TNF-α、IFN-γ、IL-10、TGF-β和IL-6基因多态性在巴西亚马逊地区第一波大流行工作人员队列中的研究

IF 0.8 4区 医学 Q4 IMMUNOLOGY
Beatriz Dos Reis Marcelino, Marcelo Cleyton da Silva Vieira, Marcos Jessé Abrahão Silva, Lilian Cristina Santos Sinfronio da Silva, Ellen Polyana da Costa Gurrão, Everaldina Cordeiro Dos Santos, Jeanne Gonçalves Cabral, Alex Brito Souza, Daniele Melo Sardinha, Rebecca Lobato Marinho, Sebastião Kauã de Sousa Bispo, Karla Valéria Batista Lima, Luana Nepomuceno Gondim Costa Lima
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引用次数: 0

摘要

能够产生有效宿主免疫应答的基因中的遗传多态性,如IL-6、inf - α、ifn - γ、IL-10、tgf - β基因中的单核苷酸多态性(SNPS),可导致不利的临床状况或对病理的易感性。这项工作的目的是评估卫生机构专业人员在第一波大流行期间的流行病学和遗传概况。对巴西北部bel - pa的卫生机构(HI)工作人员进行了一项病例对照研究(N = 213),分为症状组(无症状- as, N = 91;症状性si (n = 122);胸部计算机断层扫描- cct数据分类的严重程度组(有肺部受累症状- scp, n = 37;对TNF-α -308 G/A (rs1800629)、IFN-γ +874 T/A (rs2430561)、TGF-β密码子10 (rs1982073)、密码子25 (rs1800471)、IL-6 - 174 G/C (rs180079)、IL-10 - 1082 A/T (rs1800896)、-819 C/T (rs1800871)、-592 A/C (rs1800872)进行基因分型,并通过Epilfo程序进行统计学分析。观察到合并症的存在与COVID-19预后不良之间存在显著相关性(特别是COVID-19与超重和肥胖之间)。只有TNF-α 308 G/A snp与COVID-19的症状和严重程度显著相关。这些关于该TNF-α SNP的发现在多次检测校正中以错误发现率(FDR)< 0.05通过。这些数据可以帮助医学界和科学界了解遗传学和流行病学参数对抗击COVID-19的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of TNF-α, IFN-γ, IL-10, TGF-β and IL-6 Gene Polymorphisms in a Cohort of Professionals Who Worked in the First Pandemic Wave in the Brazilian Amazon.

Genetic polymorphisms in genes that enable the production of an effective host immune response, such as single nucleotide polymorphisms (SNPS) in the IL-6, INF-alpha, IFN-gamma, IL-10, TGF-beta genes can cause unfavorable clinical conditions or susceptibility to pathologies. The objective of this work is to evaluate the epidemiological and genetic profile of professionals from health institutions during the first pandemic wave. A case-control study was performed with convenience sampling from health institutions (HI) workers from Belém-PA, Northern Brazil (N = 213), divided into symptomatology groups (Asymptomatic-AS, n = 91; and Symptomatic-SI, n = 122); and severity groups classified by chest computerized tomography-CCT data (symptomatic with pulmonary involvement-SCP, n = 37; symptomatic without pulmonary involvement-SSP, n = 8). Genotyping was performed by sanger sequencing for SNP TNF-α -308 G/A (rs1800629), IFN-γ +874 T/A (rs2430561), TGF-β codon 10 (rs1982073), codon 25 (rs1800471), IL-6 - 174 G/C (rs180079), IL-10 - 1082 A/T (rs1800896), -819 C/T (rs1800871), and -592 A/C (rs1800872), and statistical analysis through the Epilfo program. Significant association was observed between the presence of comorbidities and poor prognosis of COVID-19 (especially between COVID-19 and overweight and obesity). Only the TNF-α 308 G/A snp was significantly associated with the symptoms and severity of COVID-19. These findings about this TNF-α SNP passed in the multiple testing correction at a false discovery rate (FDR)< 0.05. These data can help medicine and the scientific community understand the influence of genetics and epidemiological parameters in combating COVID-19.

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
14
审稿时长
>12 weeks
期刊介绍: Immunology covers a broad spectrum of investigations at the genes, molecular, cellular, organ and system levels to reveal defense mechanisms against pathogens as well as protection against tumors and autoimmune diseases. The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in medical sciences. Critical ReviewsTM in Immunology (CRI) seeks to present a balanced overview of contemporary adaptive and innate immune responses related to autoimmunity, tumor, microbe, transplantation, neuroimmunology, immune regulation and immunotherapy from basic to translational aspects in health and disease. The articles that appear in CRI are mostly obtained by invitations to active investigators. But the journal will also consider proposals from the scientific community. Interested investigators should send their inquiries to the editor before submitting a manuscript.
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