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Exploring the maternal inheritance transmitted by the oocyte to its progeny. 探索卵母细胞传给后代的母性遗传。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-06-18 DOI: 10.5802/crbiol.155
Marie-Hélène Verlhac
{"title":"Exploring the maternal inheritance transmitted by the oocyte to its progeny.","authors":"Marie-Hélène Verlhac","doi":"10.5802/crbiol.155","DOIUrl":"10.5802/crbiol.155","url":null,"abstract":"<p><p>Fertility is declining worldwide and many couples are turning towards assisted reproductive technologies (ART) to conceive babies. Organisms that propagate via sexual reproduction often come from the fusion between two gametes, an oocyte and a sperm, whose qualities seem to be decreasing in the human species. Interestingly, while the sperm mostly transmits its haploid genome, the oocyte transmits not only its haploid set of chromosomes but also its huge cytoplasm to its progeny. This is what can be defined as the maternal inheritance composed of chromosomes, organelles, lipids, metabolites, proteins and RNAs. To decipher the decline in oocyte quality, it is essential to explore the nature of the maternal inheritance, and therefore study the last stages of murine oogenesis, namely the end of oocyte growth followed by the two meiotic divisions. These divisions are extremely asymmetric in terms of the size of the daughter cells, allowing to preserve the maternal inheritance accumulated during oocyte growth within these huge cells to support early embryo development. Studies performed in Marie-Hélène Verlhac's lab have allowed to discover the unprecedented impact of original acto-myosin based mechanisms in the constitution as well as the preservation of this maternal inheritance and the consequences when these processes go awry.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology. 植物定量免疫的分子复杂性：从 QTL 图谱到功能和系统生物学。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-05-21 DOI: 10.5802/crbiol.153
Carine Chauveau, Dominique Roby
{"title":"Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology.","authors":"Carine Chauveau, Dominique Roby","doi":"10.5802/crbiol.153","DOIUrl":"https://doi.org/10.5802/crbiol.153","url":null,"abstract":"<p><p>In nature, plants defend themselves against pathogen attack by activating an arsenal of defense mechanisms. During the last decades, work mainly focused on the understanding of qualitative disease resistance mediated by a few genes conferring an almost complete resistance, while quantitative disease resistance (QDR) remains poorly understood despite the fact that it represents the predominant and more durable form of resistance in natural populations and crops. Here, we review our past and present work on the dissection of the complex mechanisms underlying QDR in Arabidopsis thaliana. The strategies, main steps and challenges of our studies related to one atypical QDR gene, RKS1 (Resistance related KinaSe 1), are presented. First, from genetic analyses by QTL (Quantitative Trait Locus) mapping and GWAs (Genome Wide Association studies), the identification, cloning and functional analysis of this gene have been used as a starting point for the exploration of the multiple and coordinated pathways acting together to mount the QDR response dependent on RKS1. Identification of RKS1 protein interactors and complexes was a first step, systems biology and reconstruction of protein networks were then used to decipher the molecular roadmap to the immune responses controlled by RKS1. Finally, exploration of the potential impact of key components of the RKS1-dependent gene network on leaf microbiota offers interesting and challenging perspectives to decipher how the plant immune systems interact with the microbial communities' systems.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[What Charles Darwin owed to Joseph Banks]. [查尔斯-达尔文欠约瑟夫-班克斯的】。］
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-05-13 DOI: 10.5802/crbiol.152
Hervé Le Guyader
{"title":"[What Charles Darwin owed to Joseph Banks].","authors":"Hervé Le Guyader","doi":"10.5802/crbiol.152","DOIUrl":"https://doi.org/10.5802/crbiol.152","url":null,"abstract":"<p><p>History has remembered Joseph Banks as the explorer-botanist of the first voyage of James Cook. Yet, shortly after his return, he got elected president of the Royal Society and, for over 40 years, he then played in Great Britain an eminent role in reorganizing natural sciences and advocating an \"economic botany\". He actively intervened in acclimatization and varietal selection of plants and animals in Great Britain as in the future English colonies. Thus he built an intellectual environment which will promote the emergence of Charles Darwin's thoughts.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome. 多囊卵巢综合征（PCOS）：在更好地了解和治疗该综合征方面取得的进展。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-04-19 DOI: 10.5802/crbiol.147
N. Mimouni, P. Giacobini
{"title":"Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome.","authors":"N. Mimouni, P. Giacobini","doi":"10.5802/crbiol.147","DOIUrl":"https://doi.org/10.5802/crbiol.147","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in women of reproductive age. It has a strong hereditary component estimated at 60 to 70% in daughters. It has been suggested that environmental factors during the fetal period may be involved in the development of the syndrome in adulthood. However, the underlying mechanisms of its transmission remain unknown, thus limiting the development of effective therapeutic strategies.This article highlights how an altered fetal environment (prenatal exposure to high levels of anti-Müllerian hormone) can contribute to the onset of PCOS in adulthood and lead to the transgenerational transmission of neuroendocrine and metabolic traits through alterations in the DNA methylation process.The originality of the translational findings summarized here involves the identification of potential biomarkers for early diagnosis of the syndrome, in addition to the validation of a promising therapeutic avenue in a preclinical model of PCOS, which can improve the management of patients suffering from the syndrome.","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140682676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Development of antibiotic resistance in animals not receiving antibiotic therapy]. [未接受抗生素治疗的动物产生抗药性]。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.116
Jean-Yves Madec
{"title":"[Development of antibiotic resistance in animals not receiving antibiotic therapy].","authors":"Jean-Yves Madec","doi":"10.5802/crbiol.116","DOIUrl":"10.5802/crbiol.116","url":null,"abstract":"<p><p>The fight against antibiotic resistance in the animal sector over the last ten years in France (Ecoantibio plans) has largely focused on reducing the veterinary use of antibiotics. However, antibiotic resistance in an animal is not necessarily due to antibiotic therapy, but can also result from the transmission of resistant bacteria or resistance plasmids. Several examples illustrate the importance of this transmission of antibiotic resistance in the animal world, which are detailed in this communication. Like in human medicine, this nosocomial transmission can be observed in veterinary care institutions, as well as in animal husbandry. It also explains the presence of antibiotic resistance on the surface of foodstuffs, which by definition are not treated with antibiotics. At the international level, countries that are very virtuous in their use of veterinary antibiotics can display high levels of antibiotic resistance through the importation of carrier animals. Finally, the presence of antibiotic resistance in wildlife is likewise explained by contamination and not by antibiotic treatment. All these situations demonstrate that, in addition to paying attention to antibiotic prescription, an equally important facet of the fight against antibiotic resistance is to control the transmission routes of resistant bacteria.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10503018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Messenger RNA in differentiating muscle cells-my experience in François Gros' lab in the 1970s and 80s. 分化肌肉细胞中的信使核糖核酸--20 世纪 70 年代和 80 年代我在弗朗索瓦-格罗斯（François Gros）实验室的经历。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.132
Margaret Buckingham
{"title":"Messenger RNA in differentiating muscle cells-my experience in François Gros' lab in the 1970s and 80s.","authors":"Margaret Buckingham","doi":"10.5802/crbiol.132","DOIUrl":"10.5802/crbiol.132","url":null,"abstract":"<p><p>I joined François Gros' laboratory as a postdoc at the end of 1971 and continued working with him as a research scientist until 1987, when I became an independent group leader at the Institut Pasteur. In the early 1970s, it was the beginning of research in his lab on muscle cell differentiation, as a model eukaryotic system for studying mRNAs and gene regulation. In this article, I recount our work on myogenesis and mention the other research themes in his lab and the people concerned. I remained in close contact with François and pay tribute to him as a major figure in French science and as my personal mentor who provided me with constant support.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tracking transfers of resistance-carrying bacteria between animals, humans and the environment]. [追踪携带抗药性的细菌在动物、人类和环境之间的转移]。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.114
Sylvain Meyer, Lucie Laval, Mélanie Pimenta, Yolanda González-Flores, Margaux Gaschet, Elodie Couvé-Deacon, Olivier Barraud, Christophe Dagot, Marie-Cécile Ploy
{"title":"[Tracking transfers of resistance-carrying bacteria between animals, humans and the environment].","authors":"Sylvain Meyer, Lucie Laval, Mélanie Pimenta, Yolanda González-Flores, Margaux Gaschet, Elodie Couvé-Deacon, Olivier Barraud, Christophe Dagot, Marie-Cécile Ploy","doi":"10.5802/crbiol.114","DOIUrl":"10.5802/crbiol.114","url":null,"abstract":"<p><p>The fight against antibiotic resistance must incorporate the \"One Health\" concept to be effective. This means having a holistic approach embracing the different ecosystems, human, animal, and environment. Transfers of resistance genes may exist between these three domains and different stresses related to the exposome may influence these transfers. Various targeted or pan-genomic molecular biology techniques can be used to better characterise the dissemination of bacterial clones and to identify exchanges of genes and mobile genetic elements between ecosystems.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10484320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[François Gros, Permanent Secretary of the French Academy of Sciences]. [弗朗索瓦-格罗斯，法国科学院常务秘书]。
IF 0.7 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.144
Jean-François Bach
{"title":"[François Gros, Permanent Secretary of the French Academy of Sciences].","authors":"Jean-François Bach","doi":"10.5802/crbiol.144","DOIUrl":"10.5802/crbiol.144","url":null,"abstract":"<p><p>François Gros was Permanent Secretary of the French Academy of Sciences from 1991 to 2000. His immense scientific knowledge, his tireless efforts to develop international relations, particularly with developing countries, and his exceptional personality have greatly contributed to the modernisation and influence of the Academy.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[François Gros: an intelligent, kind-hearted man who couldn't say no]. [弗朗索瓦-格罗斯：一个聪明、善良、不会拒绝的人]。
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.133
Marie-Hélène Buc
{"title":"[François Gros: an intelligent, kind-hearted man who couldn't say no].","authors":"Marie-Hélène Buc","doi":"10.5802/crbiol.133","DOIUrl":"10.5802/crbiol.133","url":null,"abstract":"<p><p>Here I recall some privileged moments in my interactions with François: when he helped me obtain a grant for an NGO; when I participated in the work of COPED; when I returned to hospital medicine, his support for writing and publishing books that give patients a voice.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[François Gros, my boss]. [弗朗索瓦-格罗斯，我的老板]
IF 2 4区 生物学
Comptes Rendus Biologies Pub Date : 2024-03-29 DOI: 10.5802/crbiol.128
Michel Elie Goldberg
{"title":"[François Gros, my boss].","authors":"Michel Elie Goldberg","doi":"10.5802/crbiol.128","DOIUrl":"10.5802/crbiol.128","url":null,"abstract":"<p><p>This article shares the author's memories of his collaborations with François Gros when the latter was Professor at the University of Paris 7, then Director of the Institut Pasteur, then President of the Pasteur-Weizmann Council. He underlines the major contributions of \"his boss\" in the exercise of these functions.</p>","PeriodicalId":55231,"journal":{"name":"Comptes Rendus Biologies","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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