运动因子:糖尿病性心肌病的潜在调节因子。

IF 12.4 1区 医学 Q1 CELL BIOLOGY
Fengzhi Yu , Boyi Zong , Zhenjun Tian , Dandan Jia , Ru Wang
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引用次数: 0

摘要

糖尿病性心肌病(DCM)是糖尿病相关死亡率的重要因素,表现为进行性舒张功能障碍、心肌细胞凋亡和病理性纤维化重塑。虽然运动被提倡作为DCM的治疗干预措施,但其心脏保护作用的分子基础仍然不完全清楚,特别是关于由运动诱导的信号因子介导的全身器官间通讯。新出现的证据强调运动因子,一类由骨骼肌(肌因子)、脂肪组织(脂肪因子)、骨骼(骨因子)、肝脏(肝因子)和其他器官在运动反应中分泌的肽和核酸,是DCM发病的关键调节因子。这篇综述系统地探讨了运动素在减轻DCM的功能性和结构性心肌损伤方面的心脏保护潜力。本研究的主要重点是阐明运动因子调节关键病理生理过程的机制,包括心肌氧化应激、钙稳态失调、程序性细胞死亡、肾素-血管紧张素-醛固酮系统激活失调、内质网应激、炎症信号和线粒体功能障碍。通过综合目前对运动因子介导的跨组织通信的理解,该分析为针对DCM的多方面病理生理的基于运动的治疗策略提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exerkines: Potential regulators of diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a significant contributor to diabetes-related mortality, manifesting through progressive diastolic dysfunction, cardiomyocyte apoptosis, and pathological fibrotic remodeling. While exercise is advocated as a therapeutic intervention for DCM, the molecular basis of its cardioprotective effects remains incompletely understood, particularly regarding systemic interorgan communication mediated by exercise-induced signaling factors. Emerging evidence highlights exerkines, a class of peptides and nucleic acids secreted by skeletal muscle (myokines), adipose tissue (adipokines), bone (osteokines), liver (hepatokines), and other organs in response to physical exercise-as key regulators of DCM pathogenesis. This review systematically examines the cardioprotective potential of exerkines in mitigating functional and structural myocardial impairments characteristic of DCM. The primary focus of this study is to elucidate the mechanisms through which exerkines modulate critical pathophysiological processes, including myocardial oxidative stress, calcium homeostasis dysregulation, programmed cell death, maladaptive renin-angiotensin-aldosterone system activation, endoplasmic reticulum stress, inflammatory signaling, and mitochondrial dysfunction. By synthesizing current understanding of exerkines-mediated cross-tissue communication, this analysis provides novel insights into exercise-based therapeutic strategies targeting the multifaceted pathophysiology of DCM.
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来源期刊
Ageing Research Reviews
Ageing Research Reviews 医学-老年医学
CiteScore
19.80
自引率
2.30%
发文量
216
审稿时长
55 days
期刊介绍: With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.
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