环化酶相关蛋白：具有多种神经元功能的肌动蛋白调节因子。

IF 18.1 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI:10.1016/j.tcb.2025.01.007

Marco B Rust, Sharof Khudayberdiev

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引用次数: 0

摘要

过去十年的研究证实环化酶相关蛋白（CAP）是肌动蛋白动力学的关键调节因子，并将其失调与人类大脑疾病联系起来。然而，它的神经元功能仍然未知，直到最近的研究破译了与神经元分化或突触形态发生相关的cap依赖机制，这篇论坛文章对此进行了总结和讨论。

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Cyclase-associated protein: an actin regulator with multiple neuronal functions.

Studies of the past decade established cyclase-associated protein (CAP) as a key regulator of actin dynamics and associated its dysregulation with human brain disorders. However, its neuronal functions remained unknown until recent studies deciphered CAP-dependent mechanisms relevant for neuron differentiation or synapse morphogenesis, which are summarized and discussed in this forum article.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.