线粒体底物氧化调节不同的细胞分化结果。

IF 18.1 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-04-01 Epub Date: 2025-02-25 DOI:10.1016/j.tcb.2025.02.004

Woo Yong Park, Claudia Montufar, Elma Zaganjor

引用次数: 0

摘要

线粒体代谢、信号和动力学是细胞命运的关键调节因子。虽然糖酵解支持干细胞，但线粒体扩张和氧化磷酸化（OXPHOS）促进分化。本次论坛提出的新证据表明，线粒体氧化的底物类型，无论是氨基酸、碳水化合物还是脂肪酸，都会显著影响分化结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mitochondrial substrate oxidation regulates distinct cell differentiation outcomes.

Mitochondrial metabolism, signaling, and dynamics are key regulators of cell fate. While glycolysis supports stemness, mitochondrial expansion and oxidative phosphorylation (OXPHOS) facilitate differentiation. This forum presents emerging evidence that the type of substrate, whether amino acids, carbohydrates, or fatty acids, oxidized by mitochondria significantly influences differentiation outcomes.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.