Pediatrics and Neonatology最新文献_第9页

Near-infrared spectroscopy (NIRS) as a tool to prevent cerebral desaturation in newborns with bradycardia events: A systematic review 近红外光谱（NIRS）作为预防新生儿心动过缓事件脑去饱和的工具：系统综述。

IF 2.3 4区医学

Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.07.011

Raffaele Falsaperla , Guido Leone , Alessandro Giallongo , Valentina Giacchi , Giulia Lombardo , Agata Polizzi , Catia Romano , Martino Ruggieri

{"title":"Near-infrared spectroscopy (NIRS) as a tool to prevent cerebral desaturation in newborns with bradycardia events: A systematic review","authors":"Raffaele Falsaperla , Guido Leone , Alessandro Giallongo , Valentina Giacchi , Giulia Lombardo , Agata Polizzi , Catia Romano , Martino Ruggieri","doi":"10.1016/j.pedneo.2024.07.011","DOIUrl":"10.1016/j.pedneo.2024.07.011","url":null,"abstract":"<div><h3>Objective</h3><div>Near infrared spectroscopy (NIRS) is a non-invasive tool providing real-time continuous measurement of regional cerebral blood oxygenation and indirect blood flow. The aim of this review is to determine the best evidence to guide the use of NIRS to detect and avoid abnormalities of cerebral perfusion and oxygenation in newborns with bradycardia.</div></div><div><h3>Design</h3><div>For this systematic review according to PRISMA Statement, we reviewed papers from 2000 to 2023. Research articles, trial, classical articles, observational studies applying NIRS in term and preterm neonates with bradycardia were selected if the title and/or abstract suggested an association between bradycardia or bradycardia associated with apnoea and modification of cerebral oxygenation.</div></div><div><h3>Main results</h3><div>All included studies (Table 1) were conducted on male and female newborns with gestational age (GA) between 22.6 and 42 weeks and birth weight (BW) between 212 and 3460 g. The definition of bradycardia and cerebral desaturation differed among authors. Seven out of nine papers agreed on association between bradycardia and cerebral desaturation, but no author indicated the cut-off of heart rate (HR) under which cerebral desaturations occur. No study focused on long-term outcome related to cerebral desaturation.</div></div><div><h3>Conclusions</h3><div>Even if cut-off values of HR causing cerebral desaturation are not clear and a well-fixed definition of cerebral desaturation has not yet been standardized, the studies demonstrated that bradycardia events lead to reduction of cerebral saturation. Continuous monitoring of HR and cerebral saturation by non-invasive tools could play a key role in the assessment of newborns.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 94-101"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orbital complications of pediatric acute rhinosinusitis in the pneumococcal conjugate vaccine era 肺炎球菌结合疫苗时代小儿急性鼻窦炎的眼眶并发症

IF 2.3 4区医学

Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2023.12.009

Lior Friedrich , Re'em Sadeh , Itai Hazan , Sofia Kordeluk , El-Saied Sabri , Erez Tsumi , Elchanan Zloczower , Ron Leibovitz , Eugene Leibovitz , Daniel Kaplan , Mordechai Kraus , Oren Ziv

{"title":"Orbital complications of pediatric acute rhinosinusitis in the pneumococcal conjugate vaccine era","authors":"Lior Friedrich , Re'em Sadeh , Itai Hazan , Sofia Kordeluk , El-Saied Sabri , Erez Tsumi , Elchanan Zloczower , Ron Leibovitz , Eugene Leibovitz , Daniel Kaplan , Mordechai Kraus , Oren Ziv","doi":"10.1016/j.pedneo.2023.12.009","DOIUrl":"10.1016/j.pedneo.2023.12.009","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the impact of the pneumococcal conjugate vaccines (PCVs) introduction on the orbital complications of acute rhino-sinusitis (OC-ARS).</div></div><div><h3>Methods</h3><div>A retrospective cohort study of all pediatric patients with OC-ARS during the period 2002–2019. Data included clinical, demographic, laboratory, and microbiology findings. Patients were divided into three groups: before PCV7 introduction (group 1), after PCV7 and before PCV13 (group 2), and after PCV13 (group 3).</div></div><div><h3>Results</h3><div>Of 265 enrolled patients, 117, 39, and 109 were assigned to groups 1, 2, and 3. During the study period, a significant decrease was recorded in the percentages of patients in Chandler classification severity category 1, with an increase in patients in category 3 (P = 0.011). The yearly incidence of OC-ARS decreased from 12.64 cases per 100,000 population in 2002 to 5.56 per 100,000 in 2008, and 2.99 per 100,000 in 2019 (P < 0.001). Patients aged 0–4 years showed a dramatic decrease from 29 cases per 100,000 population in 2002 to 4.27 per 100,000 in 2019 (P < 0.001). The pathogens retrieved from all cultures performed were <em>Streptococcus pneumoniae</em> (32.5%), non-typeable <em>Haemophilus influenzae</em> (27.5%), <em>Streptococcus</em> Species, (12.5%), and <em>Staphylococcus aureus</em> (20%), with no changes in distribution during the study periods. Surgery was performed in 28 (10.6%) patients.</div></div><div><h3>Conclusions</h3><div>A significant decrease was seen in the overall incidence of OC-ARS, mainly attributable to the decrease in patients aged 0–4 years. An increase was recorded in the severity of the disease following PCVs introduction.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 116-121"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141414825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic granulomatous disease: A single-center experience in Central Anatolia 慢性肉芽肿病：安纳托利亚中部的单中心经验。

IF 2.3 4区医学

Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.02.008

Yahya Gul , Esra Hazar , Hasan Kapaklı , Şukru Nail Guner , Rabia Nayir , Sinan Kutuk , Mustafa Yavuz Köker , Sevgi Keleş , İsmail Reisli

{"title":"Chronic granulomatous disease: A single-center experience in Central Anatolia","authors":"Yahya Gul , Esra Hazar , Hasan Kapaklı , Şukru Nail Guner , Rabia Nayir , Sinan Kutuk , Mustafa Yavuz Köker , Sevgi Keleş , İsmail Reisli","doi":"10.1016/j.pedneo.2024.02.008","DOIUrl":"10.1016/j.pedneo.2024.02.008","url":null,"abstract":"<div><h3>Background</h3><div>Chronic granulomatous disease (CGD), one of the phagocytic cell defects, is the primary immunodeficiency caused by dysfunction of the NADPH oxidase complex in neutrophils.</div></div><div><h3>Methods</h3><div>The clinical, demographic and laboratory findings of 17 CGD patients who were followed-up between 2002 and 2021 were obtained retrospectively from the records of the patients.</div></div><div><h3>Results</h3><div>The number of male and female patients was 10/7. The median age at diagnosis was 5.3 months (range 4–120) for 3 patients with X-CGD, and 42.4 months (range 8–350) for 14 patients with AR-CGD. We have investigated rare <em>CYBA</em> exon 3–6 deletion in 7 patients and hotspot mutation with delGT at the beginning of exon 2 of <em>NCF1</em> in 5 patients. The most common clinical findings were pneumonia and lymphadenitis with recurrent fever, respectively (41.2%, 35.3%). A total of 154 microbial infections requiring hospital admission (27 in 3 XL and 127 in 14 AR patients) were detected in the follow-up of the patients and median infection number for a patient was 9 in both groups. Eight of 17 patients had stem cell transplantation and the survival rate was 87.5%.</div></div><div><h3>Conclusions</h3><div>X-CGD patients are more rapidly recognized by family history and severe infections than those with AR-CGD and early prophylaxis may decrease infectious episodes. We have investigated the large deletion suggesting a possible founder effect for <em>CYBA</em> exon 3–6 deletion in Central Anatolia. Additionally, HSCT transplantation leads to a high survival rate for the patients with CGD.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 134-141"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accidental ingestion of a sharp metal divider 误食锋利的金属隔板。

IF 2.3 4区医学

Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.10.007

Chetan Padashetty, Shalini G. Hegde

引用次数: 0

The Omicron BA.2 outbreak in Taiwan: Pediatric healthcare challenges and lessons learned 台湾Omicron BA.2疫情：儿科医疗挑战和经验教训。

IF 2.3 4区医学

Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2025.01.004

Daniel Tsung-Ning Huang MD, PhD

引用次数: 0

Costs and outcomes associated with the administration of Intravenous Acetaminophen in neonates after esophageal atresia and tracheoesophageal fistula repair 食管闭锁和气管食管瘘修补术后新生儿静脉注射对乙酰氨基酚的相关成本和疗效。

IF 2.3 4区医学

Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.02.010

Michael A. Phillipi , Ashley Y. Song , Leah Yieh , Cynthia L. Gong

{"title":"Costs and outcomes associated with the administration of Intravenous Acetaminophen in neonates after esophageal atresia and tracheoesophageal fistula repair","authors":"Michael A. Phillipi , Ashley Y. Song , Leah Yieh , Cynthia L. Gong","doi":"10.1016/j.pedneo.2024.02.010","DOIUrl":"10.1016/j.pedneo.2024.02.010","url":null,"abstract":"<div><h3>Background</h3><div>Over the last decade, the intravenous (IV) formulation of acetaminophen (APAP) has gained popularity as a safe and effective first-line analgesic in the neonatal intensive care unit and it is especially useful in peri-operative settings where oral agents are contraindicated. The primary objective was to examine the outcomes and costs associated with the use of IV APAP in combination with opioids versus opioids alone as a pain management strategy after neonatal esophageal atresia (EA) and tracheoesophageal fistula (TEF) repair.</div></div><div><h3>Methods</h3><div>Data from the Pediatric Health Information System was used to examine 1137 hospitalizations for EA/TEF repair from October 2015 to September 2018. Neonates administered opioids only, or IV APAP in combination with opioids as pain management, were included.</div></div><div><h3>Results</h3><div>Neonates receiving IV APAP experienced a longer median LOS, but a significantly lower mortality rate, a decreased mean daily cost, and reduced opioid use compared to neonates given only opioids. The two groups had no significant differences in pharmacy and total costs.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that the use of IV APAP alongside opioids in EA/TEF repair is associated with reduced mortality and opioid use, as well as longer LOS.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 157-161"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of neonatal COVID-19 encephalopathy: White matter injury and subsequent infantile spasms 一例新生儿 COVID-19 脑病：白质损伤和随后的婴儿痉挛。

IF 2.3 4区医学

Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.07.009

Jung Sook Yeom , Young-Soo Kim

引用次数: 0

Fetal and postmortem MRI findings highlight the progression of brainstem compression from a fetal brain tumor 胎儿和死后MRI检查结果突出了胎儿脑肿瘤引起的脑干压迫的进展。

IF 2.3 4区医学

Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.10.010

Syunsuke Nagara , Emi Tannaka , Shinji Usui , Miwa Kawashiri , Kana Hayashi , Shigenori Iwagaki , Atsushi Yamagishi

引用次数: 0

Infantile Tullio phenomenon: Ocular tilt reaction to high-pitched sound in a 7-month-old preterm infant 婴儿图利奥现象：7个月早产儿对高音声音的眼倾斜反应。

IF 2.3 4区医学

Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.11.003

Yoshiko Seki , Hiromi Watanabe , Satoshi Takei , Kazushige Ikeda

引用次数: 0

The shifting landscape of orbital complications in the pneumococcal vaccine era: Progress, paradoxes, and perspectives 肺炎球菌疫苗时代眼眶并发症的变化：进展、悖论和观点。

IF 2.3 4区医学

Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2025.01.003

Chun-Hsien Yu

引用次数: 0