Comptes Rendus Biologies最新文献

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Cell migration in dense microenvironments. 密集微环境中的细胞迁移。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-09-21 DOI: 10.5802/crbiol.124
Guilherme Pedreira de Freitas Nader, Juan Manuel García-Arcos
{"title":"Cell migration in dense microenvironments.","authors":"Guilherme Pedreira de Freitas Nader,&nbsp;Juan Manuel García-Arcos","doi":"10.5802/crbiol.124","DOIUrl":"10.5802/crbiol.124","url":null,"abstract":"<p><p>The nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense interstitial spaces, the nuclear envelope folds stretch, increasing nuclear envelope tension and sometimes causing rupture. Different degrees of nuclear envelope tension regulate cellular behaviors and functions, especially in cells that move and grow within dense matrices. The crosstalk between extracellular mechanical inputs and the cell nucleus is a critical component in the modulation of cell function of cells that navigate within packed microenvironments. Moreover, there is a link between regimes of nuclear envelope unfolding and different cellular behaviors, from orchestrated signaling cascades to cellular perturbations and damage.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41140299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Henri Décamps, an ecology open to societal concerns]. [Henri d<s:1>坎普斯,一个对社会关注开放的生态]。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-06-22 DOI: 10.5802/crbiol.121
Jean-Dominique Lebreton
{"title":"[Henri Décamps, an ecology open to societal concerns].","authors":"Jean-Dominique Lebreton","doi":"10.5802/crbiol.121","DOIUrl":"https://doi.org/10.5802/crbiol.121","url":null,"abstract":"","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9691627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cauliflowers or how the perseverance of a plant to make flowers produces an amazing fractal structure. 花椰菜或植物如何坚持不懈地制造花朵,产生惊人的分形结构。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-06-14 DOI: 10.5802/crbiol.120
Eugenio Azpeitia, François Parcy, Christophe Godin
{"title":"Cauliflowers or how the perseverance of a plant to make flowers produces an amazing fractal structure.","authors":"Eugenio Azpeitia,&nbsp;François Parcy,&nbsp;Christophe Godin","doi":"10.5802/crbiol.120","DOIUrl":"10.5802/crbiol.120","url":null,"abstract":"<p><p>Biological organisms have an immense diversity of forms. Some of them exhibit conspicuous and fascinating fractal structures that present self-similar patterns at all scales. How such structures are produced by biological processes is intriguing. In a recent publication, we used a multi-scale modelling approach to understand how gene activity can produce macroscopic cauliflower curds. Our work provides a plausible explanation for the appearance of fractal-like structures in plants, linking gene activity with development.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10059523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional and developmental convergence in the reproductive "nurse cells" of flowering plants. 开花植物生殖“护理细胞”的功能和发育趋同。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-05-30 DOI: 10.5802/crbiol.119
Nicolas Max Doll, Jekaterina Truskina, Gwyneth Ingram
{"title":"Functional and developmental convergence in the reproductive \"nurse cells\" of flowering plants.","authors":"Nicolas Max Doll,&nbsp;Jekaterina Truskina,&nbsp;Gwyneth Ingram","doi":"10.5802/crbiol.119","DOIUrl":"10.5802/crbiol.119","url":null,"abstract":"<p><p>The successful sexual reproduction of flowering plants depends upon double fertilisation, during which pollen grains, produced within the male floral organ (the anther) deliver two sperm cells to the ovule, buried deep within the ovary, triggering the development of the embryo and the surrounding tissues of the seed. Although much attention has been given to pollen and embryo development, less has been focused on the supporting tissues surrounding these organisms as they develop, the tapetum and the endosperm. Intriguingly, despite their very different origins, these tissues appear to have converged functionally and developmentally. Here we will discuss this apparent convergence and its molecular and physiological basis.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9550954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Madeleine Gans (1920-2018): a pioneer in developmental genetics. 玛德琳·甘斯(1920-2018):发育遗传学的先驱。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-05-30 DOI: 10.5802/crbiol.117
Odile Ozier-Kalogeropoulos, Anne-Marie Pret, Denise Cabet-Busson
{"title":"Madeleine Gans (1920-2018): a pioneer in developmental genetics.","authors":"Odile Ozier-Kalogeropoulos,&nbsp;Anne-Marie Pret,&nbsp;Denise Cabet-Busson","doi":"10.5802/crbiol.117","DOIUrl":"https://doi.org/10.5802/crbiol.117","url":null,"abstract":"","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9569216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The symbiotic origin of the eukaryotic cell. 真核细胞的共生起源。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-05-30 DOI: 10.5802/crbiol.118
Purificación López-García, David Moreira
{"title":"The symbiotic origin of the eukaryotic cell.","authors":"Purificación López-García,&nbsp;David Moreira","doi":"10.5802/crbiol.118","DOIUrl":"10.5802/crbiol.118","url":null,"abstract":"<p><p>Eukaryogenesis represented a major evolutionary transition that led to the emergence of complex cells from simpler ancestors. For several decades, the most accepted scenario involved the evolution of an independent lineage of proto-eukaryotes endowed with an endomembrane system, including a nuclear compartment, a developed cytoskeleton and phagocytosis, which engulfed the alphaproteobacterial ancestor of mitochondria. However, the recent discovery by metagenomic and cultural approaches of Asgard archaea, which harbour many genes in common with eukaryotes and are their closest relatives in phylogenomic trees, rather supports scenarios based on the symbiosis of one Asgard-like archaeon and one or more bacteria at the origin of the eukaryotic cell. Here, we review the recent discoveries that led to this conceptual shift, briefly evoking current models of eukaryogenesis and the challenges ahead to discriminate between them and to establish a detailed, plausible scenario that accounts for the evolution of eukaryotic traits from those of their prokaryotic ancestors.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9550956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
[Deadliest flu]. 致命的流感。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-05-10 DOI: 10.5802/crbiol.112
Laura Spinney
{"title":"[Deadliest flu].","authors":"Laura Spinney","doi":"10.5802/crbiol.112","DOIUrl":"https://doi.org/10.5802/crbiol.112","url":null,"abstract":"<p><p>Many questions remain unanswered regarding the so-called \"Spanish\" influenza pandemic of 1918. This article addresses three of them and describes the state of knowledge for each of them: Where did the pandemic start? How many people died? And why was it so deadly?</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9556790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The unexpected role of the STING protein in lipid metabolism. STING蛋白在脂质代谢中出乎意料的作用。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-04-18 DOI: 10.5802/crbiol.110
Isabelle K Vila, Nadine Laguette
{"title":"The unexpected role of the STING protein in lipid metabolism.","authors":"Isabelle K Vila,&nbsp;Nadine Laguette","doi":"10.5802/crbiol.110","DOIUrl":"10.5802/crbiol.110","url":null,"abstract":"<p><p>Detection of cytosolic pathological nucleic acids is a key step for the initiation of innate immune responses. In the past decade, the stimulator of interferon genes (STING) adaptor protein has emerged as a central platform enabling the activation of inflammatory responses in the presence of cytosolic DNAs. This has prompted a plethora of approaches aiming at modulating STING activation in order to boost or inhibit inflammatory responses. However, recent work has revealed that STING is also a direct regulator of metabolic homeostasis. In particular, STING regulates lipid metabolism directly, a function that is conserved throughout evolution. This indicates that STING targeting strategies must take into consideration potential metabolic side effects that may alter disease course, but also suggests that targeting STING may open the route to novel treatments for metabolic disorders. Here we discuss recent work describing the metabolic function of STING and the implications of these findings.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9544704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research facing the challenge of Homo bureaucraticus]. [面临官僚人挑战的研究]。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-04-12 DOI: 10.5802/crbiol.108
André Sentenac
{"title":"[Research facing the challenge of Homo bureaucraticus].","authors":"André Sentenac","doi":"10.5802/crbiol.108","DOIUrl":"https://doi.org/10.5802/crbiol.108","url":null,"abstract":"","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9569215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long non-coding RNAs reveal new regulatory mechanisms controlling gene expression. 长链非编码rna揭示了控制基因表达的新调控机制。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-02-16 DOI: 10.5802/crbiol.106
Martin Crespi
{"title":"Long non-coding RNAs reveal new regulatory mechanisms controlling gene expression.","authors":"Martin Crespi","doi":"10.5802/crbiol.106","DOIUrl":"https://doi.org/10.5802/crbiol.106","url":null,"abstract":"<p><p>A plethora of non-coding RNAs have been found in eukaryotes, notably with the advent of modern sequencing technologies to analyze the transcriptome. Apart from the well-known housekeeping RNA genes (such as the ribosomal RNA or the transfer RNA), many thousands of transcripts detected are not evidently linked to a protein-coding gene. These, so called non-coding RNAs, may code for crucial regulators of gene expression, the small si/miRNAs, for small peptides (translated under specific conditions) or may act as long RNA molecules (antisense, intronic or intergenic long non-coding RNAs or lncRNAs). The lncRNAs interact with members of multiple machineries involved in gene regulation. In this review, we discussed about how plant lncRNAs permitted to discover new regulatory mechanisms acting in epigenetic control, chromatin 3D structure and alternative splicing. These novel regulations diversified the expression patterns and protein variants of target protein-coding genes and are an important element of the response of plants to environmental stresses and their adaptation to changing conditions.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10783373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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