{"title":"运动因子:糖尿病性心肌病的潜在调节因子。","authors":"Fengzhi Yu , Boyi Zong , Zhenjun Tian , Dandan Jia , Ru Wang","doi":"10.1016/j.arr.2025.102816","DOIUrl":null,"url":null,"abstract":"<div><div>Diabetic cardiomyopathy (DCM) is a significant contributor to diabetes-related mortality, manifesting through progressive diastolic dysfunction, cardiomyocyte apoptosis, and pathological fibrotic remodeling. While exercise is advocated as a therapeutic intervention for DCM, the molecular basis of its cardioprotective effects remains incompletely understood, particularly regarding systemic interorgan communication mediated by exercise-induced signaling factors. Emerging evidence highlights exerkines, a class of peptides and nucleic acids secreted by skeletal muscle (myokines), adipose tissue (adipokines), bone (osteokines), liver (hepatokines), and other organs in response to physical exercise-as key regulators of DCM pathogenesis. This review systematically examines the cardioprotective potential of exerkines in mitigating functional and structural myocardial impairments characteristic of DCM. The primary focus of this study is to elucidate the mechanisms through which exerkines modulate critical pathophysiological processes, including myocardial oxidative stress, calcium homeostasis dysregulation, programmed cell death, maladaptive renin-angiotensin-aldosterone system activation, endoplasmic reticulum stress, inflammatory signaling, and mitochondrial dysfunction. By synthesizing current understanding of exerkines-mediated cross-tissue communication, this analysis provides novel insights into exercise-based therapeutic strategies targeting the multifaceted pathophysiology of DCM.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"110 ","pages":"Article 102816"},"PeriodicalIF":12.4000,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exerkines: Potential regulators of diabetic cardiomyopathy\",\"authors\":\"Fengzhi Yu , Boyi Zong , Zhenjun Tian , Dandan Jia , Ru Wang\",\"doi\":\"10.1016/j.arr.2025.102816\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Diabetic cardiomyopathy (DCM) is a significant contributor to diabetes-related mortality, manifesting through progressive diastolic dysfunction, cardiomyocyte apoptosis, and pathological fibrotic remodeling. While exercise is advocated as a therapeutic intervention for DCM, the molecular basis of its cardioprotective effects remains incompletely understood, particularly regarding systemic interorgan communication mediated by exercise-induced signaling factors. Emerging evidence highlights exerkines, a class of peptides and nucleic acids secreted by skeletal muscle (myokines), adipose tissue (adipokines), bone (osteokines), liver (hepatokines), and other organs in response to physical exercise-as key regulators of DCM pathogenesis. This review systematically examines the cardioprotective potential of exerkines in mitigating functional and structural myocardial impairments characteristic of DCM. The primary focus of this study is to elucidate the mechanisms through which exerkines modulate critical pathophysiological processes, including myocardial oxidative stress, calcium homeostasis dysregulation, programmed cell death, maladaptive renin-angiotensin-aldosterone system activation, endoplasmic reticulum stress, inflammatory signaling, and mitochondrial dysfunction. By synthesizing current understanding of exerkines-mediated cross-tissue communication, this analysis provides novel insights into exercise-based therapeutic strategies targeting the multifaceted pathophysiology of DCM.</div></div>\",\"PeriodicalId\":55545,\"journal\":{\"name\":\"Ageing Research Reviews\",\"volume\":\"110 \",\"pages\":\"Article 102816\"},\"PeriodicalIF\":12.4000,\"publicationDate\":\"2025-06-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ageing Research Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S156816372500162X\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ageing Research Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S156816372500162X","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Exerkines: Potential regulators of diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a significant contributor to diabetes-related mortality, manifesting through progressive diastolic dysfunction, cardiomyocyte apoptosis, and pathological fibrotic remodeling. While exercise is advocated as a therapeutic intervention for DCM, the molecular basis of its cardioprotective effects remains incompletely understood, particularly regarding systemic interorgan communication mediated by exercise-induced signaling factors. Emerging evidence highlights exerkines, a class of peptides and nucleic acids secreted by skeletal muscle (myokines), adipose tissue (adipokines), bone (osteokines), liver (hepatokines), and other organs in response to physical exercise-as key regulators of DCM pathogenesis. This review systematically examines the cardioprotective potential of exerkines in mitigating functional and structural myocardial impairments characteristic of DCM. The primary focus of this study is to elucidate the mechanisms through which exerkines modulate critical pathophysiological processes, including myocardial oxidative stress, calcium homeostasis dysregulation, programmed cell death, maladaptive renin-angiotensin-aldosterone system activation, endoplasmic reticulum stress, inflammatory signaling, and mitochondrial dysfunction. By synthesizing current understanding of exerkines-mediated cross-tissue communication, this analysis provides novel insights into exercise-based therapeutic strategies targeting the multifaceted pathophysiology of DCM.
期刊介绍:
With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends.
ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research.
The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.