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IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-06 DOI: 10.1016/s0962-8924(24)00105-3
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0962-8924(24)00105-3","DOIUrl":"https://doi.org/10.1016/s0962-8924(24)00105-3","url":null,"abstract":"No Abstract","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141517067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic immunity against microbes. 对微生物的代谢免疫。
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2023-11-29 DOI: 10.1016/j.tcb.2023.10.013
Sebastian Kreimendahl, Lena Pernas
{"title":"Metabolic immunity against microbes.","authors":"Sebastian Kreimendahl, Lena Pernas","doi":"10.1016/j.tcb.2023.10.013","DOIUrl":"10.1016/j.tcb.2023.10.013","url":null,"abstract":"<p><p>Pathogens, including viruses, bacteria, fungi, and parasites, remodel the metabolism of their host to acquire the nutrients they need to proliferate. Thus, host cells are often perceived as mere exploitable nutrient pools during infection. Mounting reports challenge this perception and instead suggest that host cells can actively reprogram their metabolism to the detriment of the microbial invader. In this review, we present metabolic mechanisms that host cells use to defend against pathogens. We highlight the contribution of domesticated microbes to host defenses and discuss examples of host-pathogen arms races that are derived from metabolic conflict.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tetraspanins: structure, dynamics, and principles of partner-protein recognition. 四萜类：伴侣蛋白识别的结构、动力学和原理。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2023-09-30 DOI: 10.1016/j.tcb.2023.09.003
Katherine J Susa, Andrew C Kruse, Stephen C Blacklow
{"title":"Tetraspanins: structure, dynamics, and principles of partner-protein recognition.","authors":"Katherine J Susa, Andrew C Kruse, Stephen C Blacklow","doi":"10.1016/j.tcb.2023.09.003","DOIUrl":"10.1016/j.tcb.2023.09.003","url":null,"abstract":"<p><p>Tetraspanins are a large, highly conserved family of four-pass transmembrane (TM) proteins that play critical roles in a variety of essential cellular functions, including cell migration, protein trafficking, maintenance of membrane integrity, and regulation of signal transduction. Tetraspanins carry out these biological functions primarily by interacting with partner proteins. Here, we summarize significant advances that have revealed fundamental principles underpinning structure-function relationships in tetraspanins. We first review the structural features of tetraspanin ectodomains and full-length apoproteins, and then discuss how recent structural studies of tetraspanin complexes have revealed plasticity in partner-protein recognition that enables tetraspanins to bind to remarkably different protein families, viral proteins, and antibody fragments. Finally, we discuss major questions and challenges that remain in studying tetraspanin complexes.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10980598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interplay between hormonal and mechanical signals in mammary morphodynamics. 激素和机械信号在乳腺形态动力学中的相互作用
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.1016/j.tcb.2024.03.004
Alişya A Anlaş, Celeste M Nelson
{"title":"Interplay between hormonal and mechanical signals in mammary morphodynamics.","authors":"Alişya A Anlaş, Celeste M Nelson","doi":"10.1016/j.tcb.2024.03.004","DOIUrl":"10.1016/j.tcb.2024.03.004","url":null,"abstract":"<p><p>Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fumarate hydratase as a metabolic regulator of immunity. 富马酸水合酶作为免疫的代谢调节剂。
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2023-11-06 DOI: 10.1016/j.tcb.2023.10.005
Christian G Peace, Shane M O'Carroll, Luke A J O'Neill
{"title":"Fumarate hydratase as a metabolic regulator of immunity.","authors":"Christian G Peace, Shane M O'Carroll, Luke A J O'Neill","doi":"10.1016/j.tcb.2023.10.005","DOIUrl":"10.1016/j.tcb.2023.10.005","url":null,"abstract":"<p><p>Tricarboxylic acid (TCA) cycle metabolites have been implicated in modulating signalling pathways in immune cells. Notable examples include succinate and itaconate, which have pro- and anti-inflammatory roles, respectively. Recently, fumarate has emerged as having specific roles in macrophage activation, regulating the production of such cytokines as interleukin (IL)-10 and type I interferons (IFNs). Fumarate hydratase (FH) has been identified as a control point. Notably, FH loss in different models and cell types has been found to lead to DNA and RNA release from mitochondria which are sensed by cytosolic nucleic acid sensors including retinoic acid-inducible gene (RIG)-I, melanoma differentiation-associated protein (MDA)5, and cyclic GMP-AMP synthase (cGAS) to upregulate IFN-β production. These findings may have relevance in the pathogenesis and treatment of diseases associated with decreased FH levels such as systemic lupus erythematosus (SLE) or FH-deficient kidney cancer.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71523510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Responses of organ precursors to correct and incorrect inductive signals. 器官前体对正确和不正确感应信号的反应。
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2023-09-20 DOI: 10.1016/j.tcb.2023.08.008
Yun Yang, Shuang Li, Lingfei Luo
{"title":"Responses of organ precursors to correct and incorrect inductive signals.","authors":"Yun Yang, Shuang Li, Lingfei Luo","doi":"10.1016/j.tcb.2023.08.008","DOIUrl":"10.1016/j.tcb.2023.08.008","url":null,"abstract":"<p><p>During embryonic development, the inductive molecules produced by local origins normally arrive at their target tissues in a nondirectional, diffusion manner. The target organ precursor cells must correctly interpret these inductive signals to ensure proper specification/differentiation, which is dependent on two prerequisites: (i) obtaining cell-intrinsic competence; and (ii) receiving correct inductive signals while resisting incorrect ones. Gain of intrinsic competence could avoid a large number of misinductions because the incompetent cells are nonresponsive to inductive signals. However, in cases of different precursor cells with similar competence and located in close proximity, resistance to incorrect inductive signals is essential for accurate determination of cell fate. Here we outline the mechanisms of how organ precursors respond to correct and incorrect inductive signals.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotypic noise and plasticity in cancer evolution. 癌症进化中的表型噪声和可塑性。
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2023-11-15 DOI: 10.1016/j.tcb.2023.10.002
Frederick J H Whiting, Jacob Househam, Ann-Marie Baker, Andrea Sottoriva, Trevor A Graham
{"title":"Phenotypic noise and plasticity in cancer evolution.","authors":"Frederick J H Whiting, Jacob Househam, Ann-Marie Baker, Andrea Sottoriva, Trevor A Graham","doi":"10.1016/j.tcb.2023.10.002","DOIUrl":"10.1016/j.tcb.2023.10.002","url":null,"abstract":"<p><p>Non-genetic alterations can produce changes in a cell's phenotype. In cancer, these phenomena can influence a cell's fitness by conferring access to heritable, beneficial phenotypes. Herein, we argue that current discussions of 'phenotypic plasticity' in cancer evolution ignore a salient feature of the original definition: namely, that it occurs in response to an environmental change. We suggest 'phenotypic noise' be used to distinguish non-genetic changes in phenotype that occur independently from the environment. We discuss the conceptual and methodological techniques used to identify these phenomena during cancer evolution. We propose that the distinction will guide efforts to define mechanisms of phenotype change, accelerate translational work to manipulate phenotypes through treatment, and, ultimately, improve patient outcomes.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding polygenic diseases: advances in noncoding variant prioritization and validation. 解码多基因疾病：非编码变体优先排序和验证的进展。
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2024-05-07 DOI: 10.1016/j.tcb.2024.03.005
Iris M Chin, Zachary A Gardell, M Ryan Corces
{"title":"Decoding polygenic diseases: advances in noncoding variant prioritization and validation.","authors":"Iris M Chin, Zachary A Gardell, M Ryan Corces","doi":"10.1016/j.tcb.2024.03.005","DOIUrl":"10.1016/j.tcb.2024.03.005","url":null,"abstract":"<p><p>Genome-wide association studies (GWASs) provide a key foundation for elucidating the genetic underpinnings of common polygenic diseases. However, these studies have limitations in their ability to assign causality to particular genetic variants, especially those residing in the noncoding genome. Over the past decade, technological and methodological advances in both analytical and empirical prioritization of noncoding variants have enabled the identification of causative variants by leveraging orthogonal functional evidence at increasing scale. In this review, we present an overview of these approaches and describe how this workflow provides the groundwork necessary to move beyond associations toward genetically informed studies on the molecular and cellular mechanisms of polygenic disease.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma membrane damage is a new trigger of cellular senescence. 质膜损伤是细胞衰老的新诱因。
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2024-03-15 DOI: 10.1016/j.tcb.2024.03.002
Nadine Martin, Céline Margand, David Bernard
{"title":"Plasma membrane damage is a new trigger of cellular senescence.","authors":"Nadine Martin, Céline Margand, David Bernard","doi":"10.1016/j.tcb.2024.03.002","DOIUrl":"10.1016/j.tcb.2024.03.002","url":null,"abstract":"<p><p>By blocking proliferation and inducing a secretory phenotype, cellular senescence has beneficial and deleterious effects, the latter being linked to aging. Suda et al. recently reported that plasma membrane (PM) damage (PMD) triggers senescence, suggesting that PMD inducers promote senescence and that the PMD repair machinery can regulate it.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lighting ATR/Chk1 by mesoscale TopBP1 condensates. 通过中尺度 TopBP1 凝聚物点亮 ATR/Chk1。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2024-05-06 DOI: 10.1016/j.tcb.2024.04.002
Yan Qin, Lei Shi
{"title":"Lighting ATR/Chk1 by mesoscale TopBP1 condensates.","authors":"Yan Qin, Lei Shi","doi":"10.1016/j.tcb.2024.04.002","DOIUrl":"10.1016/j.tcb.2024.04.002","url":null,"abstract":"<p><p>Biomolecular condensation has gained considerable attention as a fundamental mechanism in cell signaling and various biological processes. A recent study by Egger et al. provides valuable insights into the constituents of topoisomerase IIβ binding protein 1 (TopBP1) condensates and sheds light on the mechanism of Chk1 activation by ataxia telangiectasia-mutated and Rad3-related (ATR) at the interface of these condensates.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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