When RNA damage induces DNA breaks.

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-05-01 Epub Date: 2025-04-09 DOI:10.1016/j.tcb.2025.03.004

Ivan Mikicic, Petra Beli

引用次数: 0

Abstract

While alkylated mRNAs are known to activate ribosome quality control in the cytoplasm, how do cells deal with damaged RNAs in the nucleus? In their current work, Tsao et al. discover a new pathway of RNA damage repair and unexpectedly find that RNA alkylation can induce R-loops and DNA breaks.

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当RNA损伤导致DNA断裂。

烷基化mrna可以激活细胞质中的核糖体质量控制，那么细胞如何处理细胞核中受损的rna呢？在目前的工作中，Tsao等人发现了RNA损伤修复的新途径，并意外地发现RNA烷基化可以诱导r -环和DNA断裂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.