Ainur Donayeva, Dinara Kulzhanova, Ainur Amanzholkyzy, Ibrahim A Abdelazim, Talgar Abilov, Zhenisbek Baubekov, Ihab I Samaha
{"title":"维生素 D 与青少年甲状腺功能减退症之间的关系--一项横断面研究。","authors":"Ainur Donayeva, Dinara Kulzhanova, Ainur Amanzholkyzy, Ibrahim A Abdelazim, Talgar Abilov, Zhenisbek Baubekov, Ihab I Samaha","doi":"10.5114/pm.2023.133280","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>To detect the relationship between 25(OH)D and hypothyroidism in adolescents.</p><p><strong>Material and methods: </strong>A total of 180 adolescents were included in the current study, which was conducted in West Kazakhstan (Aktobe) over 2 years. After thorough evaluation, blood samples were collected from the studied participants to measure the thyroid stimulating hormone (TSH), free thyroxine (T4), prolactin, glycosylated haemoglobin, and 25(OH)D. Participants were classified into a 25(OH)D-deficient group (study group) and controls. MedCalc and correlation analysis (Pearson's correlation) were used to detect the odds of hypothyroidism and the relationship between 25(OH)D and adolescents' hypothyroidism, respectively.</p><p><strong>Results: </strong>Thyroid-stimulating hormone was statistically higher in the 25(OH)D-deficient group than in the normal controls (3.71 ±1.4 mIU/ml vs. 2.67 ±0.99) (<i>p</i> = 0.0006), and the free T4 was statistically lower in the 25(OH)D-deficient group than in normal controls (1.4 ±0.56 ng/ml vs. 1.5 ±0.4) (<i>p</i> = 0.0008). The 25(OH)D deficient group had higher odds of subclinical (OR 4.89; <i>p</i> = 0.016), and clinical hypothyroidism (OR 4.3; <i>p</i> = 0.013) compared to controls. A significant negative correlation between the 25(OH)D and TSH (<i>r</i> = -0.793; <i>p</i> < 0.00001), and a significant positive correlation between the 25(OH)D and free T4 (<i>r</i> 0.55; <i>p</i> < 0.00001) were detected in this study.</p><p><strong>Conclusions: </strong>The thyroid-stimulating hormone was statistically higher and the free T4 was statistically lower in the 25(OH)D-deficient group than in normal controls. The 25(OH)D-deficient group had higher odds of both subclinical and clinical hypothyroidism compared to controls. A significant negative correlation between the 25(OH)D and TSH, and a significant positive correlation between the 25(OH)D and the free T4 were detected in this study.</p>","PeriodicalId":55643,"journal":{"name":"Przeglad Menopauzalny","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793608/pdf/","citationCount":"0","resultStr":"{\"title\":\"Relationship between vitamin D and adolescents' hypothyroidism - a cross-sectional study.\",\"authors\":\"Ainur Donayeva, Dinara Kulzhanova, Ainur Amanzholkyzy, Ibrahim A Abdelazim, Talgar Abilov, Zhenisbek Baubekov, Ihab I Samaha\",\"doi\":\"10.5114/pm.2023.133280\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>To detect the relationship between 25(OH)D and hypothyroidism in adolescents.</p><p><strong>Material and methods: </strong>A total of 180 adolescents were included in the current study, which was conducted in West Kazakhstan (Aktobe) over 2 years. After thorough evaluation, blood samples were collected from the studied participants to measure the thyroid stimulating hormone (TSH), free thyroxine (T4), prolactin, glycosylated haemoglobin, and 25(OH)D. Participants were classified into a 25(OH)D-deficient group (study group) and controls. MedCalc and correlation analysis (Pearson's correlation) were used to detect the odds of hypothyroidism and the relationship between 25(OH)D and adolescents' hypothyroidism, respectively.</p><p><strong>Results: </strong>Thyroid-stimulating hormone was statistically higher in the 25(OH)D-deficient group than in the normal controls (3.71 ±1.4 mIU/ml vs. 2.67 ±0.99) (<i>p</i> = 0.0006), and the free T4 was statistically lower in the 25(OH)D-deficient group than in normal controls (1.4 ±0.56 ng/ml vs. 1.5 ±0.4) (<i>p</i> = 0.0008). The 25(OH)D deficient group had higher odds of subclinical (OR 4.89; <i>p</i> = 0.016), and clinical hypothyroidism (OR 4.3; <i>p</i> = 0.013) compared to controls. A significant negative correlation between the 25(OH)D and TSH (<i>r</i> = -0.793; <i>p</i> < 0.00001), and a significant positive correlation between the 25(OH)D and free T4 (<i>r</i> 0.55; <i>p</i> < 0.00001) were detected in this study.</p><p><strong>Conclusions: </strong>The thyroid-stimulating hormone was statistically higher and the free T4 was statistically lower in the 25(OH)D-deficient group than in normal controls. The 25(OH)D-deficient group had higher odds of both subclinical and clinical hypothyroidism compared to controls. A significant negative correlation between the 25(OH)D and TSH, and a significant positive correlation between the 25(OH)D and the free T4 were detected in this study.</p>\",\"PeriodicalId\":55643,\"journal\":{\"name\":\"Przeglad Menopauzalny\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793608/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Przeglad Menopauzalny\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/pm.2023.133280\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/11/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Przeglad Menopauzalny","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/pm.2023.133280","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/29 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Relationship between vitamin D and adolescents' hypothyroidism - a cross-sectional study.
Introduction: To detect the relationship between 25(OH)D and hypothyroidism in adolescents.
Material and methods: A total of 180 adolescents were included in the current study, which was conducted in West Kazakhstan (Aktobe) over 2 years. After thorough evaluation, blood samples were collected from the studied participants to measure the thyroid stimulating hormone (TSH), free thyroxine (T4), prolactin, glycosylated haemoglobin, and 25(OH)D. Participants were classified into a 25(OH)D-deficient group (study group) and controls. MedCalc and correlation analysis (Pearson's correlation) were used to detect the odds of hypothyroidism and the relationship between 25(OH)D and adolescents' hypothyroidism, respectively.
Results: Thyroid-stimulating hormone was statistically higher in the 25(OH)D-deficient group than in the normal controls (3.71 ±1.4 mIU/ml vs. 2.67 ±0.99) (p = 0.0006), and the free T4 was statistically lower in the 25(OH)D-deficient group than in normal controls (1.4 ±0.56 ng/ml vs. 1.5 ±0.4) (p = 0.0008). The 25(OH)D deficient group had higher odds of subclinical (OR 4.89; p = 0.016), and clinical hypothyroidism (OR 4.3; p = 0.013) compared to controls. A significant negative correlation between the 25(OH)D and TSH (r = -0.793; p < 0.00001), and a significant positive correlation between the 25(OH)D and free T4 (r 0.55; p < 0.00001) were detected in this study.
Conclusions: The thyroid-stimulating hormone was statistically higher and the free T4 was statistically lower in the 25(OH)D-deficient group than in normal controls. The 25(OH)D-deficient group had higher odds of both subclinical and clinical hypothyroidism compared to controls. A significant negative correlation between the 25(OH)D and TSH, and a significant positive correlation between the 25(OH)D and the free T4 were detected in this study.
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