旧工具的新工作：PI3Kβ磷酸化OGT以调节胶质母细胞瘤中的乙酰辅酶a。

IF 18.1 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-05-01 Epub Date: 2025-04-16 DOI:10.1016/j.tcb.2025.04.002

Riley G Young, Nusaiba N Ahmed, Mauricio J Reginato

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引用次数: 0

摘要

磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基β (PI3Kβ)作为一种脂质激酶在细胞信号传导中发挥作用。他和同事最近报道了PI3Kβ的非规范功能，即在高葡萄糖条件下，它磷酸化并激活O-GlcNAc转移酶（OGT）。这种激活增强了atp -柠檬酸合成酶（ACLY） o - glcn酰化，增加了乙酰辅酶a的产生，促进了脂肪酸代谢和组蛋白乙酰化，并促进了胶质母细胞瘤（GBM）的生长。

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New job for an old tool: PI3Kβ phosphorylates OGT to regulate acetyl-CoA in glioblastoma.

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PI3Kβ) is recognized for its role in cellular signaling as a lipid kinase. He and colleagues recently reported a non-canonical function of PI3Kβ where, under high glucose, it phosphorylates and activates O-GlcNAc transferase (OGT). This activation enhances ATP-citrate synthase (ACLY) O-GlcNAcylation, increasing acetyl-CoA production, fueling fatty acid metabolism and histone acetylation, and driving glioblastoma (GBM) growth.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.