Przeglad Menopauzalny最新文献_第6页

Interstitial pregnancy - from diagnosis to treatment: case report and literature review. 间质性妊娠——从诊断到治疗：病例报告及文献复习。

IF 1.7

Przeglad Menopauzalny Pub Date : 2025-03-01 Epub Date: 2025-04-28 DOI: 10.5114/pm.2025.150027

Nikoleta Stoyanova, Angel Yordanov, Nikola Popovski

{"title":"Interstitial pregnancy - from diagnosis to treatment: case report and literature review.","authors":"Nikoleta Stoyanova, Angel Yordanov, Nikola Popovski","doi":"10.5114/pm.2025.150027","DOIUrl":"10.5114/pm.2025.150027","url":null,"abstract":"Interstitial pregnancy (IP) is a rare kind of tubal pregnancy, which occurs in 2-4% of all ectopic pregnancies. It occurs as a result of implantation of the gestational sac in the proximal intramural part of the fallopian tube. Risk factors include the following: pregnancy conceived after assisted reproductive technologies, ipsilateral salpingectomy, previous ectopic pregnancy, congenital tubal and uterine malformations, pelvic inflammatory disease, and the presence of an intrauterine device. Given the rare and complex nature of interstitial pregnancies, diagnosis and management are difficult. Transvaginal ultrasound is the most specific instrumental method for early diagnosis that can decrease possible complications, such as rupture, severe haemorrhage, and risk of future infertility in the case of misdiagnosis. There are various surgical and non-surgical methods for the treatment of interstitial pregnancy. The method of choice depends on gestational age, whether the pregnancy is intact or ruptured, and the patient's desire for future fertility. However, surgery is still the main option for the treatment of IP because it offers definitive treatment. Generally, complicated IP is associated with high rate of mortality due to delayed diagnosis and treatment. We present a case report related to a multiparous woman with amenorrhoea and ultrasound findings corresponding to sonographic criteria for interstitial pregnancy. Laparoscopy was performed, which confirmed the diagnosis. Bilateral salpingectomy and right cornual resection were performed because the patient had no intention for future pregnancies.","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"24 1","pages":"79-83"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effect of the type of hysterectomy on the incidence of stress urinary incontinence. 子宫切除术类型对应激性尿失禁发生率影响的评价。

IF 1.7

Przeglad Menopauzalny Pub Date : 2025-03-01 Epub Date: 2025-04-28 DOI: 10.5114/pm.2025.150036

Oliwia Biegańska, Emilia Biczak, Grzegorz Przywara, Adam Jagodziński, Edyta Wlaźlak, Marek Murawski

{"title":"Evaluation of the effect of the type of hysterectomy on the incidence of stress urinary incontinence.","authors":"Oliwia Biegańska, Emilia Biczak, Grzegorz Przywara, Adam Jagodziński, Edyta Wlaźlak, Marek Murawski","doi":"10.5114/pm.2025.150036","DOIUrl":"10.5114/pm.2025.150036","url":null,"abstract":"Hysterectomy is performed by various surgical methods: abdominal, vaginal, laparoscopic, or robotic, and with different extents: supracervical, total, or radical. Scientific reports indicate that hysterectomy is a risk factor for stress urinary incontinence (SUI). The aim of this paper is to review scientific studies on the effect of the type of hysterectomy on the incidence of SUI. Original open-access articles in English language available in the PubMed, Google Scholar, and ScienceDirect databases published in the period 2004-2024 were included. Studies suggest the following: vaginal hysterectomy is associated with a higher risk of SUI than abdominal hysterectomy; abdominal hysterectomy is associated with a higher risk of SUI than laparoscopic hysterectomy; and it is likely that supracervical hysterectomy is associated with a higher risk of SUI than total hysterectomy; however, some scientific reports do not show significant differences in SUI between the above types of hysterectomy, so the first 3 conclusions should be approached with caution; it is uncertain whether the removal of the adnexa during hysterectomy increases the risk of SUI; and there were no differences between traditional laparoscopic hysterectomy and robotic-assisted laparoscopic hysterectomy. More good-quality studies on the effect of the type of hysterectomy on the incidence of SUI are necessary.","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"24 1","pages":"45-52"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is concurrent training effective in the symptomatology of menopause, depression, sexual function, and the aging perspective of women during menopause? A randomised clinical trial. 同时训练对绝经期妇女的症状学、抑郁、性功能和衰老观点有效吗？一项随机临床试验。

IF 1.7

Przeglad Menopauzalny Pub Date : 2025-03-01 Epub Date: 2025-05-05 DOI: 10.5114/pm.2025.150142

Cibele Medeiros Scarpel, Danielly Yani Fausto, Julia Beatriz Bocchi Martins, Adriana Coutinho de Azevedo Guimarães

{"title":"Is concurrent training effective in the symptomatology of menopause, depression, sexual function, and the aging perspective of women during menopause? A randomised clinical trial.","authors":"Cibele Medeiros Scarpel, Danielly Yani Fausto, Julia Beatriz Bocchi Martins, Adriana Coutinho de Azevedo Guimarães","doi":"10.5114/pm.2025.150142","DOIUrl":"10.5114/pm.2025.150142","url":null,"abstract":"Introduction: To analyse the effect of concurrent training after 4 months of intervention compared to the control group on the symptomatology of menopause, symptoms of depression, sexual function, and aging perspective of women during menopause.Material and methods: This is a randomized 2-arm clinical trial. A total of 42 menopausal women (53.21 ±3.65 years of age) were included. Questionnaires related to symptoms of menopause (menopause rating scale - MRS), depression (hospital anxiety and depression scale), sexual function (female sexual function index), and aging perspective (Sheppard inventory) were applied. Intention-to-treat and protocol adherence analysis were performed.Results: In the analysis by protocol, there was an improvement in menopausal symptoms in all domains of the MRS, specifically somatic symptoms (p = 0.001), psychological symptoms (p = 0.001), urogenital symptoms (p = 0.001), and total score (p = 0.001), as well as a reduction in depressive symptoms (p = 0.016). Additionally, improvements were observed in sexual function across 4 domains, including desire (p = 0.007), lubrication (p = 0.024), satisfaction (p = 0.030), and the overall sexual function score (p = 0.022). Furthermore, concerning the aspect of 'finitude', there was a significant improvement between groups in the domain of happiness (p = 0.046).Conclusions: Concurrent training was shown to be effective for improving the symptomatology of menopause, depression, sexual function and happiness in menopause.","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"24 1","pages":"33-44"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimal access nipple-sparing mastectomy - the current European landscape. 保留乳头的乳房切除术-目前欧洲的情况。

IF 1.7

Przeglad Menopauzalny Pub Date : 2025-03-01 Epub Date: 2025-05-03 DOI: 10.5114/pm.2025.150082

Piotr Pluta, Gauthier Rathat, Lydia Blay, Oreste Davide Gentilini, Daniela Emanuela Huber, Martinez Daniel, Peralta Guillermo, Younan Rami J, Vergauwen Glenn, Toesca Antonio

{"title":"Minimal access nipple-sparing mastectomy - the current European landscape.","authors":"Piotr Pluta, Gauthier Rathat, Lydia Blay, Oreste Davide Gentilini, Daniela Emanuela Huber, Martinez Daniel, Peralta Guillermo, Younan Rami J, Vergauwen Glenn, Toesca Antonio","doi":"10.5114/pm.2025.150082","DOIUrl":"10.5114/pm.2025.150082","url":null,"abstract":"Minimal access nipple-sparing mastectomy (M-NSM), performed with endoscopic systems or with surgical robot assistance, is a novel alternative to the classic approach to nipple-sparing mastectomies. Leading advancements in M-NSM have primarily come from Asia. We gather experts' opinions from six European countries to establish the current status of M-NSM in Europe. An eight-question survey was designed to explore M-NSM's historical background and current standing in various local settings. We collected data from 6 European countries, including Italy, Spain, France, Switzerland, Belgium, and Poland. The number of centers offering M-NSM procedures in each reported country ranges 1-9. The number of procedures performed annually in four centers exceeds 10. In all reported countries, current national breast cancer recommendations do not include M-NSM, and this procedure is not explicitly covered by any of the national health care providers. All experts have indicated the need for training in M-NSM surgery as a primary way to incorporate these techniques as a standard procedure. Minimal access nipple-sparing mastectomy is still a tool used by a narrow group of specialists in Europe. The main obstacle to broader implementation remains the extra cost of M-NSM, which requires reimbursement from the health care providers. Training courses, data collection, and demonstration of its benefits are the key to promoting M-NSM among breast surgeons and patients.","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"24 1","pages":"66-71"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of age at menopause with type 2 diabetes mellitus in postmenopausal women: a systematic review and meta-analysis. 绝经后妇女绝经年龄与2型糖尿病的关系：一项系统回顾和荟萃分析。

IF 2.5

Przeglad Menopauzalny Pub Date : 2024-12-01 Epub Date: 2024-12-22 DOI: 10.5114/pm.2024.145954

Faezeh Zakerinasab, Taif Haiham Al Saraireh, Amirhesam Amirbeik, Rasoul Hossein Zadeh, Fariba Arbab Mojeni, Qumars Behfar

{"title":"Association of age at menopause with type 2 diabetes mellitus in postmenopausal women: a systematic review and meta-analysis.","authors":"Faezeh Zakerinasab, Taif Haiham Al Saraireh, Amirhesam Amirbeik, Rasoul Hossein Zadeh, Fariba Arbab Mojeni, Qumars Behfar","doi":"10.5114/pm.2024.145954","DOIUrl":"10.5114/pm.2024.145954","url":null,"abstract":"The onset of menopause usually occurs between the ages of 48 and 52, leading to diverse symptoms in various body systems due to a decrease in estrogen level. Visceral obesity and diminished estrogen level during the menopausal phase are associated with unfavorable metabolic changes, resulting in insulin resistance and increased risk of type 2 diabetes mellitus (T2DM). Owing to the increase in the incidence and prevalence of T2DM in recent decades, it is important to identify predisposing factor such as menopausal age to improve T2DM prevention and management. We searched PubMed, Scopus, and Google Scholar databases to find all studies related to menopause and type 2 diabetes up to August 4, 2023. Studies were reviewed for compliance with the inclusion criteria. Sample size and number of post-menopausal T2DM cases were extracted from studies. Effect sizes and related confidence intervals were calculated for them. The combined analysis of 17 studies demonstrated a significant association between menopausal age and risk of T2DM. The calculated odds ratio (OR) demonstrated that women with menopausal age > 45 had significantly decreased risk of developing T2DM with OR of 0.13 (95% CI: 0.04, 0.22). This effect changed to OR = 0.44 (95% CI: -1.12, 2.00) and 0.21 (95% CI: -1.39, 1.82) for menopausal age > 50 and > 55, respectively. In conclusion, this present meta-analysis emphasizes the importance of the complex relationship between earlier menopausal age and risk of T2DM development.","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 4","pages":"207-215"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Müllerianosis of the urinary bladder in pre- and postmenopausal women: a literature review. 绝经前和绝经后妇女膀胱<s:1>勒氏症：文献综述。

IF 2.5

Przeglad Menopauzalny Pub Date : 2024-12-01 Epub Date: 2024-12-22 DOI: 10.5114/pm.2024.145955

Dimitrios Diamantidis, Georgios Tsakaldimis, Stavros Lailisidis, Evangelia Deligeorgiou, Nikolaos Panagiotopoulos, Nektraria Kritsotaki, Charalampos Kafalis, Chousein Chousein, Stilianos Giannakopoulos, Christos Kalaitzis

{"title":"Müllerianosis of the urinary bladder in pre- and postmenopausal women: a literature review.","authors":"Dimitrios Diamantidis, Georgios Tsakaldimis, Stavros Lailisidis, Evangelia Deligeorgiou, Nikolaos Panagiotopoulos, Nektraria Kritsotaki, Charalampos Kafalis, Chousein Chousein, Stilianos Giannakopoulos, Christos Kalaitzis","doi":"10.5114/pm.2024.145955","DOIUrl":"10.5114/pm.2024.145955","url":null,"abstract":"Müllerianosis of the urinary bladder is a rare pathological condition involving ectopic Müllerian-derived tissues within the bladder. Despite its benign nature, due to its ability to mimic malignant conditions such as bladder carcinoma, diagnosis might be challenging. In this review, data from 36 cases across 32 studies were analyzed, focusing on patient demographics, symptomatology, diagnostic imaging, and histopathological features. The average patient age was 42.4 years. Common symptoms included dysuria, hematuria, and pelvic pain. Diagnostic challenges arise from the nonspecific nature of symptoms and imaging findings, making histopathological confirmation necessary. Surgical treatment is mainly involved, with transurethral resection being the most common approach. In some cases, hormonal therapy is also explored. While the prognosis is generally favorable, recurrence is possible, emphasizing the need for long-term follow-up. The review underscores the importance of early diagnosis and individualized management strategies to improve patient outcomes.","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 4","pages":"216-224"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of hyaluronic acid fillers in patients with autoimmune endocrinopathies; in particular, women with Hashimoto's disease - hints for aesthetic doctors. 透明质酸填充剂在自身免疫性内分泌疾病患者中的应用尤其是患有桥本氏病的女性——这对美容医生来说是个提示。

IF 2.5

Przeglad Menopauzalny Pub Date : 2024-12-01 Epub Date: 2024-12-22 DOI: 10.5114/pm.2024.145952

Katarzyna Bornikowska, Paweł Kubik, Wojciech Zgliczyński

{"title":"The use of hyaluronic acid fillers in patients with autoimmune endocrinopathies; in particular, women with Hashimoto's disease - hints for aesthetic doctors.","authors":"Katarzyna Bornikowska, Paweł Kubik, Wojciech Zgliczyński","doi":"10.5114/pm.2024.145952","DOIUrl":"10.5114/pm.2024.145952","url":null,"abstract":"The increase of the incidence of autoimmune diseases and, at the same time, a significant surge in the number of regenerative/anti-aging medicine treatments carried out, raises the need to systematise the current knowledge on the safety of the use of hyaluronic acid fillers in patients with autoimmune diseases and to frame management guidelines for aesthetic doctors. One of the most prevalent autoimmune diseases is chronic lymphocytic thyroiditis, so-called Hashimoto's disease, which affects one in every 5-10 women who visit a regenerative medicine doctor. Women in the perimenopausal and menopausal period, aged 40-54 years, were the single largest target group for aesthetic treatments. At the same time, Hashimoto's disease, similarly to other autoimmune disorders, constitutes a contraindication to most treatments with hyaluronic acid fillers and biostimulators. Due to the dysfunction of the immune system in this group of patients, there is a higher risk of adverse side effects, especially those of immunological nature. Based on the available literature, the incidence of adverse reactions after the use of hyaluronic acid-based fillers amounts to 0.01-1% and is undoubtedly underestimated. The most typical one is recurrent oedema and granulomas. The following paper reviews the existing literature on the safety of hyaluronic acid fillers in patients with autoimmune endocrinopathies.","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 4","pages":"200-206"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small bowel obstruction secondary to uterine fibroids: a case presentation. 子宫肌瘤继发小肠梗阻1例。

IF 2.5

Przeglad Menopauzalny Pub Date : 2024-12-01 Epub Date: 2024-12-22 DOI: 10.5114/pm.2024.145956

Andreas Antzoulas, Georgios-Ioannis Verras, Vasileios Leivaditis, Athanasios Papatriantafyllou, Levan Tchabashvili, Nikolaos Benetatos, Francesk Mulita

{"title":"Small bowel obstruction secondary to uterine fibroids: a case presentation.","authors":"Andreas Antzoulas, Georgios-Ioannis Verras, Vasileios Leivaditis, Athanasios Papatriantafyllou, Levan Tchabashvili, Nikolaos Benetatos, Francesk Mulita","doi":"10.5114/pm.2024.145956","DOIUrl":"10.5114/pm.2024.145956","url":null,"abstract":"Small bowel obstruction (SBO) is a serious condition with distinct symptoms such as constipation, vomiting, and abdominal distension. It is commonly caused by well-recognised factors. Recent advancements in imaging techniques and minimally invasive procedures have significantly improved our ability to accurately select patients for surgical intervention and promptly identify common SBO causes. Nonetheless, it is crucial to recognise that diagnosing rare SBO causes remains a challenge. We present a rare case of mechanical bowel obstruction caused by massive uterine fibroids in a 44-year-old woman. Large uterine fibroids can cause mechanical small intestine obstruction, although this is not a common cause. Diagnostic imaging, particularly computed tomography, plays a crucial role in diagnosing and determining appropriate management plans. Accurate monitoring and imaging can lead to improved patient outcomes by avoiding unnecessary surgical intervention and reducing morbidity and mortality rates. Treatment options include both medical and surgical methods. Both approaches have proven effective, with surgical procedures being the last resort if medical treatments are unsuccessful. The accuracy and efficacy of these surgical methods have shown promising results and significant prognostic benefits. It is critical to identify and report rare causes of bowel obstruction to improve future recognition and enhance patient outcomes.","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 4","pages":"225-228"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triple-negative breast cancer patients treated with subcutaneous mastectomy with immediate reconstruction: single institution experience. 三阴性乳腺癌患者皮下乳房切除术立即重建：单一机构的经验。

IF 2.5

Przeglad Menopauzalny Pub Date : 2024-12-01 Epub Date: 2024-12-22 DOI: 10.5114/pm.2024.145951

Artur Bocian, Paweł Macek, Piotr Kędzierawski

{"title":"Triple-negative breast cancer patients treated with subcutaneous mastectomy with immediate reconstruction: single institution experience.","authors":"Artur Bocian, Paweł Macek, Piotr Kędzierawski","doi":"10.5114/pm.2024.145951","DOIUrl":"10.5114/pm.2024.145951","url":null,"abstract":"Introduction: Triple-negative breast cancer (TNBC) accounts for approximately 15-20% of all breast carcinomas. In the last two decades, both nipple-sparing mastectomy (NSM) and skin-sparing mastectomy (SSM) with immediate reconstruction have been used in the surgical management. The aim of our study was to analyze the outcomes of the combined treatment of patients with TNBC treated with NSM or SSM.Material and methods: A total of 114 women with TNBC were enrolled in this study. All diagnostic, therapeutic and follow-up procedures were conducted in one center of the Holycross Cancer Centre in Kielce. In all patients, subcutaneous mastectomy was performed. Overall survival was estimated by the Kaplan-Meier method. The influence of selected prognostic factors on the risk of death was analyzed using the Cox proportional hazards models.Results: The probability of survival at 1, 3, and 5 years was 0.982, 0.894, 0.850, respectively. Based on the 5-factor Cox model, all included features had a significant relationship with the risk of death. In conclusion, the presence of a genetic mutation, adjuvant chemotherapy, complete pathological regression, and the absence of radiotherapy significantly reduced the risk of death.Conclusions: The results of the treatment with subcutaneous mastectomy are good. The early stage of the cancer is associated with a better prognosis. Complete pathological regression after systemic treatment, particularly in patients with BRCA1 mutation, is a good prognostic factor and can help diminish the range of surgery in the axilla region.","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 4","pages":"192-199"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The clinicopathological role of miRNA-196a and its SNP variant rs11614913 in high-grade ovarian cancer. miRNA-196a及其SNP变体rs11614913在高级别卵巢癌中的临床病理作用

IF 2.5

Przeglad Menopauzalny Pub Date : 2024-12-01 Epub Date: 2024-12-22 DOI: 10.5114/pm.2024.145949

Edyta Leśniak, Emilia Stec-Martyna, Daria Domańska-Senderowska, Hanna Romanowicz, Tomasz Krawczyk, Jan Bieńkiewicz, Andrzej Malinowski, Miłosz Wilczyński

{"title":"The clinicopathological role of miRNA-196a and its SNP variant rs11614913 in high-grade ovarian cancer.","authors":"Edyta Leśniak, Emilia Stec-Martyna, Daria Domańska-Senderowska, Hanna Romanowicz, Tomasz Krawczyk, Jan Bieńkiewicz, Andrzej Malinowski, Miłosz Wilczyński","doi":"10.5114/pm.2024.145949","DOIUrl":"10.5114/pm.2024.145949","url":null,"abstract":"Introduction: Ovarian cancer is a significant cause of death among females. MiRNAs, particularly the miR-196 family, can influence tumor progression by targeting specific pathways. Detecting ovarian cancer early is challenging, highlighting the need for additional biomarkers such as miRNAs to improve diagnosis and treatment strategies.Material and methods: Healthy controls and patients with high-grade serous carcinoma (n = 50) were recruited for this study. Samples for testing were obtained from archival paraffin blocks obtained from intraoperative material.Results: The study found that miRNA 196a expression was significantly elevated in ovarian cancer patients compared to the control group (p < 0.05). Higher miRNA 196a expression was also noted in patients with advanced FIGO stages (III, IV). Increased miRNA expression was significantly associated with higher mortality and chemoresistance (p < 0.05). Genotype analysis revealed differing distributions of SNPs (C/C, C/T, T/T) between the study and control groups, but no significant correlation with malignancy was observed.Conclusions: This study supports the critical role of microRNA-196a in the progression of ovarian cancer.","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":"23 4","pages":"180-184"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0