Pediatrics and Neonatology最新文献

{"title":"Evaluating treatment efficacy in attention-deficit/hyperactivity disorder by analyzing the movement-induced deformation of load cells under a chair in a simulated classroom: A pilot study.","authors":"Rong-Ching Wu, Yi-Hung Chiu, Chen-Sen Ouyang, Rei-Cheng Yang, Lung-Chang Lin","doi":"10.1016/j.pedneo.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.08.008","url":null,"abstract":"<p><strong>Background: </strong>Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children. Several tools are available for evaluating the efficacy of ADHD treatment, such as, for example, the Swanson, Nolan, and Pelham (SNAP-IV) questionnaire; and the Vanderbilt ADHD Diagnostic Rating Scale. However, these scales are subjective. In this study, we developed an objective method by using load cells for evaluating the efficacy of ADHD treatment.</p><p><strong>Methods: </strong>A situational classroom was prepared to simulate a real classroom. The setup included a desk, a chair, and a large screen. The four legs of the chair were equipped with load cells-materials that deform under force. These cells are used to detect the activity of patients with ADHD. This study included 13 patients with ADHD (12 boys and 1 girl). Before and after 1-month treatment with methylphenidate 10 mg p.o. QD, the patients were instructed to watch an age-appropriate educational video on Mathematics while sitting. Their movements were indicated by data gathered from the load cells under the chair. The average trajectory length (ATL) was measured to analyze the signal from the load cells. SNAP-IV questionnaires were completed by parents and teachers before and after treatment.</p><p><strong>Results: </strong>The ATL values before and after treatment were 0.0316 ± 0.0139 and 0.0208 ± 0.0127 (p = 0.0055), respectively. The patients' SNAP-IV scores assigned by parents before and after treatment were 38.89 ± 8.07 and 23.67 ± 16.87 (p = 0.0167) and those provided by teachers were 44.11 ± 11.47 and 22.22 ± 13.50 (p = 0.0048), respectively. The coefficients of the correlations between ATL values and SNAP-IV hyperactivity-impulsivity scores from parents and from teachers were 0.109 and 0.200, respectively.</p><p><strong>Conclusion: </strong>In conclusion, the smart chair equipped with load cells is an effective tool for objectively evaluating the efficacy of ADHD treatment on hyperactivity of children with ADHD.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The outcome of kidney transplantation in lupus patients.","authors":"Ting-Chih Lin, Meng-Kun Tsai, Jyh-Hong Lee, Yao-Hsu Yang, Yu-Tsan Lin, Hsin-Hui Yu, Bor-Luen Chiang, Li-Chieh Wang","doi":"10.1016/j.pedneo.2024.09.008","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.09.008","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplantation represents a therapeutic option for individuals with end-stage renal disease due to lupus. However, the influence of lupus activity and immunosuppressive medications on graft survival remains a matter of concern and it has not been thoroughly elucidated.</p><p><strong>Methods: </strong>In this study, we conducted a retrospective review of 45 lupus patients who underwent kidney transplantation, with the aim of analyzing graft survival and identifying factors influencing the outcome of kidney transplantation in lupus patients.</p><p><strong>Results: </strong>Graft survival rates at 1, 5, 10, 15, and 20 years were 98%, 98%, 88%, 85%, and 78%, respectively. Univariate logistic regression revealed hypertension, positive panel reactive antibodies against HLA class II antigens, retransplant, young age at lupus nephritis onset, low postoperative C4 levels, and HBsAg and/or anti-HBe antibody presence were significantly correlated with decreased graft survival (p < 0.05). Multiple regression confirmed the significant association of HBsAg and/or anti-HBe antibody with graft failure (p = 0.0161), with all patients testing negative for anti-HBc antibody. Preoperative markers (C3, C4, anti-dsDNA antibody) and recurrent lupus nephritis did not impact graft failure.</p><p><strong>Conclusion: </strong>In lupus patients undergoing kidney transplantation, hepatitis B serology emerges as a potential singular predictor for graft failure, while preoperative lupus activity markers and recurrent lupus nephritis do not affect outcomes.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical presentation of immunoglobulin G4-related sclerosing cholangitis with a coexistent gallbladder hydrops in a child","authors":"Termpong Dumrisilp,&nbsp;Nichakorn Tuchinda","doi":"10.1016/j.pedneo.2025.01.009","DOIUrl":"10.1016/j.pedneo.2025.01.009","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 4","pages":"Pages 396-397"},"PeriodicalIF":2.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early diagnosis and prophylactic treatment with emicizumab in premature infants with severe hemophilia A","authors":"Jhao-Jhuang Ding,&nbsp;Sheng-Yuan Ho","doi":"10.1016/j.pedneo.2025.01.007","DOIUrl":"10.1016/j.pedneo.2025.01.007","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 3","pages":"Pages 280-281"},"PeriodicalIF":2.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of non-cyanotic congenital heart disease on Children's brain studied by voxel-based morphometry: A case-control study","authors":"Xiaohui Ma ,&nbsp;Qiang Shu ,&nbsp;Weiqun Ao ,&nbsp;Xuan Jia ,&nbsp;Haichun Zhou ,&nbsp;Tingting Liu ,&nbsp;Jiawei Liang ,&nbsp;Can Lai ,&nbsp;Xiandi Zhu","doi":"10.1016/j.pedneo.2024.03.014","DOIUrl":"10.1016/j.pedneo.2024.03.014","url":null,"abstract":"<div><h3>Background</h3><div>Considerable research has shown brain injury during surgery for patients with cyanotic congenital heart disease (CHD), but the preoperative neurodevelopment and brain injury in children with non-cyanotic CHD are not well understood. The aim of this study is to investigate changes in global and local grey matter (GM) volumes of pediatric patients with non-cyanotic CHD before catheter-based procedure using voxel-based morphometry (VBM).</div></div><div><h3>Methods</h3><div>One-to three-year-old toddlers with acyanotic CHD (n = 54) hospitalized for treatment were prospectively enrolled. Each toddler underwent a 3D T1-weighted brain Magnetic Resonance Imaging (MRI) scan before catheter-based procedure. Meanwhile, 3D T1-weighted brain MR images of age- and sex-matched healthy controls (n = 35) were retrospectively analyzed. The volume of GM and total intracranial volume (TIV) were assessed by VBM within the SPM 12 (Statistical Parametric Mapping software), and regional differences in GM volume were analyzed by two-sample <em>t</em>-test and familywise error (FWE) rate correction.</div></div><div><h3>Results</h3><div>There was no difference in gross GM volume and TIV between the two groups (p &gt; 0.05), but VBM analysis showed reduced structures of GM in middle frontal gyrus (both sides), inferior frontal gyrus, orbital gyrus, subcallosal gyrus, thalamus (both sides), medial globus pallidus (both sides) and culmen (both sides) of the non-cyanotic CHD group compared with the controls (<em>p</em> &lt; 0.05, FWE correction).</div></div><div><h3>Conclusion</h3><div>Toddlers aged 1–3 years with acyanotic CHD suffer a decrease in local GM volume before catheter-based procedure, which tends to be distributed across the bilateral frontal lobe, thalamus, globus pallidus, and cerebellum.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 3","pages":"Pages 266-271"},"PeriodicalIF":2.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History, mystery, and prospects in SCN1A channelopathies/channelepsies","authors":"Shyi-Jou Chen MD, PhD","doi":"10.1016/j.pedneo.2025.03.001","DOIUrl":"10.1016/j.pedneo.2025.03.001","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 3","pages":"Pages 187-188"},"PeriodicalIF":2.3,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopmental risks in infants born during the COVID-19 pandemic","authors":"Syeda Zainab Ali ,&nbsp;Syeda Umme Abiha Rizvi ,&nbsp;Rida e Fatima","doi":"10.1016/j.pedneo.2024.12.003","DOIUrl":"10.1016/j.pedneo.2024.12.003","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 3","pages":"Pages 291-292"},"PeriodicalIF":2.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Adenovirus infection is a risk factor for recurrent intussusception in pediatric patients” [Pediatr Neonatol 64 (2023) 428–434]","authors":"Wen-Yu Tseng ,&nbsp;Hsun-Chin Chao ,&nbsp;Chien-Chang Chen ,&nbsp;Ming-Wei Lai ,&nbsp;Yi-Jung Chang","doi":"10.1016/j.pedneo.2025.01.005","DOIUrl":"10.1016/j.pedneo.2025.01.005","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Page 186"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effects on growth in preterm and small for gestational age infants: A national birth cohort study","authors":"Yi-Yu Su ,&nbsp;Chi-Jen Chen ,&nbsp;Mei-Huei Chen ,&nbsp;Hsi Chang ,&nbsp;Chung-Ming Chen ,&nbsp;Hsiu-Chen Lin ,&nbsp;Yueliang Leon Guo ,&nbsp;Wu-Shiun Hsieh ,&nbsp;Pau-Chung Chen","doi":"10.1016/j.pedneo.2024.06.007","DOIUrl":"10.1016/j.pedneo.2024.06.007","url":null,"abstract":"<div><h3>Background</h3><div>Premature and small-for-gestational-age (SGA) infants tend to have long-term growth morbidities such as short stature, failure to thrive, and obesity. Although most of these infants show catch-up growth at 2–4 years of age, they are still more susceptible to childhood obesity and related metabolic disorders. Those who fail to achieve catch-up will suffer from pathological short stature and neurodevelopmental impairment through adulthood. This study aims to depict the growth pattern of premature or SGA infants and their growth morbidities in Taiwan.</div></div><div><h3>Methods</h3><div>Data were obtained from a nationally representative cohort of 24,200 pairs of postpartum women and newborns in the Taiwan Birth Cohort Study (TBCS), using structured questionnaire interviews. A total of 16,358 infants were included and three follow-up surveys were completed at 6, 18, and 36 months after the deliveries. We constructed growth curves to conduct an in-depth investigation into anthropometric data, applying a linear mixed model. Logistic regression was used to model the relevant outcomes, with adjustment for various potential confounding factors.</div></div><div><h3>Results</h3><div>Despite being born shorter and lighter, preterm and SGA infants generally showed catch-up growth and had no higher odds ratios (ORs) of developing short stature or failure to thrive compared to appropriate-for-gestational-age (AGA) term infants before 3 years of age. Preterm SGA infants, particularly females, had higher ORs for obesity at the 36-month follow-up.</div></div><div><h3>Conclusion</h3><div>This is the first nationwide population-based study depicting the growth of SGA infants in Taiwan. The growth patterns of preterm and term SGA infants are different from those of preterm and term AGA infants. Further research is necessary to understand the growth trajectories of preterm and SGA infants and their associations with later diseases.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 168-175"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retropharyngeal and parapharyngeal infections in children: A retrospective analysis","authors":"Savithiri Ratnapalan ,&nbsp;Jeffrey Thevaranjan ,&nbsp;Niranjala Perera ,&nbsp;Basheer Nassarallah ,&nbsp;Nikolaus E. Wolter","doi":"10.1016/j.pedneo.2023.12.014","DOIUrl":"10.1016/j.pedneo.2023.12.014","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe presentations, management and outcomes of retropharyngeal and parapharyngeal infections in children presenting to a tertiary care pediatric emergency department.</div></div><div><h3>Methods</h3><div>A retrospective chart review of children with deep neck infections such as retropharyngeal or parapharyngeal infection from January 2008 to December 2018 was conducted at a pediatric hospital.</div></div><div><h3>Results</h3><div>There were 176 retropharyngeal, 18 parapharyngeal and 6 with both retropharyngeal and parapharyngeal infections treated during the 10-year study period. Males were 60% of the cohort and the mean age was 4.3 (SD: 3.2) years. No significant differences in age or sex ratio or presentations were seen in children with retropharyngeal infections compared with parapharyngeal infections. All received parenteral antibiotics; 42% (84/200) of children underwent surgery and four of them had more than one surgical drainage. Age &lt;12 months and the diagnosis of parapharyngeal infections were associated with significantly higher rates of surgical treatment. Children under 12 months of age were sicker at presentation and had a high complication rate of 23% compared with 1% in the older children (p = 0.002). Seven children had co-existence of Kawasaki disease with deep neck infections.</div></div><div><h3>Conclusions</h3><div>Early diagnosis of retropharyngeal and parapharyngeal infections especially in infants under a year of age is important as they are more likely to have complications and need surgical management. Most paediatric patients with retropharyngeal and parapharyngeal infections have a phlegmon or very small abscesses and are treated non-operatively with parenteral antibiotics.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 162-167"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}