Current Topics in Developmental Biology最新文献_第4页

Paternal contributions to mammalian zygote - Beyond sperm-oocyte fusion. 父亲对哺乳动物受精卵的贡献——超越精卵融合。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI: 10.1016/bs.ctdb.2025.02.002

Peter Sutovsky, Michal Zigo, Filip Tirpak, Richard Oko

{"title":"Paternal contributions to mammalian zygote - Beyond sperm-oocyte fusion.","authors":"Peter Sutovsky, Michal Zigo, Filip Tirpak, Richard Oko","doi":"10.1016/bs.ctdb.2025.02.002","DOIUrl":"10.1016/bs.ctdb.2025.02.002","url":null,"abstract":"Contrary to a common misconception that the fertilizing spermatozoon acts solely as a vehicle for paternal genome delivery to the zygote, this chapter aims to illustrate how the male gamete makes other essential contributions , including the sperm borne-oocyte activation factors, centrosome components, and components of the sperm proteome and transcriptome that help to lay the foundation for pregnancy establishment and maintenance to term, and the newborn and adult health. Our inquiry starts immediately after sperm plasma membrane fusion with its oocyte counterpart, the oolemma. Parallel to and following sperm incorporation in the egg cytoplasm, some of the sperm structures (perinuclear theca) are dissolved and spent to induce development, others (nucleus, centriole) are transformed into zygotic structures enabling it, and yet others (mitochondrial and fibrous sheath, axonemal microtubules and outer dense fibers) are recycled as to not stand in its way. Noteworthy advances in this research include the identification of several sperm-borne oocyte activating factor candidates, the role of autophagy in the post-fertilization sperm mitochondrion degradation, new insight into zygotic centrosome origins and function, and the contributions of sperm-delivered RNA cargos to early embryo development. In concluding remarks, the unresolved issues, and clinical and biotechnological implications of sperm-vectored paternal inheritance are discussed.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"162 ","pages":"387-446"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activating the C. elegans egg: Molecular players, current knowledge, and unanswered questions. 激活秀丽隐杆线虫卵：分子玩家，当前的知识，和悬而未决的问题。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1016/bs.ctdb.2025.01.007

Aimee Jaramillo-Lambert, Amber R Krauchunas

引用次数: 0

Rethinking retinoic acid self-regulation: A signaling robustness network approach. 重新思考维甲酸的自我调节：信号稳健性网络方法

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1016/bs.ctdb.2024.11.002

Abraham Fainsod, Rajanikanth Vadigepalli

{"title":"Rethinking retinoic acid self-regulation: A signaling robustness network approach.","authors":"Abraham Fainsod, Rajanikanth Vadigepalli","doi":"10.1016/bs.ctdb.2024.11.002","DOIUrl":"10.1016/bs.ctdb.2024.11.002","url":null,"abstract":"All-trans retinoic acid (ATRA) signaling is a major pathway regulating numerous differentiation, proliferation, and patterning processes throughout life. ATRA biosynthesis depends on the nutritional availability of vitamin A and other retinoids and carotenoids, while it is sensitive to dietary and environmental toxicants. This nutritional and environmental influence requires a robustness response that constantly fine-tunes the ATRA metabolism to maintain a context-specific, physiological range of signaling levels. The ATRA metabolic and signaling network is characterized by the existence of multiple enzymes, transcription factors, and binding proteins capable of performing the same activity. The partial spatiotemporal expression overlap of these enzymes and proteins yields different network compositions in the cells and tissues where this pathway is active. Genetic polymorphisms affecting the activity of individual network components further impact the network composition variability and the self-regulatory feedback response to ATRA fluctuations. Experiments directly challenging the robustness response uncovered a Pareto optimality in the ATRA network, such that some genetic backgrounds efficiently deal with excess ATRA but are very limited in their robustness response to reduced ATRA and vice versa. We discuss a network-focused framework to describe the robustness response and the Pareto optimality of the ATRA metabolic and signaling network.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"113-141"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing and regenerating a sense of taste. 味觉的：发展和再生味觉的

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-04-09 DOI: 10.1016/bs.ctdb.2025.03.006

Christina M Piarowski, Trevor J Isner, Linda A Barlow

{"title":"Developing and regenerating a sense of taste.","authors":"Christina M Piarowski, Trevor J Isner, Linda A Barlow","doi":"10.1016/bs.ctdb.2025.03.006","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2025.03.006","url":null,"abstract":"Gustation, or the sense of taste, is essential for distinguishing harmful and nutritious substances, and therefore crucial for health and survival. Taste buds (TBs) located in specialized gustatory papillae on the dorsal surface of the tongue are assemblages of specialized epithelial cells called taste receptor cells (TRCs). With the help of saliva, TRCs transduce sweet, sour, salt, bitter and umami stimuli into electrochemical signals that are transmitted to the brain via gustatory sensory neurons of the VIIth and IXth cranial ganglia. TBs in the anterior tongue are derived from embryonic ectoderm, while those in the posterior tongue arise from the endoderm. However, regardless of origin and location, all cells in adult taste buds are continually and reliably renewed, such that the sense of taste remains constant. Disruption of this regenerative process in disease or injury can lead to taste dysfunction, or dysgeusia, which negatively impacts quality of life. Decades of research into development and maintenance of adult taste epithelium have revealed molecular and cellular mechanisms underlying these processes. Here, we discuss current findings in the context of the original discoveries related to taste development and regeneration, as well as the transition from developmental to homeostatic mechanisms. Additionally, we review what is currently understood of how cancer therapies cause taste dysfunction and how the taste periphery responds to injury and inflammation. Finally, we consider future directions for the taste field and discuss several outstanding questions for further investigation.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"165 ","pages":"353-404"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The genesis of neurons and glia in the developing retina. 发育中的视网膜中神经元和神经胶质的形成。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-09-12 DOI: 10.1016/bs.ctdb.2025.05.001

Lew Kaplan, Juliette Wohlschlegel, Thomas A Reh

{"title":"The genesis of neurons and glia in the developing retina.","authors":"Lew Kaplan, Juliette Wohlschlegel, Thomas A Reh","doi":"10.1016/bs.ctdb.2025.05.001","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2025.05.001","url":null,"abstract":"The retina is a highly complex neural organ that captures light and converts it into electrochemical signals that are transmitted to the brain to generate vision. There are five basic types of neurons that can be further divided into many specific subtypes, and one type of glial cell, all of which are generated during development from a common progenitor cell. The process by which this diversity of neurons is generated during development has been the subject of active investigation for over 40 years, and this review attempts to summarize the key concepts that have emerged. For example, many of the transcription factors that drive the progenitor to specific neuron types have been identified. Recent single cell genomic technologies have confirmed many of the discoveries in this field, but also highlighted gaps in our knowledge, e.g., the mechanisms of neuron subtype specification. In addition, several key issues in retinal neurogenesis are still unknown and require further study. We suggest that studying animals beyond the traditional model systems may shed light on some of the unresolved questions by highlighting mechanisms that allow species specializations in vision.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"165 ","pages":"405-448"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-organization, error-correction and homeorhesis in renal development. 肾脏发育中的自组织、错误纠正和同源性。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/bs.ctdb.2024.11.004

Jamie A Davies, Rhiannon Beadman

{"title":"Self-organization, error-correction and homeorhesis in renal development.","authors":"Jamie A Davies, Rhiannon Beadman","doi":"10.1016/bs.ctdb.2024.11.004","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2024.11.004","url":null,"abstract":"Development is often described as following a 'genetic programme', yet perturbations to normal development, whether applied by an experimenter, the environment, or a mutation affecting development of a nearby part of the body, show developmental biology to be remarkably adaptable. This paper examines the evidence for adaptability in kidney development, focusing specifically on error-correction, self-organization, and homeorhesis (the dynamic equivalent to homeostasis: return of a perturbed system to a standard developmental trajectory, rather than a return to a fixed state that is seen in homeostasis). We present evidence for self-organization of renal tissue from randomly-aggregated progenitor cells, and also for the limitations of this self-organization and how they can be transcended by experimentally-applied symmetry-breaking cues. We provide evidence for error-correcting systems, and some evidence in the literature, generally in papers devoted to other problems, for genuine homeorhesis in aspects of kidney development. This review is not intended to be a 'last word' on any of these topics, and certainly not on the last-mentioned, for which data are very scant. It is instead intended to stimulate research in these areas, particularly homeorhesis, partly to increase understanding of natural development and partly as an aid to renal tissue engineering.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"163 ","pages":"105-128"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 DOI: 10.1016/S0070-2153(25)00080-8

Roberto Mayor

引用次数: 0

Control of sensory cell differentiation in the inner ear by extracellular signals and transcriptional regulators. 细胞外信号和转录调节因子对内耳感觉细胞分化的控制。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-04-03 DOI: 10.1016/bs.ctdb.2025.03.002

Joel C Nelson, Ishwar V Hosamani, Andrew K Groves

引用次数: 0

Not a hair out of place: Polarizing and orienting sensory hair cells. 没有一根头发不合适：极化和定向感觉毛细胞。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI: 10.1016/bs.ctdb.2025.03.004

Katie S Kindt, Basile Tarchini

{"title":"Not a hair out of place: Polarizing and orienting sensory hair cells.","authors":"Katie S Kindt, Basile Tarchini","doi":"10.1016/bs.ctdb.2025.03.004","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2025.03.004","url":null,"abstract":"Hair cells (HCs) are specialized sensory receptors in auditory, vestibular, and lateral-line organs that convert mechanical stimuli into neural signals. Auditory HCs transduce sound vibrations, vestibular HCs detect head movements for balance, and lateral-line HCs in aquatic vertebrates sense water currents, providing environmental awareness. A key feature of all HCs is their directional sensitivity, determined by the graded height architecture of their hair bundle. This arrangement ensures optimal HC activation when the hair bundle is deflected towards its tallest side. Within sensory organs, HCs and their hair bundles are precisely aligned within the epithelium plane, another key feature which produces coherent responses for accurate sensory representation. HC alignment is governed by planar cell polarity (PCP) cues relayed between neighboring cells. In some epithelia, such as the mammalian auditory epithelium, HCs are uniformly oriented. In other epithelia, PCP cues can be interpreted differently, and HCs exhibit a normal or reversed orientation creating a mirror-image HC organization. Several mechanisms generate directional sensors with proper alignment. During early development, the apical cytoskeleton breaks central symmetry and produces a staircase-like hair bundle. Over time, the asymmetrical apical cytoskeleton couples with distinct PCP mechanisms and signaling molecules at cell-cell junctions, orienting HCs properly within the sensory epithelium. This chapter highlights our current understanding of the intricate polarization processes that enable HCs to function as directional sensors, providing insights into their critical role in sensory perception and spatial orientation.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"165 ","pages":"85-124"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional development and differentiation of mammalian vestibular hair cells and their synapses. 哺乳动物前庭毛细胞及其突触的功能发育和分化。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-08-25 DOI: 10.1016/bs.ctdb.2025.07.001

Ruth Anne Eatock

{"title":"Functional development and differentiation of mammalian vestibular hair cells and their synapses.","authors":"Ruth Anne Eatock","doi":"10.1016/bs.ctdb.2025.07.001","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2025.07.001","url":null,"abstract":"In the vestibular inner ear, multiple hair-cell organs decompose head movements into angular or linear components with distinct planes of action, time course, frequencies, and amplitudes. The hair cell responses are transmitted to vestibular afferents and propagated to the brain, where the signals contribute to orientation and heading perception and drive reflexes that stabilize vision and posture during movement. Mammalian and other amniote vestibular epithelia feature two hair cell types (I and II) with distinctive afferent synaptic contacts (calyx and bouton) and transmission mechanisms (nonquantal versus quantal), and are organized into central and peripheral zones that generate afferent populations with fundamentally different encoding properties. In altricial rodents like mice, physiological differences between hair cells, afferents and zones emerge prenatally and develop over several postnatal weeks. The mouse utricle is a model system for investigating developmental differentiation of afferent signals by virtue of its highly organized epithelium, accessibility of immature stages, and genetic tractability. Physiological studies demonstrate that selective acquisition of low-voltage-activated potassium channels from the KV1 (Kcna) and KV7 (Kcnq) families profoundly shapes the maturing sensory signal at multiple stages: hair cell receptor potentials become faster, synaptic transmission from type I hair cells becomes nonquantal, and afferent spike patterns become more irregular. Targeted genetic manipulations coupled with behavioral assessments have revealed transcription factors that regulate the physiological differentiation of hair cell and afferent types. Developmental mechanisms to create new hair cells, hair bundles and functional synapses persist at low levels in mature vestibular epithelia, allowing some regeneration and repair to sustain transduction and transmission for years.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"165 ","pages":"235-306"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0