Ageing Research Reviews最新文献

{"title":"Oligodendrocytes at the crossroads: Central players and interactive partners in white matter aging","authors":"Xinxin Zhang ,&nbsp;Peiyao Yu ,&nbsp;Yicheng Chen ,&nbsp;Yanzhi Xu ,&nbsp;Ruofei Xu ,&nbsp;Xinyu Yang ,&nbsp;Shichao Lv ,&nbsp;Hongcai Shang ,&nbsp;Yue Hu","doi":"10.1016/j.arr.2026.103034","DOIUrl":"10.1016/j.arr.2026.103034","url":null,"abstract":"<div><div>White matter degeneration in aging drives cognitive and motor decline. Oligodendrocytes (OLs) and their precursors are central to this process. Their intrinsic aging, marked by differentiation failure, metabolic and mitochondrial deficits, and transcriptional epigenetic dysregulation, causes myelin thinning and axonal support loss. Degeneration is amplified by dysfunctional crosstalk: microglia clear debris poorly and turn inflammatory; astrocytes disrupt lipid balance and secrete inflammatory signals; vascular defects impair metabolic supply; and T cell infiltration injures OLs. We review therapies targeting OL lineage, glial networks, vascular health, and lifestyle. Positioning OLs as integrative hubs of white matter integrity offers new strategies to maintain brain function during aging.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"115 ","pages":"Article 103034"},"PeriodicalIF":12.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional human brain organoids: A next-generation model to decode Alzheimer’s disease","authors":"Sneha Kumari ,&nbsp;Ashvin ,&nbsp;Rishika Dhapola ,&nbsp;Prajjwal Sharma ,&nbsp;Mohit Paidlewar ,&nbsp;Balachandar Vellingiri ,&nbsp;Bikash Medhi ,&nbsp;Dibbanti HariKrishnaReddy","doi":"10.1016/j.arr.2025.102928","DOIUrl":"10.1016/j.arr.2025.102928","url":null,"abstract":"<div><div>Brain organoids are an emerging <em>in vitro</em> three-dimensional (3D) brain model derived from pluripotent stem cells. This model emulates the developmental processes of the human brain and associated disease phenotypes to some degree, while facilitating the advancement into human brain-inspired biological intelligence. This review highlights the evolution of brain organoid technology from conventional 2D cultures to advanced 3D models, emphasizing methodological innovations such as guided differentiation, bioengineering, and patient-derived induced pluripotent stem cells (iPSCs). We focus on their applications in Alzheimer’s disease (AD), including elucidation of disease pathophysiology, modeling of amyloid-β and tau pathology, investigation of neuroinflammatory and blood-brain barrier (BBB) dysfunction, and their utility in drug screening and describe the diverse categories of brain organoids, including neural organoids, neuroimmune organoids, myelinoids, BBB organoids, and choroid plexus organoids. We discuss key technological advancements, guided differentiation, bioengineering approaches, microfluidic systems, and assembloid strategies that enhance cellular diversity, maturation, and functional relevance. Furthermore, we discuss therapeutic insights gained from organoid-based studies, current limitations such as incomplete maturation and vascularization, and future directions involving immune cell integration, vascularized models, and AI-driven analysis. We have also discussed some current drug screening and therapeutic development for AD using brain organoids. Together, this review provides a comprehensive perspective on the potential of brain organoids as powerful platforms for advancing AD research and accelerating therapeutic discovery.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102928"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-based emotion recognition in dementia through facial expression: A scoping review","authors":"Noelia Gerbaudo-González ,&nbsp;Nelly Condorí-Fernández ,&nbsp;Alejandro Catalá ,&nbsp;Manuel Gandoy-Crego","doi":"10.1016/j.arr.2025.102975","DOIUrl":"10.1016/j.arr.2025.102975","url":null,"abstract":"<div><div>Emotion assessment in dementia care is vital for patient well-being and effective care planning. Traditional methods are often subjective and time-consuming. This study examines the use of AI-based facial expression analysis for emotion recognition in dementia patients. A scoping review was conducted using the SPIDER strategy. Five databases—PubMed, Scopus, PsycInfo, ProQuest, and IEEE Xplore —were consulted, with additional records identified through snowballing. Data on participant characteristics, intervention details, non-AI comparisons, and clinical outcomes were categorized. Two authors independently screened records and extracted data on AI driven tools. The review analyzed 11 studies, primarily using deep neural networks. While most studies relied on pre-existing datasets, some collected original data. The studies focused on assessing a variety of emotions, with an emphasis on detecting basic emotions and, in some cases, more complex emotional states. AI applications included early detection, diagnosis, intervention impact assessment, and reliability testing. Comparisons were made with traditional assessment tools. This scoping review highlights the potential of AI tools to improve dementia care. However, standardized data collection and processing protocols are needed to advance AI in emotion recognition for dementia patients. Integrating multiple data sources and addressing dataset limitations are crucial for improving model accuracy and representativeness. Ethical considerations, including privacy and data security, must be prioritized when developing and implementing AI tools in this population. Interdisciplinary collaboration is essential to fully harness their potential.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102975"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflamm-aging as a diverse and context-dependent process: From species and population differences to individual trajectories","authors":"Maximilien Franck ,&nbsp;Camille Daunizeau ,&nbsp;Jacob E. Aronoff ,&nbsp;Kamaryn Tanner ,&nbsp;Benjamin C. Trumble ,&nbsp;Claudio Franceschi ,&nbsp;Johannes Hertel ,&nbsp;Tamás Fülöp ,&nbsp;Maël Lemoine ,&nbsp;Michael Gurven ,&nbsp;Alan A. Cohen","doi":"10.1016/j.arr.2025.102880","DOIUrl":"10.1016/j.arr.2025.102880","url":null,"abstract":"<div><div>Inflamm-aging is widely considered a hallmark of aging, yet emerging evidence challenges its universality. Here, we re-examine inflamm-aging through an eco-evolutionary lens, underlining its context dependence across biological scales. Combining mechanistic, evolutionary, comparative, anthropological, genetic, and environmental evidence, we show how fundamental inflammatory mechanisms are integrated and regulated in diverse biological contexts, representing a suite of flexible stress responses. Drawing on studies from non-industrialized populations, which suggest that inflamm-aging reflects mismatches between evolved human biology and industrialized exposomes, we explore how population-specific evolutionary histories and environmental exposures shape differential predispositions and trajectories of inflamm-aging. We propose that, to the extent that inflammation represents this broad suite of stress responses, increases in at least some dimensions of inflammation with age should be nearly universal, as other physiological processes break down and internal stresses mount. However, the particular set of internal stressors that is triggered in a given species, environmental context, or individual is likely more specific, implying that there is unlikely to be any universal signature of inflamm-aging. The question of whether inflamm-aging is universal thus hinges on whether it is defined broadly as any increase in activation of any inflammatory systems, or more narrowly as a particular suite, such as those activated in industrialized populations with high levels of sedentary behavior and cardiometabolic diseases. Inflamm-aging is ultimately a norm of reaction—an aging-related inflammatory profile whose phenotypic expression varies with genotype and environment—and research should therefore focus on understanding how ecological, evolutionary, and environmental factors modulate inflammation and its age-related trajectory.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"113 ","pages":"Article 102880"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review","authors":"Michael G. Slee ,&nbsp;Joanne Scotney ,&nbsp;Stephanie R. Rainey-Smith ,&nbsp;Kirk I. Erickson ,&nbsp;Hamid R. Sohrabi ,&nbsp;Giuseppe Verdile ,&nbsp;Belinda M. Brown","doi":"10.1016/j.arr.2025.102956","DOIUrl":"10.1016/j.arr.2025.102956","url":null,"abstract":"<div><h3>Background</h3><div>Type 2 diabetes is associated with increased Alzheimer’s disease risk and brain beta amyloid (Aβ) burden, suggesting an underlying mechanistic relationship between Alzheimer’s disease and type 2 diabetes. Animal studies show exercise reduces levels of brain Aβ and tau, and while human studies are somewhat limited, some studies have reported physical activity is associated with lower brain Aβ and tau levels. Exercise has well established links to reductions in insulin resistance; thus, as physical activity can impact both insulin resistance and Alzheimer’s disease pathology and/or biomarkers, it is reasonable to hypothesise that a mediating relationship may exist. The objective of this review was to identify what evidence exists that examines the association between insulin, physical activity, Aβ and tau in research conducted on animal models and in human cohorts. We specifically aimed to identify whether insulin resistance has a mediating role in the relationship between physical activity and Aβ and tau.</div></div><div><h3>Methods</h3><div>A systematic search was performed in Cochrane library, PsycINFO, PubMed and World of Science to identify publications. The search identified 343 articles with 20 articles meeting the full inclusion criteria.</div></div><div><h3>Results</h3><div>Most animal studies showed that exercise could simultaneously reduce insulin resistance and Alzheimer’s disease pathology and/or biomarkers. We found limited evidence from human research that physical activity was associated with both reduced insulin resistance and Aβ or tau levels. We did not find any evidence that insulin resistance mediates the physical activity – Aβ or tau relationship.</div></div><div><h3>Conclusion</h3><div>Exercise can simultaneously impact insulin resistance and Alzheimer’s disease pathology in animal models. Results from human research are limited, and no robust evaluation of the potential mediating role of insulin resistance in the physical activity – Aβ or tau relationship exists. Future research should focus on identifying the mediating pathways that may link physical activity to biomarkers of Alzheimer’s disease.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102956"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145600529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein post-translational modifications in sepsis: Molecular mechanisms and biomarkers","authors":"Yuze Wang ,&nbsp;Hongyi Li ,&nbsp;Qian Zhao ,&nbsp;Xiang Li ,&nbsp;Xuefan Bu ,&nbsp;Chenye Ma ,&nbsp;Zhihui Liu ,&nbsp;Jinghua Yang ,&nbsp;Tongwen Sun","doi":"10.1016/j.arr.2025.102958","DOIUrl":"10.1016/j.arr.2025.102958","url":null,"abstract":"<div><div>Sepsis is a common and highly fatal condition in intensive care units and is one of the leading causes of death worldwide. As a clinically complex syndrome with intricate pathophysiology, early identification and assessment of sepsis remain challenging. Deeper insights at the molecular level are crucial for understanding the complex pathophysiological mechanisms, discovering new biomarkers, and improving prognosis. Post-translational modifications (PTMs) refer to the attachment of specific chemical groups to amino acid side chains through covalent, enzymatic, or non-enzymatic means, greatly expanding protein diversity and playing critical roles in many cellular signaling pathways. Here, we elucidate the regulatory roles of PTMs in sepsis pathways and key proteins, including immune response, late-stage inflammatory mediators, cellular metabolic reprogramming, and endothelial injury. We also summarize the progress in research on PTM-related sepsis biomarkers, covering diagnosis, prognosis, and organ dysfunction assessment, with a particular focus on the potential of glycosylation as a biomarker. Furthermore, we review current methodologies for studying PTMs. Continued focus on PTMs will pave the way for new possibilities in sepsis research and treatment.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102958"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barrier breakdown in ageing and age-related diseases: The potential role of hierarchical epigenetic control of microRNAs on surfactant collectins, S100 alarmins and fibronectin","authors":"Chiara Bontempo ,&nbsp;Lucio Publio Gallo ,&nbsp;Marco Mattiacci ,&nbsp;Sabrina Valente ,&nbsp;Annalisa Astolfi ,&nbsp;Maria Conte ,&nbsp;Gaetano La Manna ,&nbsp;Gianandrea Pasquinelli ,&nbsp;Mauro Gargiulo ,&nbsp;Fabiola Olivieri ,&nbsp;Miriam Capri","doi":"10.1016/j.arr.2025.103003","DOIUrl":"10.1016/j.arr.2025.103003","url":null,"abstract":"<div><div>Surfactant proteins, particularly SP-A and SP-D, S100 family members and fibronectin belong to the group of so-called stress-related molecules and share the characteristic of being expressed at anatomical barriers such as the skin, pulmonary/respiratory epithelia, and the intestinal tract. In this context, they constitute part of the body’s first line of defence, acting in concert with immune cells to counter a broad spectrum of external and internal stressors (exposomes), potentially fuelling chronic low-grade inflammation (inflammaging). The levels of the above-mentioned molecules in the blood or local tissues result altered in a range of age-associated pathologies and have been proposed as potential diagnostic/prognostic biomarkers, although they generally lack specificity for a single pathological condition. Evidence from in silico analyses further suggests that most of these molecules may be regulated by members of the microRNA-29 family, pointing towards hierarchical epigenetic mechanisms that merit detailed investigation as potential contributors to ageing-related biomarker signatures. Despite research advances, the identification of robust biomarkers capable of predicting disease onset at the individual level, an essential prerequisite for precise geromedicine, remains an elusive goal in clinical practice. Although individuals differ biologically, this does not preclude the existence of overarching principles that could be reflected in hierarchical biomarkers. Within this framework, a pragmatic strategy for immediate application may involve the systematic use of currently available longitudinal data, for example, from hospitalised patients or through dedicated software programs utilised by general practitioners.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 103003"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ergothioneine and exercise: A match made in (cognitive) heaven?","authors":"Vanessa Kristina Wazny ,&nbsp;Jozo Grgic ,&nbsp;Pedro L. Valenzuela ,&nbsp;Lei Feng ,&nbsp;Andrea B. Maier","doi":"10.1016/j.arr.2025.102993","DOIUrl":"10.1016/j.arr.2025.102993","url":null,"abstract":"<div><div>Cognitive decline is one of the key challenges with aging, with significant implications for independence, quality of life, and healthcare burden. As pharmacological treatments remain limited in efficacy and often carry adverse effects, there is growing interest in safe, accessible, non-pharmacological strategies to preserve cognitive function. This <em>Short Review</em> explores the potential of combining two approaches that, individually, have shown beneficial effects on cognitive function: ergothioneine, a naturally occurring amino acid with antioxidant and anti-inflammatory properties, and physical exercise. Ergothioneine accumulates in the brain and other high-stress organs, where it modulates the redox balance, dampens chronic inflammation and supports mitochondrial function. Meanwhile, physical exercise has well-documented benefits for neuroplasticity, cerebral perfusion, and cognitive performance. Preclinical studies suggest ergothioneine supports exercise performance and muscle recovery without attenuating adaptive responses. Despite their distinct and complementary mechanisms, currently there are no available studies exploring the combined effects of ergothioneine and exercise on cognition. We propose a future research agenda that includes mechanistic animal studies, dose-response trials, and clinical interventions in at-risk populations. Together, the combination of ergothioneine and exercise may offer a low-risk, multifaceted approach to enhancing cognitive resilience in aging.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102993"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145748169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stage-specific risk factors of cardiometabolic multimorbidity: A systematic review and meta-analysis from incidence to mortality","authors":"Lin Yang ,&nbsp;Zirui Zhang ,&nbsp;Jie Zhang ,&nbsp;Jingyou Miao ,&nbsp;Hui Zhang ,&nbsp;Yihui Du ,&nbsp;Lilu Ding","doi":"10.1016/j.arr.2025.102991","DOIUrl":"10.1016/j.arr.2025.102991","url":null,"abstract":"<div><h3>Background</h3><div>Cardiometabolic multimorbidity (CMM)—the co-occurrence of diabetes, cardiovascular disease, and related conditions—is a growing global health burden. Identifying risk factors across its developmental trajectory is critical for targeted prevention.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis to quantify risk factors for the incidence and progression of CMM across five transitions: health → first cardiometabolic disease (FCMD), FCMD→CMM, CMM→death, FCMD→death, and health→death. For incidence, we used conventional random-effects meta-analysis to estimate pooled odds ratios (ORs). For disease progression, we applied Bayesian multi-state meta-analysis to estimate pooled hazard ratios (HRs). Subgroup analyses were performed to assess heterogeneity.</div></div><div><h3>Results</h3><div>Nine modifiable risk factors were identified for CMM incidence. Metabolic factors (overweight: OR=1.82, obesity: OR=3.13, hypertension: OR=2.05) and socioeconomic determinants (low income: OR=1.24, living alone: OR=1.58) showed the strongest associations. Depression (OR=1.70) and behavioral factors (smoking, physical inactivity, alcohol use) further increased risk. Trajectory analyses revealed stage-specific drivers: overweight/obesity drove transitions from healthy to FCMD (OR=1.69) and FCMD to CMM (OR=1.36), while smoking showed escalating effects across stages (health→FCMD: OR=1.22; FCMD→CMM: OR=1.37; CMM→death: OR=1.83). Alcohol use and physical inactivity increased mortality risk (13–28 %). Heterogeneity primarily stemmed from outcome measurement methods (i.e., objective vs. self-reported) and CMM composition.</div></div><div><h3>Conclusion</h3><div>CMM prevention requires stage-specific prioritization: early weight management, hypertension control and depression intervention to mitigate incidence; smoking cessation to curb progression; and intensified lifestyle interventions targeting smoking and alcohol cessation in established CMM. This evidence underscores the need for dynamic, trajectory-informed interventions to reduce the CMM burden.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102991"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145749204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivitamin and mineral use: A rapid review of meta-analyses on health outcomes","authors":"Weilan Wang ,&nbsp;Vanessa Kristina Wazny ,&nbsp;Muhammad Daniel Azlan Mahadzir ,&nbsp;Andrea Britta Maier","doi":"10.1016/j.arr.2025.102965","DOIUrl":"10.1016/j.arr.2025.102965","url":null,"abstract":"<div><div>Multivitamin and mineral (MVM) supplements are among the most widely used dietary supplements globally, however, their role in promoting healthspan and longevity remains unclear. This review evaluated comprehensive findings from meta-analyses to clarify their health effects. A rapid review of MEDLINE and EMBASE identified 19 eligible meta-analyses published from 2000 to 2025, encompassing 5535,426 participants, including over 333,943 pregnancies and 904,947 children exposed to maternal MVM supplementation. Randomized controlled trials indicated that MVM use improved global cognition, episodic memory, and immediate recall in older or cognitively intact adults, reduced psychological symptoms in healthy individuals, and lowered systolic blood pressure in at-risk populations. However, no benefits were found for all-cause mortality, COVID-19 outcomes, visual acuity, or multiple cognitive domains, and a higher risk of age-related macular degeneration progression was reported. Observational studies found associations between MVM use and a reduced risk of colorectal cancer, coronary heart disease, cataracts, and fragility hip fractures, but not breast or prostate cancer, stroke, or overall mortality. During pregnancy, MVM supplementation was linked to reduced risks of small-for-gestational-age births and pediatric cancers, but not to preterm birth, stillbirth, or low birth weight. Overall, the findings revealed a lack of consistency in the definition of MVM supplementation, and substantial variability in MVM effectiveness depending on population, age, and health status. These results highlighted the importance of shifting from generalized supplementation approaches to more targeted, personalized nutritional strategies to support healthspan and longevity.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"114 ","pages":"Article 102965"},"PeriodicalIF":12.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145625221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}