Current Topics in Developmental Biology最新文献_第9页

Polarity in skin development and cancer. 皮肤发育和癌症中的极性。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2023.02.003

Alexandra Prado-Mantilla, Terry Lechler

引用次数: 0

Wnt signaling in stem cells during development and cell lineage specification. 干细胞发育过程中的Wnt信号传导和细胞谱系规范。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2023.01.005

Rony Chidiac, Stephane Angers

{"title":"Wnt signaling in stem cells during development and cell lineage specification.","authors":"Rony Chidiac, Stephane Angers","doi":"10.1016/bs.ctdb.2023.01.005","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2023.01.005","url":null,"abstract":"During embryo development, cell proliferation, cell fate specification and tissue patterning are coordinated and tightly regulated by a handful of evolutionarily conserved signaling pathways activated by secreted growth factor families including fibroblast growth factor (FGF), Nodal/bone morphogenetic protein (BMP), Hedgehog and Wnt. The spatial and temporal activation of these signaling pathways elicit context-specific cellular responses that ultimately shape the different tissues of the embryo. Extensive efforts have been dedicated to identifying the molecular mechanisms underlying these signaling pathways during embryo development, adult tissue homeostasis and regeneration. In this review, we first describe the role of the Wnt/β-catenin signaling pathway during early embryo development, axis specification and cell differentiation as a prelude to highlight how this knowledge is being leveraged to manipulate Wnt/β-catenin signaling activity with small molecules and biologics for the directed differentiation of pluripotent stem cells into various cell lineages that are physiologically relevant for stem cell therapy and regenerative medicine.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"153 ","pages":"121-143"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9256027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gene×environment associations in orofacial clefting. Gene×environment与唇腭裂的关系。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2022.10.006

Mary L Marazita

引用次数: 0

Phase separation in controlling meiotic chromosome dynamics. 控制减数分裂染色体动态的相位分离。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2022-06-09 DOI: 10.1016/bs.ctdb.2022.04.004

Ruirui Zhang, Yuanyuan Liu, Jinmin Gao

引用次数: 0

Preface. 前言。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/S0070-2153(23)00014-5

Francesca Cole

引用次数: 0

The role of genes and environment in the etiology of congenital diaphragmatic hernias. 基因和环境在先天性膈疝病因中的作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2022-11-23 DOI: 10.1016/bs.ctdb.2022.10.004

Nathan G Burns, Gabrielle Kardon

{"title":"The role of genes and environment in the etiology of congenital diaphragmatic hernias.","authors":"Nathan G Burns, Gabrielle Kardon","doi":"10.1016/bs.ctdb.2022.10.004","DOIUrl":"10.1016/bs.ctdb.2022.10.004","url":null,"abstract":"Structural birth defects are a common cause of abnormalities in newborns. While there are cases of structural birth defects arising due to monogenic defects or environmental exposures, many birth defects are likely caused by a complex interaction between genes and the environment. A structural birth defect with complex etiology is congenital diaphragmatic hernias (CDH), a common and often lethal disruption in diaphragm development. Mutations in more than 150 genes have been implicated in CDH pathogenesis. Although there is generally less evidence for a role for environmental factors in the etiology of CDH, deficiencies in maternal vitamin A and its derivative embryonic retinoic acid are strongly associated with CDH. However, the incomplete penetrance of CDH-implicated genes and environmental factors such as vitamin A deficiency suggest that interactions between genes and environment may be necessary to cause CDH. In this review, we examine the genetic and environmental factors implicated in diaphragm and CDH development. In addition, we evaluate the potential for gene-environment interactions in CDH etiology, focusing on the potential interactions between the CDH-implicated gene, Gata4, and maternal vitamin A deficiency.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"152 ","pages":"115-138"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-environment interactions in birth defect etiology: Challenges and opportunities. 出生缺陷病因学中基因与环境的相互作用：挑战与机遇。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2022-11-14 DOI: 10.1016/bs.ctdb.2022.10.001

Robert J Lipinski, Robert S Krauss

{"title":"Gene-environment interactions in birth defect etiology: Challenges and opportunities.","authors":"Robert J Lipinski, Robert S Krauss","doi":"10.1016/bs.ctdb.2022.10.001","DOIUrl":"10.1016/bs.ctdb.2022.10.001","url":null,"abstract":"Birth defects are relatively common congenital outcomes that significantly impact affected individuals, their families, and communities. Effective development and deployment of prevention and therapeutic strategies for these conditions requires sufficient understanding of etiology, including underlying genetic and environmental causes. Tremendous progress has been made in defining the genetic basis of familial and syndromic forms of birth defects. However, the majority of birth defect cases are considered nonsyndromic and thought to result from multifactorial gene-environment interactions. While substantial advances have been made in elucidating the genetic landscape of these etiologically complex conditions, significant biological and technical constraints have stymied progress toward a refined knowledge of environmental risk factors. Defining specific gene-environment interactions in birth defect etiology is even more challenging. However, progress has been made, including demonstration of critical proofs of concept and development of new conceptual and technical approaches for resolving complex gene-environment interactions. In this review, we discuss current views of multifactorial birth defect etiology, comparing them with other diseases that also involve gene-environment interactions, including primary immunodeficiency and cancer. We describe how various model systems have illuminated mechanisms of multifactorial etiology and these models' individual strengths and weaknesses. Finally, suggestions for areas of future emphasis are proposed.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"152 ","pages":"1-30"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942595/pdf/nihms-1871554.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meiotic crossover interference: Methods of analysis and mechanisms of action. 减数分裂交叉干扰：分析方法和作用机制

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2022-08-24 DOI: 10.1016/bs.ctdb.2022.04.006

Yu-Chien Chuang, Gerald R Smith

引用次数: 0

In vitro spermatogenesis: Why meiotic checkpoints matter. 体外精子发生：减数分裂检查点为何重要

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2022-06-09 DOI: 10.1016/bs.ctdb.2022.04.009

Qijing Lei, Ans M M van Pelt, Geert Hamer

{"title":"In vitro spermatogenesis: Why meiotic checkpoints matter.","authors":"Qijing Lei, Ans M M van Pelt, Geert Hamer","doi":"10.1016/bs.ctdb.2022.04.009","DOIUrl":"10.1016/bs.ctdb.2022.04.009","url":null,"abstract":"Successful in vitro spermatogenesis would generate functional haploid spermatids, and thus, form the basis for novel approaches to treat patients with impaired spermatogenesis or develop alternative strategies for male fertility preservation. Several culture strategies, including cell cultures using various stem cells and ex vivo cultures of testicular tissue, have been investigated to recapitulate spermatogenesis in vitro. Although some studies have described complete meiosis and subsequent generation of functional spermatids, key meiotic events, such as chromosome synapsis and homologous recombination required for successful meiosis and faithful in vitro-derived gametes, are often not reported. To guarantee the generation of in vitro-formed spermatids without persistent DNA double-strand breaks (DSBs) and chromosomal aberrations, criteria to evaluate whether all meiotic events are completely executed in vitro need to be established. In vivo, these meiotic events are strictly monitored by meiotic checkpoints that eliminate aberrant spermatocytes. To establish criteria to evaluate in vitro meiosis, we review the meiotic events and checkpoints that have been investigated by previous in vitro spermatogenesis studies. We found that, although major meiotic events such as initiation of DSBs and recombination, complete chromosome synapsis, and XY-body formation can be achieved in vitro, crossover formation, chiasmata frequency, and checkpoint mechanisms have been mostly ignored. In addition, complete spermiogenesis, during which round spermatids differentiate into elongated spermatids, has not been achieved in vitro by various cell culture strategies. Finally, we discuss the implications of meiotic checkpoints for in vitro spermatogenesis protocols and future clinical use.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"151 ","pages":"345-369"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10579700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of Wnt signaling in Xenopus neural induction. Wnt信号在爪蟾神经诱导中的作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2023.01.011

Ian Velloso, Wonhee Han, Xi He, Jose G Abreu

{"title":"The role of Wnt signaling in Xenopus neural induction.","authors":"Ian Velloso, Wonhee Han, Xi He, Jose G Abreu","doi":"10.1016/bs.ctdb.2023.01.011","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2023.01.011","url":null,"abstract":"Development of the central nervous system in amphibians has called attention from scientists for over a century. Interested in the matter of embryonic inductions, Hans Spemann and Hilde Mangold found out that the dorsal blastopore lip of the salamander's embryo has organizer properties. Such an ectopic graft could induce structures in the host embryo, including a neural tube overlying the notochord of a perfect secondary body axis. A couple of decades later, the frog Xenopus laevis emerged as an excellent embryological experimental model and seminal concepts involving embryonic inductions began to be revealed. The so-called primary induction is, in fact, a composition of signaling and inductive events that are triggered as soon as fertilization takes place. In this regard, since early 1990s an intricate network of signaling pathways has been built. The Wnt pathway, which began to be uncovered in cancer biology studies, is crucial during the establishment of two signaling centers in Xenopus embryogenesis: Nieuwkoop center and the blastula chordin noggin expression center (BCNE). Here we will discuss the historical events that led to the discovery of those centers, as well as the molecular mechanisms by which they operate. This chapter highlights the cooperation of both signaling centers with potential to be further explored in the future. We aim to address the essential morphological transformation during gastrulation and neurulation as well as the role of Wnt signaling in patterning the organizer and the neural plate.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"153 ","pages":"229-254"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9256026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0