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[Which contribution of wastewater treatment plants in the fight against antimicrobial resistance?] [废水处理厂在对抗抗菌药耐药性方面有何贡献？］
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.113
Charlotte Arnal, Faten Belhadj-Kaabi, Valérie Ingrand
{"title":"[Which contribution of wastewater treatment plants in the fight against antimicrobial resistance?]","authors":"Charlotte Arnal, Faten Belhadj-Kaabi, Valérie Ingrand","doi":"10.5802/crbiol.113","DOIUrl":"10.5802/crbiol.113","url":null,"abstract":"<p><p>Due to the massive use of antibiotics, antimicrobial resistance (AMR) continues to spread, endangering global disease control and environmental quality. The sources of bacteria or antimicrobial resistance genes are linked to human activities: urban, hospital and industrial discharges, livestock farms). The role of sanitation systems-sewerage, wastewater treatment and sludge treatment (WWTP)-in the problem of AMR has not yet been clearly established by the scientific community. The data available to date show that they eliminate part of the bacteria, genes and antibiotics, although this is not their primary vocation. WWTPs thus play an important filtering role to limit dissemination in the environment. On the other hand, some authors warn against their potential involvement in the selection of new resistant germs, given the conditions conducive to the exchange of genetic material between microbial strains of various types and exposed to selective agents. Today, knowledge of the mechanisms involved in the selection of antibiotic resistance and the fate of bacteria and resistance genes within sanitation systems remains limited. Research is needed to better characterize the contribution of wastewater systems and the performance of wastewater, recycled water, stormwater and sludge treatment processes.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"23-33"},"PeriodicalIF":2.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10129163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Memories of Professor François Gros. 回忆弗朗索瓦-格罗斯教授
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.141
Shin'ichi Takeda
{"title":"Memories of Professor François Gros.","authors":"Shin'ichi Takeda","doi":"10.5802/crbiol.141","DOIUrl":"10.5802/crbiol.141","url":null,"abstract":"<p><p>I joined the laboratory of Professor Francois Gros in 1987 and worked there as a postdoc with Robert Whalen until 1992. I recount the research we carried out and mention that of the other scientists also working on skeletal muscle on the 6th floor of the Molecular Biology Department of the Institut Pasteur at that time. I then present my subsequent research when I returned to Japan. I pay tribute to the influence of Professor Gros and to his support in establishing Japanese/French meetings on muscle biology and muscular dystrophy. I also invoke personal memories of Robert Whalen and Margaret Buckingham and remember the occasions when I returned to Paris to honour François Gros.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"45-49"},"PeriodicalIF":0.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Our journey with François Gros. 我们与弗朗索瓦-格罗斯的旅程
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.140
Gillian Butler-Browne, Vincent Mouly
{"title":"Our journey with François Gros.","authors":"Gillian Butler-Browne, Vincent Mouly","doi":"10.5802/crbiol.140","DOIUrl":"10.5802/crbiol.140","url":null,"abstract":"<p><p>Gillian Butler-Browne began working on muscle at the Institut Pasteur in the laboratory of François Gros in 1978. She characterized the expression profile of different myosin isoforms during both human and rodent development. Vincent Mouly joined this laboratory for his PhD in 1982, and defined the different populations of myoblasts appearing during development in birds and then in humans. Together, they demonstrated the impact of the limit in proliferation of the precursor cells on the regenerative capacity of human skeletal muscle, and their group developed models to evaluate the regenerative potential of skeletal muscle in vitro, measuring the telomeric erosion, and identified the involvement of a stress pathway in the proliferative arrest of muscle progenitors. A platform to produce human immortalized muscle cell lines was the successful result of this research, initiated with François Gros and W. E. Wright. The in vivo regenerative potential of human muscle cells was evaluated by injection into muscles of immunodeficient mice. Their group in collaboration with the clinical team of Professor Jean Lacau St-Guily and Professor Sophie Perié completed a successful autologous myoblast transplantation clinical trial for Oculo-pharyngeal muscular dystrophy. This common scientific career was made possible thanks to the precious and always benevolent support of François Gros.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"59-63"},"PeriodicalIF":0.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Memories of a young student: the early days of splicing regulation with François Gros. 一个年轻学生的回忆：与弗朗索瓦-格罗斯（François Gros）一起研究拼接调节的早期阶段。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.138
Domenico Libri
{"title":"Memories of a young student: the early days of splicing regulation with François Gros.","authors":"Domenico Libri","doi":"10.5802/crbiol.138","DOIUrl":"10.5802/crbiol.138","url":null,"abstract":"<p><p>I joined the laboratory of François Gros as a young student in the mid-1980s and worked on the characterization of the <math><mi>β</mi></math>-tropomyosin gene in chicken and the regulation of alternative splicing of its transcript, under the supervision of Marc Fiszman. In particular, I was interested in how secondary structures of the RNA influence the recognition of exons specifically used in muscle cells. I will recall a few memories on how interacting with François on this project shaped my perception of the scientific process and of the relationships between models and data. Later I worked on many aspects of RNA biology, from transcription to mRNP biogenesis and non-coding RNAs.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"55-57"},"PeriodicalIF":0.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139486841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[François Gros: a leading figure, a secretive man]. [弗朗索瓦-格罗斯：领袖人物，神秘人物]。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.142
Benoît Robert
{"title":"[François Gros: a leading figure, a secretive man].","authors":"Benoît Robert","doi":"10.5802/crbiol.142","DOIUrl":"10.5802/crbiol.142","url":null,"abstract":"<p><p>I joined François Gros' laboratory in 1975, to study mechanisms of gene expression in eukaryotes. Despite the lack of powerful tools, that would be brought later by genetic engineering, I obtained publishable results and was allowed to defend a third cycle thesis. Thereafter, I joined Margaret Buckingham's group, which was empowering within François' laboratory. I maintained regular meetings with François, a leading figure but a secretive man, who did not readily open up. It was my privilege, over the more than 45 years I have been around him, to have glimpses over what had been really significant to him. This has been a rich and very precious experience.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"41-43"},"PeriodicalIF":2.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Along the road with François]. [与弗朗索瓦同行]
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.136
Didier Montarras
{"title":"[Along the road with François].","authors":"Didier Montarras","doi":"10.5802/crbiol.136","DOIUrl":"10.5802/crbiol.136","url":null,"abstract":"<p><p>It was at the Pasteur Institute, in François Gros' laboratory, that I had the opportunity to discover the world of research. An opportunity in more ways than one, first because of the nature of the subject, myogenesis, which lent itself particularly well to cellular and genetic approaches to development and differentiation in vertebrates. An opportunity also because the head of the laboratory, François Gros, who was responsible for the choice of this topic, had created an environment in which researchers could develop their projects with great confidence and freedom.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"51-53"},"PeriodicalIF":0.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the involvement of the second heart field in congenital heart defects. 关于先天性心脏缺陷中第二心场的参与。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-15 DOI: 10.5802/crbiol.151
Clara Guijarro, Robert G Kelly
{"title":"On the involvement of the second heart field in congenital heart defects.","authors":"Clara Guijarro, Robert G Kelly","doi":"10.5802/crbiol.151","DOIUrl":"10.5802/crbiol.151","url":null,"abstract":"<p><p>Congenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract development with neural crest cells. Genetic or environmental perturbation of SHF deployment thus underlies a spectrum of common forms of CHD affecting conotruncal and septal morphogenesis. Here we review the major properties of SHF cells as well as recent insights into the developmental programs that drive normal cardiac progenitor cell addition and the origins of CHD.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"9-18"},"PeriodicalIF":2.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solving an enigma in the tree of life, at the origins of teleost fishes. 解开生命之树上的一个谜团--远洋鱼类的起源。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-05 DOI: 10.5802/crbiol.150
Elise Parey, Camille Berthelot, Hugues Roest Crollius, Yann Guiguen
{"title":"Solving an enigma in the tree of life, at the origins of teleost fishes.","authors":"Elise Parey, Camille Berthelot, Hugues Roest Crollius, Yann Guiguen","doi":"10.5802/crbiol.150","DOIUrl":"10.5802/crbiol.150","url":null,"abstract":"<p><p>Tracing the phylogenetic relationships between species is one of the fundamental objectives of evolutionary biology. Since Charles Darwin's seminal work in the 19th century, considerable progress has been made towards establishing a tree of life that summarises the evolutionary history of species. Nevertheless, substantial uncertainties still remain. Specifically, the relationships at the origins of teleost fishes have been the subject of extensive debate over the last 50 years. This question has major implications for various research fields: there are almost 30,000 species in the teleost group, which includes invaluable model organisms for biomedical, evolutionary and ecological studies. Here, we present the work in which we solved this enigma. We demonstrated that eels are more closely related to bony-tongued fishes than to the rest of teleost fishes. We achieved this by taking advantage of new genomic data and leveraging innovative phylogenetic markers. Notably, in addition to traditional molecular phylogeny methods based on the evolution of gene sequences, we also considered the evolution of gene order along the DNA molecule. We discuss the challenges and opportunities that these new markers represent for the field of molecular phylogeny, and in particular the possibilities they offer for re-examining other controversial branches in the tree of life.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"1-8"},"PeriodicalIF":0.7,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antibiotic resistance: a good example of the "one health" concept]. [抗生素耐药性："同一健康 "理念的典范]。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-01-23 DOI: 10.5802/crbiol.139
Vincent Jarlier
{"title":"[Antibiotic resistance: a good example of the \"one health\" concept].","authors":"Vincent Jarlier","doi":"10.5802/crbiol.139","DOIUrl":"10.5802/crbiol.139","url":null,"abstract":"<p><p>Antibiotic resistance is the direct deleterious consequence of two synergistic causes linked to human activity: the massive use of antibiotics in human and animal health, which leads to the selection of the most resistant bacteria, and the spread of these selected resistant bacteria, directly by cross-transmission within human and animal populations and indirectly via the environment. The \"one health\" concept enables an integrated approach of the various components of the issue, linking human, animal and environmental ecosystems and their dynamics.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139522255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal reproduction by seed of a cultivated hybrid plant: a new perspective for small-scale rice growers. 栽培杂交植物种子的克隆繁殖：小规模水稻种植者的新视角。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-01-11 DOI: 10.5802/crbiol.125
Aurore Vernet, Donaldo Meynard, Emmanuel Guiderdoni
{"title":"Clonal reproduction by seed of a cultivated hybrid plant: a new perspective for small-scale rice growers.","authors":"Aurore Vernet, Donaldo Meynard, Emmanuel Guiderdoni","doi":"10.5802/crbiol.125","DOIUrl":"10.5802/crbiol.125","url":null,"abstract":"<p><p>Transferring an asexual mode of reproduction by seeds (apomixis) to cultivated plants would enable clonal reproduction of heterozygous genotypes such as F1 hybrids with hybrid vigor (heterosis), facilitating their access and multiplication by small-scale growers. Although sources of apomixis and the genetic loci controlling its constituent elements have been identified in wild species, their transfer by crossing to cultivated species has so far been unsuccessful. Here, we have introduced synthetic apomixis in hybrid rice to produce a high (95-100%) frequency of clonal seeds, via the inactivation of three meiotic genes-resulting in unreduced, non-recombined gametes-and the addition of an egg cell parthenogenesis trigger. The genotype and phenotype, including grain quality, of the F1 hybrid are reproduced identically in the clonal apomictic progenies. These results make synthetic apomixis compatible with future use in agriculture.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"346 ","pages":"107-116"},"PeriodicalIF":0.7,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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