Kanako Higashi ,&nbsp;Kenichi Tetsuhara ,&nbsp;Hazumu Nagata ,&nbsp;Satoshi Nakagawa ,&nbsp;Yasuyuki Kakihana ,&nbsp;Akira Shiose ,&nbsp;Shouichi Ohga","doi":"10.1016/j.pedneo.2024.04.005","DOIUrl":"10.1016/j.pedneo.2024.04.005","url":null,"abstract":"<div><h3>Background</h3><div>To assess the performance of pediatric extracorporeal membrane oxygenation (ECMO) centers, outcomes were compared between metropolitan and other areas.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted at three regional centers on Kyushu Island and the largest center in the Tokyo metropolitan area of Japan. The clinical outcomes of patients of ≤15 years of age who received ECMO during 2010–2019 were investigated, targeting the survival and performance at discharge from intensive care units (ICUs), using medical charts.</div></div><div><h3>Results</h3><div>One hundred and fifty-five patients were analyzed (regional, n = 70; metropolitan, n = 85). Survival rates at ICU discharge were similar between the two areas (64%). In regional centers, deterioration of Pediatric Cerebral Performance Category (PCPC) scores were more frequent (65.7% <em>vs.</em> 49.4%; p = 0.042), but survival rates and ΔPCPC scores (PCPC at ICU discharge–PCPC before admission) improved in the second half of the study period (p = 0.005 and p = 0.046, respectively). Veno-arterial ECMO (odds ratio [OR], 3.00; p &lt; 0.03), extracorporeal cardiopulmonary resuscitation (OR, 8.98; p &lt; 0.01), and absence of myocarditis (OR, 5.47; p &lt; 0.01) were independent risk factors for deterioration of the PCPC score. A sub-analysis of patients with acute myocarditis (n = 51), the main indicator for ECMO, revealed a significantly higher proportion of cases with deteriorated PCPC scores in regional centers (51.9% <em>vs.</em> 25.0%; p = 0.049).</div></div><div><h3>Conclusions</h3><div>The survival rates of pediatric patients supported by ECMO in regional centers were similar to those in a metropolitan center. However, neurological outcomes must be improved, particularly in patients with acute myocarditis.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 55-59"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141133186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control study","authors":"Pei-Chen Tsao ,&nbsp;Hung-Chih Lin ,&nbsp;Shang-Po Shen ,&nbsp;Yu-Chia Chang","doi":"10.1016/j.pedneo.2024.04.006","DOIUrl":"10.1016/j.pedneo.2024.04.006","url":null,"abstract":"<div><h3>Background</h3><div>We conducted a nationwide population-based case-control study to analyse potential predisposing factors for hearing loss (HL) that present during the fetal, perinatal, and postnatal periods in prematurely born children.</div></div><div><h3>Methods</h3><div>This study enrolled 21,576 children born at &lt; 37 weeks of gestation; 3,596 with HL and 17,980 with normal hearing born between 2002 and 2015, matched for sex, age at diagnosis, and enrollment time. Data were abstracted from the concatenation of three nationwide databases for overall risk factors till the diagnosis of HL.</div></div><div><h3>Results</h3><div>Maternal HL, maternal diabetes, particularly type 1 diabetes mellitus, and at or before 32 weeks of gestation were the major obstetric risk factors for HL. Prematurely born children who were born via cesarean section and received a combination of antenatal steroids and magnesium sulfate exhibited a significantly reduced risk of developing HL. Ear malformation was a critical predictor for HL. The major postnatal risk factors included seizure and ototoxic drugs use. Premature infants diagnosed with more than 1 diagnosis of bronchopulmonary dysplasia, necrotizing enterocolitis, and intracerebral hemorrhage were at an increased risk of developing HL. Congenital CMV infection and recurrent acute otitis were also independent postnatal factors for HL in prematurely born children.</div></div><div><h3>Conclusion</h3><div>To reduce the incidence of childhood HL in prematurely born children, aggressive management of premature birth-related consequences and treatable causes and longitudinal audiological follow-up with early detection and adequate intervention are crucial.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 37-43"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141144631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric outlet obstruction associated with gastric ectopic pancreas in children: Report of two cases","authors":"Chia-Wei Liu ,&nbsp;Hsun-Chin Chao ,&nbsp;Wan-Hsin Su","doi":"10.1016/j.pedneo.2024.07.010","DOIUrl":"10.1016/j.pedneo.2024.07.010","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 78-80"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracardiac air bubbles in a neonate with necrotizing enterocolitis","authors":"Yu Fukushima ,&nbsp;Kei Tamai ,&nbsp;Shigehiro Mori ,&nbsp;Akihito Takeuchi ,&nbsp;Makoto Nakamura ,&nbsp;Misao Kageyama","doi":"10.1016/j.pedneo.2024.09.002","DOIUrl":"10.1016/j.pedneo.2024.09.002","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 85-86"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}