Ageing Research Reviews最新文献

{"title":"Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming","authors":"Hangyuan Jiang ,&nbsp;Hengxing Qi ,&nbsp;Anying Tang ,&nbsp;Shaohua Hu ,&nbsp;Jianbo Lai","doi":"10.1016/j.arr.2025.102808","DOIUrl":"10.1016/j.arr.2025.102808","url":null,"abstract":"<div><div>The decline of adult neurogenesis and neuronal function during aging underlies the onset and progression of neurodegenerative diseases such as Alzheimer’s disease. Conventional therapies, including neurotransmitter modulators and antibodies targeting pathogenic proteins, offer only symptomatic improvement. As the most abundant glial cells in the brain, astrocytes outnumber neurons nearly fivefold. However, their proliferative and transdifferentiation potential renders them ideal candidates for in situ neuronal replacement. Direct astrocyte-to-neuron reprogramming offers a promising regenerative approach to restore damaged neural circuits. Herein, we propose a “car start-up” model to conceptualize this process, emphasizing the need to inhibit non-neuronal fate pathways (release the handbrake), suppress transcriptional repressors (release the footbrake), and activate neuron-specific gene expression (step on the gas). Additionally, overcoming metabolic barriers in the cytoplasm is essential for successful lineage conversion. Viral or non-viral vectors deliver reprogramming factors, while small molecules serve as metabolic and epigenetic fuel to boost efficiency. In summary, we review the current evidence supporting direct astrocyte-to-neuron reprogramming as a viable regenerative strategy in the aging brain. We also highlight the conceptual “car start-up” model as a useful framework to dissect the molecular logic of lineage conversion and emphasize its promising therapeutic potential for combating neurodegenerative diseases.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"110 ","pages":"Article 102808"},"PeriodicalIF":12.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can cognitive reserve offset APOE-related Alzheimer’s risk? A systematic review","authors":"Sayonara Pereira da Silva ,&nbsp;Charikleia Lampraki ,&nbsp;Tainá dos Santos Rêgo ,&nbsp;Paolo Ghisletta ,&nbsp;Matthias Kliegel ,&nbsp;Jürgen Maurer ,&nbsp;Matthias Studer ,&nbsp;Élvio Rúbio Gouveia ,&nbsp;Marcelo de Maio Nascimento ,&nbsp;Andreas Ihle","doi":"10.1016/j.arr.2025.102809","DOIUrl":"10.1016/j.arr.2025.102809","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a neurocognitive disorder that affects a significant part of the population. Its symptoms include progressive loss of memory and executive dysfunction. Genetic susceptibility to AD can be influenced by allele variants of the APOE gene. On the other hand, lifelong experiences such as educational attainment, occupational complexity, and leisure activities, known proxies for cognitive reserve (CR), may modulate gene expression, ultimately impacting AD susceptibility. In this study, we systematically investigated research that explored the interaction between <em>APOE</em>-related AD outcomes and CR. The literature search was conducted using PubMed and all Web of Science databases. We screened 33,861 references, of which 15 met the inclusion criteria. The studies varied in research design, population characteristics, proxies for CR, and measured outcomes. The publications presented mixed results, with some indicating protective effects (n = 7), others showing detrimental effects (n = 4), and still others suggesting no significant interaction effects (n = 4). Some of these findings may be attributed to the reliance on individual proxies, which may capture only limited aspects or different dimensions of the broader CR framework. Overall, our analysis suggests that individual risk factors may interact in complex ways and that even genetic predispositions can potentially be influenced by CR. Implications for CR and aging research as well as public health policies are discussed.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"110 ","pages":"Article 102809"},"PeriodicalIF":12.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese herbal medicines for the treatment of ischemic stroke in China","authors":"Xiaomeng Dong ,&nbsp;Tianya Zhang ,&nbsp;Cong Zhang ,&nbsp;Wenyan Shang ,&nbsp;Yuqing Zhang ,&nbsp;Xiangjian Zhang","doi":"10.1016/j.arr.2025.102803","DOIUrl":"10.1016/j.arr.2025.102803","url":null,"abstract":"<div><div>Ischemic stroke (IS) is a devastating disease with high disability and mortality rates worldwide. Despite advances in medical treatment, managing IS remains a significant challenge. In China, traditional Chinese herbal medicines (TCHMs) are often sought as alternative pharmacotherapies for both prevention and rehabilitation because of their proven efficacy and relatively low incidence of adverse reactions. While TCHMs do have certain limitations, their value cannot be overlooked. Centuries of clinical experience in China have established TCHMs as promising approaches for improving clinical outcomes and accelerating drug discovery in the treatment of IS. In this review, we summarize the potential mechanisms and clinical evidence of TCHMs in the treatment of IS in China. These findings suggest that TCHMs can treat IS through various pharmacological mechanisms, mainly anti-inflammatory, antiapoptotic, antioxidative stress, and mitochondrial regulatory mechanisms. Additionally, TCHMs provide protection to the blood-brain barrier, inhibit excitotoxicity, promote angiogenesis, reduce ferroptosis, modulate the gut-brain axis, prevent thrombosis, improve blood rheology, and regulate neural stem cells. These effects contribute to improved therapeutic outcomes at various stages of IS and poststroke complications, especially when combined with Western medicine, while also offering a favorable safety profile. In conclusion, TCHMs represent a promising strategy for managing IS and advancing related drug development. We hope that this review will inspire further exploration into the mechanisms underlying the anti-IS effects of TCHMs, thereby enhancing the scientific understanding of traditional Chinese medicine.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"110 ","pages":"Article 102803"},"PeriodicalIF":12.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian aging at single-cell resolution: Current paradigms and perspectives","authors":"Junzhi Liang ,&nbsp;Shurui Gai ,&nbsp;Xinni Na ,&nbsp;Jia Hu ,&nbsp;Zhongyu Zhao ,&nbsp;Duo Zi ,&nbsp;Zhijing Na ,&nbsp;Wenyan Gao ,&nbsp;Fangfang Bi ,&nbsp;Da Li","doi":"10.1016/j.arr.2025.102807","DOIUrl":"10.1016/j.arr.2025.102807","url":null,"abstract":"<div><div>Ovarian failure is a key event in female reproductive aging, resulting in the depletion of follicular reserve and a decline in fertility. In addition, it triggers systemic pathological changes, including osteoporosis and cardiovascular disease, due to decreased estrogen levels. Despite extensive study, mapping senescent ovarian cells is challenging due to the multicellular composition and heterogeneity of the ovary. In the past decade, single-cell resolution technologies have provided new insights into ovarian aging by enabling the molecular characterization of individual cells. Here, we comprehensively review the application of these technologies in delaying ovarian aging and promoting reproductive health. We summarize their value in uncovering cell-type-specific mechanisms and their potential uses in the research of ovarian aging, ultimately deepening our understanding of its pathogenesis and molecular basis.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"110 ","pages":"Article 102807"},"PeriodicalIF":12.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of microRNAs in the pathophysiology of the aging eye","authors":"Mohammadsaber Tamaddon ,&nbsp;Mohammadreza Fazel ,&nbsp;Delsuz Rezaee ,&nbsp;Mohammad Amin Khalilzad ,&nbsp;Jamal Majidpoor ,&nbsp;Hamid Ahmadieh ,&nbsp;Mohammad-Davood Fattahi ,&nbsp;Kosar Namakin ,&nbsp;Fatemeh Suri ,&nbsp;Sajad Najafi","doi":"10.1016/j.arr.2025.102805","DOIUrl":"10.1016/j.arr.2025.102805","url":null,"abstract":"<div><div>The human eye is a complex organ integral to visual perception, comprising multiple structures, including the retina, cornea, and lens. Vision loss affects over 2.2 billion individuals globally, with conditions, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy, recognized as responsible for a majority of visual-impairing conditions. Recent research highlights the critical roles of microRNAs (miRNAs)—small non-coding RNAs involved in post-transcriptional gene regulation—in ocular physiology and pathophysiology. miRNAs regulate gene expression by binding to target mRNA, modulating multiple processes like cell growth, apoptosis, and differentiation. Dysregulation of miRNAs has been implicated in various age-related ocular disorders like retinopathy, glaucoma and age-related macular degeneration, thereby disrupting cellular homeostasis and promoting disease progression. Experimental evidence, primarily from murine models, reveals that miRNAs regulate photoreceptor differentiation, retinal development, and the survival of postmitotic retinal cells. Additionally, miRNA dysregulation offers potential diagnostic and therapeutic insights. This study explores the roles of miRNAs in ocular pathophysiology, emphasizing their involvement in the maintenance of retinal cell integrity and visual system homeostasis. Furthermore, the significance of miRNAs in the pathogenesis of various human ophthalmic diseases associated with advancing age is reviewed.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"111 ","pages":"Article 102805"},"PeriodicalIF":12.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of community-based health education on modifiable risk factors for Alzheimer's disease among older adults: a scoping review","authors":"Ziliang Hao ,&nbsp;Jing Du,&nbsp;Xinhao Ding,&nbsp;Yu Shi,&nbsp;Zhiyuan Wang","doi":"10.1016/j.arr.2025.102800","DOIUrl":"10.1016/j.arr.2025.102800","url":null,"abstract":"<div><div>A scoping review of community health education studies for dementia prevention was conducted to clarify the form, content, outcome indicators, evaluation tools, and effects of community health education interventions for dementia prevention and to inform future research in this area. This scoping review of community-based health education interventions for Alzheimer's disease prevention across eight databases identified five intervention approaches—culturally adapted interventions, health knowledge lectures, mental health education, multidimensional comprehensive intervention, and telephone coaching. These interventions primarily aimed to enhance AD knowledge and lifestyle modifications while evaluating outcomes across nine domains including knowledge level, cognitive functioning, attitudinal beliefs, psychological status, health behaviors, health status, life quality, self-management, and other indicators. The findings demonstrated significant improvements in dementia knowledge, increased adoption of protective behaviors, and particularly strong effects in collectivist cultural settings. Most notably, multimodal interventions showed synergistic benefits for both cognitive performance and community health aging outcomes. While current evidence supports the feasibility and effectiveness of community-based health interventions across age groups, large-scale randomized controlled trials incorporating geroscience principles are needed to establish causal efficacy in Alzheimer's prevention and optimize evidence-based intervention frameworks for diverse populations.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"110 ","pages":"Article 102800"},"PeriodicalIF":12.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Definitions of healthspan: A systematic review","authors":"Siti Masfiah ,&nbsp;Alfarid Kurnialandi ,&nbsp;Johannes Jacobus Meij ,&nbsp;Andrea Britta Maier","doi":"10.1016/j.arr.2025.102806","DOIUrl":"10.1016/j.arr.2025.102806","url":null,"abstract":"<div><div>The term healthspan has been widely used in academic literature, technical reports and brochures, however, it is unclear if the same definitions and operationalizations for healthspan are being used. The objective of the systematic review (registration number CRD42023404872) was to summarize definitions of healthspan and their operationalization searching using four databases: PubMed, Embase, Web of Science, and Scopus. Out of 14,551 records, 207 records met the inclusion criteria and 187 articles gave a definition of healthspan. Of these, 113 definitions were considered primary definitions, which refer to an authors' definition without referencing other definitions. Healthspan definitions varied widely, describing the absence of various disease and or disability and were operationalized by measuring the onset of chronic diseases, disability or performance limitations. Two definitions included subjective measures, such as quality of life. In conclusion, definitions of healthspan and their operationalization are not standardized, hampering comparisons of data. A consensus on the definition and operationalization of healthspan is urgently needed.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"111 ","pages":"Article 102806"},"PeriodicalIF":12.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic pathways in Parkinson's disease: The promise of FGF21 and ACE2","authors":"Tingting Liu ,&nbsp;Jingwen Li ,&nbsp;Zhengjia Yang ,&nbsp;Jianshe Wei","doi":"10.1016/j.arr.2025.102804","DOIUrl":"10.1016/j.arr.2025.102804","url":null,"abstract":"<div><div>Parkinson’s disease (PD), the second most prevalent neurodegenerative disorder globally, is pathologically characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (SN). Current therapeutic strategies primarily alleviate clinical symptoms but lack efficacy in halting or reversing neurodegeneration. Recent studies have highlighted the FGF21-ACE2 signaling axis—a synergistic interaction between fibroblast growth factor 21 (FGF21) and angiotensin-converting enzyme 2 (ACE2)—as an emerging therapeutic target in PD due to its tripartite roles in neuroprotection, anti-inflammatory modulation, and metabolic homeostasis. Mechanistically, FGF21 activates neuroprotective pathways including phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and the extracellular signal-regulated kinase (ERK)1/2, suppressing apoptotic cascades, amplifying antioxidant defenses, and stimulating dopaminergic neuron differentiation. Conversely, ACE2 counterbalances neurotoxicity by converting angiotensin II (Ang II) to angiotensin-(1-7) [Ang-(1-7)], thereby mitigating neuroinflammation and oxidative stress. Their coordinated activity potently inhibits M1 microglial activation, downregulates pro-inflammatory cytokines (e.g., TNF-α), and bolsters astrocytic antioxidant responses while preserving metabolic equilibrium. Notably, this axis ameliorates mitochondrial dysfunction and attenuates α-synuclein (α-syn) aggregationvia modulation of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling networks, collectively decelerating PD pathogenesis. Therapeutic interventions such as small-molecule agonists (e.g., diminazene aceturate, DIZE) and CRISPR-Cas9-mediated gene editing show potential to upregulate FGF21-ACE2 activity, while non-pharmacological approaches including exercise and ketogenic diets may synergistically enhance pathway efficacy. However, translational hurdles persist, including limited blood-brain barrier (BBB) permeability of therapeutics, off-target effects, and insufficient clinical validation. Future directions should prioritize deciphering dynamic molecular crosstalk within this pathway, engineering BBB-penetrant nanocarriers for targeted delivery, and conducting large-scale randomized controlled trials. This review underscores the FGF21-ACE2 axis as a multi-mechanistic therapeutic paradigm for PD, with its capacity for simultaneous modulation of neurodegeneration, inflammation, and metabolism positioning it as a superior candidate to conventional single-target therapies in achieving disease modification.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"110 ","pages":"Article 102804"},"PeriodicalIF":12.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases","authors":"Giovanni Brandi ,&nbsp;Chiara Delbaldo ,&nbsp;Marzia Deserti ,&nbsp;Valeria Relli ,&nbsp;Simone Rimedio ,&nbsp;Andrea Palloni ,&nbsp;Chiara Deiana ,&nbsp;Gioconda Saccoccio ,&nbsp;Raffaele Ingenito ,&nbsp;Simona Tavolari","doi":"10.1016/j.arr.2025.102802","DOIUrl":"10.1016/j.arr.2025.102802","url":null,"abstract":"<div><div>Aging represents the main risk factor for the development of several diseases, including cardiovascular and metabolic conditions, neurodegenerative disorders and cancer. As the number of elderly people is increasing worldwide, different strategies to counteract age-related diseases have been investigated. Recently, the use of molecular hydrogen (H₂) as a preventive and therapeutic approach has been proposed due to its antioxidant and anti-inflammatory properties, its ability to regulate cell senescence and death, and to restore intestinal eubiosis. Although the studies investigating the role of H₂ in slowing-down aging and age-related diseases are still limited, current findings support the idea that its administration may be able to affect different hallmarks of these processes. The “democratic” characteristics of H₂ rely on its potential widespread use due to its pleiotropic activity, the lack of toxicities and low costs. In this review we provide a comprehensive state of the art on current knowledge on the molecular and clinical features of aging and age-related diseases. Current therapeutic approaches to slow down these processes will be also discussed, with a main focus on the potential use of H₂ as an innovative preventive and therapeutic strategy.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"110 ","pages":"Article 102802"},"PeriodicalIF":12.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of curcumin on cardiometabolic diseases in the elderly: A systematic review of randomized controlled trials","authors":"Fatemeh Rajabinasab ,&nbsp;Faeze Sadat Ahmadi Tabatabaei ,&nbsp;Ali Kheirandish ,&nbsp;Pooya Hajimirzaei ,&nbsp;Sajad Abolfazli ,&nbsp;Ademuyiwa S. Aromolaran ,&nbsp;Tannaz Jamialahmadi ,&nbsp;Amirhossein Sahebkar","doi":"10.1016/j.arr.2025.102801","DOIUrl":"10.1016/j.arr.2025.102801","url":null,"abstract":"<div><h3>Introduction</h3><div>As people age, the incidence of cardiometabolic diseases rises, negatively impacting their quality of life; therefore, it is important to supplement the diet with compounds that can manage these conditions. Curcumin (Cur), a common dietary spice, may benefit the health of the elderly. This systematic review evaluates Cur’s effectiveness in improving cardiometabolic disease symptoms.</div></div><div><h3>Methods</h3><div>Relevant studies were identified from searches conducted in Scopus, Embase, and PubMed. The risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool.</div></div><div><h3>Results and Discussion</h3><div>Seven randomized controlled trials (RCTs) were included. Cur supplementation (CurS) in elderly individuals resulted in significant improvements in several metabolic and inflammatory markers, including reductions in C-reactive protein (CRP) (p = 0.03), systolic blood pressure (p = 0.04), fasting blood sugar (p = 0.02), and HOMA-IR (p = 0.01) compared with controls. Additionally, a significant decrease in triglyceride levels (p = 0.04) and an increase in HDL (p = 0.03) were observed. However, effects on other cardiovascular indices were inconsistent across the studies.</div></div><div><h3>Conclusions</h3><div>These findings suggest that Cur may serve as an adjunctive therapy for age-related cardiometabolic diseases; however, variability in outcomes and protocols limits the ability to make broad recommendations. Future research should focus on large, well-powered RCTs with standardized dosing, formulations, and treatment durations, including long-term follow-up to assess sustained efficacy and delayed adverse effects. Comprehensive safety monitoring and detailed documentation of supplement composition and patient characteristics are also needed to clarify heterogeneity and identify those at higher risk for complications.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"110 ","pages":"Article 102801"},"PeriodicalIF":12.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}