Przeglad Menopauzalny最新文献

{"title":"Handgrip and its relation to age, fragility fractures, and BMD between sexes in a population aged 50+ years.","authors":"Jarosław Amarowicz, Maja Warzecha, Agnieszka Krawczyk","doi":"10.5114/pm.2024.145947","DOIUrl":"10.5114/pm.2024.145947","url":null,"abstract":"<p><strong>Introduction: </strong>A decrease in bone mineral density (BMD) accompanied by muscle weakness during aging significantly increases the probability of low-energy fracture occurrence, but it can also happen in those with a non-osteoporotic score (treatment gap). To improve the identification process of those at risk, the authors proposed using the interconnectivity between bone mineral density and muscle tissue.</p><p><strong>Material and methods: </strong>A total of 20,776 patient records were collected from the database in the period 2008-2021. After applying inclusion criteria, a total of 7159 records were used in the study. Questionnaires regarding patients' history were collected at admission. Patients underwent lumbar spine and/or femoral neck DXA examination and handgrip testing with a handheld dynamometer. Statistical analysis was conducted using tests suitable for the distribution of the data.</p><p><strong>Results: </strong>Osteoporosis was diagnosed in a total of 1914 patients. Depending on the diagnosis there was a significant (<i>p</i> < 0.001) difference in handgrip strength (HGS) between the BMD statuses (norm-osteopenia-osteoporosis). HGS was significantly (<i>p</i> < 0.001) correlated with both BMD neck (<i>r</i> = 0.2) and spine (<i>r</i> = 0.1) in females, and with BMD neck (<i>r</i> = 0.11) in the male population. In our study group HGS was significantly (<i>p</i> < 0.001) higher for all the analysed fractures in the no-fracture group of women. There was no such relationship in reference to the male population.</p><p><strong>Conclusions: </strong>Due to its relationship with BMD, its low cost, and availability, HGS might prove useful in identifying women at risk of a fragility fracture.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 4","pages":"167-172"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variants of the <i>XRCC3</i> DNA repair gene: risk implications in breast cancer among Iraqi patients.","authors":"Zainab Sabah Al-Khalidi, Rand Muhammed Abdul-Hussein Al-Husseini","doi":"10.5114/pm.2024.145948","DOIUrl":"10.5114/pm.2024.145948","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer is the predominant form of malignancy among women. Polymorphisms in DNA repair genes, such as X-ray repair cross complementing 3 (XRCC3), can influence an individual's capability to repair damaged DNA. This can result in genetic instability and potentially contribute to the development of cancer. This study investigates the correlation between the XRCC3 Thr241Met genetic variants and the risk of breast cancer.</p><p><strong>Material and methods: </strong>This study is considered the first study in Iraq that sheds light on studying the effect of the XRCC3 Thr241Met genotype variants and their relationship with increased risk of breast cancer. The blood of 75 Iraqi women who had been diagnosed with breast cancer was used in this study to extract DNA, in addition to using 50 blood samples from women who appeared to be healthy and without a family history of any other cancer, as a control group. Genotyping of the XRCC3 Thr241Met gene was studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The single nucleotide polymorphism (SNP) genotypes were determined in all participants.</p><p><strong>Results: </strong>The findings of this study demonstrated that the Met/Met allele occurred more frequently in patients than controls (OR = 3.3, 95% CI: 1.8-6.04; <i>p</i> = 0.0001), particularly in patients with positive lymph node metastases, grade II and III, and stages III/IV.</p><p><strong>Conclusions: </strong>These findings established the association of the Thr241Met genotype with breast cancer among Iraqi women; specifically, the homozygous (Met/Met) genotype appeared to be correlated with risk of breast cancer and cancer prognosis. This genotype was notably more prevalent among women diagnosed with high-grade tumours, as well as advanced stage and metastatic breast cancer.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 4","pages":"173-179"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New MUSA classification of adenomyosis: correlation of symptoms and clinical severity with direct and indirect features.","authors":"Sangam Jha, Nikita Prakash, Vikas C Jha, Upasna Sinha","doi":"10.5114/pm.2024.145950","DOIUrl":"10.5114/pm.2024.145950","url":null,"abstract":"<p><strong>Introduction: </strong>To correlate the direct and indirect morphological uterus sonographic assessment (MUSA) features of adenomyosis with clinical symptoms severity.</p><p><strong>Material and methods: </strong>This observational prospective study was conducted at a tertiary care institute from April 2023 to March 2024, involving 254 women aged 18 to 45 years with a regular menstrual cycle and ultrasound-confirmed diagnosis of adenomyosis. Detailed clinicodemographic data were collected, including symptoms such as painful menses, heavy menstrual bleeding (HMB), chronic pelvic pain (CPP), and bowel/bladder symptoms. Severity of symptoms was graded using a visual analogue scale and pictorial blood loss analysis chart. All participants underwent a 2D transvaginal ultrasound during the secretory phase, performed by blinded sonographers. Diagnosis of adenomyosis was based on the presence of direct or indirect MUSA features.</p><p><strong>Results: </strong>The study's primary findings showed that 94.4% of participants had at least one direct feature, with myometrial cysts being the most common (83.75%). Statistical analysis revealed significant associations between clinical symptoms and specific MUSA features. Heavy menstrual bleeding was linked with asymmetrical myometrial thickening, interrupted junctional zone, and globular uterus. Chronic pelvic pain was significantly associated with myometrial cysts, and dysmenorrhoea was linked with myometrial cysts and hyperechogenic islands. On stepwise logistic regression, HMB was found to be significantly associated with asymmetrical myometrial thickening, interrupted JZ, and globular uterus with odds ratios (OR) of 2.84, 2.01, and 4.03, respectively. Chronic pelvic pain was significantly associated with myometrial cyst (OR = 3.07), as was dysmenorrhoea (OR = 1.13).</p><p><strong>Conclusions: </strong>The findings of the study highlight that few sonographic direct and indirect signs of adenomyosis are linearly associated with the severity of disease symptoms.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 4","pages":"185-191"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid dysfunction in women with a menopausal syndrome.","authors":"Oksana Pavlovska, Olga Savelyeva, Kateryna Pavlovska","doi":"10.5114/pm.2024.143481","DOIUrl":"10.5114/pm.2024.143481","url":null,"abstract":"<p><strong>Introduction: </strong>The thyroid gland has a significant impact on the morphofunctional state of the organs of the female reproductive system, the regulation of the ovarian-menstrual cycle, as well as the age-related decline of the generative and endocrine function of the ovaries.</p><p><strong>Material and methods: </strong>The study involved 102 women aged 49-62 years, who were divided into 2 groups. Group I included 54 patients who suffered from manifestations of the menopausal syndrome, and the control group comprised 48 patients whose menopausal period proceeded physiologically. All patients underwent clinical, laboratory, and instrumental examinations in accordance with the requirements of modern protocols.</p><p><strong>Results: </strong>A thyroid dysfunction has a significant impact on the course of menopause. In women who suffered from manifestations of pathological menopause, the thyroid dysfunction was detected in 64.81% of patients, with the most frequently diagnosed being hypothyroid state (61.11%). Among thyroid diseases, chronic autoimmune thyroiditis prevailed (37.04%), and diffuse focal and focal changes were observed in 24.07% of cases. In patients with uncomplicated menopause, thyroid pathology was diagnosed 3.9 times less frequently. No autoimmune thyropathies were identified among the patients in the control group; focal pathology (category TI-RADS1 and TI-RADS2) was detected in 14.58% of cases.</p><p><strong>Conclusions: </strong>Thyroid dysfunction accompanied by hypothyroidism can be considered as a risk-stratification factor for the development of pathological menopause.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 3","pages":"145-151"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncosexology - selected issues taking into account the problem of sexological care of patients with cancer.","authors":"Katarzyna Plagens-Rotman, Piotr Merks, Magdalena Pisarska-Krawczyk, Ewa Jakubek, Małgorzata Mizgier, Justyna Jaskulska, Małgorzata Wójcik, Urszula Religioni, Grażyna Jarząbek-Bielecka, Witold Kędzia","doi":"10.5114/pm.2024.143481","DOIUrl":"10.5114/pm.2024.143481","url":null,"abstract":"<p><p>As can be seen from research, 44% of oncological problems disclose problems in relationships with a partner. About 80% of oncological patients report deterioration of the quality of their sexual life. Although the situation improves, a significant majority of ill persons do not obtain assistance in the scope of sexuality during oncological treatment. Intimacy is an important sphere of life and can support the process of recovery. Intimacy plays special role in the difficult period of the fight against disease. Independently of the applied method of oncological treatment, side effects of therapy can influence one's sexual life. This means that an increasing number of persons who are healed from cancerous disease are exposed to the long-term undesirable influence of treatment. The process of oncological treatment has an essential impact on the intimate life of those who suffer from oncological diseases. To a great extent, this process and the disease itself contribute to a decrease of the quality of life due to the appearance of symptoms caused by earlier menopause, they negatively influence the feeling desire and sexual performance. Unfortunately, despite the development of oncosexology, sexual problems of oncologically ill persons are not noticed, and sometimes they are played down or overlooked due to everyday problems.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 3","pages":"152-158"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical carcinoma and diabetes mellitus among women in Southern India.","authors":"Mahima Advaitha Ramakrishnan, Prasanna Mithra, Sourjya Banerjee, Poulomi Chatterjee, Shilpa N Bijoor, Adarsh Sugathan, Aparna Tripathy, Pratik Kumar Chatterjee","doi":"10.5114/pm.2024.143480","DOIUrl":"10.5114/pm.2024.143480","url":null,"abstract":"<p><strong>Introduction: </strong>Cervical carcinoma is the second commonest malignancy among females worldwide. In India, about 365.71 million women aged over 15 years are more vulnerable to cervical carcinoma. Risk factors may include immunodeficiency diseases, herpes, smoking and oral contraceptives. Scientific literature has documented that type 2 diabetes mellitus (T2DM) could aggravate the risk of some malignancies (hepatic, pancreatic, endometrial). This study aimed to evaluate the potential association between cervical carcinoma and diabetes mellitus in women.</p><p><strong>Material and methods: </strong>Patients with cervical carcinoma, with or without diabetes, were assigned to two groups based on attainment of menopause. SPSS version 11.5 was used for data analysis. Odds ratios were calculated, and the chi-square test was used. <i>P-</i>values ≤ 0.05 were considered statistically significant.</p><p><strong>Results: </strong>It was observed that 29% of patients with cervical cancer were sixty to seventy years old, with a majority (40%) of them being multiparous. Though the association of body mass index as a risk factor for diabetic patients with cervical carcinoma was not significant in pre- and post-menopausal age groups, T2DM in cervical carcinoma is a useful prognostic indicator.</p><p><strong>Conclusions: </strong>Diabetic females after attaining menopause have a higher risk of developing cervical carcinoma and therefore should mandatorily receive routine screening. Future research with a longer timeframe is needed in order to generalize the results.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 3","pages":"127-132"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 phobia, personality traits and menopausal symptoms in women in the climacteric period.","authors":"Hülya Özberk, Dilek Bilgiç, Fatma Gül Arı, Mehmet Özeren, Melih Başoğlu","doi":"10.5114/pm.2024.143468","DOIUrl":"10.5114/pm.2024.143468","url":null,"abstract":"<p><strong>Introduction: </strong>Menopausal symptoms in women are influenced by personality traits as well as physical and psychological characteristics. The effects of coronavirus disease 2019 (COVID-19) phobia on personality traits and menopausal symptoms in premenopausal and postmenopausal women were examined in this study.</p><p><strong>Material and methods: </strong>The study was conducted in a cross-sectional and descriptive design with 410 women. The data were collected using a descriptive data form, the COVID-19 phobia scale, the menopause rating scale, and the Cervantes personality scale.</p><p><strong>Results: </strong>In this study, 46.8% of the women were premenopausal and 53.2% were postmenopausal. The mean age was 42.9 ±1.97 years in premenopausal women and 50.9 ±2.94 years in postmenopausal women. The psychological, social, and total COVID-19 phobia scores were found to be higher in postmenopausal women than premenopausal women. Postmenopausal women showed more introverted personality traits than premenopausal women. COVID-19 phobia affected postmenopausal women more than premenopausal women in terms of psychological, social and all menopausal symptoms. As COVID-19 phobia increased, neurotic personality traits increased in premenopausal women, and introverted and neurotic personality traits increased in postmenopausal women (p < 0.05). Menopausal symptoms increased with neurotic personality traits in premenopausal women and with introverted personality traits in postmenopausal women (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>COVID-19 phobia affected both groups in terms of menopausal symptoms and personality traits. For the management of menopausal symptoms, it is recommended to consider neurotic personality traits in premenopausal women and introverted personality traits in postmenopausal women.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 3","pages":"133-139"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Level of body mass index, functional fitness, quality of life, and satisfaction with life among women aged 60+ years participating in an organised pro-health training programme.","authors":"Maria Krystyna Gacek, Agnieszka Wojtowicz, Grażyna Kosiba, Magdalena Majer, Joanna Gradek, Olga Czerwińska-Ledwig","doi":"10.5114/pm.2024.143478","DOIUrl":"10.5114/pm.2024.143478","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study is to assess changes in body mass index (BMI), functional fitness, satisfaction with and quality of life among women 60+ years after participating in a 9-month organised health training programme.</p><p><strong>Material and methods: </strong>Research on a group of 74 women aged 60-83 years (M = 67.8; SD = 5.1) was conducted twice, at the beginning and after 9 months of the health training programme (90 minutes, twice a week). The following tools were used in the research: SECA model 764 device, Fullerton functional fitness test, the World Health Organization Quality of Life questionnaire, and the satisfaction with life scale. Calculations were performed using the Statistica 13.1 program, via Pearson's and Spearman's correlation coefficients as well as Student's <i>t</i>-test for dependent measurements and the Wilcoxon paired test. Interactive repeated measures analysis of variance was also used. The assumed level of significance was α = 0.05.</p><p><strong>Results: </strong>Comparing the results before and after implementing the health training programme, it was found that the average BMI value decreased (<i>p</i> < 0.001), while the functional fitness indicators, including the tests: 30-second chair stand (<i>p</i> < 0.001), 30-second arm curl (<i>p</i> < 0.001), back scratch (<i>p</i> = 0.001) and two-minute step-in-place (<i>p</i> = 0.002), increased. Between the first and second measurement, differences in quality of life profiles were also demonstrated, with 3 aspects of quality of life intensifying (somatic, psychological, and environmental), the psychological aspect increasing the most.</p><p><strong>Conclusions: </strong>The obtained results confirmed the positive impact of the 9-month health training programme on the BMI, functional fitness, and quality of life of women above the age of 60 years.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 3","pages":"117-126"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative uterine artery embolisation before hysterectomy in women with giant uterine fibroid and HIV-associated nephropathy.","authors":"Filip Szkodziak, Sławomir Woźniak, Łukasz Światłowski, Emilia Maleszyk, Piotr Szkodziak, Krzysztof Pyra, Viktor Berczi, Tomasz Paszkowski, Tomasz Jargiełło","doi":"10.5114/pm.2024.143483","DOIUrl":"10.5114/pm.2024.143483","url":null,"abstract":"<p><p>Uterine fibroids are the most common pelvic benign tumours occurring in women of reproductive age. Current treatment options include surgical procedures, pharmacological therapies, and minimally invasive procedures. The most commonly applied and accepted minimally invasive procedure used in the treatment of symptomatic uterine fibroid is uterine artery embolisation (UAE). Uterine artery embolisation is a minimally invasive procedure that can be used either as an auxiliary method or the main treatment method of symptomatic uterine fibroids. We would like to present the application of pre-operative UAE before hysterectomy in anaemic women with giant uterine fibroid (21.9 × 14.9 × 10.4 cm) and HIV-associated nephropathy. Among the possible treatment options for uterine fibroids in cases like the one presented in our manuscript, hysterectomy is the treatment of choice. However, surgical treatment in a patient with severe comorbid conditions and giant uterine fibroid carries serious risk of perioperative complications. Pre-operative UAE decreases such risk by reducing blood loss during hysterectomy and shortening operation/anaesthesia time. Although the benefits of pre-operative UAE before planned myomectomy or hysterectomy in high surgical risk patients with large fibroids has yet to be confirmed in a well-designed clinical trial, this procedure seems to be a promising tool to reduce the risk of perioperative complications in such patients.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 3","pages":"159-162"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the paper by Carranza-Lira S <i>et al</i>. The relationship between carotid intima-media thickness and cognitive function and depression in postmenopausal women. Prz Menopauz 2023; 22: 21-23.","authors":"Christian Saleh, Hrvoje Budincevic","doi":"10.5114/pm.2024.143467","DOIUrl":"10.5114/pm.2024.143467","url":null,"abstract":"","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 3","pages":"163-165"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}