Association of LEP rs7799039 and LEPR rs1137101 polymorphisms with obesity in Vietnamese preschool children.

IF 2.3 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology Pub Date : 2025-02-19 DOI:10.1016/j.pedneo.2024.09.007

Thi Tuyet Le, Bui Quang Minh Pham, Thi Trung Thu Nguyen, Thi Hong Hanh Nguyen, Thi Thuy Dung Le

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引用次数: 0

Abstract

Background: Single nucleotide polymorphisms (SNPs) in genes that regulate body weight and energy homeostasis, such as LEP and LEPR, may influence susceptibility to obesity. The present study aims to evaluate the association of LEP rs7799039 and LEPR rs1137101 polymorphisms with obesity in Vietnamese preschool children.

Methods: A case-control study was conducted on 1146 preschool children aged 3-6 years (360 obese children and 786 normal-weight children). Genotypes at rs7799039 and rs1137101 loci were identified by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.

Results: After adjusting for age and sex, single SNP analysis indicated an association of LEP rs7799039 with obesity (OR∗ = 1.41, P∗ = 0.01 in the recessive model), but no association between LEPR rs1137101 and obesity was found. In SNP-SNP interaction analysis, the combination of LEP rs7799039 AA and LEPR rs1137101 GG genotypes conferred a greater risk of obesity (OR∗ = 1.48, P∗ = 0.015).

Conclusions: This study implies a synergistic effect of LEP rs7799039 and LEPR rs1137101 on obesity susceptibility. Therefore, these two polymorphisms are potential genetic markers to predict childhood obesity in the Vietnamese population.

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来源期刊

Pediatrics and Neonatology PEDIATRICS-

CiteScore

3.10

自引率

0.00%

发文量

170

审稿时长

48 days

期刊介绍： Pediatrics and Neonatology is the official peer-reviewed publication of the Taiwan Pediatric Association and The Society of Neonatology ROC, and is indexed in EMBASE and SCOPUS. Articles on clinical and laboratory research in pediatrics and related fields are eligible for consideration.