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Comptes Rendus Biologies最新文献

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Memories of a young student: the early days of splicing regulation with François Gros. 一个年轻学生的回忆：与弗朗索瓦-格罗斯（François Gros）一起研究拼接调节的早期阶段。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.138
Domenico Libri
{"title":"Memories of a young student: the early days of splicing regulation with François Gros.","authors":"Domenico Libri","doi":"10.5802/crbiol.138","DOIUrl":"10.5802/crbiol.138","url":null,"abstract":"<p><p>I joined the laboratory of François Gros as a young student in the mid-1980s and worked on the characterization of the <math><mi>β</mi></math>-tropomyosin gene in chicken and the regulation of alternative splicing of its transcript, under the supervision of Marc Fiszman. In particular, I was interested in how secondary structures of the RNA influence the recognition of exons specifically used in muscle cells. I will recall a few memories on how interacting with François on this project shaped my perception of the scientific process and of the relationships between models and data. Later I worked on many aspects of RNA biology, from transcription to mRNP biogenesis and non-coding RNAs.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"55-57"},"PeriodicalIF":0.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[François Gros: a leading figure, a secretive man]. [弗朗索瓦-格罗斯：领袖人物，神秘人物]。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.142
Benoît Robert
{"title":"[François Gros: a leading figure, a secretive man].","authors":"Benoît Robert","doi":"10.5802/crbiol.142","DOIUrl":"10.5802/crbiol.142","url":null,"abstract":"<p><p>I joined François Gros' laboratory in 1975, to study mechanisms of gene expression in eukaryotes. Despite the lack of powerful tools, that would be brought later by genetic engineering, I obtained publishable results and was allowed to defend a third cycle thesis. Thereafter, I joined Margaret Buckingham's group, which was empowering within François' laboratory. I maintained regular meetings with François, a leading figure but a secretive man, who did not readily open up. It was my privilege, over the more than 45 years I have been around him, to have glimpses over what had been really significant to him. This has been a rich and very precious experience.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"41-43"},"PeriodicalIF":2.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Along the road with François]. [与弗朗索瓦同行]
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.136
Didier Montarras
{"title":"[Along the road with François].","authors":"Didier Montarras","doi":"10.5802/crbiol.136","DOIUrl":"10.5802/crbiol.136","url":null,"abstract":"<p><p>It was at the Pasteur Institute, in François Gros' laboratory, that I had the opportunity to discover the world of research. An opportunity in more ways than one, first because of the nature of the subject, myogenesis, which lent itself particularly well to cellular and genetic approaches to development and differentiation in vertebrates. An opportunity also because the head of the laboratory, François Gros, who was responsible for the choice of this topic, had created an environment in which researchers could develop their projects with great confidence and freedom.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"51-53"},"PeriodicalIF":0.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the involvement of the second heart field in congenital heart defects. 关于先天性心脏缺陷中第二心场的参与。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-15 DOI: 10.5802/crbiol.151
Clara Guijarro, Robert G Kelly
{"title":"On the involvement of the second heart field in congenital heart defects.","authors":"Clara Guijarro, Robert G Kelly","doi":"10.5802/crbiol.151","DOIUrl":"10.5802/crbiol.151","url":null,"abstract":"<p><p>Congenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract development with neural crest cells. Genetic or environmental perturbation of SHF deployment thus underlies a spectrum of common forms of CHD affecting conotruncal and septal morphogenesis. Here we review the major properties of SHF cells as well as recent insights into the developmental programs that drive normal cardiac progenitor cell addition and the origins of CHD.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"9-18"},"PeriodicalIF":2.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solving an enigma in the tree of life, at the origins of teleost fishes. 解开生命之树上的一个谜团--远洋鱼类的起源。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-05 DOI: 10.5802/crbiol.150
Elise Parey, Camille Berthelot, Hugues Roest Crollius, Yann Guiguen
{"title":"Solving an enigma in the tree of life, at the origins of teleost fishes.","authors":"Elise Parey, Camille Berthelot, Hugues Roest Crollius, Yann Guiguen","doi":"10.5802/crbiol.150","DOIUrl":"10.5802/crbiol.150","url":null,"abstract":"<p><p>Tracing the phylogenetic relationships between species is one of the fundamental objectives of evolutionary biology. Since Charles Darwin's seminal work in the 19th century, considerable progress has been made towards establishing a tree of life that summarises the evolutionary history of species. Nevertheless, substantial uncertainties still remain. Specifically, the relationships at the origins of teleost fishes have been the subject of extensive debate over the last 50 years. This question has major implications for various research fields: there are almost 30,000 species in the teleost group, which includes invaluable model organisms for biomedical, evolutionary and ecological studies. Here, we present the work in which we solved this enigma. We demonstrated that eels are more closely related to bony-tongued fishes than to the rest of teleost fishes. We achieved this by taking advantage of new genomic data and leveraging innovative phylogenetic markers. Notably, in addition to traditional molecular phylogeny methods based on the evolution of gene sequences, we also considered the evolution of gene order along the DNA molecule. We discuss the challenges and opportunities that these new markers represent for the field of molecular phylogeny, and in particular the possibilities they offer for re-examining other controversial branches in the tree of life.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"1-8"},"PeriodicalIF":0.7,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antibiotic resistance: a good example of the "one health" concept]. [抗生素耐药性："同一健康 "理念的典范]。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-01-23 DOI: 10.5802/crbiol.139
Vincent Jarlier
{"title":"[Antibiotic resistance: a good example of the \"one health\" concept].","authors":"Vincent Jarlier","doi":"10.5802/crbiol.139","DOIUrl":"10.5802/crbiol.139","url":null,"abstract":"<p><p>Antibiotic resistance is the direct deleterious consequence of two synergistic causes linked to human activity: the massive use of antibiotics in human and animal health, which leads to the selection of the most resistant bacteria, and the spread of these selected resistant bacteria, directly by cross-transmission within human and animal populations and indirectly via the environment. The \"one health\" concept enables an integrated approach of the various components of the issue, linking human, animal and environmental ecosystems and their dynamics.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139522255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal reproduction by seed of a cultivated hybrid plant: a new perspective for small-scale rice growers. 栽培杂交植物种子的克隆繁殖：小规模水稻种植者的新视角。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-01-11 DOI: 10.5802/crbiol.125
Aurore Vernet, Donaldo Meynard, Emmanuel Guiderdoni
{"title":"Clonal reproduction by seed of a cultivated hybrid plant: a new perspective for small-scale rice growers.","authors":"Aurore Vernet, Donaldo Meynard, Emmanuel Guiderdoni","doi":"10.5802/crbiol.125","DOIUrl":"10.5802/crbiol.125","url":null,"abstract":"<p><p>Transferring an asexual mode of reproduction by seeds (apomixis) to cultivated plants would enable clonal reproduction of heterozygous genotypes such as F1 hybrids with hybrid vigor (heterosis), facilitating their access and multiplication by small-scale growers. Although sources of apomixis and the genetic loci controlling its constituent elements have been identified in wild species, their transfer by crossing to cultivated species has so far been unsuccessful. Here, we have introduced synthetic apomixis in hybrid rice to produce a high (95-100%) frequency of clonal seeds, via the inactivation of three meiotic genes-resulting in unreduced, non-recombined gametes-and the addition of an egg cell parthenogenesis trigger. The genotype and phenotype, including grain quality, of the F1 hybrid are reproduced identically in the clonal apomictic progenies. These results make synthetic apomixis compatible with future use in agriculture.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"346 ","pages":"107-116"},"PeriodicalIF":0.7,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stable coding of aversive associations in medial prefrontal populations. 内侧前额叶群体对厌恶联想的稳定编码
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-12-20 DOI: 10.5802/crbiol.126
Cyril Herry, Daniel Jercog
{"title":"Stable coding of aversive associations in medial prefrontal populations.","authors":"Cyril Herry, Daniel Jercog","doi":"10.5802/crbiol.126","DOIUrl":"10.5802/crbiol.126","url":null,"abstract":"<p><p>The medial prefrontal cortex (mPFC) is at the core of numerous psychiatric conditions, including fear and anxiety-related disorders. Whereas an abundance of evidence suggests a crucial role of the mPFC in regulating fear behaviour, the precise role of the mPFC in this process is not yet entirely clear. While studies at the single-cell level have demonstrated the involvement of this area in various aspects of fear processing, such as the encoding of threat-related cues and fear expression, an increasingly prevalent idea in the systems neuroscience field is that populations of neurons are, in fact, the essential unit of computation in many integrative brain regions such as prefrontal areas. What mPFC neuronal populations represent when we face threats? To address this question, we performed electrophysiological single-unit population recordings in the dorsal mPFC while mice faced threat-predicting cues eliciting defensive behaviours, and performed pharmacological and optogenetic inactivations of this area and the amygdala. Our data indicated that the presence of threat-predicting cues induces a stable coding dynamics of internally driven representations in the dorsal mPFC, necessary to drive learned defensive behaviours. Moreover, these neural population representations primary reflect learned associations rather than specific defensive behaviours, and the construct of such representations relies on the functional integrity of the amygdala.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"346 ","pages":"127-138"},"PeriodicalIF":2.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organizing collective cell migration through guidance by followers. 通过追随者的引导组织细胞集体迁移
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2023-12-14 DOI: 10.5802/crbiol.145
Arthur Boutillon
{"title":"Organizing collective cell migration through guidance by followers.","authors":"Arthur Boutillon","doi":"10.5802/crbiol.145","DOIUrl":"10.5802/crbiol.145","url":null,"abstract":"<p><p>Morphogenesis, wound healing, and some cancer metastases rely on the collective migration of groups of cells. In these processes, guidance and coordination between cells and tissues are critical. While strongly adherent epithelial cells have to move collectively, loosely organized mesenchymal cells can migrate as individual cells. Nevertheless, many of them migrate collectively. This article summarizes how migratory reactions to cell-cell contacts, also called \"contact regulation of locomotion\" behaviors, organize mesenchymal collective cell migration. It focuses on one recently discovered mechanism called \"guidance by followers\", through which a cell is oriented by its immediate followers. In the gastrulating zebrafish embryo, during embryonic axis elongation, this phenomenon is responsible for the collective migration of the leading tissue, the polster, and its guidance by the following posterior axial mesoderm. Such guidance of migrating cells by followers ensures long-range coordination of movements and developmental robustness. Along with other \"contact regulation of locomotion\" behaviors, this mechanism contributes to organizing collective migration of loose populations of cells.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"346 ","pages":"117-126"},"PeriodicalIF":0.7,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Madeleine Gans (1920–2018) : une pionnière en génétique du développement 马德琳·甘斯(1920 - 2018):发育遗传学的先驱
4区 生物学
Comptes Rendus Biologies Pub Date : 2023-11-15 DOI: 10.5802/crbiol.117-fr
{"title":"Madeleine Gans (1920–2018) : une pionnière en génétique du développement","authors":"","doi":"10.5802/crbiol.117-fr","DOIUrl":"https://doi.org/10.5802/crbiol.117-fr","url":null,"abstract":"","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"6 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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