Association of LEP rs7799039 and LEPR rs1137101 polymorphisms with obesity in Vietnamese preschool children.

IF 2.3 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology Pub Date : 2025-02-19 DOI:10.1016/j.pedneo.2024.09.007

Thi Tuyet Le, Bui Quang Minh Pham, Thi Trung Thu Nguyen, Thi Hong Hanh Nguyen, Thi Thuy Dung Le

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引用次数: 0

Abstract

Background: Single nucleotide polymorphisms (SNPs) in genes that regulate body weight and energy homeostasis, such as LEP and LEPR, may influence susceptibility to obesity. The present study aims to evaluate the association of LEP rs7799039 and LEPR rs1137101 polymorphisms with obesity in Vietnamese preschool children.

Methods: A case-control study was conducted on 1146 preschool children aged 3-6 years (360 obese children and 786 normal-weight children). Genotypes at rs7799039 and rs1137101 loci were identified by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.

Results: After adjusting for age and sex, single SNP analysis indicated an association of LEP rs7799039 with obesity (OR∗ = 1.41, P∗ = 0.01 in the recessive model), but no association between LEPR rs1137101 and obesity was found. In SNP-SNP interaction analysis, the combination of LEP rs7799039 AA and LEPR rs1137101 GG genotypes conferred a greater risk of obesity (OR∗ = 1.48, P∗ = 0.015).

Conclusions: This study implies a synergistic effect of LEP rs7799039 and LEPR rs1137101 on obesity susceptibility. Therefore, these two polymorphisms are potential genetic markers to predict childhood obesity in the Vietnamese population.

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越南学龄前儿童肥胖与LEP rs7799039和LEPR rs1137101多态性的关系

背景：调节体重和能量稳态的基因（如LEP和LEPR）中的单核苷酸多态性（snp）可能影响肥胖的易感性。本研究旨在评估越南学龄前儿童LEP rs7799039和LEPR rs1137101多态性与肥胖的关系。方法：对1146例3 ~ 6岁学龄前儿童（其中肥胖儿童360例，正常体重儿童786例）进行病例对照研究。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术鉴定rs7799039和rs1137101位点的基因型。结果：在调整年龄和性别后，单SNP分析显示LEP rs7799039与肥胖相关（OR∗= 1.41，在隐性模型中P∗= 0.01），而LEPR rs1137101与肥胖无关。在SNP-SNP互作分析中，LEP rs7799039 AA和LEPR rs1137101 GG基因型的组合会增加肥胖的风险（OR∗= 1.48,P∗= 0.015）。结论：本研究提示LEP rs7799039和LEPR rs1137101在肥胖易感性中具有协同作用。因此，这两种多态性是预测越南人群儿童肥胖的潜在遗传标记。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatrics and Neonatology PEDIATRICS-

CiteScore

3.10

自引率

0.00%

发文量

170

审稿时长

48 days

期刊介绍： Pediatrics and Neonatology is the official peer-reviewed publication of the Taiwan Pediatric Association and The Society of Neonatology ROC, and is indexed in EMBASE and SCOPUS. Articles on clinical and laboratory research in pediatrics and related fields are eligible for consideration.