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Cultivated meat: research opportunities to advance cell line development 养殖肉类：推动细胞系开发的研究机会
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-05-18 DOI: 10.1016/j.tcb.2024.04.005
Maanasa Ravikumar, Dean Powell, Ryan Huling
{"title":"Cultivated meat: research opportunities to advance cell line development","authors":"Maanasa Ravikumar, Dean Powell, Ryan Huling","doi":"10.1016/j.tcb.2024.04.005","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.04.005","url":null,"abstract":"<p>Cultivated meat offers an avenue to feed a growing population and reduce environmental burdens associated with conventional meat production. In this Science &amp; Society paper, we outline challenges the industry is facing in obtaining robust cell lines for the development of cultivated meat products. Through an industry survey, several knowledge gaps in cell biology were identified and are presented as research opportunities here. Continued fundamental research is essential to enhance the availability of suitable cell lines and enable cost-effective and large-scale manufacture of cultivated meat.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141063357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forward programming human pluripotent stem cells into microglia 将人类多能干细胞正向编程为小胶质细胞
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-05-03 DOI: 10.1016/j.tcb.2024.03.006
Júlia Csatári, Heinz Wiendl, Matthias Pawlowski
{"title":"Forward programming human pluripotent stem cells into microglia","authors":"Júlia Csatári, Heinz Wiendl, Matthias Pawlowski","doi":"10.1016/j.tcb.2024.03.006","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.03.006","url":null,"abstract":"<p>Microglia play vital roles in embryonic and post-natal development, homeostasis, and pathogen defence in the central nervous system. Human induced pluripotent stem cell (hiPSC)-based methods have emerged as an important source for the study of human microglia <em>in vitro</em>. Classical approaches to differentiate hiPSCs into microglia suffer from limitations including extended culture periods, consistency, and efficiency. More recently, forward programming has arisen as a promising alternative for the manufacture of bulk quantities of human microglia. This review provides a comprehensive assessment of published forward programming protocols that are based on forced expression of key lineage transcription factors (TFs). We focus on the choice of reprogramming factors, transgene delivery methods, and medium composition, which impact induction kinetics and the resulting microglia phenotype.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-05-02 DOI: 10.1016/s0962-8924(24)00080-1
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0962-8924(24)00080-1","DOIUrl":"https://doi.org/10.1016/s0962-8924(24)00080-1","url":null,"abstract":"No Abstract","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-05-02 DOI: 10.1016/s0962-8924(24)00077-1
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0962-8924(24)00077-1","DOIUrl":"https://doi.org/10.1016/s0962-8924(24)00077-1","url":null,"abstract":"No Abstract","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifaceted collagen-DDR1 signaling in cancer. 癌症中的多方面胶原-DDR1信号传导。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-05-01 Epub Date: 2023-09-12 DOI: 10.1016/j.tcb.2023.08.003
Hua Su, Michael Karin
{"title":"Multifaceted collagen-DDR1 signaling in cancer.","authors":"Hua Su, Michael Karin","doi":"10.1016/j.tcb.2023.08.003","DOIUrl":"10.1016/j.tcb.2023.08.003","url":null,"abstract":"<p><p>In addition to immune cells and fibroblasts, the tumor microenvironment (TME) comprises an extracellular matrix (ECM) which contains collagens (COLs) whose architecture and remodeling dictate cancer development and progression. COL receptors expressed by cancer cells sense signals generated by microenvironmental alterations in COL state to regulate cell behavior and metabolism. Discoidin domain receptor 1 (DDR1) is a key sensor of COL fiber state and composition that controls tumor cell metabolism and growth, response to therapy, and patient survival. This review focuses on DDR1 to NRF2 signaling, its modulation of autophagy and macropinocytosis (MP), and its role in cancer and other diseases. Elucidating the regulation of DDR1 activity and expression under different pathophysiological conditions will facilitate the discovery of new therapeutics.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10927612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10246127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards solving the mystery of peroxisomal matrix protein import. 致力于解开过氧化物酶体基质蛋白进口之谜。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-05-01 Epub Date: 2023-09-22 DOI: 10.1016/j.tcb.2023.08.005
Michael L Skowyra, Peiqiang Feng, Tom A Rapoport
{"title":"Towards solving the mystery of peroxisomal matrix protein import.","authors":"Michael L Skowyra, Peiqiang Feng, Tom A Rapoport","doi":"10.1016/j.tcb.2023.08.005","DOIUrl":"10.1016/j.tcb.2023.08.005","url":null,"abstract":"<p><p>Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from the cytosol using mobile receptors. Surprisingly, the receptors can even import folded proteins, but the underlying mechanism has been a mystery. Recent results reveal how import receptors shuttle cargo into peroxisomes. The cargo-bound receptors move from the cytosol across the peroxisomal membrane completely into the matrix by a mechanism that resembles transport through the nuclear pore. The receptors then return to the cytosol through a separate retrotranslocation channel, leaving the cargo inside the organelle. This cycle concentrates imported proteins within peroxisomes, and the energy for cargo import is supplied by receptor export. Peroxisomal protein import thus fundamentally differs from other previously known mechanisms for translocating proteins across membranes.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10957506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A20: a jack of all trades. A20：万事通。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-05-01 Epub Date: 2024-03-09 DOI: 10.1016/j.tcb.2024.02.008
Pieter Hertens, Geert van Loo
{"title":"A20: a jack of all trades.","authors":"Pieter Hertens, Geert van Loo","doi":"10.1016/j.tcb.2024.02.008","DOIUrl":"10.1016/j.tcb.2024.02.008","url":null,"abstract":"<p><p>Mutations and polymorphisms in A20/TNFAIP3 have been linked to various inflammatory disorders. However, in addition to its well-known role in inflammation, A20 also controls EDAR- and receptor activator of NF-κB (RANK)-induced NF-κB signaling, regulating the development of epidermal skin appendages and bone, respectively. Furthermore, A20 regulates synapse remodeling through a mechanism dependent on NF-κB.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor-initiating cells establish a niche to overcome isolation stress. 诱发肿瘤的细胞建立了一个生态位，以克服隔离压力。
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-05-01 Epub Date: 2023-08-26 DOI: 10.1016/j.tcb.2023.08.001
Chengsheng Wu, Sara M Weis, David A Cheresh
{"title":"Tumor-initiating cells establish a niche to overcome isolation stress.","authors":"Chengsheng Wu, Sara M Weis, David A Cheresh","doi":"10.1016/j.tcb.2023.08.001","DOIUrl":"10.1016/j.tcb.2023.08.001","url":null,"abstract":"<p><p>While the tumor microenvironment is a critical contributor to cancer progression, early steps of tumor initiation and metastasis also rely on the ability of individual tumor cells to survive and thrive at locations where tumor stroma or immune infiltration has yet to be established. In this opinion article, we use the term 'isolation stress' to broadly describe the challenges that individual tumor cells must overcome during the initiation and expansion of the primary tumor beyond permissive boundaries and metastatic spread into distant sites, including a lack of cell-cell contact, adhesion to protumor extracellular matrix proteins, and access to nutrients, oxygen, and soluble factors that support growth. In particular, we highlight the ability of solitary tumor cells to autonomously generate a specialized fibronectin-enriched extracellular matrix to create their own pericellular niche that supports tumor initiation. Cancer cells that can creatively evade the effects of isolation stress not only become more broadly stress tolerant, they also tend to show enhanced stemness, drug resistance, tumor initiation, and metastasis.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10102274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spermidine - an old molecule with a new age-defying immune function. 抹茶苷--一种古老的分子，却具有新的抗衰老免疫功能。
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-05-01 Epub Date: 2023-09-16 DOI: 10.1016/j.tcb.2023.08.002
Kenji Chamoto, Baihao Zhang, Masaki Tajima, Tasuku Honjo, Sidonia Fagarasan
{"title":"Spermidine - an old molecule with a new age-defying immune function.","authors":"Kenji Chamoto, Baihao Zhang, Masaki Tajima, Tasuku Honjo, Sidonia Fagarasan","doi":"10.1016/j.tcb.2023.08.002","DOIUrl":"10.1016/j.tcb.2023.08.002","url":null,"abstract":"<p><p>Polyamines - putrescine, spermidine, and spermine - are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine insufficiency is associated with various physio-pathological processes, such as aging and cancers. Recent advances in immuno-metabolism and immunotherapy shed new light on the role of spermidine in immune cell regulation and anticancer responses. Here, we review novel works demonstrating that spermidine is produced by collective metabolic pathways of gut bacteria, bacteria-host co-metabolism, and by the host cells, including activated immune cells. We highlight the effectiveness of spermidine in enhancing antitumor responses in aged animals otherwise nonresponsive to immune checkpoint therapy and propose that spermidine supplementation could be used to enhance the efficacy of anti-PD-1 treatment.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cilia as Wnt signaling organelles 作为 Wnt 信号细胞器的纤毛
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-05-01 DOI: 10.1016/j.tcb.2024.04.001
Christof Niehrs, Fabio Da Silva, Carina Seidl
{"title":"Cilia as Wnt signaling organelles","authors":"Christof Niehrs, Fabio Da Silva, Carina Seidl","doi":"10.1016/j.tcb.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.04.001","url":null,"abstract":"<p>Cilia and Wnt signaling have a complex relationship, wherein Wnt regulates cilia and, conversely, cilia may affect Wnt signaling. Recently, it was shown that Wnt receptors are present in flagella, primary cilia, and multicilia, where they transmit an intraciliary signal that is independent of β-catenin. Intraciliary Wnt signaling promotes ciliogenesis, affecting male fertility, adipogenesis, and mucociliary clearance. Wnt also stimulates the beating of motile cilia, highlighting that these nanomotors, too, are chemosensory. Intraciliary Wnt signaling employs a Wnt–protein phosphatase 1 (PP1) signaling axis, involving the canonical Wnt pathway’s inhibition of glycogen synthase kinase 3 (GSK3) to repress PP1 activity. Collectively, these findings support that cilia are Wnt signaling organelles, with implications for ciliopathies and cancer.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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