Ageing Research Reviews最新文献_第8页

Senescence as a molecular target in skin aging and disease 衰老作为皮肤老化和疾病的分子靶点。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-08 DOI: 10.1016/j.arr.2025.102686

Henriette Thau , Bastian P. Gerjol , Katharina Hahn , Rosalie Wolff von Gudenberg , Leonard Knoedler , Kenneth Stallcup , Maximilian Y. Emmert , Timo Buhl , Saranya P. Wyles , Tamar Tchkonia , Stefan G. Tullius , Jasper Iske

{"title":"Senescence as a molecular target in skin aging and disease","authors":"Henriette Thau , Bastian P. Gerjol , Katharina Hahn , Rosalie Wolff von Gudenberg , Leonard Knoedler , Kenneth Stallcup , Maximilian Y. Emmert , Timo Buhl , Saranya P. Wyles , Tamar Tchkonia , Stefan G. Tullius , Jasper Iske","doi":"10.1016/j.arr.2025.102686","DOIUrl":"10.1016/j.arr.2025.102686","url":null,"abstract":"<div><div>Skin aging represents a multifactorial process influenced by both intrinsic and extrinsic factors, collectively known as the skin exposome. Cellular senescence, characterized by stable cell cycle arrest and secretion of pro-inflammatory molecules, has been implicated as a key driver of physiological and pathological skin aging. Increasing evidence points towards the role of senescence in a variety of dermatological diseases, where the accumulation of senescent cells in the epidermis and dermis exacerbates disease progression. Emerging therapeutic strategies such as senolytics and senomorphics offer promising avenues to target senescent cells and mitigate their deleterious effects, providing potential treatments for both skin aging and senescence-associated skin diseases. This review explores the molecular mechanisms of cellular senescence and its role in promoting age-related skin changes and pathologies, while compiling the observed effects of senotherapeutics in the skin and discussing the translational relevance.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"105 ","pages":"Article 102686"},"PeriodicalIF":12.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding of Alzheimer's disease pathophysiology for therapeutic implications of natural products as neuroprotective agents 了解阿尔茨海默病病理生理学对天然产物作为神经保护剂的治疗意义。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-06 DOI: 10.1016/j.arr.2025.102680

Sneh Prabha, Arunabh Choudhury, Asimul Islam, Sonu Chand Thakur, Md. Imtaiyaz Hassan

{"title":"Understanding of Alzheimer's disease pathophysiology for therapeutic implications of natural products as neuroprotective agents","authors":"Sneh Prabha, Arunabh Choudhury, Asimul Islam, Sonu Chand Thakur, Md. Imtaiyaz Hassan","doi":"10.1016/j.arr.2025.102680","DOIUrl":"10.1016/j.arr.2025.102680","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is a leading cause of dementia, affecting more than 24.3 million people worldwide in 2024. Sporadic AD (SAD) is more common and occurs in the geriatric population, while familial AD (FAD) is rare and appears before the age of 65 years. Due to progressive cholinergic neuronal loss and modulation in the PKC/MAPK pathway, β-secretase gets upregulated, leading to Aβ aggregation, which further activates tau kinases that form neurofibrillary tangles (NFT). Simultaneously, antioxidant enzymes are also upregulated, increasing oxidative stress (OS) and reactive species by impairing mitochondrial function, leading to DNA damage and cell death. This review discusses the classifications and components of several natural products (NPs) that target these signaling pathways for AD treatment. NPs, including alkaloids, polyphenols, flavonoids, polysaccharides, steroids, fatty acids, tannins, and polypeptides derived from plants, microbes, marine animals, venoms, insects, and mushrooms, are explored in detail. A synergistic combination of plant metabolites, together with prebiotics and probiotics has been shown to decrease Aβ aggregates by increasing the production of bioactive compounds. Toxins derived from venomous organisms have demonstrated effectiveness in modulating signaling pathways and reducing OS. Marine metabolites have also shown neuroprotective and anti-inflammatory properties. The cholera toxin B subunit and an Aβ<sub>15</sub> fragment have been combined to create a possible oral AD vaccine, that showed enhancement of cognitive function in mice. Insect tea is also a reliable source of antioxidants. A functional edible mushroom snack bar showed an increment in cognitive markers. Future directions and therapeutic approaches for the treatment of AD can be improved by focusing more on NPs derived from these sources.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"105 ","pages":"Article 102680"},"PeriodicalIF":12.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postbiotics as a therapeutic tool in Alzheimer's disease: Insights into molecular pathways and neuroprotective effects 后生物制剂作为阿尔茨海默病的治疗工具：对分子途径和神经保护作用的见解。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-06 DOI: 10.1016/j.arr.2025.102685

Khadga Raj Aran , Pratyush Porel , Garry Hunjan , Shamsher Singh , G.D. Gupta , Rohit

{"title":"Postbiotics as a therapeutic tool in Alzheimer's disease: Insights into molecular pathways and neuroprotective effects","authors":"Khadga Raj Aran , Pratyush Porel , Garry Hunjan , Shamsher Singh , G.D. Gupta , Rohit","doi":"10.1016/j.arr.2025.102685","DOIUrl":"10.1016/j.arr.2025.102685","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by oxidative stress, neuroinflammation, mitochondrial dysfunction, neurotransmitter imbalance, tau hyperphosphorylation, and amyloid beta (Aβ) accumulation in brain regions. The gut microbiota (GM) has a major impact on brain function due to its bidirectional interaction with the gut through the gut-brain axis. The gut dysbiosis has been associated with neurological disorders, emphasizing the importance of gut homeostasis in maintaining appropriate brain function. The changes in the composition of microbiomes influence neuroinflammation and Aβ accumulation by releasing pro-inflammatory cytokines, decreasing gut and blood-brain barrier (BBB) integrity, and microglial activation in the brain. Postbiotics, are bioactive compounds produced after fermentation, have been shown to provide several health benefits, particularly in terms of neuroinflammation and cognitive alterations associated with AD. Several research studies on animal models and human have successfully proven the effects of postbiotics on enhancing cognition and memory in experimental animals. This article explores the protective effects of postbiotics on cellular mechanisms responsible for AD pathogenesis and studies highlighting the influence of postbiotics as a total combination and specific compounds, including short-chain fatty acids (SCFAs). In addition, postbiotics act as a promising option for future research to deal with AD's progressive nature and improve an individual's life quality using microbiota modulation.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"106 ","pages":"Article 102685"},"PeriodicalIF":12.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond amyloid plaque, targeting α-synuclein in Alzheimer disease: The battle continues 超越淀粉样斑块，靶向α-突触核蛋白治疗阿尔茨海默病：战斗仍在继续

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-04 DOI: 10.1016/j.arr.2025.102684

Hayder M. Al-kuraishy , Ghassan M. Sulaiman , Hamdoon A. Mohammed , Ali I. Al-Gareeb , Ali K. Albuhadily , Amer Al Ali , Mohammed H. Abu-Alghayth

引用次数: 0

The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders cGAS-STING信号通路与慢性炎症在肌肉骨骼疾病发展中的串扰。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102602

Alexander Kalinkovich , Gregory Livshits

{"title":"The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders","authors":"Alexander Kalinkovich , Gregory Livshits","doi":"10.1016/j.arr.2024.102602","DOIUrl":"10.1016/j.arr.2024.102602","url":null,"abstract":"<div><div>Musculoskeletal disorders (MSDs) comprise diverse conditions affecting bones, joints, and muscles, leading to pain and loss of function, and are one of the most prevalent and major global health concerns. One of the hallmarks of MSDs is DNA damage. Once accumulated in the cytoplasm, the damaged DNA is sensed by the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway, which triggers the induction of type I interferons and inflammatory cytokines. Thus, this pathway connects the musculoskeletal and immune systems. Inhibitors of cGAS or STING have shown promising therapeutic effects in the pre-clinical models of several MSDs. Systemic, chronic, low-grade inflammation (SCLGI) underlies the development and maintenance of many MSDs. Failure to resolve SCLGI has been hypothesized to play a critical role in the development of chronic diseases, suggesting that the successful resolution of SCLGI will result in the alleviation of their related symptomatology. The process of inflammation resolution is feasible by specialized pro-resolving mediators (SPMs), which are enzymatically generated from dietary essential polyunsaturated fatty acids (PUFAs). The supplementation of SPMs or their stable, small-molecule mimetics and receptor agonists has revealed beneficial effects in inflammation-related animal models, including arthropathies, osteoporosis, and muscle dystrophy, suggesting a translational potential in MSDs. In this review, we substantiate the hypothesis that the use of cGAS-STING signaling pathway inhibitors together with SCLG-resolving compounds may serve as a promising new therapeutic approach for MSDs.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102602"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of the genes and biomarkers in Alzheimer’s disease 阿尔茨海默病的基因和生物标志物综述。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102599

Hari Krishnan Krishnamurthy , Vasanth Jayaraman , Karthik Krishna , Tianhao Wang , Kang Bei , Chithra Changalath , John J. Rajasekaran

{"title":"An overview of the genes and biomarkers in Alzheimer’s disease","authors":"Hari Krishnan Krishnamurthy , Vasanth Jayaraman , Karthik Krishna , Tianhao Wang , Kang Bei , Chithra Changalath , John J. Rajasekaran","doi":"10.1016/j.arr.2024.102599","DOIUrl":"10.1016/j.arr.2024.102599","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is the most common type of dementia and neurodegenerative disease characterized by neurofibrillary tangles (NFTs) and amyloid plaque. Familial AD is caused by mutations in the <em>APP, PSEN1</em>, and <em>PSEN2</em> genes and these mutations result in the early onset of the disease. Sporadic AD usually affects older adults over the age of 65 years and is, therefore classified as late-onset AD (LOAD). Several risk factors associated with LOAD including the <em>APOE</em> gene have been identified. Moreover, GWAS studies have identified a wide array of genes and polymorphisms that are associated with LOAD risk. Currently, the diagnosis of AD involves the evaluation of memory and personality changes, cognitive impairment, and medical and family history to rule out other diseases. Laboratory tests to assess the biomarkers in the body fluids as well as MRI, CT, and PET scans to analyze the presence of plaques and NFTs are also included in the diagnosis of AD. It is important to diagnose AD before the onset of clinical symptoms, i.e. during the preclinical stage, to delay the progression and for better management of the disease. Research has been conducted to identify biomarkers of AD in the CSF, serum, saliva, and urine during the preclinical stage. Current research has identified several biomarkers and potential biomarkers in the body fluids that enhance diagnostic accuracy. Aside from genetics, other factors such as diet, physical activity, and lifestyle factors may influence the risk of developing AD. Clinical trials are underway to find potential biomarkers, diagnostic measures, and treatments for AD mainly in the preclinical stage. This review provides an overview of the genes and biomarkers of AD.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102599"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative stress and mitochondrial impairment: Key drivers in neurodegenerative disorders 氧化应激和线粒体损伤：神经退行性疾病的关键驱动因素。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2025.102667

Pei Wen, Zhixin Sun, Fengting Gou, Jingjing Wang, Qing Fan, Deming Zhao, Lifeng Yang

引用次数: 0

Validation requirements for AI-based intervention-evaluation in aging and longevity research and practice 基于人工智能的老龄化与长寿研究与实践干预评估的验证要求

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102617

Georg Fuellen , Anton Kulaga , Sebastian Lobentanzer , Maximilian Unfried , Roberto A. Avelar , Daniel Palmer , Brian K. Kennedy

引用次数: 0

Extracellular vesicle-packed microRNAs profiling in Alzheimer’s disease: The molecular intermediary between pathology and diagnosis 阿尔茨海默病细胞外囊泡填充的microRNAs分析：病理和诊断之间的分子中介。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102614

Sandila Arif , Talal Jamil Qazi , Zhenzhen Quan , Junjun Ni , Zhaohan Li , Yunjie Qiu , Hong Qing

引用次数: 0

Glia–glia crosstalk via semaphorins: Emerging implications in neurodegeneration 信号素介导的神经胶质细胞串扰：神经退行性变的新意义。

IF 12.5 1区医学

Ageing Research Reviews Pub Date : 2025-02-01 DOI: 10.1016/j.arr.2024.102618

Claudia Palazzo , Sofia Nutarelli , Roberta Mastrantonio , Luca Tamagnone , Maria Teresa Viscomi

{"title":"Glia–glia crosstalk via semaphorins: Emerging implications in neurodegeneration","authors":"Claudia Palazzo , Sofia Nutarelli , Roberta Mastrantonio , Luca Tamagnone , Maria Teresa Viscomi","doi":"10.1016/j.arr.2024.102618","DOIUrl":"10.1016/j.arr.2024.102618","url":null,"abstract":"<div><div>The central nervous system (CNS) is wired by a complex network of integrated glial and neuronal signals, which is critical for its development and homeostasis. In this context, glia-glia communication is a complex and dynamic process that is essential for ensuring optimal CNS function. Semaphorins, which include secreted and transmembrane molecules, and their receptors, mainly found in the plexin and neuropilin families, are expressed in a wide range of cell types, including glia. In the CNS, semaphorin signalling is involved in a spectrum of processes, including neurogenesis, neuronal migration and wiring, and glial cell recruitment. Recently, semaphorins and plexins have attracted intense research aimed at elucidating their roles in instructing glial cell behavior during development or in response to inflammatory stimuli. In this review, we provide an overview of the multifaceted role of semaphorins in glia–glia communication, highlighting recent discoveries about semaphoring-dependent regulation of glia functions in healthy conditions. We also discuss the mechanisms of glia<img>glia crosstalk mediated by semaphorins under pathological conditions, and how these interactions may provide potential avenues for therapeutic intervention in neuroinflammation-mediated neurodegeneration.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"104 ","pages":"Article 102618"},"PeriodicalIF":12.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0