Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import.

IF 18.1 1区 生物学 Q1 CELL BIOLOGY
Trends in Cell Biology Pub Date : 2025-06-01 Epub Date: 2025-02-07 DOI:10.1016/j.tcb.2025.01.003
Michael J Clague, Sylvie Urbé
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引用次数: 0

Abstract

The selective removal of mitochondria by mitophagy proceeds via multiple mechanisms and is essential for human well-being. The PINK1/Parkin and NIX/BNIP3 pathways are strongly linked to mitochondrial dysfunction and hypoxia, respectively. Both are regulated by ubiquitylation and mitochondrial import. Recent studies have elucidated how the ubiquitin kinase PINK1 acts as a sensor of mitochondrial import stress through stable interaction with a mitochondrial import supercomplex. The stability of BNIP3 and NIX is regulated by the SCFFBXL4 ubiquitin ligase complex. Substrate recognition requires an adaptor molecule, PPTC7, whose availability is limited by mitochondrial import. Unravelling the functional implications of each mode of mitophagy remains a critical challenge. We propose that mitochondrial import stress prompts a switch between these two pathways.

由泛素化和线粒体输入控制的线粒体自噬的多种途径。
线粒体自噬的选择性去除通过多种机制进行,对人类健康至关重要。PINK1/Parkin和NIX/BNIP3通路分别与线粒体功能障碍和缺氧密切相关。两者都受泛素化和线粒体输入的调节。最近的研究已经阐明了泛素激酶PINK1如何通过与线粒体输入超复合体的稳定相互作用作为线粒体输入应激的传感器。BNIP3和NIX的稳定性受SCFFBXL4泛素连接酶复合物的调控。底物识别需要一个适配器分子,PPTC7,其可用性受到线粒体输入的限制。揭示每种有丝分裂模式的功能含义仍然是一个关键的挑战。我们提出,线粒体输入应激促使这两种途径之间的切换。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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