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Critical Reviews in Immunology最新文献

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The Novel Diagnostic Index Based on HLA-DRB1 Genotype and PD-L1 Expression can Predict Severe irAEs in Patients with Metastatic Melanoma Taking Immune Checkpoint Inhibitors. The Results of the Pilot Study. 基于HLA-DRB1基因型和PD-L1表达的新诊断指标可以预测使用免疫检查点抑制剂的转移性黑色素瘤患者的严重irae。试点研究的结果。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022045956
N Zhukova, R Orlova, Anna Malkova, E Kaledina, A Demchenkova, P Naimushina, V Nazarov, A Mazing, S Lapin, N Belyak, Y Shoenfeld
{"title":"The Novel Diagnostic Index Based on HLA-DRB1 Genotype and PD-L1 Expression can Predict Severe irAEs in Patients with Metastatic Melanoma Taking Immune Checkpoint Inhibitors. The Results of the Pilot Study.","authors":"N Zhukova,&nbsp;R Orlova,&nbsp;Anna Malkova,&nbsp;E Kaledina,&nbsp;A Demchenkova,&nbsp;P Naimushina,&nbsp;V Nazarov,&nbsp;A Mazing,&nbsp;S Lapin,&nbsp;N Belyak,&nbsp;Y Shoenfeld","doi":"10.1615/CritRevImmunol.2022045956","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022045956","url":null,"abstract":"<p><p>Immune-related adverse events (irAEs) occur in up to 50% of patients treated with an anti-CTLA-4 antibody and 30% of patients treated with PD-1/PD-L1 antibodies. Severe forms of toxicity are observed in 3% of patients and require systemic steroid therapy and constant monitoring. One of the considered predictor biomarkers of irAEs development is HLA-genotypes. This research aims to evaluate the diagnostic significance of HLA-DRB1 genotypes and other clinical and laboratory parameters to predict the development of irAEs. The study involved 28 patients with metastatic melanoma taking checkpoint inhibitors therapy [nivo 53.6%, Ipi+nivo 32.1%, other (pembro, prolgo) 14.3%]. The PD-L1 expression and HLA-DRB1 genotype were evaluated. After 2-3 months the development of irAES was assessed. The complications of 3-4 grade or multi-organ damage were termed as severe irAEs. Various IrAEs developed in 57.1% (16/28) of patients, while severe irAEs occurred in 35.7% (10/28). Among all patients, HLA-DRB1 genotypes associated with the risk of autoimmune diseases were found in 78.5% (22/28). The PD-L1 expression was detected in 60.7% (17/28) of individuals. Combination treatment increases the risk of toxicity, p = 0.0028, with a diagnostic sensitivity of 56% and a diagnostic specificity of 100% (RR = 2.71, OR = 31.67). An index based on the parameters studied (HLA-DRB1, absence of PD-L1 expression, and type of treatment) was created. It allows assuming the risk of developing severe irAES (p = 0.0126). When comparing this indicator between irAEs 1-2 and irAEs 3-4, the presence of an index value of more than 2 gives a sensitivity for predicting severe toxicity of 40.00% and a specificity of 83.33%.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9282957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface. 序言
IF 0.8 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.v42.i6.10
Benjamin Bonavida, Vipin Kumar
{"title":"Preface.","authors":"Benjamin Bonavida, Vipin Kumar","doi":"10.1615/CritRevImmunol.v42.i6.10","DOIUrl":"10.1615/CritRevImmunol.v42.i6.10","url":null,"abstract":"","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9755054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory T Cell Therapeutics for Neuroinflammatory Disorders. 调节性T细胞治疗神经炎性疾病。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022045080
Ashley L Harkins, Acadia L Kopec, Allison M Keeler
{"title":"Regulatory T Cell Therapeutics for Neuroinflammatory Disorders.","authors":"Ashley L Harkins,&nbsp;Acadia L Kopec,&nbsp;Allison M Keeler","doi":"10.1615/CritRevImmunol.2022045080","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022045080","url":null,"abstract":"<p><p>A delicate balance of immune regulation exists in the central nervous system (CNS) that is often dysreg-ulated in neurological diseases, making them complicated to treat. With altered immune surveillance in the diseased or injured CNS, signals that are beneficial in the homeostatic CNS can be disrupted and lead to neuroinflammation. Recent advances in niche immune cell subsets have provided insight into the complicated cross-talk between the nervous system and the immune system. Regulatory T cells (Tregs) are a subset of T cells that are capable of suppressing effector T-cell activation and regulating immune tolerance, and play an important role in neuroprotection. Tregs have been shown to be effective therapies in a variety of immune-related disorders including, graft-versus-host disease (GVHD), type 1 diabetes (T1D), and inflammatory bowel disease (IBD), as well as within the CNS. Recently, significant advancements in engineering T cells, such as chimeric antigen receptor (CAR) T cells, have led to several approved therapies suggesting the safety and efficacy for similar engineered Treg therapies. Further, as understanding of the immune system's role in neuroinflammation has progressed, Tregs have recently become a potential therapeutic in the neurology space. In this review, we discuss Tregs and their evolving role as therapies for neuroinflammatory related disorders.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9288055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NKG2D Ligands in Liquid Biopsy: The Importance of Soluble and Vesicle-Bound Proteins for Immune Modulation. 液体活检中的NKG2D配体:可溶性和囊泡结合蛋白对免疫调节的重要性。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022045263
Carmen Campos-Silva, Silvia López-Borrego, María José Felgueres, Gloria Esteso, Mar Vales-Gomez
{"title":"NKG2D Ligands in Liquid Biopsy: The Importance of Soluble and Vesicle-Bound Proteins for Immune Modulation.","authors":"Carmen Campos-Silva,&nbsp;Silvia López-Borrego,&nbsp;María José Felgueres,&nbsp;Gloria Esteso,&nbsp;Mar Vales-Gomez","doi":"10.1615/CritRevImmunol.2022045263","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022045263","url":null,"abstract":"<p><p>The identification of biomarkers allowing diagnostics, prognostics and patient classification is still a challenge in oncological research for patient management. Improvements in patient survival achieved with immunotherapies substantiate that biomarker studies rely not only on cellular pathways contributing to the pathology, but also on the immune competence of the patient. If these immune molecules can be studied in a non-invasive manner, the benefit for patients and clinicians is obvious. The immune receptor Natural Killer Group 2 Member D (NKG2D) represents one of the main systems involved in direct recognition of tumor cells by effector lymphocytes (T and Natural Killer cells), and in immune evasion. The biology of NKG2D and its ligands comprises a complex network of cellular pathways leading to the expression of these tumor-associated ligands on the cell surface or to their release either as soluble proteins, or in extracellular vesicles that potently inhibit NKG2D-mediated responses. Increased levels of NKG2D-ligands in patient serum correlate with tumor progression and poor prognosis; however, most studies did not test the biochemical form of these molecules. Here we review the biology of the NKG2D receptor and ligands, their role in cancer and in patient response to immunotherapies, as well as the changes provoked in this system by non-immune cancer therapies. Further, we discuss the use of NKG2D-L in liquid biopsy, including methods to analyse vesicle-associated proteins. We propose that the evaluation in cancer patients of the whole NKG2D system can provide crucial information about patient immune competence and risk of tumor progression.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10670231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Preface: Immune Response to Viral infections 前言:对病毒感染的免疫反应
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/critrevimmunol.2022042837
Shashank Tripathi
{"title":"Preface: Immune Response to Viral infections","authors":"Shashank Tripathi","doi":"10.1615/critrevimmunol.2022042837","DOIUrl":"https://doi.org/10.1615/critrevimmunol.2022042837","url":null,"abstract":"Viruses are omnipresent, outside in the environment and inside our bodies, some of which can cause infection leading to disease. The course and outcome of virus infection depend on the immune response mounted by the host, which is generally comprised of local broad spectrum innate immune response and subsequent pathogen-specific humoral and cellular immune response. A timely, balanced immune response can stop the viral infection in its tracks and prevent the onset of the disease. However, an imbalanced and suboptimal immune response, caused by viral factors or the host itself, can lead to disease, sometimes severe. Hence understanding the interactions between viral factors and components of host immunity is critical for developing modalities to prevent and treat viral infections. The ongoing COVID-19 pandemic has been a shrill reminder of the value of this knowledge for the development of vaccines and therapeutics. With this intent, we have collected focused well-crafted review articles on this subject in the special issue titled 'Immune response to Viral infections'.","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67425751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface: Regulatory T Cells in Immune Homeostasis. 前言:免疫稳态中的调节性T细胞。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2023047593
Xiaolei Tang, Vipin Kumar Chaturvedi
{"title":"Preface: Regulatory T Cells in Immune Homeostasis.","authors":"Xiaolei Tang,&nbsp;Vipin Kumar Chaturvedi","doi":"10.1615/CritRevImmunol.2023047593","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2023047593","url":null,"abstract":"<p><p>N/A.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9288054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Regulatory Functions of IgG in the Ontogeny of Human Natural Regulatory T Cells. IgG在人自然调节性T细胞发生中的免疫调节功能。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022045009
Alessandra Franco
{"title":"Immune Regulatory Functions of IgG in the Ontogeny of Human Natural Regulatory T Cells.","authors":"Alessandra Franco","doi":"10.1615/CritRevImmunol.2022045009","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022045009","url":null,"abstract":"<p><p>The heavy constant region of IgG (Fc) is highly immunogenic for human natural regulatory T cells (nTreg). Mature IgG+ B cells prime Fc-specific Treg via recycling of surface immunoglobulin with an antigen-processing pathway that is very efficient in presenting immunodominant Fc peptides to Treg. Some of these peptides are pan-HLA binders, explaining the presence of Fc-specific Treg in circulation in healthy pediatric and adult subjects. Following IgG+ B cell priming, further Treg expansion occurs with the presentation of Fc peptides following IgG uptake and processing by CD14+ myeloid dendritic cells type 2 (cDC2) and CD4+ immunoglobulin-like transcript 4 (ILT-4+) tolerogenic DC that secretes IL-10 when stimulated by the Fc that enters cells prevalently via Fcg receptor II. Fc-specific Treg are important in regulating naive T cell differentiation and account for a key mechanism of success for intravenous immunoglobulin therapy (IVIG) in several inflammatory conditions, including Kawasaki disease (KD) a pediatric acute vasculitis of the coronary arteries.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9288056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Part 2 Preface: Immune Checkpoint Inhibitors and Adverse Autoimmune Manifestations. 第2部分序言:免疫检查点抑制剂和不良自身免疫表现。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.v42.i4.10
Vipin Kumar, Benjamin Bonavida
{"title":"Part 2 Preface: Immune Checkpoint Inhibitors and Adverse Autoimmune Manifestations.","authors":"Vipin Kumar,&nbsp;Benjamin Bonavida","doi":"10.1615/CritRevImmunol.v42.i4.10","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.v42.i4.10","url":null,"abstract":"","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9410560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological, Cytotoxic, Immunostimulant, and Auto-Immune Activity of Thalloid Liverworts: An Overview. Thalloid Liverworts的药理学、细胞毒性、免疫刺激和自身免疫活性综述。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022047292
Rimjhim Sharma, Swati Singh, Afroz Alam
{"title":"Pharmacological, Cytotoxic, Immunostimulant, and Auto-Immune Activity of Thalloid Liverworts: An Overview.","authors":"Rimjhim Sharma,&nbsp;Swati Singh,&nbsp;Afroz Alam","doi":"10.1615/CritRevImmunol.2022047292","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022047292","url":null,"abstract":"<p><p>Bryophytes have historically been employed as verdant medicine in China, Native America and India. Phenolics, glycosides, fatty acids, other rare aromatic compounds and Terpenoids found in bryophytes may help prevent cancer and other chronic disorders. Liverworts have historically been utilized in traditional medicine and also as immu-nomodulators or immunostimulants. Diterpenoids, Lipophilic mono-, sesqui- and aromatic compounds assisting to the biological activities of liverworts. For their biological functions more than 220 aromatic compounds and 700 terpenoids and other chemicals discovered in liverworts scrutinized for their pharmacological, cytotoxic, immunostimulant and auto-immune efficacies.</p>","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9419964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface: Immune Biomarkers from Liquid Biopsies. 前言:液体活检的免疫生物标志物。
IF 1.3 4区 医学
Critical Reviews in Immunology Pub Date : 2022-01-01 DOI: 10.1615/CritRevImmunol.2022045512
Geraldo Aleixo Passos
{"title":"Preface: Immune Biomarkers from Liquid Biopsies.","authors":"Geraldo Aleixo Passos","doi":"10.1615/CritRevImmunol.2022045512","DOIUrl":"https://doi.org/10.1615/CritRevImmunol.2022045512","url":null,"abstract":"","PeriodicalId":55205,"journal":{"name":"Critical Reviews in Immunology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10670232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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