Comptes Rendus Biologies最新文献_第6页

On the involvement of the second heart field in congenital heart defects. 关于先天性心脏缺陷中第二心场的参与。

IF 2 4区生物学

Comptes Rendus Biologies Pub Date : 2024-03-15 DOI: 10.5802/crbiol.151

Clara Guijarro, Robert G Kelly

引用次数: 0

Solving an enigma in the tree of life, at the origins of teleost fishes. 解开生命之树上的一个谜团--远洋鱼类的起源。

IF 0.7 4区生物学

Comptes Rendus Biologies Pub Date : 2024-03-05 DOI: 10.5802/crbiol.150

Elise Parey, Camille Berthelot, Hugues Roest Crollius, Yann Guiguen

{"title":"Solving an enigma in the tree of life, at the origins of teleost fishes.","authors":"Elise Parey, Camille Berthelot, Hugues Roest Crollius, Yann Guiguen","doi":"10.5802/crbiol.150","DOIUrl":"10.5802/crbiol.150","url":null,"abstract":"Tracing the phylogenetic relationships between species is one of the fundamental objectives of evolutionary biology. Since Charles Darwin's seminal work in the 19th century, considerable progress has been made towards establishing a tree of life that summarises the evolutionary history of species. Nevertheless, substantial uncertainties still remain. Specifically, the relationships at the origins of teleost fishes have been the subject of extensive debate over the last 50 years. This question has major implications for various research fields: there are almost 30,000 species in the teleost group, which includes invaluable model organisms for biomedical, evolutionary and ecological studies. Here, we present the work in which we solved this enigma. We demonstrated that eels are more closely related to bony-tongued fishes than to the rest of teleost fishes. We achieved this by taking advantage of new genomic data and leveraging innovative phylogenetic markers. Notably, in addition to traditional molecular phylogeny methods based on the evolution of gene sequences, we also considered the evolution of gene order along the DNA molecule. We discuss the challenges and opportunities that these new markers represent for the field of molecular phylogeny, and in particular the possibilities they offer for re-examining other controversial branches in the tree of life.","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"1-8"},"PeriodicalIF":0.7,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Antibiotic resistance: a good example of the "one health" concept]. [抗生素耐药性："同一健康 "理念的典范]。

IF 2 4区生物学

Comptes Rendus Biologies Pub Date : 2024-01-23 DOI: 10.5802/crbiol.139

Vincent Jarlier

引用次数: 0

Clonal reproduction by seed of a cultivated hybrid plant: a new perspective for small-scale rice growers. 栽培杂交植物种子的克隆繁殖：小规模水稻种植者的新视角。

IF 0.7 4区生物学

Comptes Rendus Biologies Pub Date : 2024-01-11 DOI: 10.5802/crbiol.125

Aurore Vernet, Donaldo Meynard, Emmanuel Guiderdoni

引用次数: 0

Stable coding of aversive associations in medial prefrontal populations. 内侧前额叶群体对厌恶联想的稳定编码

IF 2 4区生物学

Comptes Rendus Biologies Pub Date : 2023-12-20 DOI: 10.5802/crbiol.126

Cyril Herry, Daniel Jercog

{"title":"Stable coding of aversive associations in medial prefrontal populations.","authors":"Cyril Herry, Daniel Jercog","doi":"10.5802/crbiol.126","DOIUrl":"10.5802/crbiol.126","url":null,"abstract":"The medial prefrontal cortex (mPFC) is at the core of numerous psychiatric conditions, including fear and anxiety-related disorders. Whereas an abundance of evidence suggests a crucial role of the mPFC in regulating fear behaviour, the precise role of the mPFC in this process is not yet entirely clear. While studies at the single-cell level have demonstrated the involvement of this area in various aspects of fear processing, such as the encoding of threat-related cues and fear expression, an increasingly prevalent idea in the systems neuroscience field is that populations of neurons are, in fact, the essential unit of computation in many integrative brain regions such as prefrontal areas. What mPFC neuronal populations represent when we face threats? To address this question, we performed electrophysiological single-unit population recordings in the dorsal mPFC while mice faced threat-predicting cues eliciting defensive behaviours, and performed pharmacological and optogenetic inactivations of this area and the amygdala. Our data indicated that the presence of threat-predicting cues induces a stable coding dynamics of internally driven representations in the dorsal mPFC, necessary to drive learned defensive behaviours. Moreover, these neural population representations primary reflect learned associations rather than specific defensive behaviours, and the construct of such representations relies on the functional integrity of the amygdala.","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"346 ","pages":"127-138"},"PeriodicalIF":2.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organizing collective cell migration through guidance by followers. 通过追随者的引导组织细胞集体迁移

IF 0.7 4区生物学

Comptes Rendus Biologies Pub Date : 2023-12-14 DOI: 10.5802/crbiol.145

Arthur Boutillon

{"title":"Organizing collective cell migration through guidance by followers.","authors":"Arthur Boutillon","doi":"10.5802/crbiol.145","DOIUrl":"10.5802/crbiol.145","url":null,"abstract":"Morphogenesis, wound healing, and some cancer metastases rely on the collective migration of groups of cells. In these processes, guidance and coordination between cells and tissues are critical. While strongly adherent epithelial cells have to move collectively, loosely organized mesenchymal cells can migrate as individual cells. Nevertheless, many of them migrate collectively. This article summarizes how migratory reactions to cell-cell contacts, also called \"contact regulation of locomotion\" behaviors, organize mesenchymal collective cell migration. It focuses on one recently discovered mechanism called \"guidance by followers\", through which a cell is oriented by its immediate followers. In the gastrulating zebrafish embryo, during embryonic axis elongation, this phenomenon is responsible for the collective migration of the leading tissue, the polster, and its guidance by the following posterior axial mesoderm. Such guidance of migrating cells by followers ensures long-range coordination of movements and developmental robustness. Along with other \"contact regulation of locomotion\" behaviors, this mechanism contributes to organizing collective migration of loose populations of cells.","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"346 ","pages":"117-126"},"PeriodicalIF":0.7,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Madeleine Gans (1920–2018) : une pionnière en génétique du développement 马德琳·甘斯(1920 - 2018):发育遗传学的先驱

4区生物学

Comptes Rendus Biologies Pub Date : 2023-11-15 DOI: 10.5802/crbiol.117-fr

引用次数: 0

Research facing the challenge of Homo bureaucraticus 面临官僚人挑战的研究

4区生物学

Comptes Rendus Biologies Pub Date : 2023-11-15 DOI: 10.5802/crbiol.108-en

引用次数: 0

Impact des R-loops sur le stress réplicatif induit par les oncogènes dans les cellules cancéreuses r -loop对癌细胞中致癌物诱导的复制应激的影响

4区生物学

Comptes Rendus Biologies Pub Date : 2023-11-13 DOI: 10.5802/crbiol.123-fr

{"title":"Impact des R-loops sur le stress réplicatif induit par les oncogènes dans les cellules cancéreuses","authors":"","doi":"10.5802/crbiol.123-fr","DOIUrl":"https://doi.org/10.5802/crbiol.123-fr","url":null,"abstract":"Replication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils or formation of R-loops. These structures form during transcription when nascent RNA reanneals with DNA behind the RNA polymerase, forming a stable DNA:RNA hybrid. In this review, we discuss how these different cotranscriptional processes disrupt the progression of replication forks and how they contribute to genetic instability in cancer cells. Le stress réplicatif correspond à une altération de la progression des fourches de réplication causé par une variété d’événements d’origine endogène ou exogène. Dans les lésions précancéreuses, ce stress est aggravé par la dérégulation de voies oncogéniques, qui perturbe notamment la coordination entre la réplication et la transcription du génome et entraine une instabilité génétique contribuant au développement du cancer. Il est maintenant bien établi que la transcription peut interférer avec la réplication du génome de différentes façons, telles que des collisions frontales entre polymérases, l’accumulation de supertours positifs de l’ADN ou la formation de R-loops. Ces structures se forment au cours de la transcription lorsque l’ARN naissant se réassocie avec l’ADN derrière l’ARN polymérase, formant un hybride ADN :ARN stable. Dans cette revue, nous discutons comment ces différents processus cotranscriptionnels perturbent la progression des fourches de réplication et comment ils contribuent à l’instabilité génétique des cellules cancéreuses.","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"43 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136347166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of R-loops on oncogene-induced replication stress in cancer cells. R环对癌症细胞中致癌物诱导的复制应激的影响。

IF 2 4区生物学

Comptes Rendus Biologies Pub Date : 2023-09-22 DOI: 10.5802/crbiol.123

Jonathan Heuzé, Yea-Lih Lin, Armelle Lengronne, Jérôme Poli, Philippe Pasero

引用次数: 0