Critical Reviews in Immunology最新文献

TREM2 in Regulating Macrophage Inflammatory Responses and Disease Pathogenesis TREM2 在调节巨噬细胞炎症反应和疾病发病机制中的作用

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-08-01 DOI: 10.1615/critrevimmunol.2024054889

Milan Medd

引用次数: 0

Commentary: Ovarian cancer; path to effective treatments 评论：卵巢癌；通往有效治疗之路

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-06-01 DOI: 10.1615/critrevimmunol.2024053766

Anahid Jewett, Sanaz Memarzadeh, Kawaljit Kaur

{"title":"Commentary: Ovarian cancer; path to effective treatments","authors":"Anahid Jewett, Sanaz Memarzadeh, Kawaljit Kaur","doi":"10.1615/critrevimmunol.2024053766","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024053766","url":null,"abstract":"Despite advancements in cancer therapeutics such as checkpoint inhibitors and some targeted therapies, we have not achieved success in effectively treating ovarian cancer, since these therapeutics only benefit a subset of patients, and also provide short-term protection or cure. The use of chemotherapy and radiation therapy can cause depletion and/or lack of immune cells’ function. CAR-T therapy is found effective against several blood-based cancers, but limited success was seen against solid tumors. Targeting fewer antigens and significant side effects of therapy decreases the efficacy of CAR-T cells as immunotherapeutic in solid tumors, even though there is a great drive and significant effort to establish these therapies around the world. Bispecific and tri-specific antibodies have recently been advocated as effective cancer therapeutics. However, these also suffer the fate of CAR-Ts since the loss of antigen on tumor cells will render these therapeutics ineffective. At the moment we should design therapeutics that may have synergistic effects on killing/treating tumors. The only way we can establish that will be by learning the mechanisms of actions of immune therapeutics. Thus, advancement in the knowledge and effective strategies are required to develop cancer immuno-therapeutics","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141253595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N6-methyladenosine (m6A) reader LRPPRC-mediated CXCL11 induces cell inflammation to drive breast cancer cell malignancy N6-甲基腺苷（m6A）阅读器 LRPPRC 介导的 CXCL11 可诱导细胞发炎，从而促使乳腺癌细胞恶变

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-06-01 DOI: 10.1615/critrevimmunol.2024053166

Qing Li, Changchun Zhang, Li Li

{"title":"N6-methyladenosine (m6A) reader LRPPRC-mediated CXCL11 induces cell inflammation to drive breast cancer cell malignancy","authors":"Qing Li, Changchun Zhang, Li Li","doi":"10.1615/critrevimmunol.2024053166","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024053166","url":null,"abstract":"Background: Breast cancer (BC) is among the most prevalent malignant cancers in women. This paper proposed to investigate the function as well as the regulatory mechanism of N6-methyladenosine (m6A) reader leucine rich pentatricopeptide repeat containing (LRPPRC) in BC inflammation and progression.\u0000Methods: The levels of LRPPRC and C-X-C motif chemokine ligand 11 (CXCL11) were detected via qRT-PCR. The regulatory mechanisms between LRPPRC and CXCL11 were investigated by RIP, MeRIP, and mRNA stability experiments. Moreover, the bio-functions of LRPPRC and CXCL11 in BC cells were explored through the CCK8, wound healing, Transwell assays. ELISA was utilized to evaluate pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) levels.\u0000Results: LRPPRC had a considerably higher level in BC samples than in healthy samples, and LRPPRC overexpression predicted poor prognosis. LRPPRC lowexpression diminished BC cell viability, migration, and invasion, whereas overexpression facilitated malignancy. LRPPRC exerted its stimulative effect through CXCL11 m6A modification. CXCL11 upregulating suppressed the LRPPRC silencing’s antitumor effect on BC cells malignancy. CXCL11 upregulation enhances inflammatory factors secretion by BC cells.\u0000Conclusion: This study demonstrated that LRPPRC aggravated BC inflammation and malignancy by upregulating m6A modification of CXCL11. These findings offered a potential to be a target for BC patients’ therapy.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141505469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The SLE Conundrum: A Comprehensive Analysis of Pathogenesis, Re-cent Developments, and the Future of Therapeutic Interventions 系统性红斑狼疮的难题：发病机理、最新进展和未来治疗干预的全面分析

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI: 10.1615/critrevimmunol.2024053504

Uddeshya Sharma

引用次数: 0

The effect of supplementation of vitamin D on hyperlipidemia and bone mass in the pediatric with obesity 补充维生素 D 对小儿肥胖症患者高脂血症和骨量的影响

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI: 10.1615/critrevimmunol.2024052129

Feifan Wang, Lingshan Bei, Xiaoyan Zhang, Yangxi Fu

{"title":"The effect of supplementation of vitamin D on hyperlipidemia and bone mass in the pediatric with obesity","authors":"Feifan Wang, Lingshan Bei, Xiaoyan Zhang, Yangxi Fu","doi":"10.1615/critrevimmunol.2024052129","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024052129","url":null,"abstract":"Objective\u0000Vitamin D deficiency is known to be a significant factor in metabolic diseases such as obesity and diabetes. However, there is currently a lack of evidence regarding the effects of vitamin D on hyperlipidemia, glucose metabolism, and bone mass in pediatric patients with obesity.\u0000Methods\u0000Our study aimed to determine the relationship between Serum 25(OH)D and metabolic syndrome, as well as investigate the effect of Vitamin D3 supplementation on hyperlipidemia, glucose metabolism, and bone mass in pediatric patients with obesity. We conducted a cross-sectional study between January 2018 and January 2020, with a total of 723 children invited to participate. Of these, 283 were in the supplemented group (SG) and 440 were in the placebo group (PG). We evaluated blood pressure, fasting glucose, high-density lipoprotein, total cholesterol, low-density lipoprotein, and bone mineral density (BMD) among all subjects.\u0000Results\u0000We found that cholesterol, triglyceride, and glucose levels were strongly associated with 25(OH)D3 levels at baseline. After vitamin D3 supplementation, we observed a significant increase in body mass index (BMI) (P=0.02) and serum 25(OH)D3(P<0.01) levels in the vitamin D3 group compared to the placebo group. Additionally, serum lipids such as total cholesterol(P<0.01), HDL-c(P<0.01), Total cholesterol/HDL-c (P<0.01), LDL-c/HDL-c (P<0.01), Triglycerides/HDL-c(P<0.01) were significantly decreased in the Vit D group compared to the placebo group. Serum 25(OH)D was inversely associated with cholesterol, triglycerides, and fasting glucose.\u0000Conclusion\u0000Our results suggest that vitamin D3 supplementation can enhance the beneficial effect of hyperlipi","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140805052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the mechanism of Isoforskolin against asthma based on network pharmacology and experimental verification 基于网络药理学和实验验证的异佛司可林抗哮喘机制探索

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI: 10.1615/critrevimmunol.2024050244

Yan Fang, Shibo Sun, Chuang Xiao, Min Li, Yuanyuan Zheng, Anju Zu, Zhuang Luo

{"title":"Exploring the mechanism of Isoforskolin against asthma based on network pharmacology and experimental verification","authors":"Yan Fang, Shibo Sun, Chuang Xiao, Min Li, Yuanyuan Zheng, Anju Zu, Zhuang Luo","doi":"10.1615/critrevimmunol.2024050244","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024050244","url":null,"abstract":"Objective: In this study, network pharmacology combined with biological experimental verification was utilized to screen the targets of Isoforskolin (ISOF) and investigate the potential underlying mechanism of ISOF acting on asthma.\u0000Methods: Asthma-related targets were screened from the Genecards and DisGeNET databases. SEA and Super-PRED databases were used to obtain the targets of ISOF. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were employed to identify key targets and enriched regulatory pathways of ISOF acting on asthma. Then, a protein-protein interaction (PPI) network was constructed via STRING database and hub genes of ISOF against asthma were further screened using molecular docking. Finally, CCK-8, qPCR, and western blotting were performed to assess the targets of ISOF in treating asthma.\u0000Results: A total of 96 drug-related-disease targets from the relevant databases were screened out. KEGG pathway enrichment analysis predicted that the target genes might be involved in the PI3K-Akt pathway. The core targets of ISOF in treating asthma were identified by the PPI network and molecular docking, including MAPK1, mTOR, and NFKB1. Consistently, in vitro experiments showed that ISOF acting on asthma was involved in inflammatory response by reducing the expression of MAPK1, mTOR, and NFKB1.\u0000Conclusions: The present study reveals that MAPK1, mTOR, and NFKB1 might be key targets of Isoforskolin in asthma treatment and the anti-asthma effect might be related to the PI3K-AKT signaling pathway.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anoikis and Mitophagy-Related Gene Signature for Predicting the Survival and Tumor Cell Progression in Colon Cancer 预测结肠癌存活率和肿瘤细胞进展的无丝分裂和有丝分裂相关基因特征

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI: 10.1615/critrevimmunol.2024053203

Jian Shen, Minzhe Li

{"title":"Anoikis and Mitophagy-Related Gene Signature for Predicting the Survival and Tumor Cell Progression in Colon Cancer","authors":"Jian Shen, Minzhe Li","doi":"10.1615/critrevimmunol.2024053203","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024053203","url":null,"abstract":"Background: Anoikis is a specialized form of programmed cell death and is also related mitophagy process.\u0000Objective:We aimed to identify an anoikis and mitophagy-related genes (AMRGs) prognostic model and explore the role of SPHK1 in colon cancer (CC).\u0000Methods: Bioinformatic methods were used to screen the AMRGs. Based on these genes, all the samples were divided into different subtypes. Furthermore, LASSO was conducted to optimized the AMRGs. Based on the optimal genes, a prognostic risk score model was established and evaluated. Finally, the effects of downregulated SPHK1 on the CC cell proliferation, migration, invasion, and anoikis were investigated.\u0000Results: Based on the AMRGs, all the CC samples were divided into subtype 1 and subtype 2. An AMRGs signature containing three key genes (SPHK1, CDC25C, and VPS37A) that exhibiting predicting ability in CC survival is confirmed. Subtype2 and low-risk groups exhibited better survival and higher immune cell infiltration. Moreover, down-regulated SPHK1 is related to lower cell proliferation, migration, and invasion ability, as well as higher anoikis in CC cell line (P < 0.01).\u0000Conclusion: The AMRGs risk score model exhibits promising predicting ability on patients with CC. SPHK1 might inhibit CC cell growth, migration, and invasion through stimulating anoikis.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of key chondrocyte apoptosis-related genes in osteoarthritis based on weighted gene co-expression network analysis and experimental verification 基于加权基因共表达网络分析和实验验证的骨关节炎软骨细胞凋亡相关关键基因的鉴定

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI: 10.1615/critrevimmunol.2024051935

Wei Wang, Junyi Hong, Tianyi Cao, Fusheng Ye, Junwei Gao, Shumei Qin

{"title":"Identification of key chondrocyte apoptosis-related genes in osteoarthritis based on weighted gene co-expression network analysis and experimental verification","authors":"Wei Wang, Junyi Hong, Tianyi Cao, Fusheng Ye, Junwei Gao, Shumei Qin","doi":"10.1615/critrevimmunol.2024051935","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024051935","url":null,"abstract":"Objective: Osteoarthritis (OA) is the primary cause of disability worldwide. Chondrocyte apoptosis has important implications for OA onset and progression. This work was designed to explore the mechanisms of chondrocyte apoptosis in OA and identify key chondrocyte apoptosis-related genes (CARGs).\u0000Methods: GSE32317 and GSE55235 datasets were acquired from the Gene Expression Omnibus (GEO) database. OA-associated module genes were determined via weighted gene co-expression network analysis (WGCNA) in GSE32317. CARGs were acquired from public databases. ClusterProfiler was employed for GO and KEGG analyses. Protein-protein interaction (PPI) network establishment was realized via STRING database and Cytoscape, and the hub genes were screened by MCC, MNC, and DMNC algorithms of cytoHubba. The diagnostic values of the hub CARGs in OA in GSE55235 was verified via receiver operating characteristic (ROC) curve analysis. C28/I2 cells were stimulated with IL-1β to establish the in vitro OA model.\u0000Results: WGCNA identified 9,141 OA-related genes and 248 CARGs, resulting in 75 CARGs in OA. GO and KEGG analyses demonstrated that the 75 CARGs were primarily enriched in response to lipopolysaccharide, transcription regulator complex, DNA-binding transcription factor binding, along with NF-kappa B and TNF signaling pathways. NFKB1 and ICAM1 were identified as the hub CARGs in OA through the three algorithms, which showed favorable prognostic values for OA. Notably, both bioinformatics analysis and in vitro assays revealed upregulated NFKB1 and ICAM1 expression in OA.\u0000Conclusions: NFKB1 and ICAM1 were the hub CARGs in OA, which might serve as the diagnostic signatures and therapeutic","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140569998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Vaccines, Checkpoint Blockade and Chimeric Antigen Receptor based Cancer Immunotherapeutics 基于疫苗、检查点阻断和嵌合抗原受体的癌症免疫疗法的进展

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-04-01 DOI: 10.1615/critrevimmunol.2024053025

Disha Agarwal, Gaurav Sharma, Alka Khadwal, Devinder Toor, Pankaj Malhotra

引用次数: 0

Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway 电针通过激活 mTOR/SREBP1 通路缓解缺血性中风

IF 1.3 4区医学

Critical Reviews in Immunology Pub Date : 2024-03-01 DOI: 10.1615/critrevimmunol.2024051934

Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang

{"title":"Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway","authors":"Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang","doi":"10.1615/critrevimmunol.2024051934","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2024051934","url":null,"abstract":"Objective: Ischemic stroke (IS) is one of the leading causes of death and disability worldwide. Electroacupuncture (EA) has been shown to exert a neuroprotective effect in IS. However, the specific anti-IS mechanisms of EA remain to be further elucidated. Thus, we aimed to investigate the anti-IS role of EA and its mechanism.\u0000Methods: By constructing a rat IS (middle cerebral artery occlusion, MCAO) model and performing EA treatment, the neurological deficit score, brain water content, and cerebral infarction were evaluated. ELISA was used to measure the levels of oxidative stress (OS)-related molecules (MDA, SOD, GSH, and CAT). Ferroptosis-related proteins (GPX4, SLC7A11, TfR1, L-ferritin, and hepcidin), neurological damage-related proteins (GFAP, Iba-1, and Nestin), α7nAChR, and mTOR pathway-related proteins (mTOR, p-mTOR, and SREBP1) in rat brain penumbra were assessed using western blotting.\u0000Results: Following EA treatment, the neurological deficit score, brain water content, cerebral infarction, and GFAP, Iba-1, and Nestin expression were reduced in the brain penumbra of MCAO rats. Additionally, EA treatment decreased MDA level and increased SOD, GSH, and CAT levels in the brain penumbra of MCAO rats. Moreover, MCAO rats showed elevated GPX4 and SLC7A11 expression and reduced TfR1, L-ferritin, and hepcidin in the brain penumbra following EA treatment. After EA treatment, α7nAChR, mTOR, p-mTOR, and SREBP1 expression were upregulated in the brain penumbra of MCAO rats.\u0000Conclusions: EA treatment inhibited OS and ferroptosis to exert a neuroprotective effect in IS, which might be realized via the activation of mTOR/SREBP1 signaling.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140035956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0