Pediatrics and Neonatology最新文献

{"title":"Cerebral tissue oxygen desaturations and increased fractional oxygen extraction events vary by gestational age in preterm infants","authors":"M. Mohamed ,&nbsp;M. Frasketi ,&nbsp;H. Hoffman ,&nbsp;M. Elgendy ,&nbsp;S. Aly ,&nbsp;H. Aly","doi":"10.1016/j.pedneo.2023.12.008","DOIUrl":"10.1016/j.pedneo.2023.12.008","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Cerebral tissue oxygen saturation (SctO₂) and cerebral fractional tissue oxygen extraction (cFTOE) changes with GA in preterm infants. This study examines changes in frequency, duration, and severity of SctO₂ desaturation and increased cFTOE with GA.</div></div><div><h3>Study design</h3><div>The lower limit of normal SctO₂, the event threshold, was calculated using a tolerance interval method with 95% confidence interval (CI) and 90% probability. Cerebral desaturation events were defined as: 1) a drop below event threshold for at least 30 s (s), 2) preceded by a period above the event threshold for at least 30s, and 3) followed by a period above the threshold for at least 60s.</div></div><div><h3>Results</h3><div>86% of infants &lt;28 wk experienced one or more SctO₂ desaturation event compared to 57% in &gt;28 wk, odds ratios (OR) 4.5 (CI:1.3–15.3, <em>p</em> = 0.016). The severity of SctO₂ desaturation events decreases at a rate of 77.9 units per wk increase in GA (<em>p</em> &lt; 0.001). 39.3% of infants &lt;28 wk experienced one or more increased cFTOE events compared to 28.6% in &gt;28 wk, OR 1.6 (CI:0.6–4.4, <em>p</em> = 0.35). The severity of increasing cFTOE events decreased by 69.7 units per wk increase in GA (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Cerebral tissue oxygen desaturation events decrease in frequency and severity with increasing GA. The severity of increased cFTOE episodes decrease with GA.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 60-65"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic performance of mean neutrophil volume in neonatal sepsis: A systematic review and meta-analysis","authors":"Alpana Mishra ,&nbsp;Pratap Kumar Jena ,&nbsp;Santosh Kumar Panda","doi":"10.1016/j.pedneo.2024.03.007","DOIUrl":"10.1016/j.pedneo.2024.03.007","url":null,"abstract":"<div><h3>Background</h3><div>There is a need for reliable diagnostic tests for early identification of sepsis to prevent neonatal mortality and antibiotic misuse. During sepsis, many immature neutrophils came into the bloodstream, altering the mean neutrophil volume (MNV) shown in the previous studies.</div></div><div><h3>Objectives</h3><div>To summarize the diagnostic performance of mean neutrophil volume (MNV) in neonatal sepsis from the published literature.</div></div><div><h3>Method</h3><div>Databases such as PubMed, Scopus, and Web of Science were searched from January 1990 to April 2023 for studies reporting MNV as a diagnostic test in neonatal sepsis. The pooled sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC) of the summary receiver operating characteristic (SROC) curve of MNV were estimated with reference blood culture-positive sepsis and clinical sepsis for meta-analysis.</div></div><div><h3>Result</h3><div>The diagnostic performance of MNV was analyzed in 1685 neonates, including 829 septic and 856 non-septic neonates, from six prospective studies. The pooled sensitivity and specificity of MNV were 0.87 and 0.75, respectively, for neonatal sepsis; the DOR was 20.01 (95% CI: 5.90–67.82); and the AUC of the SROC for MNV was 0.81 (95% CI: 0.69–0.88). Higgins I² was 92.1% (95% CI: 85.5%–95.7%). The diagnostic performance of MNV was better during sub-group analysis of studies reporting culture-positive sepsis (DOR 85.61).</div></div><div><h3>Conclusion</h3><div>The diagnostic performance of MNV is moderate for neonatal sepsis. As the evidence originated from a small number of studies with marked heterogeneity, further large-scale diagnostic accuracy studies are recommended to resolve heterogeneity in the future.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 71-75"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141391946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features of iatrogenic Pharyngo-esophageal perforation in very low birth weight infants","authors":"Shu Eguchi,&nbsp;Yoshiya Hisaeda,&nbsp;Toshiko Ukawa,&nbsp;Mayu Koto,&nbsp;Miku Hosokawa,&nbsp;Chisa Tsurisawa,&nbsp;Tomohiro Takeda,&nbsp;Shusuke Amagata,&nbsp;Atsushi Nakao","doi":"10.1016/j.pedneo.2023.11.011","DOIUrl":"10.1016/j.pedneo.2023.11.011","url":null,"abstract":"<div><h3>Background</h3><div>Iatrogenic pharyngoesophageal perforation (IPEP) is one of the complications of gastric tube insertion and it tends to occur more frequently in premature infants. Although the frequency is significantly low, attention should be paid as it can lead to serious outcomes with high mortality. This study will help raise awareness with respect to early diagnosis, management, and prevention.</div></div><div><h3>Methods</h3><div>We performed a retrospective cohort study of all very low birth weight infants diagnosed with IPEP between 1993 and 2022.</div></div><div><h3>Results</h3><div>A total of 6 patients (0.27% of very low birth weight infants) with the diagnosis of IPEP were included. The median gestational age was 27 + 1 weeks (range 23+5–28 + 6 weeks), and the median birth weight was 823 g (range 630–1232 g). Symptoms included difficulty with gastric tube insertion, bloody secretions in the oral cavity, and increased oral secretions. X-rays revealed aberrant running of the gastric tube in all patients. In three cases, contrast studies demonstrated contrasted mediastinum tapering like a bead. Laryngoscope was used to view the perforation sites but this was not useful in the smallest patient. All patients were treated conservatively with antibiotics and survived.</div></div><div><h3>Conclusions</h3><div>When inserting a gastric tube for premature infants, it is critical to remember that these infants are at risk of IPEP. In addition to a frontal X-ray, a lateral X-ray and contrast study may be useful for early diagnosis.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 25-30"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141043310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal hemorrhage in neonates: Incidence, perinatal characteristics and follow-up outcomes","authors":"Tek-Jū Tân ,&nbsp;Yi-Li Hung ,&nbsp;Chung-Min Shen ,&nbsp;Wu-Shiun Hsieh","doi":"10.1016/j.pedneo.2023.11.013","DOIUrl":"10.1016/j.pedneo.2023.11.013","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Neonatal adrenal hemorrhage (NAH) is relatively uncommon in neonates and it is often noted accidently by abdominal ultrasonogram. Few studies discussed risk factors for and impacts of NAH. This study aimed to assess incidence, perinatal characteristics and follow-up outcomes in neonates with adrenal hemorrhage.</div></div><div><h3>Methods</h3><div>This was a retrospective cohort study in a single institute from April 2008 to August 2018. All neonates who received abdominal ultrasonogram within seven days-of-life were recruited and divided in to 2 groups according to the presence of NAH. The perinatal characteristics and anthropometric measurements, the follow-up course and the clinical impact of NAH were reviewed in detail.</div></div><div><h3>Results</h3><div>7217 neonates had received abdominal ultrasonogram within seven days-of-life and 29 of them (0.4%) were diagnosed with NAH. Mean gestation age was 38 ± 1.2 weeks and mean birth weight was 3406 ± 403 g. Most infants (96.6%) had unilateral hemorrhage over the right adrenal gland. Compared with the control group, infants with NAH were significantly heavier (3406 vs. 3094 gm, p &lt; 0.001), longer in body length (50.1 vs. 48.8 cm, p &lt; 0.001) and wider in chest girth (33.2 vs. 32.4 cm, p = 0.006). They also tended to be delivered via vaginal delivery with vacuum-extraction rather than cesarean section. The prevalence of nuchal cord, neonatal jaundice and subgaleal hemorrhage was higher in the NAH group. The hemorrhage area of adrenal gland had a positive correlation with the peak bilirubin level (r = 0.422, p &lt; 0.001) and the days to resolution (r = 0.198, p = 0.033). All infants had resolution of AH before 7 months of age.</div></div><div><h3>Conclusions</h3><div>NAH occurred more frequently in heavier neonates that were delivered via vaginal delivery with vacuum extraction. The hemorrhage involved mostly over the right adrenal gland. Neonatal jaundice was the major comorbidity. All infants had spontaneous resolution of AH before 7 months of age.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 66-70"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ureterocele eversion with lower pole vesicoureteral reflux in a duplex renal collecting system","authors":"Cheng-Yen Ho ,&nbsp;Jin-Cherng Sheu ,&nbsp;Tung-Yao Chang ,&nbsp;Chun-Chen Lin ,&nbsp;Jeng-Daw Tsai","doi":"10.1016/j.pedneo.2024.06.008","DOIUrl":"10.1016/j.pedneo.2024.06.008","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 83-84"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent hypertrophic pyloric stenosis: Neonatal age and pyloric canal length as risk factors","authors":"Naser El-Mefleh","doi":"10.1016/j.pedneo.2024.10.009","DOIUrl":"10.1016/j.pedneo.2024.10.009","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 2-6"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CDKL5 deficiency disorder in an infant presenting as drug-refractory epilepsy after TdaP-Hib-IPV vaccination: A case report","authors":"Hong-Yu Chen ,&nbsp;Li-Ping Tsai ,&nbsp;Shi-Bing Wong","doi":"10.1016/j.pedneo.2024.06.009","DOIUrl":"10.1016/j.pedneo.2024.06.009","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 76-77"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Starry sky and leukodystrophy-like pattern in multiple neurocysticercosis","authors":"Sarbesh Tiwari ,&nbsp;Pradeep Kumar Gunasekaran ,&nbsp;Kandha Kumar UK ,&nbsp;Lokesh Saini","doi":"10.1016/j.pedneo.2024.07.008","DOIUrl":"10.1016/j.pedneo.2024.07.008","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 87-88"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor regarding “Epidemiological predictors of quality of life and the role of early markers in children with cerebral palsy: A multi-centric cross-sectional study”","authors":"Xin Zhao,&nbsp;Kanglong Peng,&nbsp;Xianrong Liang,&nbsp;Guojun Yun","doi":"10.1016/j.pedneo.2024.08.004","DOIUrl":"10.1016/j.pedneo.2024.08.004","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 89-90"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic profiles of preterm small-for-gestational age infants","authors":"Koh Okuda,&nbsp;Nobuhiko Nagano,&nbsp;Kimitaka Nakazaki,&nbsp;Kengo Matsuda,&nbsp;Wataru Tokunaga,&nbsp;Kazumasa Fuwa,&nbsp;Ryoji Aoki,&nbsp;Aya Okahashi,&nbsp;Ichiro Morioka","doi":"10.1016/j.pedneo.2023.11.012","DOIUrl":"10.1016/j.pedneo.2023.11.012","url":null,"abstract":"<div><div>We aimed to characterize the metabolomic profiles in preterm small-for-gestational age (SGA) infants using cord blood. We conducted a gestational age (GA)-matched case-control study that included 30 preterm infants who were categorized into two groups: SGA infants, with a birth weight (BW) &lt; 10th percentile for GA (n = 15) and non-SGA infants, with BW ≥ 10th percentile for GA (n = 15). SGA infants with chromosomal or genetic abnormalities were excluded. At birth, the umbilicus was double-clamped, and the cord blood was sampled from the umbilical vein. Metabolomic analyses were performed using capillary electrophoresis time-of-flight mass spectrometry. The median GA at birth was not significantly different between the two groups [SGA, 32 (26–36) weeks; non-SGA, 32 (25–35) weeks; p = 0.661)]. Of the 255 metabolites analyzed, 19 (7.5%) showed significant differences between SGA and non-SGA infants. There were significant reductions in the carnosine, hypotaurine, and S-methylcysteine levels in SGA infants as compared to non-SGA infants (p &lt; 0.05). Carnosine was correlated with gestational age, BMI before pregnancy, body weight gain during pregnancy (p = 0.002, p = 0.023, and p = 0.020, respectively). In conclusion, preterm SGA infants have low levels of cord blood antioxidative- and antiglycation-related metabolites, making them vulnerable to oxidative stress.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 1","pages":"Pages 50-54"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}