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Patterning the nephron: Forming an axial polarity with distal and proximal specialization. 肾元模式：形成远端和近端特化的轴向极性。
2区 生物学
Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-01-28 DOI: 10.1016/bs.ctdb.2025.01.005
Nils Olof Lindström, Jessica May Vanslambrouck
{"title":"Patterning the nephron: Forming an axial polarity with distal and proximal specialization.","authors":"Nils Olof Lindström, Jessica May Vanslambrouck","doi":"10.1016/bs.ctdb.2025.01.005","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2025.01.005","url":null,"abstract":"<p><p>Nephron formation and patterning are driven by complex cell biology. Progenitors migrate, transition into epithelia, and generate an axial epithelial polarity with distinct transcriptional signatures, regulating virtually all physiologies of the maturing kidney post birth. Here we review current insights into mammalian nephrogenesis and discuss how the nephron forms and patterns along its proximal-distal axis during embryonic and fetal development. Genetic pathways that are necessary for this process are discussed and integrated into the cell biology and morphogenetic programs underpinning nephrogenesis. Together, these views outline a developmental blueprint for replicating nephron formation in vitro.</p>","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"163 ","pages":"83-103"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal ciliopathies. 肾ciliopathies。
2区 生物学
Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI: 10.1016/bs.ctdb.2025.01.009
Laura A Devlin, Rebecca M Dewhurst, Praveen D Sudhindar, John A Sayer
{"title":"Renal ciliopathies.","authors":"Laura A Devlin, Rebecca M Dewhurst, Praveen D Sudhindar, John A Sayer","doi":"10.1016/bs.ctdb.2025.01.009","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2025.01.009","url":null,"abstract":"<p><p>Primary cilia are essential cellular organelles with pivotal roles in many signalling pathways. Here we provide an overview of the role of primary cilia within the kidney, starting with primary ciliary structure and key protein complexes. We then highlight the specialised functions of primary cilia, emphasising their role in a group of diseases known as renal ciliopathies. These conditions include forms of polycystic kidney disease, nephronophthisis, and other syndromic ciliopathies, such as Joubert syndrome and Bardet-Biedl syndrome. We explore models of renal ciliopathies, both in vitro and in vivo, shedding light on the molecular mechanisms underlying these diseases including Wnt and Hedgehog signalling pathways, inflammation, and cellular metabolism. Finally, we discuss therapeutic approaches, from current treatments to cutting-edge preclinical research and clinical trials.</p>","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"163 ","pages":"229-305"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ion channels and transporters involved in calcium flux regulation in mammalian sperm. 哺乳动物精子中钙通量调节的离子通道和转运体。
2区 生物学
Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-03-13 DOI: 10.1016/bs.ctdb.2025.01.006
Claudia Sánchez-Cárdenas, Enrique I Oliver, Julio C Chávez, Guillermina M Luque, Arturo Hernández-Cruz, Mariano G Buffone, Alberto Darszon, Pablo E Visconti, Ana Romarowski
{"title":"Ion channels and transporters involved in calcium flux regulation in mammalian sperm.","authors":"Claudia Sánchez-Cárdenas, Enrique I Oliver, Julio C Chávez, Guillermina M Luque, Arturo Hernández-Cruz, Mariano G Buffone, Alberto Darszon, Pablo E Visconti, Ana Romarowski","doi":"10.1016/bs.ctdb.2025.01.006","DOIUrl":"10.1016/bs.ctdb.2025.01.006","url":null,"abstract":"<p><p>After ejaculation, mammalian spermatozoa are not capable of fertilizing a metaphase II-arrested egg. They require to undergo a series of biochemical and physiological processes collectively known as capacitation. In all these processes, the regulation of calcium ions fluxes plays essential roles and involves participation of many channels and transporters localized in the plasma membrane as well as in the membrane of intracellular organelles. In mammalian sperm, a fraction of these molecules has been proposed to contribute to mature sperm function. However, in many cases, the evidence for the presence of a given protein is based on the use of agonists and antagonists with more than one target. In this review, we will critically analyze the published evidence supporting the presence of these molecules in mammalian sperm with special emphasis to methods involving tandem mass spectrometry identification, electrophysiological evidence and controlled immunoassays.</p>","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"162 ","pages":"351-385"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human kidney organoids for modeling the development of different diseases. 人类肾脏类器官用于模拟不同疾病的发展。
2区 生物学
Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1016/bs.ctdb.2024.12.001
Elena Ceccotti, Armina Semnani, Benedetta Bussolati, Stefania Bruno
{"title":"Human kidney organoids for modeling the development of different diseases.","authors":"Elena Ceccotti, Armina Semnani, Benedetta Bussolati, Stefania Bruno","doi":"10.1016/bs.ctdb.2024.12.001","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2024.12.001","url":null,"abstract":"<p><p>The increasing incidence of kidney diseases has highlighted the need for in vitro experimental models to mimic disease development and to test new therapeutic approaches. Traditional two-dimensional in vitro experimental models are not fully able to recapitulate renal diseases. Instead, kidney organoids represent three-dimensional models that better mimic the human organ from both structural and functional points of view. Human pluripotent stem cells (PSCs), both embryonic and induced, are ideal sources for generating renal organoids. These organoids contain all renal cell types and the protocols to differentiate PSCs into renal organoids consist of three different stages that recapitulate embryonic development: mesodermal induction, nephron progenitor formation, and nephron differentiation. Recently it has been establish a renal organoid model where collecting ducts are also present. In this case, the presence of ureteric bud progenitor cells is essential. Renal organoids are particularly useful for studying genetic diseases, by introducing the specific mutations in PSCs by genome editing or generating organoids from patient-derived PSCs. Moreover, renal organoids represent promising models in toxicology studies and testing new therapeutic approaches. Renal organoids can be established also from adult stem cells. This type of organoid, named tubuloid, is composed only of epithelial cells and recapitulates the tissue repair process. The tubuloids can be generated from adult stem or progenitor cells, obtained from renal biopsies or urine, and are promising in vitro models for studying tubular functions, diseases, and regeneration. Tubuloids can be derived from patients and permit the study of genetic diseases, performing personalized drug screening and modeling renal pathologies.</p>","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"163 ","pages":"364-393"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No transcription, no problem: Protein phosphorylation changes and the transition from oocyte to embryo. 没有转录，没有问题：蛋白磷酸化的改变和从卵母细胞到胚胎的转变。
2区 生物学
Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-02-18 DOI: 10.1016/bs.ctdb.2025.01.001
Jonathon M Thomalla, Mariana F Wolfner
{"title":"No transcription, no problem: Protein phosphorylation changes and the transition from oocyte to embryo.","authors":"Jonathon M Thomalla, Mariana F Wolfner","doi":"10.1016/bs.ctdb.2025.01.001","DOIUrl":"10.1016/bs.ctdb.2025.01.001","url":null,"abstract":"<p><p>Although mature oocytes are arrested in a differentiated state, they are provisioned with maternally-derived macromolecules that will start embryogenesis. The transition to embryogenesis, called 'egg activation', occurs without new transcription, even though it includes major cell changes like completing stalled meiosis, translating stored mRNAs, cytoskeletal remodeling, and changes to nuclear architecture. In most animals, egg activation is triggered by a rise in free calcium in the egg's cytoplasm, but we are only now beginning to understand how this induces the egg to transition to totipotency and proliferation. Here, we discuss the model that calcium-dependent protein kinases and phosphatases modify the phosphorylation landscape of the maternal proteome to activate the egg. We review recent phosphoproteomic mass spectrometry analyses that revealed broad phospho-regulation during egg activation, both in number of phospho-events and classes of regulated proteins. Our interspecies comparisons of these proteins pinpoints orthologs and protein families that are phospho-regulated in activating eggs, many of which function in hallmark events of egg activation, and others whose regulation and activity warrant further study. Finally, we discuss key phospho-regulating enzymes that may act apically or as intermediates in the phosphorylation cascades during egg activation. Knowing the regulators, targets, and effects of phospho-regulation that cause an egg to initiate embryogenesis is crucial at both fundamental and applied levels for understanding female fertility, embryo development, and cell-state transitions.</p>","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"162 ","pages":"165-205"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Satellite cells in the growth and maintenance of muscle. 卫星细胞在肌肉生长和维持过程中的作用。
2区 生物学
Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI: 10.1016/bs.ctdb.2024.01.020
John F Bachman, Joe V Chakkalakal
{"title":"Satellite cells in the growth and maintenance of muscle.","authors":"John F Bachman, Joe V Chakkalakal","doi":"10.1016/bs.ctdb.2024.01.020","DOIUrl":"10.1016/bs.ctdb.2024.01.020","url":null,"abstract":"<p><p>Embryonic skeletal muscle growth is contingent upon a population of somite derived satellite cells, however, the contribution of these cells to early postnatal skeletal muscle growth remains relatively high. As prepubertal postnatal development proceeds, the activity and contribution of satellite cells to skeletal muscle growth diminishes. Eventually, at around puberty, a population of satellite cells escapes terminal commitment, continues to express the paired box transcription factor Pax7, and reside in a quiescent state orbiting the myofiber periphery adjacent to the basal lamina. After adolescence, some satellite cell contributions to muscle maintenance and adaptation occur, however, their necessity is reduced relative to embryonic, early postnatal, and prepubertal growth.</p>","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"158 ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscle stem cells as immunomodulator during regeneration. 肌肉干细胞作为再生过程中的免疫调节剂
2区 生物学
Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI: 10.1016/bs.ctdb.2024.01.010
H Rex Xu, Victor V Le, Stephanie N Oprescu, Shihuan Kuang
{"title":"Muscle stem cells as immunomodulator during regeneration.","authors":"H Rex Xu, Victor V Le, Stephanie N Oprescu, Shihuan Kuang","doi":"10.1016/bs.ctdb.2024.01.010","DOIUrl":"10.1016/bs.ctdb.2024.01.010","url":null,"abstract":"<p><p>The skeletal muscle is well known for its remarkable ability to regenerate after injuries. The regeneration is a complex and dynamic process that involves muscle stem cells (also called muscle satellite cells, MuSCs), fibro-adipogenic progenitors (FAPs), immune cells, and other muscle-resident cell populations. The MuSCs are the myogenic cell populaiton that contribute nuclei directly to the regenerated myofibers, while the other cell types collaboratively establish a microenvironment that facilitates myogenesis of MuSCs. The myogenic process includes activation, proliferation and differentiationof MuSCs, and subsequent fusion their descendent mononuclear myocytes into multinuclear myotubes. While the contributions of FAPs and immune cells to this microenvironment have been well studied, the influence of MuSCs on other cell types remains poorly understood. This review explores recent evidence supporting the potential role of MuSCs as immunomodulators during muscle regeneration, either through cytokine production or ligand-receptor interactions.</p>","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"158 ","pages":"221-238"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophage lineages in heart development and regeneration. 心脏发育和再生过程中的巨噬细胞系
2区 生物学
Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-24 DOI: 10.1016/bs.ctdb.2024.01.004
Na Xu, Brittany A Gonzalez, Katherine E Yutzey
{"title":"Macrophage lineages in heart development and regeneration.","authors":"Na Xu, Brittany A Gonzalez, Katherine E Yutzey","doi":"10.1016/bs.ctdb.2024.01.004","DOIUrl":"10.1016/bs.ctdb.2024.01.004","url":null,"abstract":"<p><p>During development, macrophage subpopulations derived from hematopoietic progenitors take up residence in the developing heart. Embryonic macrophages are detectable at the early stages of heart formation in the nascent myocardium, valves and coronary vasculature. The specific subtypes of macrophages present in the developing heart reflect the generation of hematopoietic progenitors in the yolk sac, aorta-gonad-mesonephros, fetal liver, and postnatal bone marrow. Ablation studies have demonstrated specific requirements for embryonic macrophages in valve remodeling, coronary and lymphatic vessel development, specialized conduction system maturation, and myocardial regeneration after neonatal injury. The developmental origins of macrophage lineages change over time, with embryonic lineages having more reparative and remodeling functions in comparison to the bone marrow derived myeloid lineages of adults. Here we review the contributions and functions of cardiac macrophages in the developing heart with potential regenerative and reparative implications for cardiovascular disease.</p>","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"156 ","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The cardiac conduction system: History, development, and disease. 心脏传导系统：历史、发展和疾病。
2区 生物学
Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-03-06 DOI: 10.1016/bs.ctdb.2024.02.006
Carissa Lee, Sidra Xu, Tahmina Samad, William R Goodyer, Alireza Raissadati, Paul Heinrich, Sean M Wu
{"title":"The cardiac conduction system: History, development, and disease.","authors":"Carissa Lee, Sidra Xu, Tahmina Samad, William R Goodyer, Alireza Raissadati, Paul Heinrich, Sean M Wu","doi":"10.1016/bs.ctdb.2024.02.006","DOIUrl":"10.1016/bs.ctdb.2024.02.006","url":null,"abstract":"<p><p>The heart is the first organ to form during embryonic development, establishing the circulatory infrastructure necessary to sustain life and enable downstream organogenesis. Critical to the heart's function is its ability to initiate and propagate electrical impulses that allow for the coordinated contraction and relaxation of its chambers, and thus, the movement of blood and nutrients. Several specialized structures within the heart, collectively known as the cardiac conduction system (CCS), are responsible for this phenomenon. In this review, we discuss the discovery and scientific history of the mammalian cardiac conduction system as well as the key genes and transcription factors implicated in the formation of its major structures. We also describe known human diseases related to CCS development and explore existing challenges in the clinical context.</p>","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"156 ","pages":"157-200"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genetics of cardiomyocyte polyploidy. 心肌细胞多倍体的遗传学。
2区 生物学
Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-06 DOI: 10.1016/bs.ctdb.2024.01.008
Tyler Buddell, Alexandra L Purdy, Michaela Patterson
{"title":"The genetics of cardiomyocyte polyploidy.","authors":"Tyler Buddell, Alexandra L Purdy, Michaela Patterson","doi":"10.1016/bs.ctdb.2024.01.008","DOIUrl":"10.1016/bs.ctdb.2024.01.008","url":null,"abstract":"<p><p>The regulation of ploidy in cardiomyocytes is a complex and tightly regulated aspect of cardiac development and function. Cardiomyocyte ploidy can range from diploid (2N) to 8N or even 16N, and these states change during key stages of development and disease progression. Polyploidization has been associated with cellular hypertrophy to support normal growth of the heart, increased contractile capacity, and improved stress tolerance in the heart. Conversely, alterations to ploidy also occur during cardiac pathogenesis of diseases, such as ischemic and non-ischemic heart failure and arrhythmia. Therefore, understanding which genes control and modulate cardiomyocyte ploidy may provide mechanistic insight underlying cardiac growth, regeneration, and disease. This chapter summarizes the current knowledge regarding the genes involved in the regulation of cardiomyocyte ploidy. We discuss genes that have been directly tested for their role in cardiomyocyte polyploidization, as well as methodologies used to identify ploidy alterations. These genes encode cell cycle regulators, transcription factors, metabolic proteins, nuclear scaffolding, and components of the sarcomere, among others. The general physiological and pathological phenotypes in the heart associated with the genetic manipulations described, and how they coincide with the respective cardiomyocyte ploidy alterations, are further discussed in this chapter. In addition to being candidates for genetic-based therapies for various cardiac maladies, these genes and their functions provide insightful evidence regarding the purpose of widespread polyploidization in cardiomyocytes.</p>","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"156 ","pages":"245-295"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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