Current Topics in Developmental Biology最新文献_第4页

Chromatin organization of muscle stem cell. 肌肉干细胞的染色质组织

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-16 DOI: 10.1016/bs.ctdb.2024.01.014

Philina Santarelli, Valentina Rosti, Maria Vivo, Chiara Lanzuolo

引用次数: 0

Effects of the immune system on muscle regeneration. 免疫系统对肌肉再生的影响

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-04-08 DOI: 10.1016/bs.ctdb.2024.01.013

Ping Hu

引用次数: 0

Navigating translational control of gene expression in satellite cells. 卫星细胞基因表达的翻译控制导航

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-03-19 DOI: 10.1016/bs.ctdb.2024.02.013

Holly Jiogo, Colin Crist

{"title":"Navigating translational control of gene expression in satellite cells.","authors":"Holly Jiogo, Colin Crist","doi":"10.1016/bs.ctdb.2024.02.013","DOIUrl":"10.1016/bs.ctdb.2024.02.013","url":null,"abstract":"Satellite cells, named for their satellite position around the sarcolemma of the myofibre, are responsible for skeletal muscle regeneration. Satellite cells normally reside in a quiescent state, but rapidly activate the myogenic program and the cell cycle in response to injury. Translational control of gene expression has emerged as an important regulator of satellite cell activity. Quiescent satellite cells maintain low levels of protein synthesis and selectively translate specific mRNAs to conserve limited energy. Activated satellite cells rapidly restore global protein synthesis to meet the demands of proliferating myogenic progenitors that participate in muscle repair. We propose a model by which translational control enables rapid protein level changes in response to injury-induced environmental shifts, serving as both a brake mechanism during quiescence and an accelerator for injury response. In this Chapter, we navigate the processing, translation and metabolism of newly transcribed mRNAs. We review the modifications of mRNA that occur during mRNA processing in the nucleus of satellite cells, and illustrate how these modifications impact the translation and stability of mRNAs. In the cytoplasm, we review how pathways work in concert to regulate protein synthesis globally, while trans acting microRNAs and RNA binding proteins modify specific mRNA translation within a context of tightly regulated protein synthesis. While navigating translational control of gene expression in satellite cells, this chapter reveals that despite significant progress, the field remains nascent in the broader scope of translational control in cell biology. We propose that future investigations will benefit from incorporating emerging global analyses to study translational control of gene expression in rare satellite cells, and we pose unanswered questions that warrant future exploration.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"158 ","pages":"253-277"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the forces that shape muscle stem cell function. 解码塑造肌肉干细胞功能的力量

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-03-05 DOI: 10.1016/bs.ctdb.2024.02.009

Jo Nguyen, Penney M Gilbert

引用次数: 0

Making developmental sense of the senses, their origin and function. 从发展的角度认识感官、感官的起源和功能。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1016/bs.ctdb.2024.01.015

Brittany M Edens, Marianne E Bronner

引用次数: 0

Shaping gene expression and its evolution by chromatin architecture and enhancer activity. 通过染色质结构和增强子活性塑造基因表达及其进化。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-01 DOI: 10.1016/bs.ctdb.2024.01.001

Jorge Mañes-García, Raquel Marco-Ferreres, Leonardo Beccari

{"title":"Shaping gene expression and its evolution by chromatin architecture and enhancer activity.","authors":"Jorge Mañes-García, Raquel Marco-Ferreres, Leonardo Beccari","doi":"10.1016/bs.ctdb.2024.01.001","DOIUrl":"10.1016/bs.ctdb.2024.01.001","url":null,"abstract":"Transcriptional regulation plays a pivotal role in orchestrating the intricate genetic programs governing embryonic development. The expression of developmental genes relies on the combined activity of several cis-regulatory elements (CREs), such as enhancers and silencers, which can be located at long linear distances from the genes that they regulate and that interact with them through establishment of chromatin loops. Mutations affecting their activity or interaction with their target genes can lead to developmental disorders and are thought to have importantly contributed to the evolution of the animal body plan. The income of next-generation-sequencing approaches has allowed identifying over a million of sequences with putative regulatory potential in the human genome. Characterizing their function and establishing gene-CREs maps is essential to decode the logic governing developmental gene expression and is one of the major challenges of the post-genomic era. Chromatin 3D organization plays an essential role in determining how CREs specifically contact their target genes while avoiding deleterious off-target interactions. Our understanding of these aspects has greatly advanced with the income of chromatin conformation capture techniques and fluorescence microscopy approaches to visualize the organization of DNA elements in the nucleus. Here we will summarize relevant aspects of how the interplay between CRE activity and chromatin 3D organization regulates developmental gene expression and how it relates to pathological conditions and the evolution of animal body plan.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"159 ","pages":"406-437"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140905032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biophysics of morphogenesis in the vertebrate lung. 脊椎动物肺部形态发生的生物物理学。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-06-04 DOI: 10.1016/bs.ctdb.2024.05.003

Samhita P Banavar, Eric W Fowler, Celeste M Nelson

引用次数: 0

The organizer and neural induction in birds and mammals. 鸟类和哺乳动物的组织器和神经诱导。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-21 DOI: 10.1016/bs.ctdb.2024.02.004

Claudio D Stern

{"title":"The organizer and neural induction in birds and mammals.","authors":"Claudio D Stern","doi":"10.1016/bs.ctdb.2024.02.004","DOIUrl":"10.1016/bs.ctdb.2024.02.004","url":null,"abstract":"In avian and mammalian embryos the \"organizer\" property associated with neural induction of competent ectoderm into a neural plate and its subsequent patterning into rostro-caudal domains resides at the tip of the primitive streak before neurulation begins, and before a morphological Hensen's node is discernible. The same region and its later derivatives (like the notochord) also have the ability to \"dorsalize\" the adjacent mesoderm, for example by converting lateral plate mesoderm into paraxial (pre-somitic) mesoderm. Both neural induction and dorsalization of the mesoderm involve inhibition of BMP, and the former also requires other signals. This review surveys the key experiments done to elucidate the functions of the organizer and the mechanisms of neural induction in amniotes. We conclude that the mechanisms of neural induction in amniotes and anamniotes are likely to be largely the same; apparent differences are likely to be due to differences in experimental approaches dictated by embryo topology and other practical constraints. We also discuss the relationships between \"neural induction\" assessed by grafts of the organizer and normal neural plate development, as well as how neural induction relates to the generation of neuronal cells from embryonic and other stem cells in vitro.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"157 ","pages":"43-65"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The organizer: What it meant, and still means, to developmental biology. 组织者：它对发育生物学意味着什么，现在仍然意味着什么。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2023-12-20 DOI: 10.1016/bs.ctdb.2023.12.001

Jonathan Slack

{"title":"The organizer: What it meant, and still means, to developmental biology.","authors":"Jonathan Slack","doi":"10.1016/bs.ctdb.2023.12.001","DOIUrl":"10.1016/bs.ctdb.2023.12.001","url":null,"abstract":"This article is about how the famous organizer experiment has been perceived since it was first published in 1924. The experiment involves the production of a secondary embryo under the influence of a graft of a dorsal lip from an amphibian gastrula to a host embryo. The early experiments of Spemann and his school gave rise to a view that the whole early amphibian embryo was \"indifferent\" in terms of determination, except for a special region called \"the organizer\". This was viewed mainly as an agent of neural induction, also having the ability to generate an anteroposterior body pattern. Early biochemical efforts to isolate a factor emitted by the organizer were not successful but culminated in the definition of \"neuralizing (N)\" and \"mesodermalizing (M)\" factors present in a wide variety of animal tissues. By the 1950s this view became crystallized as a \"two gradient\" model involving the N and M factors, which explained the anteroposterior patterning effect. In the 1970s, the phenomenon of mesoderm induction was characterized as a process occurring before the commencement of gastrulation. Reinvestigation of the organizer effect using lineage labels gave rise to a more precise definition of the sequence of events. Since the 1980s, modern research using the tools of molecular biology, combined with microsurgery, has explained most of the processes involved. The organizer graft should now be seen as an experiment which involves multiple interactions: dorsoventral polarization following fertilization, mesoderm induction, the dorsalizing signal responsible for neuralization and dorsoventral patterning of the mesoderm, and additional factors responsible for anteroposterior patterning.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"157 ","pages":"1-42"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissues and signals with true organizer properties in craniofacial development. 颅面发育过程中具有真正组织者特性的组织和信号。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2023-12-30 DOI: 10.1016/bs.ctdb.2023.12.002

Shruti S Tophkhane, Joy M Richman

{"title":"Tissues and signals with true organizer properties in craniofacial development.","authors":"Shruti S Tophkhane, Joy M Richman","doi":"10.1016/bs.ctdb.2023.12.002","DOIUrl":"10.1016/bs.ctdb.2023.12.002","url":null,"abstract":"Transplantation experiments have shown that a true organizer provides instructive signals that induce and pattern ectopic structures in the responding tissue. Here, we review craniofacial experiments to identify tissues with organizer properties and signals with organizer properties. In particular, we evaluate whether transformation of identity took place in the mesenchyme. Using these stringent criteria, we find the strongest evidence for the avian foregut ectoderm. Transplanting a piece of quail foregut endoderm to a host chicken embryo caused ectopic beaks to form derived from chicken mesenchyme. The beak identity, whether upper or lower as well as orientation, was controlled by the original anterior-posterior position of the donor endoderm. There is also good evidence that the nasal pit is necessary and sufficient for lateral nasal patterning. Finally, we review signals that have organizer properties on their own without the need for tissue transplants. Mouse germline knockouts of the endothelin pathway result in transformation of identity of the mandible into a maxilla. Application of noggin-soaked beads to post-migratory neural crest cells transforms maxillary identity. This suggests that endothelin or noggin rich ectoderm could be organizers (not tested). In conclusion, craniofacial, neural crest-derived mesenchyme is competent to respond to tissues with organizer properties, also originating in the head. In future, we can exploit such well defined systems to dissect the molecular changes that ultimately lead to patterning of the upper and lower jaw.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"157 ","pages":"67-82"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0