Current Topics in Developmental Biology最新文献_第8页

Fertilization mechanisms in hermaphroditic ascidians and nematodes: Common mechanisms with mammals and plants. 雌雄同体海鞘和线虫的受精机制：哺乳动物和植物的共同机制。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-03-05 DOI: 10.1016/bs.ctdb.2025.01.010

Hitoshi Sawada, Takako Saito, Yoshihiro Shimada, Hitoshi Nishimura

引用次数: 0

Cell migration during development: Is it always collective and never as a single cell? 细胞在发育过程中的迁移：是否总是集体迁移，而不是单个细胞迁移？

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-02-20 DOI: 10.1016/bs.ctdb.2024.10.004

Jorge Diaz, Amrutha Patkunarajah, Roberto Mayor

{"title":"Cell migration during development: Is it always collective and never as a single cell?","authors":"Jorge Diaz, Amrutha Patkunarajah, Roberto Mayor","doi":"10.1016/bs.ctdb.2024.10.004","DOIUrl":"10.1016/bs.ctdb.2024.10.004","url":null,"abstract":"Cell migration is a fundamental process essential for homeostasis, disease progression, and developmental biology. This review explores the mechanisms of cell migration, focusing on both single-cell and collective migration modes, and highlights their roles in early development. We examine the characteristics of amoeboid and mesenchymal migration, emphasizing their regulation and implications across various classical developmental models. By analyzing examples of single-cell migration, such as primordial germ cell migration in zebrafish and Drosophila melanogaster, and examples of collective cell migration in the lateral line of zebrafish, border cells, and testis myotubes in Drosophila, we illustrate the complexity and significance of cell-cell interactions, cell-matrix interactions, and the chemical and mechanical cues that drive migration. The review also highlights the \"supracellular organization\" observed in many systems where supracellular actomyosin cables are present, which allow for coordinated and cooperative movement. This cooperativity is crucial for effective positioning and function, ensuring proper tissue formation and responsive adaptation to environmental cues. This review provides insights and raises questions about the mechanisms of cell migration during development, supporting the idea that cells never migrate entirely alone. We propose that even in those cases normally described as single cell migration, some degree of collectiveness or cooperation is involved, suggesting that during development, cells always migrate in collective coordination when forming complex tissue and organ structures.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"164 ","pages":"153-185"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collective migration in complex environments: The case of the trunk neural crest. 复杂环境下的集体迁移：以主干神经嵴为例。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.ctdb.2025.01.004

Hanna-Maria Häkkinen, Soraya Villaseca, Marie De La Burgade, Zainalabdeen Alhashem, Elena Scarpa

{"title":"Collective migration in complex environments: The case of the trunk neural crest.","authors":"Hanna-Maria Häkkinen, Soraya Villaseca, Marie De La Burgade, Zainalabdeen Alhashem, Elena Scarpa","doi":"10.1016/bs.ctdb.2025.01.004","DOIUrl":"10.1016/bs.ctdb.2025.01.004","url":null,"abstract":"The neural crest is a highly invasive, multipotent embryonic cell population common to all vertebrates. Neural crest cells migrate all along the anteroposterior axis of the vertebrate embryos, crossing complex microenvironments during their journey and eventually halting their migration to give rise to a variety of derivatives. At cranial levels, neural crest cells originate cartilage and bone of the skull and face, cranial ganglia and glia and pigment cells. In contrast, neural crest of the trunk is unable to form ectomesenchymal tissues such as cartilage and bone, but instead contributes to the cardiac outflow tract, enteric neurons, sensory and sympathetic neurons, Schwann cells and pigment across the vertebrate trunk. Defects in neural crest formation and migration can result in an array of birth defects and childhood malignancies collectively known as neurocristopathies, and investigation of the mechanisms underlying neural crest migration has significant clinical relevance. Considerable progress has been made in recent years in our understanding of the principles underlying collective cell migration of cranial neural crest cells. However, the extracellular environment trunk neural crest traverse in vivo is radically different from that experienced by cranial neural crest cells. Here, we review collective cell migration, fate specification and current in vivo and in vitro models of trunk neural crest migration under the lens of the complex interaction of this extraordinary cell population with its complex tissue environment.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"164 ","pages":"109-151"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifelong dynamic maintenance of stereocilia bundles in mammalian auditory hair cells. 哺乳动物听觉毛细胞中立体纤毛束的终身动态维持。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-04-09 DOI: 10.1016/bs.ctdb.2025.03.003

A Catalina Vélez-Ortega, Gregory I Frolenkov

引用次数: 0

Genetic and epigenetic control of photoreceptor development. 光感受器发育的遗传和表观遗传控制。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-04-10 DOI: 10.1016/bs.ctdb.2025.03.007

Zepeng Qu, Anand Swaroop, Carolina Beltrame Del Debbio

引用次数: 0

Rethinking retinoic acid self-regulation: A signaling robustness network approach. 重新思考维甲酸的自我调节：信号稳健性网络方法

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1016/bs.ctdb.2024.11.002

Abraham Fainsod, Rajanikanth Vadigepalli

{"title":"Rethinking retinoic acid self-regulation: A signaling robustness network approach.","authors":"Abraham Fainsod, Rajanikanth Vadigepalli","doi":"10.1016/bs.ctdb.2024.11.002","DOIUrl":"10.1016/bs.ctdb.2024.11.002","url":null,"abstract":"All-trans retinoic acid (ATRA) signaling is a major pathway regulating numerous differentiation, proliferation, and patterning processes throughout life. ATRA biosynthesis depends on the nutritional availability of vitamin A and other retinoids and carotenoids, while it is sensitive to dietary and environmental toxicants. This nutritional and environmental influence requires a robustness response that constantly fine-tunes the ATRA metabolism to maintain a context-specific, physiological range of signaling levels. The ATRA metabolic and signaling network is characterized by the existence of multiple enzymes, transcription factors, and binding proteins capable of performing the same activity. The partial spatiotemporal expression overlap of these enzymes and proteins yields different network compositions in the cells and tissues where this pathway is active. Genetic polymorphisms affecting the activity of individual network components further impact the network composition variability and the self-regulatory feedback response to ATRA fluctuations. Experiments directly challenging the robustness response uncovered a Pareto optimality in the ATRA network, such that some genetic backgrounds efficiently deal with excess ATRA but are very limited in their robustness response to reduced ATRA and vice versa. We discuss a network-focused framework to describe the robustness response and the Pareto optimality of the ATRA metabolic and signaling network.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"113-141"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The action of retinoic acid on spermatogonia in the testis. 维甲酸对睾丸精原细胞的作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.1016/bs.ctdb.2024.10.005

Shelby L Havel, Michael D Griswold

{"title":"The action of retinoic acid on spermatogonia in the testis.","authors":"Shelby L Havel, Michael D Griswold","doi":"10.1016/bs.ctdb.2024.10.005","DOIUrl":"10.1016/bs.ctdb.2024.10.005","url":null,"abstract":"For mammalian spermatogenesis to proceed normally, it is essential that the population of testicular progenitor cells, A undifferentiated spermatogonia (Aundiff), undergoes differentiation during the A to A1 transition that occurs at the onset of spermatogenesis. The commitment of the Aundiff population to differentiation and leaving a quiescent, stem-like state gives rise to all the spermatozoa produced across the lifespan of an individual, and ultimately determines male fertility. The action of all-trans retinoic acid (atRA) on the Aundiff population is the determining factor that induces this change. Sertoli cells, omnipresent, nurse cells within the mammalian testis are responsible for synthesizing the atRA that prompts this change in the neonatal testicular environment. The mechanism of atRA synthesis and signaling has been robustly explored and, in this review, we have summarized what is currently known about the action of testicular atRA at the onset of spermatogenesis. We have combined this with evidence gained from prominent genetic studies that have further elucidated the function of genes critical to atRA synthesis. We have additionally described the effects of the first pulse of atRA delivered to the germ cells of the testis, which has been investigated using WIN 18,446 treatment which prevents atRA synthesis and induces spermatogenic synchrony. This method provides unparalleled resolution into cell and stage specific testicular changes, and combined with transgenic animal models, has allowed researchers to elucidate much regarding the onset of spermatogenesis.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"143-166"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paternal contributions to mammalian zygote - Beyond sperm-oocyte fusion. 父亲对哺乳动物受精卵的贡献——超越精卵融合。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI: 10.1016/bs.ctdb.2025.02.002

Peter Sutovsky, Michal Zigo, Filip Tirpak, Richard Oko

{"title":"Paternal contributions to mammalian zygote - Beyond sperm-oocyte fusion.","authors":"Peter Sutovsky, Michal Zigo, Filip Tirpak, Richard Oko","doi":"10.1016/bs.ctdb.2025.02.002","DOIUrl":"10.1016/bs.ctdb.2025.02.002","url":null,"abstract":"Contrary to a common misconception that the fertilizing spermatozoon acts solely as a vehicle for paternal genome delivery to the zygote, this chapter aims to illustrate how the male gamete makes other essential contributions , including the sperm borne-oocyte activation factors, centrosome components, and components of the sperm proteome and transcriptome that help to lay the foundation for pregnancy establishment and maintenance to term, and the newborn and adult health. Our inquiry starts immediately after sperm plasma membrane fusion with its oocyte counterpart, the oolemma. Parallel to and following sperm incorporation in the egg cytoplasm, some of the sperm structures (perinuclear theca) are dissolved and spent to induce development, others (nucleus, centriole) are transformed into zygotic structures enabling it, and yet others (mitochondrial and fibrous sheath, axonemal microtubules and outer dense fibers) are recycled as to not stand in its way. Noteworthy advances in this research include the identification of several sperm-borne oocyte activating factor candidates, the role of autophagy in the post-fertilization sperm mitochondrion degradation, new insight into zygotic centrosome origins and function, and the contributions of sperm-delivered RNA cargos to early embryo development. In concluding remarks, the unresolved issues, and clinical and biotechnological implications of sperm-vectored paternal inheritance are discussed.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"162 ","pages":"387-446"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The multifaceted roles of retinoids in eye development, vision, and retinal degenerative diseases. 类维甲酸在眼睛发育、视力和视网膜退行性疾病中的多方面作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-23 DOI: 10.1016/bs.ctdb.2024.10.003

Zachary J Engfer, Krzysztof Palczewski

引用次数: 0

Activating the C. elegans egg: Molecular players, current knowledge, and unanswered questions. 激活秀丽隐杆线虫卵：分子玩家，当前的知识，和悬而未决的问题。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1016/bs.ctdb.2025.01.007

Aimee Jaramillo-Lambert, Amber R Krauchunas

引用次数: 0