猎犬追逐血细胞的起源。

IF 18.1 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-04-10 DOI:10.1016/j.tcb.2025.03.003

Lauren N Randolph, Claudia Castiglioni, Manuela Tavian, Christopher M Sturgeon, Andrea Ditadi

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引用次数: 0

摘要

在胚胎发育过程中，血细胞的产生涉及一个类似谱系重编程的过程，在这个过程中，脉管系统中的特化细胞变成了造血细胞。这些造血细胞经历了快速的转录和形态变化，因为它们似乎从内皮细胞转变为血液细胞。是什么控制着这个过程，以及造血细胞的确切性质仍然存在争议，有证据支持几种假设。在这种观点下，我们综合了现有的知识，提出了一个模型来调和相互矛盾的观察结果，将进化和机制的见解整合到血细胞的出现中。

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Bloodhounds chasing the origin of blood cells.

The generation of blood cells during embryonic development involves a process resembling lineage reprogramming, where specialized cells within the vasculature become blood forming, or hemogenic. These hemogenic cells undergo rapid transcriptional and morphological changes as they appear to switch from an endothelial to blood identity. What controls this process and the exact nature of the hemogenic cells remains debated, with evidence supporting several hypotheses. In this opinion, we synthesize current knowledge and propose a model reconciling conflicting observations, integrating evolutionary and mechanistic insights into blood cell emergence.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.