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Critical Reviews in Immunology最新文献

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Preface: Regulatory T Cells in Immune Homeostasis. 前言:免疫稳态中的调节性T细胞。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2023047593
Xiaolei Tang, Vipin Kumar Chaturvedi
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引用次数: 0
Immune Regulatory Functions of IgG in the Ontogeny of Human Natural Regulatory T Cells. IgG在人自然调节性T细胞发生中的免疫调节功能。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022045009
Alessandra Franco
{"title":"Immune Regulatory Functions of IgG in the Ontogeny of Human Natural Regulatory T Cells.","authors":"Alessandra Franco","doi":"10.1615/CritRevImmunol.2022045009","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022045009","url":null,"abstract":"<p><p>The heavy constant region of IgG (Fc) is highly immunogenic for human natural regulatory T cells (nTreg). Mature IgG+ B cells prime Fc-specific Treg via recycling of surface immunoglobulin with an antigen-processing pathway that is very efficient in presenting immunodominant Fc peptides to Treg. Some of these peptides are pan-HLA binders, explaining the presence of Fc-specific Treg in circulation in healthy pediatric and adult subjects. Following IgG+ B cell priming, further Treg expansion occurs with the presentation of Fc peptides following IgG uptake and processing by CD14+ myeloid dendritic cells type 2 (cDC2) and CD4+ immunoglobulin-like transcript 4 (ILT-4+) tolerogenic DC that secretes IL-10 when stimulated by the Fc that enters cells prevalently via Fcg receptor II. Fc-specific Treg are important in regulating naive T cell differentiation and account for a key mechanism of success for intravenous immunoglobulin therapy (IVIG) in several inflammatory conditions, including Kawasaki disease (KD) a pediatric acute vasculitis of the coronary arteries.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"42 2","pages":"29-33"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9288056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Part 2 Preface: Immune Checkpoint Inhibitors and Adverse Autoimmune Manifestations. 第2部分序言:免疫检查点抑制剂和不良自身免疫表现。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.v42.i4.10
Vipin Kumar, Benjamin Bonavida
{"title":"Part 2 Preface: Immune Checkpoint Inhibitors and Adverse Autoimmune Manifestations.","authors":"Vipin Kumar,&nbsp;Benjamin Bonavida","doi":"10.1615/CritRevImmunol.v42.i4.10","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.v42.i4.10","url":null,"abstract":"","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"42 4","pages":"v-vi"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9410560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological, Cytotoxic, Immunostimulant, and Auto-Immune Activity of Thalloid Liverworts: An Overview. Thalloid Liverworts的药理学、细胞毒性、免疫刺激和自身免疫活性综述。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022047292
Rimjhim Sharma, Swati Singh, Afroz Alam
{"title":"Pharmacological, Cytotoxic, Immunostimulant, and Auto-Immune Activity of Thalloid Liverworts: An Overview.","authors":"Rimjhim Sharma,&nbsp;Swati Singh,&nbsp;Afroz Alam","doi":"10.1615/CritRevImmunol.2022047292","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022047292","url":null,"abstract":"<p><p>Bryophytes have historically been employed as verdant medicine in China, Native America and India. Phenolics, glycosides, fatty acids, other rare aromatic compounds and Terpenoids found in bryophytes may help prevent cancer and other chronic disorders. Liverworts have historically been utilized in traditional medicine and also as immu-nomodulators or immunostimulants. Diterpenoids, Lipophilic mono-, sesqui- and aromatic compounds assisting to the biological activities of liverworts. For their biological functions more than 220 aromatic compounds and 700 terpenoids and other chemicals discovered in liverworts scrutinized for their pharmacological, cytotoxic, immunostimulant and auto-immune efficacies.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"42 5","pages":"9-19"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9419964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface: Immune Biomarkers from Liquid Biopsies. 前言:液体活检的免疫生物标志物。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022045512
Geraldo Aleixo Passos
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引用次数: 0
γδ T Cell-Mediated Immune Responses for Cancer Therapy: Special Focus on Breast Cancer. γδ T细胞介导的癌症治疗免疫反应:特别关注乳腺癌。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2023047363
Rama Rao Malla, Priyamvada Bhamidipati
{"title":"γδ T Cell-Mediated Immune Responses for Cancer Therapy: Special Focus on Breast Cancer.","authors":"Rama Rao Malla,&nbsp;Priyamvada Bhamidipati","doi":"10.1615/CritRevImmunol.2023047363","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2023047363","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) is a type of breast cancer (BC) with high aggressive nature, devoid of receptors for estrogen and progesterone hormones and with overexpression of the HER2/neu protein. It is more aggressive than other types of BC, common occurring in younger women. Recently, preclinical and clinical studies have investigated the use of immune therapies to treat TNBC patients. However, a subset of patients is responding to immunotherapy due to the high level of tumor mutation burden. The bidirectional communication among the tumor microenvironment (TME) cells via signal molecules modulates γδ T cells to support or impair tumor growth. This review emphasizes γδ T cell-mediated immune responses with a special focus on breast cancer. We present the cytotoxic characteristics of γδ T cells. We also present the promising role of γδ T cells in mounting pro-tumor and anti-tumor responses in the TME. Finally, our review focuses on prominent features of γδ T cells as a curse in breast cancer development.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"42 6","pages":"9-15"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9761930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic and Therapeutic Application of Exosomal microRNAs Inducing Inflammation in Type 2 Diabetes Mellitus. 诱导炎症的外泌体microrna在2型糖尿病中的诊断和治疗应用。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022044927
K Auxzilia Preethi, Sushmaa Chandralekha Selvakumar, Durairaj Sekar
{"title":"Diagnostic and Therapeutic Application of Exosomal microRNAs Inducing Inflammation in Type 2 Diabetes Mellitus.","authors":"K Auxzilia Preethi,&nbsp;Sushmaa Chandralekha Selvakumar,&nbsp;Durairaj Sekar","doi":"10.1615/CritRevImmunol.2022044927","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022044927","url":null,"abstract":"<p><p>Diabetes mellitus is a class of noncommunicable chronic metabolic disorders marked by hyperglycemia due to insulin production, insulin action or both and has reached epidemic levels around the world. The two most frequent types of diabetes are type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Despite substantial improvements in the knowledge and treatment of DM, the associated incidence and mortality rates remain steadily increased. Reliable markers for the early detection, monitoring and focused treatment of DM are desperately required. Conversely, microRNAs (miRNAs) have received much significance due to their regulatory involvement in gene expression. Fascinatingly, exosomes can be enclosed into miRNAs to transport or distribute them into the target cells or tissues in which they have a physiological regulatory action. Thus, exosomal miRNAs are proving to be important regulators in the establishment and maintenance of DM, however, further mode of action will be needed to investigate in order to fully comprehend the pathophysiological process. Hereby, this review outlines the recent findings on the role of exosomal miRNAs intending to understand the precise function in diagnostic and therapeutic aspects in T2DM disease.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"42 1","pages":"1-11"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10670234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
γδ T Cells in Skin Inflammation. 皮肤炎症中的γδ T细胞。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022047288
Wenwu Zhang, Abigail Pajulas, Mark H Kaplan
{"title":"γδ T Cells in Skin Inflammation.","authors":"Wenwu Zhang,&nbsp;Abigail Pajulas,&nbsp;Mark H Kaplan","doi":"10.1615/CritRevImmunol.2022047288","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022047288","url":null,"abstract":"<p><p>Gamma delta (γδ) T cells are a subset of T lymphocytes that express T cell receptor γ and 5 chains and display structural and functional heterogeneity. γδ T cells are typically of low abundance in the body and account for 1-5% of the blood lymphocytes and peripheral lymphoid tissues. As a bridge between innate and adaptive immunity, γδ T cells are uniquely poised to rapidly respond to stimulation and can regulate immune responses in peripheral tissues. The dendritic epidermal T cells in the skin epidermis can secrete growth factors to regulate skin homeostasis and re-epithelization and release inflammatory factors to mediate wound healing during skin inflammatory responses. Dermal γδ T cells can regulate the inflammatory process by producing interleukin-17 and other cytokines or chemokines. Here, we offer a review of the immune functions of γδ T cells, intending to understand their role in regulating skin barrier integrity and skin wound healing, which may be crucial for the development of novel therapeutics in skin diseases like atopic dermatitis and psoriasis.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"42 5","pages":"43-56"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439530/pdf/nihms-1924463.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Liquid Biopsy and Its Emerging Role in Rheumatology. 液体活检及其在风湿病学中的新作用。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022045288
Marta Świecka, Maria Maślińska
{"title":"Liquid Biopsy and Its Emerging Role in Rheumatology.","authors":"Marta Świecka,&nbsp;Maria Maślińska","doi":"10.1615/CritRevImmunol.2022045288","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022045288","url":null,"abstract":"<p><p>Liquid biopsy is a rapidly evolving diagnostic technique used to analyze tissue-derived information found in the blood or other bodily fluids. It represents a new way to guide therapeutic decisions, mainly in cancer, but its application in other fields of medicine is still growing. Here, we discuss how liquid biopsy has been used in autoimmune rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, or primary Sjögren's syndrome. Additionally, in aspect of liquid biopsy, we analyze the molecular biomarkers utilized in the field of rheumatology, including circulating cell-free DNA, microRNA, and proteomic content.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"42 1","pages":"13-19"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9170585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface: Gamma-Delta T Cells in Inflammation Part 1. 前言:γ - δ T细胞在炎症第1部分。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.v42.i5.10
Benjamin Bonavida, Vipin Kumar
{"title":"Preface: Gamma-Delta T Cells in Inflammation Part 1.","authors":"Benjamin Bonavida,&nbsp;Vipin Kumar","doi":"10.1615/CritRevImmunol.v42.i5.10","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.v42.i5.10","url":null,"abstract":"","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":"42 5","pages":"v"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9412934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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