Association between the inflammageing biomarkers and clinical outcomes amongst the community-dwelling middle-aged and older adults: A systematic review and meta-analysis

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-06-23 DOI:10.1016/j.arr.2025.102811

Delphine Chen , Wilson Wai San Tam , Jinghua Zhang , Jinhua Lu , Vivien Xi Wu

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引用次数: 0

Abstract

Background

Inflammageing biomarkers have been implicated in frailty among middle-aged and older adults. However, there is a paucity of information regarding inflammageing biomarkers association with adverse clinical outcomes, particularly when it is elevated. Understanding this knowledge may allow clinicians to utilise these biomarkers to provide early preventive strategies. This review investigated the association between the elevated inflammageing biomarkers namely C-Reactive Proteins (CRP) including High-Sensitivity (Hs)-CRP, Interleukin-6 (IL-6) and TNF-α (TNF-α) in community-dwelling adults aged 40 years and above on the outcomes of the risk of all-cause mortality, risk of all-cause hospitalisation and risk of all-cause re-admission. Secondary outcomes included risk of depression and anxiety.

Method

Studies were searched in PubMed, Embase, Biosis Preview, Web of Science, Scopus and ProQuest Dissertations and Theses along with grey literature. A total of 22 cohort studies were included for analysis. Experimental, quasi-experimental, cross-sectional and case-control studies were excluded.

Results

Community-dwelling adults aged 40 years and above have a significantly higher risk of all-cause mortality by 1.54 times and by 1.47 times with elevated CRP/Hs-CRP and elevated IL-6 respectively (p = 0.001; p = 0.001). Those with elevated CRP/Hs-CRP has significantly higher odds of depression by 1.48 times (p < 0.001). Limited evidence exists pertaining to the effect of the inflammageing biomarkers on the risk of hospitalisation, risk of re-admission and risk of anxiety.

Conclusion

Precision care interventions of biomarkers monitoring implemented into chronic disease follow-up on the CRP or Hs-CRP as well as IL-6 levels may reduce the risk of mortality and depression.

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在社区居住的中老年人中，炎症生物标志物与临床结果之间的关系：一项系统回顾和荟萃分析

背景：炎症生物标志物与中老年人身体虚弱有关。然而，关于炎症生物标志物与不良临床结果的关联的信息缺乏，特别是当它升高时。了解这些知识可以让临床医生利用这些生物标志物来提供早期预防策略。本综述调查了40岁及以上社区居民中c反应蛋白（CRP）（包括高敏(Hs)-CRP）、白细胞介素-6 （IL-6）和TNF-α (TNF-α)升高的炎症生物标志物与全因死亡风险、全因住院风险和全因再入院风险的关系。次要结果包括抑郁和焦虑的风险。方法：检索PubMed、Embase、Biosis Preview、Web of Science、Scopus、ProQuest等论文和灰色文献。共纳入22项队列研究进行分析。排除了实验性、准实验性、横断面和病例对照研究。结果：40岁及以上社区居民CRP/Hs-CRP升高和IL-6升高的全因死亡风险分别是前者的1.54倍和1.47倍(p=0.001；p = 0.001)。结论：在慢性病随访中实施生物标志物监测的精准护理干预，对CRP或Hs-CRP及IL-6水平的监测可降低患者死亡和抑郁的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.