Comptes Rendus Biologies最新文献_第6页

Research facing the challenge of Homo bureaucraticus 面临官僚人挑战的研究

4区生物学

Comptes Rendus Biologies Pub Date : 2023-11-15 DOI: 10.5802/crbiol.108-en

引用次数: 0

Impact des R-loops sur le stress réplicatif induit par les oncogènes dans les cellules cancéreuses r -loop对癌细胞中致癌物诱导的复制应激的影响

4区生物学

Comptes Rendus Biologies Pub Date : 2023-11-13 DOI: 10.5802/crbiol.123-fr

{"title":"Impact des R-loops sur le stress réplicatif induit par les oncogènes dans les cellules cancéreuses","authors":"","doi":"10.5802/crbiol.123-fr","DOIUrl":"https://doi.org/10.5802/crbiol.123-fr","url":null,"abstract":"Replication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils or formation of R-loops. These structures form during transcription when nascent RNA reanneals with DNA behind the RNA polymerase, forming a stable DNA:RNA hybrid. In this review, we discuss how these different cotranscriptional processes disrupt the progression of replication forks and how they contribute to genetic instability in cancer cells. Le stress réplicatif correspond à une altération de la progression des fourches de réplication causé par une variété d’événements d’origine endogène ou exogène. Dans les lésions précancéreuses, ce stress est aggravé par la dérégulation de voies oncogéniques, qui perturbe notamment la coordination entre la réplication et la transcription du génome et entraine une instabilité génétique contribuant au développement du cancer. Il est maintenant bien établi que la transcription peut interférer avec la réplication du génome de différentes façons, telles que des collisions frontales entre polymérases, l’accumulation de supertours positifs de l’ADN ou la formation de R-loops. Ces structures se forment au cours de la transcription lorsque l’ARN naissant se réassocie avec l’ADN derrière l’ARN polymérase, formant un hybride ADN :ARN stable. Dans cette revue, nous discutons comment ces différents processus cotranscriptionnels perturbent la progression des fourches de réplication et comment ils contribuent à l’instabilité génétique des cellules cancéreuses.","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"43 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136347166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of R-loops on oncogene-induced replication stress in cancer cells. R环对癌症细胞中致癌物诱导的复制应激的影响。

IF 2 4区生物学

Comptes Rendus Biologies Pub Date : 2023-09-22 DOI: 10.5802/crbiol.123

Jonathan Heuzé, Yea-Lih Lin, Armelle Lengronne, Jérôme Poli, Philippe Pasero

引用次数: 0

Cell migration in dense microenvironments. 密集微环境中的细胞迁移。

IF 2 4区生物学

Comptes Rendus Biologies Pub Date : 2023-09-21 DOI: 10.5802/crbiol.124

Guilherme Pedreira de Freitas Nader, Juan Manuel García-Arcos

{"title":"Cell migration in dense microenvironments.","authors":"Guilherme Pedreira de Freitas Nader, Juan Manuel García-Arcos","doi":"10.5802/crbiol.124","DOIUrl":"10.5802/crbiol.124","url":null,"abstract":"<p><p>The nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense interstitial spaces, the nuclear envelope folds stretch, increasing nuclear envelope tension and sometimes causing rupture. Different degrees of nuclear envelope tension regulate cellular behaviors and functions, especially in cells that move and grow within dense matrices. The crosstalk between extracellular mechanical inputs and the cell nucleus is a critical component in the modulation of cell function of cells that navigate within packed microenvironments. Moreover, there is a link between regimes of nuclear envelope unfolding and different cellular behaviors, from orchestrated signaling cascades to cellular perturbations and damage.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"346 ","pages":"89-93"},"PeriodicalIF":2.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41140299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Henri Décamps, an ecology open to societal concerns]. [Henri d<s:1>坎普斯，一个对社会关注开放的生态]。

IF 2 4区生物学

Comptes Rendus Biologies Pub Date : 2023-06-22 DOI: 10.5802/crbiol.121

Jean-Dominique Lebreton

引用次数: 0

Cauliflowers or how the perseverance of a plant to make flowers produces an amazing fractal structure. 花椰菜或植物如何坚持不懈地制造花朵，产生惊人的分形结构。

IF 2 4区生物学

Comptes Rendus Biologies Pub Date : 2023-06-14 DOI: 10.5802/crbiol.120

Eugenio Azpeitia, François Parcy, Christophe Godin

引用次数: 0

Functional and developmental convergence in the reproductive "nurse cells" of flowering plants. 开花植物生殖“护理细胞”的功能和发育趋同。