Pediatrics and Neonatology最新文献

{"title":"Effectiveness and safety profile of introducing less invasive surfactant administration in management of respiratory distress syndrome: A retrospective cohort study in a tertiary neonatal unit in Hong Kong.","authors":"Wing Kan Julianna Bao, Qi Feng, King Shun Liu, Yok Chiu Ho","doi":"10.1016/j.pedneo.2023.12.013","DOIUrl":"https://doi.org/10.1016/j.pedneo.2023.12.013","url":null,"abstract":"<p><strong>Background: </strong>The objective was to evaluate the efficacy of introducing less invasive surfactant administration (LISA) for management of preterm neonates with respiratory distress syndrome (RDS).</p><p><strong>Methods: </strong>This was a retrospective cohort study identifying preterm neonates with RDS born between 2017 and 2022 in a tertiary neonatal unit, where LISA was introduced in January 2020. Time trend analysis comparing cohort of neonates born before (2017-2020) and after LISA introduction (2020-2022) was performed. The primary outcomes were incidence and severity of bronchopulmonary dysplasia (BPD). Multivariable regression models were used to estimate the association between introducing LISA to RDS management and health and safety outcomes.</p><p><strong>Results: </strong>In total, 261 neonates with RDS were included (114 born after LISA was introduced). Neonates receiving invasive surfactant administration had lower gestational age, birth weight, lower Apgar scores, and higher oxygen requirement, compared to those receiving LISA. In the time trend analysis, introduction of LISA was associated with lower incidence of BPD (odds ratio (95% confidence interval) 0.34 (0.16, 0.72)), and lower severity of BPD (0.31 (0.16, 0.59)). Pre- and post-LISA period showed similar treatment safety profiles.</p><p><strong>Conclusion: </strong>Introduction of LISA was associated with improved prognosis in neonates with RDS in Hong Kong.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should SVC flow be a routine measure when performing targeted neonatal echocardiography? A narrative review","authors":"","doi":"10.1016/j.pedneo.2024.01.001","DOIUrl":"10.1016/j.pedneo.2024.01.001","url":null,"abstract":"<div><p>Superior vena cava is commonly used in neonatal hemodynamics and is suggested to be the best available non-invasive marker for systemic circulation in preterm infants. Inter- and intra-observer variability remain to be an issue. Its association with neonatal outcomes is has not been established. This is a narrative review about this marker, its use, and its potential pitfalls.</p></div><div><h3>Objective</h3><p>This is a narrative review about SVC flow in preterm infants, physiology, techniques of measurement and its potential association with outcomes.</p></div><div><h3>Sources</h3><p>Literature revie mainly PubMED.</p></div><div><h3>Summary of the findings</h3><p>SVC flow measurement has some limitations and pitfalls.</p></div><div><h3>Conclusions</h3><p>SVC flow association with neonatal outcomes, still needs to be established in further research.</p></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 4","pages":"Pages 323-327"},"PeriodicalIF":2.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1875957224000093/pdfft?md5=3ff2850e44c910b89759fb9413fe7b1f&pid=1-s2.0-S1875957224000093-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139586225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent validity of intelligence assessments in children with developmental disabilities in an Asian setting: Comparison of the Kaufman brief intelligence test – Second edition with the Wechsler Intelligence Scales","authors":"","doi":"10.1016/j.pedneo.2023.07.005","DOIUrl":"10.1016/j.pedneo.2023.07.005","url":null,"abstract":"<div><h3>Background</h3><p>This study was carried out to compare the concurrent validity of the Kaufman Brief Intelligence Test – Second Edition (KBIT-2) with that of two Wechsler Intelligence Scales (Wechsler Intelligence Scale for Children – Fifth Edition (WISC-V) and the Wechsler Preschool and Primary Scale of Intelligence – Fourth Edition (WPPSI-IV)) in an Asian setting.</p></div><div><h3>Methods</h3><p>A retrospective study reviewed the medical records of 101 children with developmental disorders who were being followed up at a tertiary child development unit. Pearson product moment correlation coefficients were calculated between the KBIT-2 and Wechsler assessment scores. Simple regression analysis was used to calculate standard errors of estimation to assess the accuracy of predicting Wechsler scores using KBIT-2 scores.</p></div><div><h3>Results</h3><p>A strong positive correlation was observed between KBIT-2's Intelligence Quotient (IQ) Composite and WISC-V's Full-Scale IQ (FSIQ) scores (r = 0.722, p &lt; 0.01). KBIT-2 IQ composite scores showed a moderately strong positive correlation with WPPSI-IV FSIQ scores (r = 0.648, p &lt; 0.01). Simple regression analysis showed that KBIT-2 scores tended to underestimate or overestimate the Wechsler scores, with the highest variability seen in KBIT-2's Non-Verbal IQ and Wechsler's Fluid Reasoning Index scores (error limits: -53.1 to 39.7).</p></div><div><h3>Conclusion</h3><p>Our study demonstrates that KBIT-2 has good concurrent validity when compared to other IQ tests such as the Wechsler scales, and it suggests that KBIT-2 is a good screening tool for assessing intelligence in a group of children with developmental disabilities. Further studies are needed to determine whether KBIT-2 can be used for the purpose of diagnostic decision-making or special education program placement.</p></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 4","pages":"Pages 341-347"},"PeriodicalIF":2.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1875957223002115/pdfft?md5=8445be0b6e9b0878cbb2de88049b6b6f&pid=1-s2.0-S1875957223002115-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135764186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epignathus and thoracoabdominal ectopia cordis in a neonate","authors":"","doi":"10.1016/j.pedneo.2024.03.005","DOIUrl":"10.1016/j.pedneo.2024.03.005","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 4","pages":"Pages 410-411"},"PeriodicalIF":2.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1875957224000706/pdfft?md5=c5c1328715c68cb7e9d059e511ff70a8&pid=1-s2.0-S1875957224000706-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure-related complication?:Bacillus Calmette-Guérin (BCG)-induced skin granuloma in a Japanese infant","authors":"","doi":"10.1016/j.pedneo.2024.03.003","DOIUrl":"10.1016/j.pedneo.2024.03.003","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 4","pages":"Pages 406-407"},"PeriodicalIF":2.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1875957224000688/pdfft?md5=aab09f43fb992a42d3ecb92a8af874d7&pid=1-s2.0-S1875957224000688-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141053026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital apex syndrome secondary to Pseudomonas aeruginosa sinusitis in a child with hyperimmunoglobulin M syndrome","authors":"","doi":"10.1016/j.pedneo.2024.03.006","DOIUrl":"10.1016/j.pedneo.2024.03.006","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 4","pages":"Pages 412-413"},"PeriodicalIF":2.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1875957224000743/pdfft?md5=f0d4ba84aab96417811f66fc409d7376&pid=1-s2.0-S1875957224000743-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-care ultrasound (POCUS) for tip localization of neonatal peripherally inserted central catheter (PICC): A prospective study","authors":"","doi":"10.1016/j.pedneo.2023.07.008","DOIUrl":"10.1016/j.pedneo.2023.07.008","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 4","pages":"Pages 375-380"},"PeriodicalIF":2.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1875957223002206/pdfft?md5=e6b4fc9e90388c0bc5588bb27a59c8f8&pid=1-s2.0-S1875957223002206-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138609138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic characteristics and clinical outcomes in fetuses with pulmonary stenosis or pulmonary atresia with intact ventricular septum","authors":"","doi":"10.1016/j.pedneo.2023.05.010","DOIUrl":"10.1016/j.pedneo.2023.05.010","url":null,"abstract":"<div><h3>Objective</h3><p>To summarize echocardiographic characteristics of the anatomy and hemodynamic and clinical outcomes in fetuses with isolated pulmonary stenosis (PS) or pulmonary atresia with intact ventricular septum (PA/IVS).</p></div><div><h3>Methods</h3><p>This was a single-center retrospective study of fetuses with isolated PS or PA/IVS. Echocardiographic variables and clinical outcomes after delivery were evaluated and compared.</p></div><div><h3>Results</h3><p>Between 2016 and 2021, 115 livebirths with isolated PS or PA/IVS were included. Proportion of fetuses with mild, moderate and critical PS and PA/IVS was 41.7 %, 18.3 %, 26.1 % and 13.9 %. Fetuses with more severe PS had worse anatomic and hemodynamic profiles. Specifically, the cardiothoracic ratio, pulmonary valve (PV) velocity, degree and velocity of tricuspid regurgitation increased as PS severity increased; and the pulmonary artery/aorta ratio, right ventricle/left ventricle long-axis (TV/MV) ratio, tricuspid valve/mitral valve annulus (TV/MV) ratio, and tricuspid valve inflow duration/cardiac cycle ratio decreased as PS severity increased (P &lt;0.001 for all). PV velocity ≥2 m/s predicted PV pressure ≥40 mm Hg after delivery, with an AUC of 0.81; TV/MV ratio combined with RV/LV ratio predicted clinical outcomes, with an AUC of 0.88. Live births with more severe PS had higher mortality rate (mild 0 vs. moderate 0 vs. critical 11 % vs. PA-IVS 36 %) and lower rate of developing bi-ventricles (mild 100 % vs. moderate 95 % vs. critical 89 % vs. PA-IVS 36 %).</p></div><div><h3>Conclusion</h3><p>Findings of this study help better understand the anatomy and hemodynamic and clinical outcomes in fetuses with isolated PS or PA/IVS, which could have implications for prenatal counseling and prediction of fetal outcome.</p></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 4","pages":"Pages 328-335"},"PeriodicalIF":2.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1875957223001766/pdfft?md5=87db0a1b7ff9ee833b144bca8d396b91&pid=1-s2.0-S1875957223001766-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of inappropriate steroid exposure before the diagnosis of Kawasaki disease","authors":"","doi":"10.1016/j.pedneo.2023.09.009","DOIUrl":"10.1016/j.pedneo.2023.09.009","url":null,"abstract":"<div><h3>Background</h3><p>Kawasaki disease (KD) is a systemic inflammatory disease characterized by vasculitis. In South Korea, some pediatric doctors empirically prescribe steroids to control febrile pediatric patients. This study aimed to evaluate the clinical characteristics of patients with KD after steroid exposure.</p></div><div><h3>Methods</h3><p>This was a single-center, retrospective, observational study. This study included patients (aged ≤15 years) between January 2020 and July 2022. We compared two groups, one group exposed to steroids and the other group who were not, using the Student's t-test or analysis of variance; otherwise, the Mann–Whitney <em>U</em> test or Kruskal–Wallis test was conducted. Statistical significance was set at p &lt; 0.05.</p></div><div><h3>Results</h3><p>In total, 190 patients with KD were enrolled; of these, 64 (33.7 %) had a history of steroid exposure, and 126 (66.3 %) had no history of steroid exposure. In the steroid exposure group, prolonged fever duration (6.72 ± 1.72 versus 5.61 ± 1.19, p-value = &lt;0.001), a lower proportion of complete KD (29.69 % vs. 88.10 %, p-value = &lt;0.001), and a significantly lower level of C-reactive protein were observed. However, no significant correlations were observed between the Transthoracic Echocardiography (TTE) results (coronary artery aneurysm, existence of pericardial effusion) and prognostic factors (days of hospitalization, the number of intravenous immunoglobulin administrations, and Kobayashi score) between the two groups.</p></div><div><h3>Conclusions</h3><p>Patients with KD and previous steroid exposure may exhibit an incomplete KD phenotype with prolonged fever. Although previous steroid exposure does not affect the prognosis of KD, including coronary artery aneurysms, it may mask the classic features of KD, resulting in a delayed diagnosis.</p></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 4","pages":"Pages 391-394"},"PeriodicalIF":2.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1875957223002462/pdfft?md5=d9e416b019a4392ad1c88efe5c5c6901&pid=1-s2.0-S1875957223002462-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139103185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of urinary tract infection among children with bronchiolitis","authors":"","doi":"10.1016/j.pedneo.2023.08.009","DOIUrl":"10.1016/j.pedneo.2023.08.009","url":null,"abstract":"<div><h3>Background</h3><p>The co-occurrence of bronchiolitis and urinary tract infections (UTI) in hospitalized children is associated with high morbidity and economic strain. However, due to a low prevalence (&lt;3%) and inconsistent diagnostic criteria, there is ongoing debate regarding the necessity of systematic screening. This study estimated the prevalence of UTI among children admitted for bronchiolitis and analyzed the associated demographic and clinical factors.</p></div><div><h3>Methods</h3><p>A 5-year (2016–2020) retrospective chart review was conducted among all children admitted for bronchiolitis at a referral pediatrics department in Jeddah, Saudi Arabia. UTI was diagnosed according to the American Association of Pediatrics criteria. Demographic, clinical, microbiological, and imaging data were extracted from the hospital electronic records.</p></div><div><h3>Results</h3><p>Of the 491 cases of children with bronchiolitis, urine culture and analysis were available for 320 patients. Based on urine culture criteria alone, the prevalence of UTI was 13.1% (95% CI 9.6–17.3), and the most common pathogens included <em>E. coli</em> (33.3%), <em>K. pneumoniae</em> (23.8%), and <em>Enterococcus faecalis</em> (14.3%), and 13 (31.0%) of the isolates were EBSL. By considering urinalysis criteria, i.e., pyuria or nitrituria, the estimated prevalence of UTI decreased to 3.4% (1.7–6.1%), and the most common pathogens were <em>K. pneumoniae</em> (5/11) and <em>E. coli</em> (3/11), with 6/11 ESBL-producing isolates. Regurgitation associated with a higher risk of UTI compared to absence of regurgitation (5.3% versus 0.8%; p = 0.031). Urinary tract ultrasound showed high specificity (98.7–100%) and negative predictive value (97.4–97.7%) in UTI using either criterion.</p></div><div><h3>Conclusions</h3><p>There is a higher prevalence of UTI among children with bronchiolitis in the study center, which has several implications in screening, diagnosis, and management. Further multicenter studies are required to enhance the external validity of these findings and assess the cost-effectiveness of screening strategy at a national level.</p></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 4","pages":"Pages 348-353"},"PeriodicalIF":2.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1875957223002139/pdfft?md5=d909ac50f093eac92012814a80b4be8e&pid=1-s2.0-S1875957223002139-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138479430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}