Pediatrics and Neonatology最新文献

{"title":"Neuroimaging of patients with headache in the pediatric emergency department: A single center retrospective study.","authors":"Donghyun Shin, Yoo Jung Lee, Yoon Hee Jo, Juhyun Kong, Yun-Jin Lee, Sang Ook Nam, Young Mi Kim","doi":"10.1016/j.pedneo.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.11.008","url":null,"abstract":"<p><strong>Background: </strong>Headache is a common neurologic complaint in children and adolescents, and the secondary causes of headache in these patients should be identified and excluded. We investigated the sensitivity and specificity of red flags in children with headache admitted to the emergency room and the associations of red flags with abnormal findings in neuroimaging, especially in serious pathologies.</p><p><strong>Methods: </strong>A retrospective review was conducted on individuals under <18 years old with headache who visited the emergency department at Pusan National University Hospital, the Republic of Korea, from January 2017 to December 2022. In total, 267 patients were included in this study.</p><p><strong>Results: </strong>Using the positive likelihood ratio, the association between each red flag with the positive results of neuroimaging was calculated. Red flags such as fever (P < 0.001), past history of neoplasm (P = 0.002), gradual worsening (P < 0.001), painful eye (P = 0.02), posttraumatic onset (P = 0.037), precipitated by exercise or Valsalva maneuver (P = 0.021) and lack of response to painkiller (P = 0.004) were statistically significant in patients with the positive neuroimaging results. Of 267 patients, 16 patients (6.0 %) had life-threatening headache that required urgent treatment and similar red flags were statistically significant in this group.</p><p><strong>Conclusions: </strong>Red flags are useful reminders for physicians regarding whether to perform neuroimaging in the emergency department for patients with headache. Clinicians should perform neuroimaging depending on each circumstance and consider the red flags.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive risk factors for meconium-related ileus requiring surgical intervention in very low birth weight infants.","authors":"Yoshinobu Tsuno, Takeshi Kumagai, Mitsuhiko Riko, Taro Goda, Yasuyuki Mitani, Takuya Sugimoto, Mina Ueda, Manabu Kawai, Daisuke Tokuhara","doi":"10.1016/j.pedneo.2024.11.007","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.11.007","url":null,"abstract":"<p><strong>Background: </strong>Meconium-related ileus (MRI) is a serious morbidity in very low birth weight infants (VLBWI). MRI can lead to intestinal perforation, which has a poor prognosis. Treatment may involve medical or surgical approaches. Our aim was to identify the risk factors predicting surgery in VLBWI with MRI, which are not well studied. We also compared clinical factors between VLBWI treated medically versus surgically.</p><p><strong>Methods: </strong>We identified VLBWI with MRI who were admitted to our institution between January 2014 and December 2022. Infants were divided into those who underwent surgery and those who received conservative medical therapy. We compared various clinical factors between the groups. In each group, we calculated the ratio of maximum dilatational diameter of the intestinal tract to the maximum abdominal transverse diameter on abdominal X-rays at different time points; we called this ratio the \"MRI index\". Using receiver operating characteristic curve analysis, we determined the MRI index cutoff value to predict surgery.</p><p><strong>Results: </strong>We evaluated 34 VLBWI with MRI; 9 underwent surgery and 25 responded to conservative medical therapy. The MRI index on day 0 and the maximum MRI index in the surgical group were significantly higher than those in the medical group (p = 0.036 and p < 0.001, respectively). The MRI index cutoff value to predict surgery was 0.205 (area under the curve: 0.900, sensitivity: 0.92, specificity: 0.78). Compared with the medical group, the surgical group required significantly longer to achieve enteral feeding at 100 ml/kg/day, had a longer duration of hospital stay (p = 0.003 and p = 0.038, respectively) and a significantly higher incidence of sepsis (p = 0.042).</p><p><strong>Conclusion: </strong>VLBWI with an MRI index ≥0.205 have a significantly high risk of requiring surgery.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D status and the adequacy of its supplementation during the first year of life in preterm infants in northern Japan.","authors":"Fumikatsu Nohara, Toshio Okamoto, Kenta Takahashi, Tatsutoshi Sugiyama, Aiko Hashimoto, Mitsumaro Nii, Yukari Yamaki, Etsushi Tsuchida, Takashi Satou, Masaru Shirai, Ken Nagaya, Satoru Takahashi","doi":"10.1016/j.pedneo.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.pedneo.2025.03.003","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D (VD) deficiency (VDD) is a major concern in preterm infants. The prevalence of VDD in mothers and infants varies between countries and is affected by a range of factors, such as geography and lifestyle. Thus, strategies aimed at preventing VDD must consider the status of each region. However, few reports have explored VDD in preterm infants in Japan and the safety and efficacy of VD supplementation in addressing VDD remain unclear.</p><p><strong>Methods: </strong>This study was conducted between September 2019 and October 2022. The participants were 108 preterm infants who were divided into three groups based on their gestational age: <28 weeks (Group 1), 28-33 weeks (Group 2), and 34-36 weeks (Group 3). VD status at birth was assessed, and 25-hydroxyvitamin D (25OHD) levels and biochemical markers were monitored during supplementation with 400 IU/day of VD over the first year of life.</p><p><strong>Results: </strong>Levels of 25OHD at birth were 10.0 (10.0-16.1), 10.5 (10.0-18.0), and 13.0 (10.0-19.0) nmol/L in Groups 1, 2, and 3, respectively. Infants in all three groups exhibited marked VDD. Their 25OHD levels gradually increased with VD supplementation before plateauing at 6 months. Nevertheless, VDD persisted in the majority of infants at 1 month of age. Serum intact parathyroid hormone levels peaked at 1 month of age and declined thereafter, negatively correlating with 25OHD levels. None of the infants exhibited symptoms of VD toxicity.</p><p><strong>Conclusion: </strong>Preterm infants in northern Japan exhibited substantial VDD, regardless of gestational age. In our cohort, VD supplementation at 400 IU/day safely increased 25OHD levels. However, VD levels improved gradually over the months, and several of these infants developed secondary hyperparathyroidism. Further studies are warranted to determine the optimal VD supplementation dose for preterm infants in this region.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric hypertension: Current definition and knowledge gaps.","authors":"You-Lin Tain","doi":"10.1016/j.pedneo.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.pedneo.2025.03.004","url":null,"abstract":"<p><p>Elevated blood pressure (BP) and hypertension are common in children and adolescents, significantly increasing the risk of cardiovascular disease (CVD) in adulthood. Accurately assessing the prevalence and significance of pediatric hypertension requires a clear definition. The use of age-, sex-, and height-dependent percentiles to define pediatric hypertension began in 1977. Since then, several national and international clinical practice guidelines have refined its classification, diagnosis, and management, with notable contributions from The Fourth Report in 2004, the European Society of Hypertension (ESH) in 2016, and the American Academy of Pediatrics (AAP) in 2017. The 2017 AAP guideline redefined pediatric hypertension, increasing the number of children classified with elevated BP or hypertension. Despite these advancements, a universal diagnostic criterion for pediatric hypertension is still lacking. This review aims to summarize recent research on pediatric hypertension, focusing on evolving definitions, persistent knowledge gaps, and future directions. Addressing pediatric hypertension early with a lifespan approach is essential to reducing the global prevalence of hypertension and its associated CVD burden. The need for continued study and innovative strategies is underscored by research gaps in the prevention, detection, classification, and treatment of pediatric hypertension.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive simple predictors of biliary atresia in cholestatic infants - A preliminary report.","authors":"Yu-Hsueh Hsiao, Wei-Li Hung, Yao-Jong Yang, Fang-Ting Lu, Fang-Min Liao, Cheng-Yu Chen, Jia-Feng Wu","doi":"10.1016/j.pedneo.2024.11.006","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.11.006","url":null,"abstract":"<p><strong>Background: </strong>Biliary atresia (BA) and other cholestatic liver diseases of early infancy share many similar clinical manifestations. We intended to investigate easy and popular non-invasive parameters to assist the differential diagnosis of BA among cholestatic infants.</p><p><strong>Methods: </strong>We enrolled 145 consecutive cholestatic infants (43.03 ± 2.00 days) who underwent cholestatic workups at our hospital as the study cohort, and another 27 cholestatic infants (47.78 ± 13.33 days) who received their initial cholestatic workups and laboratory tests at four other 4 hospitals as the validation cohort. The clinical data were surveyed retrospectively using a cross-sectional design.</p><p><strong>Results: </strong>We demonstrated that the \"GGT∗D-bil\" was significantly higher in the BA group than in the non-BA group in the study cohort (p < 0.001). The Receiver operating characteristic curve analysis of the study cohort identified the \"GGT∗D-bil\" cutoff >510 mg U/dL.L for the best prediction of BA among cholestatic infants (92 % area under the curve, p < 0.001). The sensitivity and negative predictive value (NPV) for predicting BA among cholestatic infants are 100 % in the study cohort. In the validation cohort, the \"GGT∗D-bil\" > 510 mg U/dL.L also achieved good sensitivity and NPV (92.31 % and 90.91 %, respectively) for the prediction of BA.</p><p><strong>Conclusions: </strong>We demonstrated that an easy parameter, \"GGT∗D-bil\" > 510 mg U/dL.L, may be used as part of the non-invasive cholestatic workups to assist in the diagnosis of BA among cholestatic infants in our study and validation cohorts. The application of this parameter is easy and not limited by the resources of the hospitals.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic assessment of fine motor development in children through hand-drawn shape images.","authors":"Nai-Hsuan Hwang, Sheng-Shan Chen, Tun-Wen Pai, Mary Hsin-Ju Ko, Ya-Lan Yu, Hui-Ju Chen","doi":"10.1016/j.pedneo.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.pedneo.2025.04.001","url":null,"abstract":"<p><strong>Background: </strong>Fine motor skills are closely related to neurological maturity among children and serve as critical indicators of developmental status. However, clinical assessments require significant human and material resources. This study proposes an automated evaluation mechanism designed to assess the development of children's fine motor skills, offering a streamlined and resource-efficient approach to developmental assessment.</p><p><strong>Methods: </strong>The designed system evaluated the fine motor skills of 82 children aged 36-72 months. The children were asked to replicate five geometric shapes designed by the system: circles, crosses, squares, triangles, and rhombuses. The system automatically assessed 23 distinct features across the geometric shapes using an artificial intelligence-based model. A tailored scoring system then assigned a score that reflected the child's level of fine motor skill maturity.</p><p><strong>Results: </strong>A total of 81 replicated drawings from the children in the test group were collected and automatically assessed using the assessment mechanism developed in this study. The results demonstrated a strong positive correlation between fine motor skill maturity and practical age. Additionally, the scores identified children with delayed fine motor development. The macro F1-score and accuracy of the automatic classification models for the five different geometric shapes in the validation dataset were 0.9236 and 0.9268, respectively. These evaluation outcomes can effectively support early intervention and treatment efforts.</p><p><strong>Conclusion: </strong>The system's structured drawing tasks for varying geometric shapes have substantial practical value for the automatic assessment of children's fine motor maturity. The scoring method developed in this study provides a clear distinction between the different developmental stages of children's fine motor skills. This system offers an effective online tool for assessing fine motor development among children, thereby providing essential preliminary reference information for physicians in subsequent clinical evaluations and significantly reducing the burden on healthcare professionals.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of therapeutic hypothermia on developmental outcomes in lower-middle income countries: A systematic review and meta-analysis with a health equity lens.","authors":"Cheryl C Hawkins, Elizabeth Spiegel, Diane D Allen, Kathryn Nesbit","doi":"10.1016/j.pedneo.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.09.010","url":null,"abstract":"<p><p>Hypoxic-ischemic encephalopathy (HIE) from birth asphyxia is particularly burdensome on lower-middle income countries (LMICs). Our systematic review examined early and late developmental outcomes related to neonatal therapeutic hypothermia (TH) without disability thresholds or cut-offs pre-determined by high-income countries. A search of PubMed, Web of Science, and Embase databases yielded 364 articles; 11 studies met eligibility criteria. According to published standards for reporting of studies, 3 of the 11 studies were good quality and 8 studies were excellent. Within-group changes in early and late developmental outcomes showed large, significant effect sizes (d = -2.07; CI = -0.77, -3.36; d = 3.17; CI = 2.14, 4.21). Between-group differences showed significant effect sizes in late but not early developmental outcomes (d = 0.85; CI = 0.62, 1.07; d = -0.16; CI = -0.58, 0.25). The evidence indicates that TH improves developmental outcomes prior to hospital discharge and after 6 months, and surpasses standard of care for 6-month and later developmental outcomes.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal on neural tube defects and their complexities.","authors":"Fouziya Shaikh, Mallica Sanadhya, Safa Kaleem, Tiya Verma, Richard L Jayaraj, Faizan Ahmad","doi":"10.1016/j.pedneo.2024.07.015","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.07.015","url":null,"abstract":"<p><p>Neural tube defects (NTDs), as a group of diseases, are congenital disabilities due to incomplete closure of the neural tube along its length, which otherwise forms the fully developed brain and spinal cord. An amalgamation of genetic, nutritional, and environmental factors plays a role in causing NTDs. They develop relatively early, within the first month of pregnancy-the time of neurulation, which could indicate that the pathogenesis of these diseases could stem from even pre-pregnancy causes like folic acid deficiency. This article provides an overview of the various etiology of NTDs and how they interact, as well as various preventive and curative measures like folic acid and inositol supplementation, stem cell transplant, and postnatal surgery. Identifying potential risk factors can help clinicians develop better management techniques beyond the limited scope of the presently used prophylactic and treatment methods.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staphylococcus aureus pneumonia in neonates: clinical patterns, laboratory findings and outcomes","authors":"Thi Quynh Nga Nguyen ,&nbsp;Duc Quang Le ,&nbsp;Thi Minh Hien Hoang ,&nbsp;Dang Xoay Tran","doi":"10.1016/j.pedneo.2025.03.002","DOIUrl":"10.1016/j.pedneo.2025.03.002","url":null,"abstract":"<div><h3>Background</h3><div><em>Staphylococcus aureus</em> (SA) pneumonia is a leading cause of neonatal morbidity and mortality, particularly with methicillin-resistant Staphylococcus aureus (MRSA). Despite its prevalence, limited studies have focused on clinical presentation, antimicrobial resistance patterns, and outcomes of SA pneumonia in neonates. This study aimed to explore the clinical features, laboratory findings, and outcomes of neonates with SA pneumonia at the National Children's Hospital, Vietnam.</div></div><div><h3>Methods</h3><div>We conducted a retrospective observational study on 31 neonates diagnosed with SA pneumonia from January 2022 to June 2023. Clinical data, including demographic details, symptoms, white blood cell (WBC) count, C-reactive protein (CRP) levels, antimicrobial susceptibility, and radiological findings, were collected. We analyzed the antibiotic resistance patterns of SA and evaluated factors associated with vancomycin treatment failure.</div></div><div><h3>Results</h3><div>Of the 31 neonates, 96.8 % were diagnosed with MRSA pneumonia. The main clinical symptoms were fever (77.4 %), tachypnea (83.9 %), and chest retraction (80.6 %). SA was primarily isolated from endotracheal fluid (71.0 %), pleural fluid (41.9 %), and both combined (51.6 %) with positive blood cultures. Complications were common, with pleural effusion in 54.8 %, pneumothorax in 48.4 %, necrotizing pneumonia in 25.8 %, and lung abscess in 29.0 % of cases. Vancomycin was the primary antibiotic administered, though treatment failure occurred in 38.7 % of cases, necessitating alternative antibiotics, particularly in patients with severe illness requiring mechanical ventilation, vasopressor support, and elevated CRP levels (&gt;15 mg/L). Most strains were resistant to beta-lactam antibiotics but sensitive to vancomycin, linezolid, ciprofloxacin, and levofloxacin. The average hospital stay was 24.4 ± 12.6 days, with a mortality rate of 12.9 %, mainly due to severe respiratory failure and septic shock.</div></div><div><h3>Conclusion</h3><div>These findings highlight the critical importance of early diagnosis, optimized antibiotic therapy, and careful monitoring to reduce complications and improve survival outcomes in neonates with SA pneumonia.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 4","pages":"Pages 390-395"},"PeriodicalIF":2.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic tumors in Iranian children: Characteristics and survival predictors.","authors":"Fateme Ziyaee, Seyed Mohsen Dehghani, Mehdi Forooghi, Ali Bahador, Hamidreza Foroutan, Hamed Nikoupour, Bita Geramizadeh, Mahmood Haghighat, Mohammad Hadi Imanieh, Naser Honar, Iraj Shahramian, Maryam Ataollahi, Narges Ansary, Mehdi Ghasemian, Mahsa Rouhafshari, Zahra Radaei, Maryam Moradian Shahrebabaki, Mohammad Salehi Khatouni","doi":"10.1016/j.pedneo.2024.10.014","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.10.014","url":null,"abstract":"<p><strong>Background: </strong>Hepatic tumors are rare in children. This study was conducted to determine the characteristics of liver masses in children and identify the independent predictors of their survival.</p><p><strong>Methods: </strong>Medical records of children aged <18 years with a confirmed diagnosis of hepatic tumor diagnosed between January 2008 and December 2023 at two referral centers affiliated to Shiraz University of Medical Sciences, southern Iran, were reviewed.</p><p><strong>Results: </strong>There were 153 children with hepatic tumors. The median age of the patients was 2 (IQR, 1-5) years. Abdominal pain and distension, and presence of a palpable mass and fever were the most common signs and symptoms at presentation. The most common tumor was hepatoblastoma (64.5 %) followed by hepatocellular carcinoma (HCC, 9.9 %). Right hepatectomy and hepatic segmentectomy were the most common surgical approach used. Children with hepatoblastoma were significantly (p < 0.001) younger than those with HCC. The risk of hepatoblastoma in males was twice that in females. Jaundice was not common in those with hepatoblastoma but it was in HCC. About a quarter of patients died. After adjusting for covariates, abdominal pain (adj OR = 4.90) and distension (adj OR = 3.17), and a diagnosis of HCC (adj OR = 13.63) were independent predictors of a poor prognosis.</p><p><strong>Conclusions: </strong>The characteristics of pediatric hepatic tumors in our study were similar to those reported in most studies. Abdominal pain and distension and presence of HCC or jaundice were independent predictors of a poor prognosis.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}