Przeglad Menopauzalny最新文献

{"title":"Serum fibronectin levels in malignant and benign endometrial diseases.","authors":"Dimitar Mitev, Sergei Slavov, Georgi Dimitrov, Irena Shikova, Julieta Hristova, Stoyan Kostov, Angel Yordanov","doi":"10.5114/pm.2024.143419","DOIUrl":"10.5114/pm.2024.143419","url":null,"abstract":"<p><strong>Introduction: </strong>Endometrial cancer is currently the most common malignancy of the female reproductive system. The significance of the disease is determined by the search for additional biomarkers with the aim to optimize earlier diagnosis and to help for timely treatment. The objective of this study was to assess the serum levels of fibronectin (FN) in patients with malignant endometrial pathology and to compare them with patients with benign pathology and healthy women.</p><p><strong>Material and methods: </strong>We analyzed serum FN levels in women with malignant and benign pathology of the endometrium. Blood serum samples were collected from 100 patients - 50 diagnosed with endometrial cancer and 50 with confirmed endometrial polyps. In addition, 50 control subjects were tested. Fibronectin levels were measured by enzyme-linked immunosorbent assay (ELISA) according to the protocol.</p><p><strong>Results: </strong>Statistical analysis was performed and the results demonstrated statistical significances (<i>p</i> = 0.008) of FN levels in the group with endometrial cancer (mean 482.73, median 409.12 µg/ml) compared to the control group (mean 346.86, median 258.87 µg/ml), but no significant difference in FN levels was observed between the group with endometrial malignancy and the group with benign pathology of the endometrium. In addition, in the cancer group FN levels did not show any significant differences depending on the histologic type.</p><p><strong>Conclusions: </strong>The serum FN concentration can be used as an additional tumor marker for gynecological malignancies and can be a potential diagnostic and prognostic marker for malignant endometrial pathology as well as for other gynecological malignancies.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 3","pages":"140-144"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vulval leiomyoma with acute postoperative delirium.","authors":"Manas Ranjan Behera, Aditya Pati, Shabnam K, Sweta Singh","doi":"10.5114/pm.2024.141094","DOIUrl":"10.5114/pm.2024.141094","url":null,"abstract":"<p><p>Leiomyomas are benign, well-circumscribed mesenchymal tumours. While uterine leiomyomas are common, vulval leiomyomas are rare. We report the challenging case of vulval leiomyoma in a multiparous woman, who also developed acute postoperative delirium. A 41-year-old multiparous woman presented with a mass in the perineum of one year duration and discomfort in a sitting position since a month ago. Her menstrual history, family history, and personal history were unremarkable. On examination of the vulva, there was a firm mass of size 10 x 8 cm on the left side, involving the labium majus and minus, which was distorting the introitus. The uterus and ovaries were normal. Preoperative ultrasound was suggestive of a vulval solid lobulated lesion, probably leiomyoma. Excision of the mass was performed. The patient developed postoperative delirium at 3 hours and was treated with an injection of haloperidol, antibiotics, and electrolyte correction. She recovered well and was discharged on the sixth postoperative day. Histopathology confirmed leiomyoma of the vulval mass, with areas of cystic degeneration. At 6-month follow-up the patient was asymptomatic and had no recurrence. To conclude, vulval leiomyoma is rare and treated by excision. The occurrence of postoperative delirium adds to the surgical morbidity, and gynaecologists should be aware of these conditions for optimal outcomes.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 2","pages":"113-116"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising antidiabetic medication management for type 2 diabetes and renal dysfunction in Can Tho City, Vietnam.","authors":"Khanh Duy Dang, Huynh Mai Thi Nguyen, Yen Phi Phung, Tu Quyen Nguyen Le","doi":"10.5114/pm.2024.141090","DOIUrl":"10.5114/pm.2024.141090","url":null,"abstract":"<p><strong>Introduction: </strong>The research aimed to delineate and investigate the utilisation of antidiabetic drugs in type 2 diabetes patients with kidney failure at a hospital in Can Tho City, Vietnam.</p><p><strong>Material and methods: </strong>The research analysed the use of antidiabetic drugs at various time points, determined the drug interaction rate, and evaluated the appropriate use of drugs and the relationship with the achievement of target blood glucose and HbA_1c levels. A two-tailed Student's t-test was employed to compare continuous variables, an ANOVA test was used to assess multiple values, and an χ² test was utilised to evaluate categorical variables.</p><p><strong>Results: </strong>Insulin monotherapy was the predominant regimen for treating type 2 diabetes in patients with impaired kidney function. Metformin was the most prescribed oral medication. Approximately 85.78% of patients received safe and appropriate diabetes treatment. Statistical analysis revealed a significant relationship between achieving target blood glucose and HbA_1c after 3 months and factors such as safe drug use and minimal drug interactions (p < 0.05). Patients with chronic kidney disease demonstrated better blood glucose control compared to those with acute kidney disease.</p><p><strong>Conclusions: </strong>The most common drug used for type 2 diabetes patients with impaired kidney function was insulin monotherapy, with usage increasing with the severity of chronic kidney disease. The chronic kidney disease group exhibited a higher rate of achieving target blood glucose and HbA_1c compared to the acute kidney disease group. Rational, safe, and interaction-free drug use significantly contributed to better blood sugar control compared to less prudent medication choices.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 2","pages":"75-82"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and prognostic role of soft ultrasound markers in prenatal detection and assessment of foetal abnormalities.","authors":"Behnaz Moradi, Ashkan Bahrami, Seyedeh Maryam Vafaei, Sanaz Sharifpour, Fatemeh Shariatinia, Ali Rezvanimehr, Ali Rashidi-Nezhad, Mobina Fathi, Shirin Yaghoobpoor, Hamed Ghorani","doi":"10.5114/pm.2024.141092","DOIUrl":"10.5114/pm.2024.141092","url":null,"abstract":"<p><p>Various soft markers can be detected in the ultrasonography of foetuses, which can be related to chromosomal abnormalities and increases the risk of abnormalities, or they can be considered as normal variations that can disappear due to the pregnancy progress. There are different tools to detect chromosomal abnormalities like conventional karyotyping, chromosomal microarray analysis (CMA), single nucleotide polymorphism (SNP) array, non-invasive prenatal test (NIPT), and non-invasive prenatal screening (NIPS). Therefore, in the present study, we aim to assess the accuracy of ultrasonic soft markers in the diagnosis of chromosomal abnormalities such as chromosomal structural abnormalities, aneuploidy, and triploidy, especially Trisomy 21 and Trisomy 18. A systemic literature search was performed using PubMed, Scopus, Google Scholar, and Web of Science. We gathered all articles published before August 2023. We selected English studies such as retrospective and cross-sectional ones that assessed the relationship between ultrasonic soft markers and foetal chromosomal abnormalities. A total of 10 articles with 18,580 cases were included in our systematic review article that assessed the foetal abnormalities and aneuploidies by using conventional karyotyping, SNP array, CMA, and NIPT (or NIPS). Trisomy 21, Trisomy 18, and chromosomal structural abnormalities were the most common abnormalities related to ultrasonic soft markers by karyotyping; however, Trisomy 13, 47, XXY, 45, X, and mosaic chromosomal abnormalities were other abnormalities detected. Results by CMA showed Trisomy 21 and Trisomy 18 as the most common abnormalities in the foetuses also with ultrasonic soft markers, and other abnormalities were pathogenic copy-number variations, Turner (XO), polyploidy, 22q11.2deletion, and Trisomy13, respectively. It was discovered that there is a greater possibility of having pathogenic copy number variations (CNVs) in the groups with multiple ultrasonic soft markers, while foetuses with ultrasonic soft markers have a decreased prevalence of CMA abnormality compared to those who had significant abnormalities or abnormal nuchal translucency. Trisomy 21 was the only abnormality found by NIPT in the groups with 1 and 2 soft markers, while groups with multiple soft markers were all normal. By using SNP array, it was identified that the rate of chromosomal abnormalities such as aneuploidy and triploidy, LOH, and CNVs was lower in the group with a single ultrasonic soft marker compared to the group with structural abnormalities in multiple systems. Trisomy 21, Trisomy 18, and chromosomal structural abnormalities were the most common chromosomal abnormalities that ultrasound soft markers could diagnose. Therefore, it is recommended to employ soft markers besides CMA, SNP array, and NIPS (or NIPT) for greater accuracy in detecting foetus abnormalities.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 2","pages":"94-108"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selected aspects of the sexual functioning of women - preliminary studies.","authors":"Alicja Góralska, Katarzyna Plagens-Rotman, Piotr Merks, Urszula Religioni, Witold Kędzia, Magdalena Pisarska-Krawczyk, Grażyna Jarząbek-Bielecka","doi":"10.5114/pm.2024.141091","DOIUrl":"10.5114/pm.2024.141091","url":null,"abstract":"<p><strong>Introduction: </strong>Sexology is a field of study to which too little attention has been paid over the years. It is still regarded as relatively new and is constantly expanding. Undoubtedly, sexual health affects a person's overall heath, influencing not only the development of a person's personality, but also their social communication skills and ability to love. Sexuality, in turn, is also related to reproductive health and mental well-being. The objective of the study was to evaluate female sexual functioning taking into account sociodemographic factors.</p><p><strong>Material and methods: </strong>333 women aged 20-65 years were enrolled in the study. The anonymous online Female Sexual Function Index questionnaire was distributed via social media. It was enriched with sociodemographic questions and selected questions related to gynaecology (age of first menstruation, treatment). In the descriptive analysis, the non-parametric Mann-Whitney U test was used to assess differences in a single trait between 2 groups of women. However, the correlation between the 2 variables was calculated using Spearman's R correlation coefficient.</p><p><strong>Results: </strong>The highest scores were noted in the domain of sexual-related pain (6) - average of 4.94 pts, and sexual satisfaction (5) - average of 4.77 pts. The lowest scores were observed in the domain of arousal (2) - average of 4.34 pts, and desire (1) - average of 3.5 pts. A slightly higher rate of women with possible sexual dysfunction was reported in rural areas - 31 women (33.3%), and in urban areas - 75 women (31.3%). The highest rates of women with possible sexual dysfunction (score ≤ 26 pts) were reported among women with obesity - 21 (44.7%) and overweight - 31 (31.0%), while the lowest rate was recorded in women with normal body mass index (BMI) - 51 (29.0%).</p><p><strong>Conclusions: </strong>There is a statistical relationship between demographics such as age and female sexuality. Age was in low correlation with the results of domains such as desire, arousal, lubrication, and overall sexual functioning. There was a statistical relationship between BMI and the arousal domain, which remained in low correlation with each other. There was no statistical relationship between demographics such as place of residence and women's sexuality. Body mass index did not statistically affect domains such as desire, lubrication, orgasm, sexual satisfaction, sexual pain complaints, and general sexual functioning.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 2","pages":"83-93"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical aspects and therapeutic strategy in a case of urinary bladder endocervicosis.","authors":"Dimitrios Diamantidis, Georgios Tsakaldimis, Chrysostomos Georgellis, Stavros Lailisidis, Nikolaos Panagiotopoulos, Charalampos Kafalis, Chousein Chousein, Maria Kouroupi, Evangelia Deligeorgiou, Charilaos Stamos, Alexandra Giatromanolaki, Stilianos Giannakopoulos, Christos Kalaitzis","doi":"10.5114/pm.2024.141093","DOIUrl":"10.5114/pm.2024.141093","url":null,"abstract":"<p><p>The diagnostic complexities posed by lesions within the urinary bladder underscore the need for personalised management approaches. Endocervicosis, a rare condition stemming from Müllerian tissue, is characterised by the benign infiltration of endocervical glands, predominantly affecting the urinary bladder. Despite the absence of definitive symptoms, meticulous preoperative assessment is imperative to ensure precise diagnosis and optimal surgical intervention. While typically benign, recent cases have hinted at a potential association with adenocarcinoma, underscoring the necessity for meticulous management. The management of endocervicosis lacks consensus, with suggested surgical modalities including transurethral resection or partial cystectomy. In this case, a 47-year-old woman presented to our department with chronic pelvic pain following hysterectomy for adenomyosis. Imaging tests revealed a solid lesion situated at the dome of the urinary bladder. Consequently, a segmental cystectomy with circular tumour-only excision, with minimal free surgical margins, was undertaken to preserve bladder integrity. Histopathological analysis confirmed the diagnosis of endocervicosis. While the reported cases of urinary bladder endocervicosis remain limited, this instance contributes valuable insights into its understanding and management. It underscores the pivotal role of accurate diagnosis and tailored surgical intervention in optimising patient outcomes and mitigating postoperative complications, with tumour-only excision emerging as a promising and feasible approach.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 2","pages":"109-112"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the influence of trastuzumab therapy on serum levels of HER-2 protein and breast cancer cell lines.","authors":"Qasim Ashour Kadooh, Ahmed Ghdhban Al-Ziaydi, Ali Jawad Hamza","doi":"10.5114/pm.2024.139607","DOIUrl":"10.5114/pm.2024.139607","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer is a complex disease characterised by abnormal cell growth in breast tissue. Trastuzumab is a targeted therapy that inhibits the HER-2 receptor and suppresses tumour growth. We aimed to determine if the clinical course of the disease could be predicted by early changes in serum levels of human epidermal growth factor receptor 2 (HER-2/neu) following trastuzumab-based therapy.</p><p><strong>Material and methods: </strong>The study enrolled 120 women, divided into an experimental group (60 breast cancer patients receiving trastuzumab) and a control group (60 healthy women). Serum samples were collected before each weekly trastuzumab treatment. In addition, human breast cancer cell lines MCF-7 and AMJ13 were cultured in vitro and treated with trastuzumab. The study assessed cell viability using a cytotoxicity assay (methyl thiazolyl tetrazolium) and measured HER-2 protein levels. The half maximal inhibitory concentration (IC50) was determined to evaluate the effect of trastuzumab on breast cancer.</p><p><strong>Results: </strong>The results showed that breast cancer patients had significantly lower serum levels of HER-2 compared to the control group. The cytotoxicity assay demonstrated that increasing trastuzumab concentration enhanced growth inhibition and cytotoxicity in the cell lines. There was a significant difference in IC50 between the MCF-7 and AMJ13 cell lines.</p><p><strong>Conclusions: </strong>The study provides valuable insights into the effects of trastuzumab on serum HER-2 levels and breast cancer cell lines. These findings have implications for resource allocation and treatment decisions in breast cancer management. By understanding the impact of trastuzumab on HER-2 levels and tumour cells, healthcare professionals can make more informed decisions regarding therapy options for patients.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 2","pages":"57-63"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of serum levels of heat shock protein 70 in patients with psoriasis in Basra, Iraq.","authors":"Wafaa Taresh Adday, Abdulkader A Al-Shakour, Samer A Taher, Wafaa Taresh","doi":"10.5114/pm.2024.141089","DOIUrl":"10.5114/pm.2024.141089","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is a chronic, non-infectious skin disease that affects people of all ages and has no sex preference, which is caused by environmental stressors involving skin cells, immunocytes, and several biologic signaling molecules. Psoriasis has been linked to psychological, metabolic, arthritic, and cardiovascular complications. Heat shock protein 70 (HSP70) is considered the most protective member of the HSP family. HSP70 can regulate protein homeostasis, minimize stress-induced denaturation and aggregation of intracellular proteins and operate as a protective factor in tissue damage. This study aimed to investigate the serum level of HSP70 in patients with psoriasis to assess whether there is an association of HSP70 with psoriasis and to assess the effects of age, gender, body mass index (BMI), waist circumference, and disease duration on the serum level of HSP70.</p><p><strong>Material and methods: </strong>This was a case-control study which recruited 98 patients with psoriasis and 81 apparently healthy age- and sex-matched individuals as controls. Blood samples were collected via venipuncture (5 ml) to estimate the HSP70, random blood sugar, liver enzymes, lipid profile, and complete blood count.</p><p><strong>Results: </strong>The results revealed that the level of HSP70 was significantly higher in psoriasis patients compared to the control group (p-value < 0.05). The level of HSP70 showed a significant association with gender, but a non-significant positive correlation with duration of psoriasis. The level of HSP70 showed a non-significant negative correlation with age, BMI and waist circumference.</p><p><strong>Conclusions: </strong>The study suggested that HSP70 may have a potential role in the pathophysiology of psoriasis and may help to explain the mechanisms behind the development and treatment of psoriatic lesions with different severity.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 2","pages":"64-68"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of serum phosphoglycerate dehydrogenase and glycine levels in breast cancer.","authors":"Hussam Abd Jassem, Anwar Jasib Thaaban","doi":"10.5114/pm.2024.140004","DOIUrl":"10.5114/pm.2024.140004","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer (BC) is the most frequent cancer in women and is a serious worldwide health issue. Phosphoglycerate dehydrogenase (PHGDH) is an enzyme that catalyses the first steps in the serine biosynthetic pathways downstream of glycolysis. Phosphoglycerate and glycine are produced by a series of enzymatic processes from the glycolysis intermediate 3-phosphoglycerate. The aim of the study was to indicate the levels of PHGDH and glycine in patients with breast cancer.</p><p><strong>Material and methods: </strong>The study was performed from December 2022 to March 2023. The total number of samples was 135 samples - 65 samples were collected from women with breast cancer, and 70 samples were from healthy women as a control group. Blood samples (5 ml) were obtained from all study group members. The complete blood count (CBC) neutrophils/lymphocytes, and haemoglobin ratio analysis was done on a CBC haematology analyser (Sysmex, Japan). Serum PHGDH and glycine were measure by enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>The study findings revealed a significant increase in the neutrophil/lymphocytes ratio and a decrease in PHGDH level in patients with BC compare to controls (p < 0.01), while the serum glycine level showed a significant increase in patients with BC compare to the control group (p < 0.01).</p><p><strong>Conclusions: </strong>Reduced PHGDH level and high glycine concentration in patients with BC could act as a prognostic factor in cancer development.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 2","pages":"69-74"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To B or not to B: the application of uterine compression sutures to reduce blood loss after myomectomy.","authors":"Almandouh H Bosilah, Mohamed Hussein, Mahmoud Abdelwahed Alboghdady, Ahmed Zaky, Ahmed Shafik Almorsy, Wael Soliman Taha, Mohammed Farouk Abd El Azeem, Amr Mohamed Sholkamy, Wael Abd Elatief Khafagy, Muhamed Ahmed Abdelmoaty, Ibrahim Mohamed Abo Eldahab, Bahaa Eldin Elmohamady Mohamed, Yasser Mohamed Said Diab, Ahmed Hashim Mohammed, Ahmed Samir Hamid Shaaban, Elsayed Mohammad Taha, Adel Aly Elboghdady, Sileem Ahmed Sileem, Hany Gaber Essawy, Elmetwally Farouk Elshahat, Ghada Ibrahim Elsaid Soror, Hamza Mohamed Abdelmohsen Mohamed","doi":"10.5114/pm.2024.136954","DOIUrl":"https://doi.org/10.5114/pm.2024.136954","url":null,"abstract":"<p><strong>Introduction: </strong>The aim was to assess the hemostatic impact of B-Lynch sutures following an open myomectomy for efficacy.</p><p><strong>Material and methods: </strong>In this prospective clinical research, performed in Alazhar university hospitals (Al-Hussain, Damietta, Assiut) and Minia University Maternity Hospital, 250 women scheduled for open myomectomy between January 2021 and January 2023 had multiple fibroid uteri with uterine sizes corresponding to 12-22 weeks. There were two groups of women. Group I (125) underwent standard open myomectomy surgery, whereas Group II (125) underwent normal open laparotomy surgery followed by B-Lynch sutures. Certain inclusion and exclusion criteria were applied to every patient. We recorded vital data, length of the procedure, complications (bleeding during the procedure, bleeding from multiple bites, bladder injury, fever, wound infection), complete blood count before and after surgery, need for blood transfusion, postoperative vital data, time until ambulation, passing flatus, and ability to eat and drink, as well as the amount of blood lost during and after the procedure.</p><p><strong>Results: </strong>There was no statistically significant difference between the two groups in age, parity, weight, number of fibroids, or uterine size as measured by ultrasonography. Between groups I and II, there was a significant difference in the average intraoperative blood loss (Group I lost 562.6 ml, whereas Group II lost 411.3 ml) as well as the mean blood loss following surgery (205 ±82 ml in Group I and 117 ±41 ml in Group II). No significant difference was observed in the mean length of hospital stay between groups I and II (2 ±0.3 days and 2 ±0.6 days, respectively).</p><p><strong>Conclusions: </strong>Using a B-Lynch suture can help minimize blood loss during and after an open myomectomy. Therefore, if the uterus is large and has a lot of fibroids, it is recommended to be done frequently.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 1","pages":"21-24"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11056725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}