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Sugar symphony: glycosylation in cancer metabolism and stemness. 糖交响乐：癌症代谢和干细胞中的糖基化作用
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-10-26 DOI: 10.1016/j.tcb.2024.09.006
Venkatesh Varadharaj, Wyatt Petersen, Surinder K Batra, Moorthy P Ponnusamy
{"title":"Sugar symphony: glycosylation in cancer metabolism and stemness.","authors":"Venkatesh Varadharaj, Wyatt Petersen, Surinder K Batra, Moorthy P Ponnusamy","doi":"10.1016/j.tcb.2024.09.006","DOIUrl":"10.1016/j.tcb.2024.09.006","url":null,"abstract":"<p><p>Glycosylation is a complex co-translational and post-translational modification (PTM) in eukaryotes that utilizes glycosyltransferases to generate a vast array of glycoconjugate structures. Recent studies have highlighted the role of glycans in regulating essential molecular, cellular, tissue, organ, and systemic biological processes with significant implications for human diseases, particularly cancer. The metabolic reliance of cancer, spanning tumor initiation, disease progression, and resistance to therapy, necessitates a range of uniquely altered cellular metabolic pathways. In addition, the intricate interplay between cell-intrinsic and -extrinsic mechanisms is exemplified by the communication between cancer cells, cancer stem cells (CSCs), cancer-associated fibroblasts (CAFs), and immune cells within the tumor microenvironment (TME). In this review article, we explore how differential glycosylation in cancer influences the metabolism and stemness features alongside new avenues in glycobiology.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms suppressing noncoding translation. 抑制非编码翻译的机制
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-10-22 DOI: 10.1016/j.tcb.2024.09.004
Jordan S Kesner, Xuebing Wu
{"title":"Mechanisms suppressing noncoding translation.","authors":"Jordan S Kesner, Xuebing Wu","doi":"10.1016/j.tcb.2024.09.004","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.09.004","url":null,"abstract":"<p><p>The majority of the DNA sequence in our genome is noncoding and not intended for synthesizing proteins. Nonetheless, genome-wide mapping of ribosome footprints has revealed widespread translation in annotated noncoding sequences, including long noncoding RNAs (lncRNAs), untranslated regions (UTRs), and introns of mRNAs. How cells suppress the translation of potentially toxic proteins from various noncoding sequences remains poorly understood. This review summarizes mechanisms for the mitigation of noncoding translation, including the BCL2-associated athanogene 6 (BAG6)-mediated proteasomal degradation pathway, which has emerged as a unifying mechanism to suppress the translation of diverse noncoding sequences in metazoan cells.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular vesicles from the dead: the final message. 来自死者的细胞外囊泡：最后的信息。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-10-21 DOI: 10.1016/j.tcb.2024.09.005
Bo Shi, Thanh Kha Phan, Ivan K H Poon
{"title":"Extracellular vesicles from the dead: the final message.","authors":"Bo Shi, Thanh Kha Phan, Ivan K H Poon","doi":"10.1016/j.tcb.2024.09.005","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.09.005","url":null,"abstract":"<p><p>Communication between dying and neighbouring cells is vital to ensure appropriate processes such as tissue repair or inflammation are initiated in response to cell death. As a mechanism to aid intercellular communication, cells undergoing apoptosis can release membrane-bound extracellular vesicles (EVs) called apoptotic-cell-derived EVs (ApoEVs) that can influence downstream processes through biomolecules within or on ApoEVs. ApoEVs are broadly categorised based on size as either large ApoEVs known as apoptotic bodies (ApoBDs) or small ApoEVs (s-ApoEVs). Notably, the mechanisms of ApoBD and s-ApoEV formation are different, and the functions of these two ApoEV subsets are distinct. This Review focuses on the biogenesis and functional properties of both ApoBDs and s-ApoEVs, particularly in the context of cell clearance, cell signalling and disease progression.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ERMCS Ca2+ transmission fuels cell division. ERMCS Ca2+ 传输促进细胞分裂。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-10-21 DOI: 10.1016/j.tcb.2024.10.002
Muniswamy Madesh, Neelanjan Vishnu, Dhanendra Tomar
{"title":"ERMCS Ca<sup>2+</sup> transmission fuels cell division.","authors":"Muniswamy Madesh, Neelanjan Vishnu, Dhanendra Tomar","doi":"10.1016/j.tcb.2024.10.002","DOIUrl":"10.1016/j.tcb.2024.10.002","url":null,"abstract":"<p><p>Mitosis is a cellular process that demands high energy, but it was previously unclear how this process is linked with mitochondrial ATP production. Zhao et al. describe how during mitosis, the lamin B receptor migrates to the ER membrane to enhance ER-mitochondria contact sites, coordinating Ca<sup>2+</sup> surges that increase ATP production necessary for cell division.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles of ECSIT in immunity and tumorigenesis. ECSIT 在免疫和肿瘤发生中的新作用。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-10-08 DOI: 10.1016/j.tcb.2024.09.003
Shuo Yang, Fiachra Humphries
{"title":"Emerging roles of ECSIT in immunity and tumorigenesis.","authors":"Shuo Yang, Fiachra Humphries","doi":"10.1016/j.tcb.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.09.003","url":null,"abstract":"<p><p>Mitochondria are signaling hubs that produce immunomodulatory metabolites during the immune response. In addition, mitochondria also facilitate the recruitment and anchoring of immune signaling complexes during infection. Evolutionary conserved signaling intermediate in toll (ECSIT) was initially described as a positive regulator of the transcription factor Nuclear factor kappa-light chain enhancer of activated B cells (NF-κB). More recently, ECSIT has emerged as a regulator of bacterial clearance, mitochondrial reactive oxygen species (mROS), and mitophagy. In addition, ECSIT has been identified as a control point in responding to viral infection and tumorigenesis. Notably, ECSIT loss in different models and cell types has been found to lead to enhanced tumorigenesis. Thus, ECSIT functions as a metabolic tumor suppressor and limits cancer pathogenesis. In this review, we highlight the key functions and crosstalk mechanisms that ECSIT bridges between cell metabolism and immunity and focus then on the antitumor role of ECSIT independent of immunity.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Senescent neutrophils: a hidden role in cancer progression. 衰老的中性粒细胞：癌症进展中的隐性角色
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-10-02 DOI: 10.1016/j.tcb.2024.09.001
Ryan N Rys, Arianna Calcinotto
{"title":"Senescent neutrophils: a hidden role in cancer progression.","authors":"Ryan N Rys, Arianna Calcinotto","doi":"10.1016/j.tcb.2024.09.001","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.09.001","url":null,"abstract":"<p><p>Neutrophils have recently received increased attention in cancer because they contribute to all stages of cancer. Neutrophils are so far considered to have a short half-life. However, a growing body of literature has shown that tumor-associated neutrophils (TANs) acquire a prolonged lifespan. This review discusses recent work surrounding the mechanisms by which neutrophils can persist in the tumor microenvironment (TME). It also highlights different scenarios for therapeutic targeting of protumorigenic neutrophils, supporting the idea that, in tumors, inhibition of neutrophil recruitment is not sufficient because these cells can persist and remain hidden from current interventions. Hence, the elimination of long-lived neutrophils should be pursued to increase the efficacy of standard therapy.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional analysis of cell plasticity using single-cell technologies. 利用单细胞技术对细胞可塑性进行功能分析。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-10-01 Epub Date: 2024-02-13 DOI: 10.1016/j.tcb.2024.01.006
Xiao Qin, Christopher J Tape
{"title":"Functional analysis of cell plasticity using single-cell technologies.","authors":"Xiao Qin, Christopher J Tape","doi":"10.1016/j.tcb.2024.01.006","DOIUrl":"10.1016/j.tcb.2024.01.006","url":null,"abstract":"<p><p>Metazoan organisms are heterocellular systems composed of hundreds of different cell types, which arise from an isogenic genome through differentiation. Cellular 'plasticity' further enables cells to alter their fate in response to exogenous cues and is involved in a variety of processes, such as wound healing, infection, and cancer. Recent advances in cellular model systems, high-dimensional single-cell technologies, and lineage tracing have sparked a renaissance in plasticity research. Here, we discuss the definition of cell plasticity, evaluate state-of-the-art model systems and techniques to study cell-fate dynamics, and explore the application of single-cell technologies to obtain functional insights into cell plasticity in healthy and diseased tissues. The integration of advanced biomimetic model systems, single-cell technologies, and high-throughput perturbation studies is enabling a new era of research into non-genetic plasticity in metazoan systems.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"854-864"},"PeriodicalIF":13.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CS proteins and ubiquitination: orchestrating DNA repair with transcription and cell division. CS 蛋白和泛素化：DNA 修复与转录和细胞分裂的协调。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-10-01 Epub Date: 2024-06-22 DOI: 10.1016/j.tcb.2024.06.002
Federico Costanzo, Elena Paccosi, Luca Proietti-De-Santis, Jean Marc Egly
{"title":"CS proteins and ubiquitination: orchestrating DNA repair with transcription and cell division.","authors":"Federico Costanzo, Elena Paccosi, Luca Proietti-De-Santis, Jean Marc Egly","doi":"10.1016/j.tcb.2024.06.002","DOIUrl":"10.1016/j.tcb.2024.06.002","url":null,"abstract":"<p><p>To face genotoxic stress, eukaryotic cells evolved extremely refined mechanisms. Defects in counteracting the threat imposed by DNA damage underlie the rare disease Cockayne syndrome (CS), which arises from mutations in the CSA and CSB genes. Although initially defined as DNA repair proteins, recent work shows that CSA and CSB act instead as master regulators of the integrated response to genomic stress by coordinating DNA repair with transcription and cell division. CSA and CSB exert this function through the ubiquitination of target proteins, which are effectors/regulators of these processes. This review describes how the ubiquitination of target substrates is a common denominator by which CSA and CSB participate in different aspects of cellular life and how their mutation gives rise to the complex disease CS.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"882-895"},"PeriodicalIF":13.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blebology: principles of bleb-based migration. 眼泡学：基于眼泡的迁移原理。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-10-01 Epub Date: 2024-03-27 DOI: 10.1016/j.tcb.2024.02.009
Juan Manuel García-Arcos, Ankita Jha, Clare M Waterman, Matthieu Piel
{"title":"Blebology: principles of bleb-based migration.","authors":"Juan Manuel García-Arcos, Ankita Jha, Clare M Waterman, Matthieu Piel","doi":"10.1016/j.tcb.2024.02.009","DOIUrl":"10.1016/j.tcb.2024.02.009","url":null,"abstract":"<p><p>Bleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex interactions in blebbing behavior and discuss the generation of force and its transmission during migration. Our analysis aims to deepen the understanding of the physical and molecular mechanisms of bleb-based migration, shedding light on its implications and significance for health and disease.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"838-853"},"PeriodicalIF":13.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA m6A methylation at the juxtaposition of apoptosis and RNA therapeutics. 处于细胞凋亡和 RNA 治疗并列位置的 RNA m6A 甲基化。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-10-01 Epub Date: 2024-08-31 DOI: 10.1016/j.tcb.2024.08.002
Bünyamin Akgül, Azime Akçaöz-Alasar, Buket Sağlam
{"title":"RNA m<sup>6</sup>A methylation at the juxtaposition of apoptosis and RNA therapeutics.","authors":"Bünyamin Akgül, Azime Akçaöz-Alasar, Buket Sağlam","doi":"10.1016/j.tcb.2024.08.002","DOIUrl":"10.1016/j.tcb.2024.08.002","url":null,"abstract":"<p><p>Targeting RNA m<sup>6</sup>A marks in apoptosis-related transcripts holds promise for RNA therapeutics. However, pathway-specific RNA m<sup>6</sup>A sites on pro- or antiapoptotic transcripts have not been fully unveiled, let alone characterized. This article summarizes the current knowledge and gaps in the cellular response modulated by apoptotic stimulus-specific RNA m<sup>6</sup>A marks.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"801-804"},"PeriodicalIF":13.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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