Comptes Rendus Biologies最新文献

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IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2025-06-18 DOI: 10.5802/crbiol.178
Vincent Debat, Manuela López-Villavicencio, Violaine Llaurens
{"title":"","authors":"Vincent Debat, Manuela López-Villavicencio, Violaine Llaurens","doi":"10.5802/crbiol.178","DOIUrl":"10.5802/crbiol.178","url":null,"abstract":"<p><p>How do closely related species interact in sympatry? And how do these interactions influence the evolution of their traits and the dynamics of species diversification? In this review, we show how recent research on the evolution of Morpho butterflies contributes to address these questions. We first show how sympatric species have colonized different vertical strata in the neotropical forest and how this divergence has produced cascading adaptive effects on behavioural (flight) but also morphological traits, including wing size, shape and coloration. We then focus on the evolution of peculiar dorsal blue coloration within the genus Morpho. During flight, the blue iridescence produces bright flashes that confuse predators and likely enhance the escape abilities of these butterflies. In turn, predators learn the association between such conspicuous coloration and escaping capacities. Such learning favours the locally abundant colour pattern and promotes the local convergence in sympatric species. However, this tight resemblance also induces sexual interference between mimetic species. Capture-Mark-Recapture data uncovered that mimetic species do not fly at the same hours: competition seems to have driven the divergence in the timing of flight activity between species. Overall, sympatry therefore promotes the intricated evolution of convergent and divergent traits among tightly related species, that jointly facilitate their coexistence. Whether ecological speciation was involved in this evolution is an intriguing open question. At the genomic level, analyses revealed a faster evolution of the sexual chromosome Z as compared to the autosomes, with extensive rearrangements and molecular signals of positive selection: these data thus suggest an important role for the Z chromosome in adaptive evolution in Morpho and possibly in speciation. Paving the way for future research, these various, multilevel studies show that Morpho are not just those showy butterflies in the box: they can also teach us much about evolutionary processes.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"348 ","pages":"137-148"},"PeriodicalIF":0.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolutionary convergences and divergences in sympatric species: Morpho butterflies as a case study. 同域物种的进化趋同与分化:以大闪蝶为例。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2025-06-18 DOI: 10.5802/crbiol.178
Vincent Debat, Manuela López-Villavicencio, Violaine Llaurens
{"title":"Evolutionary convergences and divergences in sympatric species: <i>Morpho</i> butterflies as a case study.","authors":"Vincent Debat, Manuela López-Villavicencio, Violaine Llaurens","doi":"10.5802/crbiol.178","DOIUrl":"10.5802/crbiol.178","url":null,"abstract":"<p><p>How do closely related species interact in sympatry? And how do these interactions influence the evolution of their traits and the dynamics of species diversification? In this review, we show how recent research on the evolution of Morpho butterflies contributes to address these questions. We first show how sympatric species have colonized different vertical strata in the neotropical forest and how this divergence has produced cascading adaptive effects on behavioural (flight) but also morphological traits, including wing size, shape and coloration. We then focus on the evolution of peculiar dorsal blue coloration within the genus Morpho. During flight, the blue iridescence produces bright flashes that confuse predators and likely enhance the escape abilities of these butterflies. In turn, predators learn the association between such conspicuous coloration and escaping capacities. Such learning favours the locally abundant colour pattern and promotes the local convergence in sympatric species. However, this tight resemblance also induces sexual interference between mimetic species. Capture-Mark-Recapture data uncovered that mimetic species do not fly at the same hours: competition seems to have driven the divergence in the timing of flight activity between species. Overall, sympatry therefore promotes the intricated evolution of convergent and divergent traits among tightly related species, that jointly facilitate their coexistence. Whether ecological speciation was involved in this evolution is an intriguing open question. At the genomic level, analyses revealed a faster evolution of the sexual chromosome Z as compared to the autosomes, with extensive rearrangements and molecular signals of positive selection: these data thus suggest an important role for the Z chromosome in adaptive evolution in Morpho and possibly in speciation. Paving the way for future research, these various, multilevel studies show that Morpho are not just those showy butterflies in the box: they can also teach us much about evolutionary processes.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"348 ","pages":"137-148"},"PeriodicalIF":0.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obligate intracellular bacterial pathogens as major players in the metabolic integration of organelles 专性细胞内细菌病原体作为细胞器代谢整合的主要参与者
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2025-06-11 DOI: 10.5802/crbiol.176
Steven Ball, Denis Baurain, Marie Leleu, Ingrid Lafontaine, Ugo Cenci, Christophe Colleoni, Olivier Vallon, Gilbert Greub, Andreas Weber, Debashish Bhattacharya
{"title":"Obligate intracellular bacterial pathogens as major players in the metabolic integration of organelles","authors":"Steven Ball, Denis Baurain, Marie Leleu, Ingrid Lafontaine, Ugo Cenci, Christophe Colleoni, Olivier Vallon, Gilbert Greub, Andreas Weber, Debashish Bhattacharya","doi":"10.5802/crbiol.176","DOIUrl":"10.5802/crbiol.176","url":null,"abstract":"<p><p>Endosymbionts are very common in nature, offering multiple occasions to recapitulate events that have led to the generation of mitochondria and plastids. However, both these organelles are unique because they are thought to derive from two individual events that gave rise to all eukaryotes and the plastids in algae and plants (excluding Paulinella chromatophora), respectively. This review focuses on the differences and similarities existing between extant endosymbionts and the two major endosymbiont derived organelles: the mitochondria and plastids. Emphasis is put on recent developments that point to the major role of intracellular pathogens in the establishment of these organelles. We argue that metabolic integration of bacterial endosymbionts into mitochondria and plastids required an unusually high degree of preadaptation not shared by most extant endosymbionts. We propose that this was achieved by either recruiting intracellular bacterial pathogens as \"helper genomes\" providing needed gene products, or by selecting endosymbionts destined to become organelles directly from such obligate intracellular bacteria.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"348 ","pages":"107-135"},"PeriodicalIF":0.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncovering the mechanisms of sexual differentiation: insights from Drosophila research. 揭示性别分化的机制:来自果蝇研究的见解。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2025-06-04 DOI: 10.5802/crbiol.177
Bruno Hudry
{"title":"Uncovering the mechanisms of sexual differentiation: insights from <i>Drosophila</i> research.","authors":"Bruno Hudry","doi":"10.5802/crbiol.177","DOIUrl":"https://doi.org/10.5802/crbiol.177","url":null,"abstract":"<p><p>The differences between males and females represent the largest phenotypic dimorphism observed in most species. In humans, this variation contributes to disparities in the risk, incidence, and treatment responses for numerous diseases, with many of these significant differences remaining unexplained. While hormones derived from sex organs play critical roles in shaping and maintaining certain sex differences, recent research using the Drosophila model underscores the significance of cell-intrinsic mechanisms linked to the sex chromosomes.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"348 ","pages":"89-105"},"PeriodicalIF":0.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use and dual use of synthetic biology. 合成生物学的使用和双重使用。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2025-03-07 DOI: 10.5802/crbiol.173
Antoine Danchin
{"title":"Use and dual use of synthetic biology.","authors":"Antoine Danchin","doi":"10.5802/crbiol.173","DOIUrl":"10.5802/crbiol.173","url":null,"abstract":"<p><p>A brief history of the field shows that the impression of novelty we have today when we talk about synthetic biology is merely the sign of a rapid loss of memory of the events surrounding its creation. The dangers of misuse were identified even before the first experiments, but this has not led to a shared awareness. Building a cell ab initio involves combining a machine (called a chassis by specialists in the field) and a program in the form of synthetic DNA. Only the latter—the program—is the subject of the vast majority of work in the field, and it is there that the risks of misuse appear. Combined with knowledge of the genomic sequence of pathogens, DNA synthesis makes it possible to reconstitute dangerous organisms or even to develop new ways of propagating malicious software. Finally, the lack of thought given to the risk of accidents when laboratories develop gain-of-function experiments that increase the virulence of a pathogen makes a world where this type of experiments is developed particularly dangerous.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"348 ","pages":"71-88"},"PeriodicalIF":0.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Socio-ecological restoration, a concrete transposition of the normative concept of nature-based solutions?] [社会生态恢复,基于自然的解决方案的规范概念的具体转换?]
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2025-03-05 DOI: 10.5802/crbiol.175
Nathalie Frascaria-Lacoste, Pierre-Antoine Versini, Chloé Duffaut, Juan Fernández-Manjarrés
{"title":"[Socio-ecological restoration, a concrete transposition of the normative concept of nature-based solutions?]","authors":"Nathalie Frascaria-Lacoste, Pierre-Antoine Versini, Chloé Duffaut, Juan Fernández-Manjarrés","doi":"10.5802/crbiol.175","DOIUrl":"10.5802/crbiol.175","url":null,"abstract":"<p><p>“Nature-based solutions” (NBS) are now widely referred to as a way of making anthropized ecosystems more sustainable. NBS stems from the principles of ecological engineering as conceptualized by H. T. Odum. Odum (1962), based on an approach centered on energy flows and ecosystem self-regulation. Despite their growing popularity, the implementation of these NBS remains complex and often focused solely on societal benefits, with little benefit to biodiversity.\u0000\u0000The current climate and ecological crisis calls for a reconsideration of our relationship with nature, integrating both social and ecological objectives in a new mobilization of societies and ecosystems in crisis. This is what is advocated by socio-ecological restoration, a recent concept developed during the reconstruction of coastal cities after the 2011 tsunami in Japan. This concept proposes the joint repair of ecosystems and human social cohesion, using elements of the ecosystem taken as historical landmarks before disturbance, enabling a local anchoring to regain a viable social and ecological trajectory. Socio-ecological restoration is not a classic program activity, but a social process in which several actors get involved by relying on each other, without using the expression itself.\u0000\u0000We propose to generalize this socio-ecological restoration, beyond post-disaster or post-conflict situations, to modify development practices and create real synergies between living humans and non-humans. In this respect, we use the reopening of the Bièvre River in the Paris region as an example of relevant socio-ecological restoration, because it involves the local community and responds to ecological issues. In conclusion, we make five recommendations for adapting the principles of socio-ecological restoration to the implementation of NBS, with a view to making not only our environments more resilient in the face of global change, but also those environments that concern the entire non-human living world and are often overlooked in field practices. By opting for a more eco-centric approach, NBSs could be in line with the IUCN’s initial definition, ultimately becoming Solutions Based For and By Nature, in line with the challenges of an effective ecological transition in the field.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"348 ","pages":"55-69"},"PeriodicalIF":0.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A possible role for epigenetics in cancer initiation. 表观遗传学在癌症发生中的可能作用。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2025-02-25 DOI: 10.5802/crbiol.171
Anne-Marie Martinez, Giacomo Cavalli
{"title":"A possible role for epigenetics in cancer initiation.","authors":"Anne-Marie Martinez, Giacomo Cavalli","doi":"10.5802/crbiol.171","DOIUrl":"10.5802/crbiol.171","url":null,"abstract":"<p><p>Cancer is one of the leading causes of mortality worldwide. Known since antiquity, its understanding has evolved over time and has significantly advanced with new technologies over the past four decades. Cancer initiation is currently admitted to be explainable by the somatic mutation theory, which postulates that DNA mutations altering the function of oncogenes and tumor suppressor genes initiate cancer. In addition to these mutations, epigenetic alterations, which heritably change gene expression without altering the DNA sequence, also play a key role. Recent data suggests that epigenetic components regulate all aspects of tumor progression, including cancer initiation. These discoveries prompt a reevaluation of the somatic mutation theory, of cancer prevention and treatment strategies.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"348 ","pages":"43-53"},"PeriodicalIF":0.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The diversification of the protein kinase R contributes to the specificity of bat-virus interactions]. [蛋白激酶R的多样化有助于蝙蝠与病毒相互作用的特异性]。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2025-02-25 DOI: 10.5802/crbiol.170
Stéphanie Jacquet, Dominique Pontier, Lucie Etienne
{"title":"[The diversification of the protein kinase R contributes to the specificity of bat-virus interactions].","authors":"Stéphanie Jacquet, Dominique Pontier, Lucie Etienne","doi":"10.5802/crbiol.170","DOIUrl":"10.5802/crbiol.170","url":null,"abstract":"<p><p>Several bat species asymptomatically harbor certain viruses that are highly pathogenic in other mammals. The underlying mechanisms involve an evolutionary balance between tolerance and immune resistance to viral infections. However, how bats innate immunity has evolved in response to viruses remains to be elucidated. Here, we review the evolution of the protein kinase R (PKR) in bats, a major antiviral protein of vertebrate innate antiviral defense. Our recent results indicate that PKR has evolved under selective pressure and has undergone genomic duplications in bats, in contrast to all mammals studied, which possess only a single copy of the gene. The genetic changes in bat PKR are probably partly the result of genetic conflicts with ancient pathogenic poxviruses, shaping a bat-specific host–virus interface. Furthermore, the duplicated PKRs in Myotis species enable them to collectively escape viruses and enhance their viral control. These results suggest that viral adaptations of PKR contribute to the specificity of modern interactions between viruses and bats, and may explain unique antiviral mechanisms in bats.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"348 ","pages":"35-41"},"PeriodicalIF":0.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Parkinson's disease: from genetics to targeted therapies]. [帕金森氏症:从遗传学到靶向治疗]。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2025-02-13 DOI: 10.5802/crbiol.174
Guillaume Cogan, Alexis Brice
{"title":"[Parkinson's disease: from genetics to targeted therapies].","authors":"Guillaume Cogan, Alexis Brice","doi":"10.5802/crbiol.174","DOIUrl":"10.5802/crbiol.174","url":null,"abstract":"<p><p>Parkinson’s disease (PD) is a multifactorial disorder involving various biological pathways. However, it is more accurate not to define PD as a unique entity, but rather as a mixture of several diseases with similar phenotypes. Attempts to classify subtypes of PD based on the clinical phenotype or biomarkers were tried. Nonetheless, for a subset of individuals, the classification based on the implied gene appears to be the most practical. Although the SNCA gene was the first identified in rare patients, pathogenic variants in GBA1 and LRRK2 are the most common genetic causes or risk factors of PD, and PRKN is the most frequent gene of autosomal recessive PD. Patients with pathogenic variants in SNCA, GBA1, LRRK2 or PRKN show various clinical, anatomopathological and biochemical aspects. Therefore, these four genes associated to PD are of particular interest for the development of targeted therapies. This fact is reinforced by the reality that current approaches are only symptomatic, and no curative treatment is available today. A number of clinical trials aiming to slow or stop disease progression are running, based on the gene involved. In this review, we will discuss the therapeutic approaches targeting SNCA, GBA1, LRRK2 and PRKN.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"348 ","pages":"21-33"},"PeriodicalIF":0.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Anthropocene and the biodiversity crisis: an eco-evolutionary perspective. 人类世与生物多样性危机:生态进化的视角。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2025-01-09 DOI: 10.5802/crbiol.172
Philippe Jarne
{"title":"The Anthropocene and the biodiversity crisis: an eco-evolutionary perspective.","authors":"Philippe Jarne","doi":"10.5802/crbiol.172","DOIUrl":"10.5802/crbiol.172","url":null,"abstract":"<p><p>A major facet of the Anthropocene is global change, such as climate change, caused by human activities, which drastically affect biodiversity with all-scale declines and homogenization of biotas. This crisis does not only affect the ecological dynamics of biodiversity, but also its evolutionary dynamics, including genetic diversity, an aspect that is generally neglected. My tenet is therefore to consider biodiversity dynamics from an eco-evolutionary perspective, i.e. explicitly accounting for the possibility of rapid evolution and its feedback on ecological processes and the environment. I represent the impact of the various avatars of global change in a temporal perspective, from pre-industrial time to the near future, allowing to visualize their dynamics and to set desired values that should not be trespassed for a given time (e.g., +2 °C for 50 years from now). After presenting the impact of various stressors (e.g., climate change) on biodiversity, this representation is used to heuristically show the relevance of an eco-evolutionary perspective: (i) to analyze how biodiversity will respond to the stressors, for example by seeking out more suitable conditions or adapting to new conditions; (ii) to serve in predictive exercises to envision future dynamics (decades to centuries) under stressor impact; (iii) to propose nature-based solutions to the crisis. Significant obstacles stand in the way of the development of such an approach, in particular the general lack of interest in intraspecific diversity, and perhaps more generally a lack of understanding that, we, humans, are only a modest part of biodiversity.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"348 ","pages":"1-20"},"PeriodicalIF":0.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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