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The dangerous biology of pathogenic germs. 病原菌的危险生物学
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-09-19 DOI: 10.5802/crbiol.157
Patrick Berche
{"title":"The dangerous biology of pathogenic germs.","authors":"Patrick Berche","doi":"10.5802/crbiol.157","DOIUrl":"10.5802/crbiol.157","url":null,"abstract":"","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"77-86"},"PeriodicalIF":0.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shedding light on the unseen: how live imaging of translation could unlock new insights in developmental biology. 揭示看不见的世界：翻译的实时成像如何开启发育生物学的新视角。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-09-11 DOI: 10.5802/crbiol.158
Jeremy Dufourt, Maelle Bellec
{"title":"Shedding light on the unseen: how live imaging of translation could unlock new insights in developmental biology.","authors":"Jeremy Dufourt, Maelle Bellec","doi":"10.5802/crbiol.158","DOIUrl":"https://doi.org/10.5802/crbiol.158","url":null,"abstract":"","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"87-93"},"PeriodicalIF":0.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tribute to Roger Guillemin, a pioneer in neuroendocrinology (1924-2024), Nobel Prize in Physiology or Medicine. 向诺贝尔生理学或医学奖获得者、神经内分泌学先驱罗杰-吉列明（1924-2024 年）致敬。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-08-27 DOI: 10.5802/crbiol.156
Christiane Mougin, Jean Rossier, Bertrand Bloch
{"title":"Tribute to Roger Guillemin, a pioneer in neuroendocrinology (1924-2024), Nobel Prize in Physiology or Medicine.","authors":"Christiane Mougin, Jean Rossier, Bertrand Bloch","doi":"10.5802/crbiol.156","DOIUrl":"10.5802/crbiol.156","url":null,"abstract":"<p><p>Roger Guillemin discovered and characterized the hypothalamic factors that control anterior pituitary functions. He consequently demonstrated that these brain peptides regulate a large number of major body activities through neuroendocrine mechanisms. This especially include growth, fertility and reproduction, endocrine gland functions and stress. These seminal works paved the way to major applications in many fields of physiology and medicine for diagnosis, pharmacology and therapy, far beyond the initial discovery and properties of these molecules, including in cancerology, immunology, inflammation, drug addiction and behavior.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"53-58"},"PeriodicalIF":0.7,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mitohormesis: a key driver of the therapy resistance in cancer cells]. [丝裂细胞生成：癌细胞耐药性的关键驱动因素】。］
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-08-22 DOI: 10.5802/crbiol.154
Emeline Boët, Estelle Saland, Sarah Skuli, Emmanuel Griessinger, Jean-Emmanuel Sarry
{"title":"[<i>Mitohormesis</i>: a key driver of the therapy resistance in cancer cells].","authors":"Emeline Boët, Estelle Saland, Sarah Skuli, Emmanuel Griessinger, Jean-Emmanuel Sarry","doi":"10.5802/crbiol.154","DOIUrl":"https://doi.org/10.5802/crbiol.154","url":null,"abstract":"<p><p>A large body of literature highlights the importance of energy metabolism in the response of haematological malignancies to therapy. In this review, we are particularly interested in acute myeloid leukaemia, where mitochondrial metabolism plays a key role in response and resistance to treatment. We describe the new concept of mitohormesis in the response to therapy-induced stress and in the initiation of relapse in this disease.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"59-75"},"PeriodicalIF":0.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the maternal inheritance transmitted by the oocyte to its progeny. 探索卵母细胞传给后代的母性遗传。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-06-18 DOI: 10.5802/crbiol.155
Marie-Hélène Verlhac
{"title":"Exploring the maternal inheritance transmitted by the oocyte to its progeny.","authors":"Marie-Hélène Verlhac","doi":"10.5802/crbiol.155","DOIUrl":"10.5802/crbiol.155","url":null,"abstract":"<p><p>Fertility is declining worldwide and many couples are turning towards assisted reproductive technologies (ART) to conceive babies. Organisms that propagate via sexual reproduction often come from the fusion between two gametes, an oocyte and a sperm, whose qualities seem to be decreasing in the human species. Interestingly, while the sperm mostly transmits its haploid genome, the oocyte transmits not only its haploid set of chromosomes but also its huge cytoplasm to its progeny. This is what can be defined as the maternal inheritance composed of chromosomes, organelles, lipids, metabolites, proteins and RNAs. To decipher the decline in oocyte quality, it is essential to explore the nature of the maternal inheritance, and therefore study the last stages of murine oogenesis, namely the end of oocyte growth followed by the two meiotic divisions. These divisions are extremely asymmetric in terms of the size of the daughter cells, allowing to preserve the maternal inheritance accumulated during oocyte growth within these huge cells to support early embryo development. Studies performed in Marie-Hélène Verlhac's lab have allowed to discover the unprecedented impact of original acto-myosin based mechanisms in the constitution as well as the preservation of this maternal inheritance and the consequences when these processes go awry.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"45-52"},"PeriodicalIF":0.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology. 植物定量免疫的分子复杂性：从 QTL 图谱到功能和系统生物学。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-05-21 DOI: 10.5802/crbiol.153
Carine Chauveau, Dominique Roby
{"title":"Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology.","authors":"Carine Chauveau, Dominique Roby","doi":"10.5802/crbiol.153","DOIUrl":"https://doi.org/10.5802/crbiol.153","url":null,"abstract":"<p><p>In nature, plants defend themselves against pathogen attack by activating an arsenal of defense mechanisms. During the last decades, work mainly focused on the understanding of qualitative disease resistance mediated by a few genes conferring an almost complete resistance, while quantitative disease resistance (QDR) remains poorly understood despite the fact that it represents the predominant and more durable form of resistance in natural populations and crops. Here, we review our past and present work on the dissection of the complex mechanisms underlying QDR in Arabidopsis thaliana. The strategies, main steps and challenges of our studies related to one atypical QDR gene, RKS1 (Resistance related KinaSe 1), are presented. First, from genetic analyses by QTL (Quantitative Trait Locus) mapping and GWAs (Genome Wide Association studies), the identification, cloning and functional analysis of this gene have been used as a starting point for the exploration of the multiple and coordinated pathways acting together to mount the QDR response dependent on RKS1. Identification of RKS1 protein interactors and complexes was a first step, systems biology and reconstruction of protein networks were then used to decipher the molecular roadmap to the immune responses controlled by RKS1. Finally, exploration of the potential impact of key components of the RKS1-dependent gene network on leaf microbiota offers interesting and challenging perspectives to decipher how the plant immune systems interact with the microbial communities' systems.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"35-44"},"PeriodicalIF":2.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[What Charles Darwin owed to Joseph Banks]. [查尔斯-达尔文欠约瑟夫-班克斯的】。］
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-05-13 DOI: 10.5802/crbiol.152
Hervé Le Guyader
{"title":"[What Charles Darwin owed to Joseph Banks].","authors":"Hervé Le Guyader","doi":"10.5802/crbiol.152","DOIUrl":"https://doi.org/10.5802/crbiol.152","url":null,"abstract":"<p><p>History has remembered Joseph Banks as the explorer-botanist of the first voyage of James Cook. Yet, shortly after his return, he got elected president of the Royal Society and, for over 40 years, he then played in Great Britain an eminent role in reorganizing natural sciences and advocating an \"economic botany\". He actively intervened in acclimatization and varietal selection of plants and animals in Great Britain as in the future English colonies. Thus he built an intellectual environment which will promote the emergence of Charles Darwin's thoughts.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":"347 ","pages":"27-33"},"PeriodicalIF":2.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Messenger RNA in differentiating muscle cells-my experience in François Gros' lab in the 1970s and 80s. 分化肌肉细胞中的信使核糖核酸--20 世纪 70 年代和 80 年代我在弗朗索瓦-格罗斯（François Gros）实验室的经历。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.132
Margaret Buckingham
{"title":"Messenger RNA in differentiating muscle cells-my experience in François Gros' lab in the 1970s and 80s.","authors":"Margaret Buckingham","doi":"10.5802/crbiol.132","DOIUrl":"10.5802/crbiol.132","url":null,"abstract":"<p><p>I joined François Gros' laboratory as a postdoc at the end of 1971 and continued working with him as a research scientist until 1987, when I became an independent group leader at the Institut Pasteur. In the early 1970s, it was the beginning of research in his lab on muscle cell differentiation, as a model eukaryotic system for studying mRNAs and gene regulation. In this article, I recount our work on myogenesis and mention the other research themes in his lab and the people concerned. I remained in close contact with François and pay tribute to him as a major figure in French science and as my personal mentor who provided me with constant support.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"27-35"},"PeriodicalIF":2.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[François Gros, Permanent Secretary of the French Academy of Sciences]. [弗朗索瓦-格罗斯，法国科学院常务秘书]。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.144
Jean-François Bach
{"title":"[François Gros, Permanent Secretary of the French Academy of Sciences].","authors":"Jean-François Bach","doi":"10.5802/crbiol.144","DOIUrl":"10.5802/crbiol.144","url":null,"abstract":"<p><p>François Gros was Permanent Secretary of the French Academy of Sciences from 1991 to 2000. His immense scientific knowledge, his tireless efforts to develop international relations, particularly with developing countries, and his exceptional personality have greatly contributed to the modernisation and influence of the Academy.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"91-93"},"PeriodicalIF":0.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tracking transfers of resistance-carrying bacteria between animals, humans and the environment]. [追踪携带抗药性的细菌在动物、人类和环境之间的转移]。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.114
Sylvain Meyer, Lucie Laval, Mélanie Pimenta, Yolanda González-Flores, Margaux Gaschet, Elodie Couvé-Deacon, Olivier Barraud, Christophe Dagot, Marie-Cécile Ploy
{"title":"[Tracking transfers of resistance-carrying bacteria between animals, humans and the environment].","authors":"Sylvain Meyer, Lucie Laval, Mélanie Pimenta, Yolanda González-Flores, Margaux Gaschet, Elodie Couvé-Deacon, Olivier Barraud, Christophe Dagot, Marie-Cécile Ploy","doi":"10.5802/crbiol.114","DOIUrl":"10.5802/crbiol.114","url":null,"abstract":"<p><p>The fight against antibiotic resistance must incorporate the \"One Health\" concept to be effective. This means having a holistic approach embracing the different ecosystems, human, animal, and environment. Transfers of resistance genes may exist between these three domains and different stresses related to the exposome may influence these transfers. Various targeted or pan-genomic molecular biology techniques can be used to better characterise the dissemination of bacterial clones and to identify exchanges of genes and mobile genetic elements between ecosystems.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":" ","pages":"13-15"},"PeriodicalIF":2.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10484320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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