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Mechanisms suppressing noncoding translation. 抑制非编码翻译的机制
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-07-01 Epub Date: 2024-10-22 DOI: 10.1016/j.tcb.2024.09.004
Jordan S Kesner, Xuebing Wu
{"title":"Mechanisms suppressing noncoding translation.","authors":"Jordan S Kesner, Xuebing Wu","doi":"10.1016/j.tcb.2024.09.004","DOIUrl":"10.1016/j.tcb.2024.09.004","url":null,"abstract":"<p><p>The majority of the DNA sequence in our genome is noncoding and not intended for synthesizing proteins. Nonetheless, genome-wide mapping of ribosome footprints has revealed widespread translation in annotated noncoding sequences, including long noncoding RNAs (lncRNAs), untranslated regions (UTRs), and introns of mRNAs. How cells suppress the translation of potentially toxic proteins from various noncoding sequences remains poorly understood. This review summarizes mechanisms for the mitigation of noncoding translation, including the BCL2-associated athanogene 6 (BAG6)-mediated proteasomal degradation pathway, which has emerged as a unifying mechanism to suppress the translation of diverse noncoding sequences in metazoan cells.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"627-635"},"PeriodicalIF":13.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell cycle regulation by the ribotoxic stress response. 核素毒性应激反应对细胞周期的调控。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-07-01 Epub Date: 2025-05-16 DOI: 10.1016/j.tcb.2025.04.005
Connor D McKenney, Sergi Regot
{"title":"Cell cycle regulation by the ribotoxic stress response.","authors":"Connor D McKenney, Sergi Regot","doi":"10.1016/j.tcb.2025.04.005","DOIUrl":"10.1016/j.tcb.2025.04.005","url":null,"abstract":"<p><p>Cells must sense and respond to numerous stimuli to maintain their function. Stress-activated protein kinases (SAPKs) are part of an integrated network that responds to these stimuli and have critical roles in determining cell behavior. Over the past 5 years, ribosomes and the ribotoxic stress response (RSR) have unexpectedly emerged as critical regulators of the SAPK network and drivers of global cell fate changes. In particular, RSR-SAPK signaling has potent effects on cellular proliferation, with important implications for senescence and cancer. In this review, we discuss cell cycle regulation by the SAPK p38, with a particular focus on how ribotoxic stress affects key cell cycle transitions.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"592-603"},"PeriodicalIF":13.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Celebrating 35 years of Trends in Cell Biology and introducing our special issue on ribosomal dynamics and cellular homeostasis. 庆祝35年的细胞生物学趋势，并介绍我们的核糖体动力学和细胞稳态特刊。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-07-01 Epub Date: 2025-06-18 DOI: 10.1016/j.tcb.2025.05.007
Ilaria Carnevale
{"title":"Celebrating 35 years of Trends in Cell Biology and introducing our special issue on ribosomal dynamics and cellular homeostasis.","authors":"Ilaria Carnevale","doi":"10.1016/j.tcb.2025.05.007","DOIUrl":"10.1016/j.tcb.2025.05.007","url":null,"abstract":"","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"539-540"},"PeriodicalIF":13.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central role of the ER proteostasis network in healthy aging. ER蛋白稳态网络在健康老龄化中的核心作用。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-07-01 Epub Date: 2024-11-14 DOI: 10.1016/j.tcb.2024.10.003
Claudio Hetz, Andrew Dillin
{"title":"Central role of the ER proteostasis network in healthy aging.","authors":"Claudio Hetz, Andrew Dillin","doi":"10.1016/j.tcb.2024.10.003","DOIUrl":"10.1016/j.tcb.2024.10.003","url":null,"abstract":"<p><p>Aging trajectories vary among individuals, characterized by progressive functional decline, often leading to disease states. One of the central hallmarks of aging is the deterioration of proteostasis, where the function of the endoplasmic reticulum (ER) is dramatically affected. ER stress is monitored and adjusted by the unfolded protein response (UPR); a signaling pathway that mediates adaptive processes to restore proteostasis. Studies in multiple model organisms (yeast, worms, flies, and mice) in addition to human tissue indicates that adaptive UPR signaling contributes to healthy aging. Strategies to improve ER proteostasis using small molecules and gene therapy reduce the decline of organ function during normal aging in mammals. This article reviews recent advances in understanding the significance of the ER proteostasis network to normal aging and its relationship with other hallmarks of aging such as senescence.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"548-561"},"PeriodicalIF":13.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Death by ribosome. 核糖体致死。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-07-01 Epub Date: 2024-12-10 DOI: 10.1016/j.tcb.2024.10.013
Anna Constance Vind, Franklin L Zhong, Simon Bekker-Jensen
{"title":"Death by ribosome.","authors":"Anna Constance Vind, Franklin L Zhong, Simon Bekker-Jensen","doi":"10.1016/j.tcb.2024.10.013","DOIUrl":"10.1016/j.tcb.2024.10.013","url":null,"abstract":"<p><p>Next to their essential role as protein production factories, ribosomes serve as molecular sensors of cell stress. Stalled and collided ribosomes trigger specific stress signaling, including the ribotoxic stress response (RSR). The RSR is initiated by the mitogen-activated protein (MAP)-3 kinase ZAKα in response to a plethora of translational aberrations, leading to activation of the stress-activated MAP kinases p38 and jun N-terminal kinase (JNK). Recent insights have highlighted an important role for the RSR pathway in triggering programmed cell death processes, including apoptosis and pyroptosis, in a broad range of physiologically relevant conditions. In this review, we summarize recent work on known links between programmed and accidental ribosome toxicity, RSR signaling, and cell death.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"615-626"},"PeriodicalIF":13.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ER-mitochondria contact sites: a refuge for mitochondrial mRNAs under ER stress. 内质网线粒体接触位点：内质网应激下线粒体mrna的避难所。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-07-01 Epub Date: 2025-02-25 DOI: 10.1016/j.tcb.2025.02.002
Philippe Pihán, Lisa M Ellerby, Claudio Hetz
{"title":"ER-mitochondria contact sites: a refuge for mitochondrial mRNAs under ER stress.","authors":"Philippe Pihán, Lisa M Ellerby, Claudio Hetz","doi":"10.1016/j.tcb.2025.02.002","DOIUrl":"10.1016/j.tcb.2025.02.002","url":null,"abstract":"<p><p>Tight mitochondria-endoplasmic reticulum (ER) contacts (MERCS) play essential roles in cellular homeostasis. Brar et al. reveal a novel mechanism where mitochondrial mRNAs escape global translational repression at novel context-specific MERCS during ER stress, uncovering spatially regulated translation as a critical adaptive strategy to cope with cellular stress.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"541-543"},"PeriodicalIF":13.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic rRNA modifications as a source of ribosome heterogeneity. 动态 rRNA 修饰是核糖体异质性的来源。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-07-01 Epub Date: 2024-11-04 DOI: 10.1016/j.tcb.2024.10.001
Ivan Milenkovic, Eva Maria Novoa
{"title":"Dynamic rRNA modifications as a source of ribosome heterogeneity.","authors":"Ivan Milenkovic, Eva Maria Novoa","doi":"10.1016/j.tcb.2024.10.001","DOIUrl":"10.1016/j.tcb.2024.10.001","url":null,"abstract":"<p><p>Ribosomal RNAs (rRNA) are the most abundant RNA molecules in almost all cell types. The general consensus in the field is that rRNA modifications are largely species-specific, with most previous works and databases solely stratifying modifications by the species of origin, without taking other levels of complexity into account. However, new evidence has emerged suggesting dynamic rRNA modifications may have additional layers of complexity and might play an important role in development and disease. In this review article, we summarize recent evidence supporting heterogeneity and dynamics in rRNA modifications in diverse biological contexts, challenging the simplistic view of 'one-species-one-rRNA-modification-pattern'. Moreover, we highlight how rRNA modification dynamics have been studied to date and how long-read sequencing methods can significantly improve our understanding of this largely unexplored yet highly abundant RNA family, across tissues, developmental stages, and diseases.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":"604-614"},"PeriodicalIF":13.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time matters: the dynamics of plasma membrane repair. 时间很重要：质膜修复的动力学。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-06-16 DOI: 10.1016/j.tcb.2025.05.005
Nikita Raj, Volker Gerke
{"title":"Time matters: the dynamics of plasma membrane repair.","authors":"Nikita Raj, Volker Gerke","doi":"10.1016/j.tcb.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.05.005","url":null,"abstract":"<p><p>The plasma membrane (PM) of eukaryotic cells is constantly exposed to many challenges that can cause wounds that necessitate rapid and efficient repair mechanisms to ensure cell survival. PM wound repair not only encompasses the immediate resealing of the membrane barrier, which involves exocytosis of internal vesicles to deliver membrane, but also subsequent processes that are essential to restore cellular homeostasis. These include restoration of membrane and cortical cytoskeleton structures, as well as replenishment of intracellular organelles consumed during resealing. Recent evidence suggests that the different steps in PM repair, resealing, restructuring, and restoration, are spatiotemporally correlated and regulated by membrane tension. Recent advances in understanding the different phases of PM repair are reviewed and a time-dependent classification of repair mechanisms is proposed.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Capabilities and challenges for the use of fluorescent RNAs in RNA dynamics research. 荧光RNA在RNA动力学研究中的应用能力和挑战。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-06-09 DOI: 10.1016/j.tcb.2025.05.004
Mengyue Fang, Ying Jiang, Xianjun Chen, Yi Yang
{"title":"Capabilities and challenges for the use of fluorescent RNAs in RNA dynamics research.","authors":"Mengyue Fang, Ying Jiang, Xianjun Chen, Yi Yang","doi":"10.1016/j.tcb.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.05.004","url":null,"abstract":"<p><p>Visualizing RNA dynamics with high spatial and temporal resolution is key to understanding their biological function. Fluorescent RNAs (FRs), which are fluorescent protein (FP)-like entities comprising RNA aptamers and their cognate fluorogenic dyes, provide an attractive approach for visualizing RNAs in live cells. In this opinion, we present the current potential of emerging FRs for real-time and multiplexed fluorescence imaging of RNA dynamics at the single molecule level or with super-resolution and provide guidance for the methodological and experimental factors that need to be considered when performing RNA imaging by FRs, thus, increasing their effectiveness. We also provide perspectives and future directions for the development of FRs for advanced RNA imaging.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The intersection between metabolism and translation through a subcellular lens. 代谢和翻译之间的交集通过亚细胞透镜。
IF 13 1区 生物学
Trends in Cell Biology Pub Date : 2025-06-09 DOI: 10.1016/j.tcb.2025.05.003
Massimo M Santoro
{"title":"The intersection between metabolism and translation through a subcellular lens.","authors":"Massimo M Santoro","doi":"10.1016/j.tcb.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.tcb.2025.05.003","url":null,"abstract":"<p><p>The crosstalk between metabolism and mRNA translation (protein synthesis) is crucial for modulating cellular physiology. Signals from metabolic pathways or various metabolic states can influence multiple aspects of RNA biology and translation machinery. In turn, cells can reprogram their metabolism by controlling mRNA translation. Current studies have revealed that localized mRNA translation is specifically regulated by distinct metabolic states, suggesting the existence of specialized subcellular machinery that coordinates this interplay. This review aims to explore recent discoveries and provide an overview of the specialized methodologies developed in recent years on novel modes of translation-metabolism cross-regulation by subcellular localized cues. Spatial compartmentalization, especially in the context of metabolism and mRNA translation, offers a unique advantage, providing a novel mechanism for cellular regulation and function.</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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