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Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer. 生物分子凝聚体：癌症中 Hippo-YAP/TAZ 信号的枢纽。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-07-01 Epub Date: 2024-05-27 DOI: 10.1016/j.tcb.2024.04.009
Karrie M Kiang, Leena Ahad, Xiaowen Zhong, Q Richard Lu
{"title":"Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer.","authors":"Karrie M Kiang, Leena Ahad, Xiaowen Zhong, Q Richard Lu","doi":"10.1016/j.tcb.2024.04.009","DOIUrl":"10.1016/j.tcb.2024.04.009","url":null,"abstract":"<p><p>Biomolecular condensates, the membraneless cellular compartments formed by liquid-liquid phase separation (LLPS), represent an important mechanism for physiological and tumorigenic processes. Recent studies have advanced our understanding of how these condensates formed in the cytoplasm or nucleus regulate Hippo signaling, a central player in organogenesis and tumorigenesis. Here, we review recent findings on the dynamic formation and function of biomolecular condensates in regulating the Hippo-yes-associated protein (YAP)/transcription coactivator with PDZ-binding motif (TAZ) signaling pathway under physiological and pathological processes. We further discuss how the nuclear condensates of YAP- or TAZ-fusion oncoproteins compartmentalize crucial transcriptional co-activators and alter chromatin architecture to promote oncogenic programs. Finally, we highlight key questions regarding how these findings may pave the way for novel therapeutics to target cancer.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial complexome and import network. 线粒体复合体和导入网络。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-07-01 Epub Date: 2023-10-31 DOI: 10.1016/j.tcb.2023.10.004
Fabian den Brave, Uwe Schulte, Bernd Fakler, Nikolaus Pfanner, Thomas Becker
{"title":"Mitochondrial complexome and import network.","authors":"Fabian den Brave, Uwe Schulte, Bernd Fakler, Nikolaus Pfanner, Thomas Becker","doi":"10.1016/j.tcb.2023.10.004","DOIUrl":"10.1016/j.tcb.2023.10.004","url":null,"abstract":"<p><p>Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis, quality control, and signaling. The systematic analysis of protein complexes and interaction networks provided exciting insights into the structural and functional organization of mitochondria. Most mitochondrial proteins do not act as independent units, but are interconnected by stable or dynamic protein-protein interactions. Protein translocases are responsible for importing precursor proteins into mitochondria and form central elements of several protein interaction networks. These networks include molecular chaperones and quality control factors, metabolite channels and respiratory chain complexes, and membrane and organellar contact sites. Protein translocases link the distinct networks into an overarching network, the mitochondrial import network (MitimNet), to coordinate biogenesis, membrane organization and function of mitochondria.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles of nuclear bodies in genome spatial organization. 核体在基因组空间组织中的新作用。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-07-01 Epub Date: 2023-11-21 DOI: 10.1016/j.tcb.2023.10.012
Lin Shan, Pan Li, Hongtao Yu, Ling-Ling Chen
{"title":"Emerging roles of nuclear bodies in genome spatial organization.","authors":"Lin Shan, Pan Li, Hongtao Yu, Ling-Ling Chen","doi":"10.1016/j.tcb.2023.10.012","DOIUrl":"10.1016/j.tcb.2023.10.012","url":null,"abstract":"<p><p>Nuclear bodies (NBs) are biomolecular condensates that participate in various cellular processes and respond to cellular stimuli in the nucleus. The assembly and function of these protein- and RNA-rich bodies, such as nucleoli, nuclear speckles, and promyelocytic leukemia (PML) NBs, contribute to the spatial organization of the nucleus, regulating chromatin activities locally and globally. Recent technological advancements, including spatial multiomics approaches, have revealed novel roles of nucleoli in modulating ribosomal DNA (rDNA) and adjacent non-rDNA chromatin activity, nuclear speckles in scaffolding active genome architecture, and PML NBs in maintaining genome stability during stress conditions. In this review, we summarize emerging functions of these important NBs in the spatial organization of the genome, aided by recently developed spatial multiomics approaches toward this direction.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triple threat: neutrophil ER stress, NETosis, airway inflammation escalation. 三重威胁：中性粒细胞 ER 应激、NETosis、气道炎症升级。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-07-01 Epub Date: 2024-06-03 DOI: 10.1016/j.tcb.2024.04.004
Mohammad Mamun Ur Rashid, Ahsan Ullah, Mst Sahida Khatun, Hyung-Ryong Kim, Han-Jung Chae
{"title":"Triple threat: neutrophil ER stress, NETosis, airway inflammation escalation.","authors":"Mohammad Mamun Ur Rashid, Ahsan Ullah, Mst Sahida Khatun, Hyung-Ryong Kim, Han-Jung Chae","doi":"10.1016/j.tcb.2024.04.004","DOIUrl":"10.1016/j.tcb.2024.04.004","url":null,"abstract":"<p><p>This report aims to propose the novel term 'neutrophil endoplasmic reticulum (ER) stress' (NERS). NERS explores the influence of neutrophil extracellular trap (NET) formation and exacerbation of respiratory ailments. This inquiry aims to advance comprehension in neutrophil biology and respiratory health.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of H3K4 methylation in biology and disease. H3K4 甲基化在生物学和疾病中的作用。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-21 DOI: 10.1016/j.tcb.2024.06.001
Hua Wang, Kristian Helin
{"title":"Roles of H3K4 methylation in biology and disease.","authors":"Hua Wang, Kristian Helin","doi":"10.1016/j.tcb.2024.06.001","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.06.001","url":null,"abstract":"<p><p>Epigenetic modifications, including posttranslational modifications of histones, are closely linked to transcriptional regulation. Trimethylated H3 lysine 4 (H3K4me3) is one of the most studied histone modifications owing to its enrichment at the start sites of transcription and its association with gene expression and processes determining cell fate, development, and disease. In this review, we focus on recent studies that have yielded insights into how levels and patterns of H3K4me3 are regulated, how H3K4me3 contributes to the regulation of specific phases of transcription such as RNA polymerase II initiation, pause-release, heterogeneity, and consistency. The conclusion from these studies is that H3K4me3 by itself regulates gene expression and its precise regulation is essential for normal development and preventing disease.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of lipids in interorganelle communication. 脂质在细胞器间通讯中的作用
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-11 DOI: 10.1016/j.tcb.2024.04.008
Neuza Domingues, Joana Pires, Ira Milosevic, Nuno Raimundo
{"title":"Role of lipids in interorganelle communication.","authors":"Neuza Domingues, Joana Pires, Ira Milosevic, Nuno Raimundo","doi":"10.1016/j.tcb.2024.04.008","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.04.008","url":null,"abstract":"<p><p>Cell homeostasis and function rely on well-orchestrated communication between different organelles. This communication is ensured by signaling pathways and membrane contact sites between organelles. Many players involved in organelle crosstalk have been identified, predominantly proteins and ions. The role of lipids in interorganelle communication remains poorly understood. With the development and broader availability of methods to quantify lipids, as well as improved spatiotemporal resolution in detecting different lipid species, the contribution of lipids to organelle interactions starts to be evident. However, the specific roles of various lipid molecules in intracellular communication remain to be studied systematically. We summarize new insights in the interorganelle communication field from the perspective of organelles and discuss the roles played by lipids in these complex processes.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The migrasome, an organelle for cell-cell communication. 移行体，一种用于细胞间通讯的细胞器。
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-11 DOI: 10.1016/j.tcb.2024.05.003
Dong Jiang, Jinzhao He, Li Yu
{"title":"The migrasome, an organelle for cell-cell communication.","authors":"Dong Jiang, Jinzhao He, Li Yu","doi":"10.1016/j.tcb.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.05.003","url":null,"abstract":"<p><p>Migrasomes, newly identified extracellular organelles produced by migrating cells, are observed widely across both in vivo and in vitro studies. These organelles, rich in signaling and bioactive molecules, are pivotal in a range of physiological functions. This opinion summarizes current understanding of migrasomes, highlighting their importance as a versatile mechanism for cell-cell communication. Furthermore, it examines their roles in health and disease and potential diagnostic and therapeutic applications, and addresses the emerging challenges and open questions in this developing field.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unique architectural features of mammalian mitochondrial protein synthesis. 哺乳动物线粒体蛋白质合成的独特结构特征。
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-08 DOI: 10.1016/j.tcb.2024.05.001
Oliver Rackham, Martin Saurer, Nenad Ban, Aleksandra Filipovska
{"title":"Unique architectural features of mammalian mitochondrial protein synthesis.","authors":"Oliver Rackham, Martin Saurer, Nenad Ban, Aleksandra Filipovska","doi":"10.1016/j.tcb.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.05.001","url":null,"abstract":"<p><p>Mitochondria rely on coordinated expression of their own mitochondrial DNA (mtDNA) with that of the nuclear genome for their biogenesis. The bacterial ancestry of mitochondria has given rise to unique and idiosyncratic features of the mtDNA and its expression machinery that can be specific to different organisms. In animals, the mitochondrial protein synthesis machinery has acquired many new components and mechanisms over evolution. These include several new ribosomal proteins, new stop codons and ways to recognise them, and new mechanisms to deliver nascent proteins into the mitochondrial inner membrane. Here we describe the mitochondrial protein synthesis machinery in mammals and its unique mechanisms of action elucidated to date and highlight the technologies poised to reveal the next generation of discoveries in mitochondrial translation.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifarious astrocyte-neuron dialog in shaping neural circuit architecture. 塑造神经回路结构的星形胶质细胞与神经元的多重对话
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-08 DOI: 10.1016/j.tcb.2024.05.002
Khai H Ngoc, Younghyeon Jeon, Jaewon Ko, Ji Won Um
{"title":"Multifarious astrocyte-neuron dialog in shaping neural circuit architecture.","authors":"Khai H Ngoc, Younghyeon Jeon, Jaewon Ko, Ji Won Um","doi":"10.1016/j.tcb.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.tcb.2024.05.002","url":null,"abstract":"<p><p>Astrocytes are multifaceted glial cell types that perform structural, functional, metabolic, and homeostatic roles in the brain. Recent studies have revealed mechanisms underlying the diversity of bidirectional communication modes between astrocytes and neurons - the fundamental organizing principle shaping synaptic properties at tripartite synapses. These astrocyte-neuron interactions are critical for the proper functioning of synapses and neural circuits. This review focuses on molecular mechanisms that direct these interactions, highlighting the versatile roles of multiple adhesion-based paths that likely modulate them, often in a context-dependent manner. It also describes how astrocyte-mediated processes go awry in certain brain disorders and provides a timely insight on the pivotal roles of astrocyte-neuron interactions in synaptic integrity and their relevance to understanding and treating neurological disorders.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 19 1区 生物学
Trends in Cell Biology Pub Date : 2024-06-06 DOI: 10.1016/s0962-8924(24)00102-8
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0962-8924(24)00102-8","DOIUrl":"https://doi.org/10.1016/s0962-8924(24)00102-8","url":null,"abstract":"No Abstract","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141546838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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