Memories of a young student: the early days of splicing regulation with François Gros.

Pub Date : 2024-03-29 DOI:10.5802/crbiol.138
Domenico Libri
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Abstract

I joined the laboratory of François Gros as a young student in the mid-1980s and worked on the characterization of the β-tropomyosin gene in chicken and the regulation of alternative splicing of its transcript, under the supervision of Marc Fiszman. In particular, I was interested in how secondary structures of the RNA influence the recognition of exons specifically used in muscle cells. I will recall a few memories on how interacting with François on this project shaped my perception of the scientific process and of the relationships between models and data. Later I worked on many aspects of RNA biology, from transcription to mRNP biogenesis and non-coding RNAs.

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一个年轻学生的回忆:与弗朗索瓦-格罗斯(François Gros)一起研究拼接调节的早期阶段。
20 世纪 80 年代中期,我作为一名年轻学生加入弗朗索瓦-格罗斯(François Gros)实验室,在马克-费兹曼(Marc Fiszman)的指导下,研究鸡的β-肌球蛋白基因特征及其转录本替代剪接的调控。我尤其感兴趣的是,RNA 的二级结构如何影响肌肉细胞中专门使用的外显子的识别。在这个项目中,我与弗朗索瓦的互动影响了我对科学过程以及模型和数据之间关系的认识。后来,我研究了 RNA 生物学的许多方面,从转录到 mRNP 生物发生和非编码 RNA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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