Current Topics in Developmental Biology最新文献_第10页

Crosstalk between the mTOR pathway and primary cilia in human diseases. 人类疾病中mTOR通路与原发纤毛之间的串扰。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2023-11-04 DOI: 10.1016/bs.ctdb.2023.09.004

Philipp P Prosseda, Svenja Dannewitz Prosseda, Matthew Tran, Paloma B Liton, Yang Sun

引用次数: 0

Mechanism of initiation of meiosis in mouse germ cells. 小鼠生殖细胞减数分裂的启动机制

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2022-06-03 DOI: 10.1016/bs.ctdb.2022.04.005

Kei-Ichiro Ishiguro

引用次数: 0

Role of Wnt signaling in the maintenance and regeneration of the intestinal epithelium. Wnt信号在肠上皮维持和再生中的作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2023.01.001

Maxime Gasnier, Hui Yi Grace Lim, Nick Barker

引用次数: 1

Polarity in breast development and cancer. 乳房发育和癌症的极性。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2023.02.009

Mara K M Whitford, Luke McCaffrey

{"title":"Polarity in breast development and cancer.","authors":"Mara K M Whitford, Luke McCaffrey","doi":"10.1016/bs.ctdb.2023.02.009","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2023.02.009","url":null,"abstract":"Mammary gland development and breast cancer progression are associated with extensive remodeling of epithelial tissue architecture. Apical-basal polarity is a key feature of epithelial cells that coordinates key elements of epithelial morphogenesis including cell organization, proliferation, survival, and migration. In this review we discuss advances in our understanding of how apical-basal polarity programs are used in breast development and cancer. We describe cell lines, organoids, and in vivo models commonly used for studying apical-basal polarity in breast development and disease and discuss advantages and limitations of each. We also provide examples of how core polarity proteins regulate branching morphogenesis and lactation during development. We describe alterations to core polarity genes in breast cancer and their associations with patient outcomes. The impact of up- or down-regulation of key polarity proteins in breast cancer initiation, growth, invasion, metastasis, and therapeutic resistance are discussed. We also introduce studies demonstrating that polarity programs are involved in regulating the stroma, either through epithelial-stroma crosstalk, or through signaling of polarity proteins in non-epithelial cell types. Overall, a key concept is that the function of individual polarity proteins is highly contextual, depending on developmental or cancer stage and cancer subtype.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"154 ","pages":"245-283"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9383903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polarity and axis formation in the Drosophila female germ line. 果蝇雌性生殖系的极性和轴的形成。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2023.02.002

Daniel St Johnston

引用次数: 1

Contractile and expansive actin networks in Drosophila: Developmental cell biology controlled by network polarization and higher-order interactions. 果蝇的收缩和扩张肌动蛋白网络:由网络极化和高阶相互作用控制的发育细胞生物学。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2023.02.005

Rodrigo Fernandez-Gonzalez, Tony J C Harris

{"title":"Contractile and expansive actin networks in Drosophila: Developmental cell biology controlled by network polarization and higher-order interactions.","authors":"Rodrigo Fernandez-Gonzalez, Tony J C Harris","doi":"10.1016/bs.ctdb.2023.02.005","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2023.02.005","url":null,"abstract":"Actin networks are central to shaping and moving cells during animal development. Various spatial cues activate conserved signal transduction pathways to polarize actin network assembly at sub-cellular locations and to elicit specific physical changes. Actomyosin networks contract and Arp2/3 networks expand, and to affect whole cells and tissues they do so within higher-order systems. At the scale of tissues, actomyosin networks of epithelial cells can be coupled via adherens junctions to form supracellular networks. Arp2/3 networks typically integrate with distinct actin assemblies, forming expansive composites which act in conjunction with contractile actomyosin networks for whole-cell effects. This review explores these concepts using examples from Drosophila development. First, we discuss the polarized assembly of supracellular actomyosin cables which constrict and reshape epithelial tissues during embryonic wound healing, germ band extension, and mesoderm invagination, but which also form physical borders between tissue compartments at parasegment boundaries and during dorsal closure. Second, we review how locally induced Arp2/3 networks act in opposition to actomyosin structures during myoblast cell-cell fusion and cortical compartmentalization of the syncytial embryo, and how Arp2/3 and actomyosin networks also cooperate for the single cell migration of hemocytes and the collective migration of border cells. Overall, these examples show how the polarized deployment and higher-order interactions of actin networks organize developmental cell biology.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"154 ","pages":"99-129"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9390433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-environment interactions underlying the etiology of neural tube defects. 神经管畸形病因中基因与环境的相互作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2022-11-23 DOI: 10.1016/bs.ctdb.2022.10.007

Carlo Donato Caiaffa, Cristiane Sá Roriz Fonteles, Lei Yunping, Richard H Finnell

{"title":"Gene-environment interactions underlying the etiology of neural tube defects.","authors":"Carlo Donato Caiaffa, Cristiane Sá Roriz Fonteles, Lei Yunping, Richard H Finnell","doi":"10.1016/bs.ctdb.2022.10.007","DOIUrl":"10.1016/bs.ctdb.2022.10.007","url":null,"abstract":"Neural tube defects (NTDs) consist of severe structural malformations of the brain and spinal cord and are the second most common structural birth defect in humans, accounting for approximately 2700 affected pregnancies every year in the United States. These numbers are highly significant, considering that birth defects remain a leading cause of infant mortality in the United States, affecting approximately 120,000 babies born annually. Survivors of these congenital malformations face long-term disability and lifelong challenges imposed by severe physical burdens compromising the afflicted individual's overall quality of life. Clearly, birth defects, and especially NTDs remain a global public health challenge, and the source of significant financial repercussions for healthcare systems worldwide. In order to better understand the role gene-environment interactions play in the etiology of NTDs, this chapter provides an overview of NTD phenotypes and their embryonic origins, discusses the genetic landscape of NTDs as it is currently understood, with a focus on experimental models that best illustrate how environmental factors modulate individual susceptibility to these birth defects. As folic acid interventions have proven to be effective in reducing the prevalence of NTDs, the chapter ends with a discussion on the impact that maternal dietary status has on NTD prevalence from a population perspective.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"152 ","pages":"193-220"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small RNAs and their protein partners in animal meiosis. 动物减数分裂过程中的小核糖核酸及其蛋白质伙伴

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2022-07-25 DOI: 10.1016/bs.ctdb.2022.06.001

María de Las Mercedes Carro, Andrew Grimson, Paula E Cohen

{"title":"Small RNAs and their protein partners in animal meiosis.","authors":"María de Las Mercedes Carro, Andrew Grimson, Paula E Cohen","doi":"10.1016/bs.ctdb.2022.06.001","DOIUrl":"10.1016/bs.ctdb.2022.06.001","url":null,"abstract":"Meiosis is characterized by highly regulated transitions in gene expression that require diverse mechanisms of gene regulation. For example, in male mammals, transcription undergoes a global shut-down in early prophase I of meiosis, followed by increasing transcriptional activity into pachynema. Later, as spermiogenesis proceeds, the histones bound to DNA are replaced with transition proteins, which are themselves replaced with protamines, resulting in a highly condensed nucleus with repressed transcriptional activity. In addition, two specialized gene silencing events take place during prophase I: meiotic silencing of unsynapsed chromatin (MSUC), and the sex chromatin specific mechanism, meiotic sex chromosome inactivation (MSCI). Notably, conserved roles for the RNA binding protein (RBP) machinery that functions with small non-coding RNAs have been described as participating in these meiosis-specific mechanisms, suggesting that RNA-mediated gene regulation is critical for fertility in many species. Here, we review roles of small RNAs and their associated RBPs in meiosis-related processes such as centromere function, silencing of unpaired chromatin and meiotic recombination. We will discuss the emerging evidence of non-canonical functions of these components in meiosis.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"151 ","pages":"245-279"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10679882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tardigrades and their emergence as model organisms. 缓步动物及其作为模式生物的出现。

2区生物学

Current Topics in Developmental Biology Pub Date : 2022-01-13 DOI: 10.20944/preprints202201.0188.v1

B. Goldstein

{"title":"Tardigrades and their emergence as model organisms.","authors":"B. Goldstein","doi":"10.20944/preprints202201.0188.v1","DOIUrl":"https://doi.org/10.20944/preprints202201.0188.v1","url":null,"abstract":"Experimentally tractable organisms like C. elegans, Drosophila, zebrafish, and mouse are popular models for addressing diverse questions in biology. In 1997, two of the most valuable invertebrate model organisms to date-C. elegans and Drosophila-were found to be much more closely related to each other than expected. C. elegans and Drosophila belong to the nematodes and arthropods, respectively, and these two phyla and six other phyla make up a clade of molting animals referred to as the Ecdysozoa. The other ecdysozoan phyla could be valuable models for comparative biology, taking advantage of the rich and continual sources of research findings as well as tools from both C. elegans and Drosophila. But when the Ecdysozoa was first recognized, few tools were available for laboratory studies in any of these six other ecdysozoan phyla. In 1999 I began an effort to develop tools for studying one such phylum, the tardigrades. Here, I describe how the tardigrade species Hypsibius exemplaris and tardigrades more generally have emerged over the past two decades as valuable new models for answering diverse questions. To date, these questions have included how animal body plans evolve and how biological materials can survive some remarkably extreme conditions.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"147 1","pages":"173-198"},"PeriodicalIF":0.0,"publicationDate":"2022-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42394627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Improving mouse models for the study of Alzheimer's disease. 改进阿尔茨海默病研究的小鼠模型。

2区生物学

Current Topics in Developmental Biology Pub Date : 2022-01-01 DOI: 10.1016/bs.ctdb.2021.12.005

Alaina M Reagan, Kristen D Onos, Sarah E Heuer, Michael Sasner, Gareth R Howell

引用次数: 0