Current Topics in Developmental Biology最新文献_第7页

The etiology of congenital obstructive uropathy: developmental and genetic perspectives. 先天性梗阻性尿路病变的病因：发育和遗传观点。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/bs.ctdb.2024.11.007

Mayke A C Ten Hoor, Brian Becknell, Peter Hohenstein, Jaap Mulder

{"title":"The etiology of congenital obstructive uropathy: developmental and genetic perspectives.","authors":"Mayke A C Ten Hoor, Brian Becknell, Peter Hohenstein, Jaap Mulder","doi":"10.1016/bs.ctdb.2024.11.007","DOIUrl":"10.1016/bs.ctdb.2024.11.007","url":null,"abstract":"Congenital obstructive uropathy (COU) encompasses a heterogeneous group of anomalies arising during critical stages of fetal development, which are characterized by functional or structural obstruction of the urinary tract. This obstruction hampers normal urine flow, and the resulting urinary pressure build-up can damage the developing kidneys and bladder. COU pathogenesis is complex and its clinical outcomes are highly variable, ranging from asymptomatic ultrasonographic abnormalities to end-stage kidney disease. This review examines the developmental and genetic mechanisms underlying COU and the associated organ damage, with a focus on intrinsic, isolated forms. Although genetic studies have improved our understanding of the molecular pathways involved in urinary tract maldevelopment, most patients lack a genetic diagnosis. Hence, multiple etiologic factors appear at play, including (epi)genetic and environmental. Closing gaps in our knowledge of kidney and urinary tract development and their interdependency for normal function is essential for developing personalized care to ultimately improve patient outcomes.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"163 ","pages":"322-363"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney development, injury and regeneration-Zebrafish. 肾脏发育、损伤和再生-斑马鱼。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-02-14 DOI: 10.1016/bs.ctdb.2025.01.008

Heiko Schenk, Iain A Drummond

{"title":"Kidney development, injury and regeneration-Zebrafish.","authors":"Heiko Schenk, Iain A Drummond","doi":"10.1016/bs.ctdb.2025.01.008","DOIUrl":"10.1016/bs.ctdb.2025.01.008","url":null,"abstract":"Acute kidney injury (AKI), acute kidney disease (AKD), and chronic kidney disease (CKD) affect millions worldwide, presenting an escalating health care and economic burden, while current treatments primarily focus on slowing further kidney function loss. Treatment failure can lead to end-stage kidney disease (ESKD), which necessitates kidney replacement therapies, including dialysis-which significantly reduces quality of life-or kidney transplantation. However, limited organ availability extends waiting times to up to 10-15 years in some European countries, such as the United Kingdom and Germany. The urgent need for regenerative therapies that promote kidney recovery and potentially enable the development of de novo human kidneys places the zebrafish as a powerful model organism for these studies. Zebrafish can regenerate kidney function after AKI by forming new nephrons that integrate into the existing tubular network. Using zebrafish to investigate kidney development and injury-induced regeneration allows for the discovery of key pathways involved in renal repair and development. Importantly, adult zebrafish possess a niche of kidney progenitor cells that facilitate regeneration after injury. This chapter provides an overview of kidney development and regeneration mechanisms, highlights current experimental approaches for modeling kidney injury, and explores potential translational implications for human kidney regenerative therapies.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"163 ","pages":"307-321"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regeneration of sensory hair cells in mature mammals. 成熟哺乳动物感觉毛细胞的再生。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-04-29 DOI: 10.1016/bs.ctdb.2025.04.002

Bradley Walters, Brandon Cox, Jennifer Stone

引用次数: 0

The photoreceptor outer segment: Development and renewal. 感光器外段：发育和更新。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-09-12 DOI: 10.1016/bs.ctdb.2025.07.002

Roni A Hazim, Steven K Fisher, David S Williams

引用次数: 0

Retinoic acid homeostasis and disease. 视黄酸平衡与疾病

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1016/bs.ctdb.2024.11.001

Maureen A Kane

{"title":"Retinoic acid homeostasis and disease.","authors":"Maureen A Kane","doi":"10.1016/bs.ctdb.2024.11.001","DOIUrl":"10.1016/bs.ctdb.2024.11.001","url":null,"abstract":"Retinoids, particularly all-trans-retinoic acid (ATRA), play crucial roles in various physiological processes, including development, immune response, and reproduction, by regulating gene transcription through nuclear receptors. This review explores the biosynthetic pathways, homeostatic mechanisms, and the significance of retinoid-binding proteins in maintaining ATRA levels. It highlights the intricate balance required for ATRA homeostasis, emphasizing that both excess and deficiency can lead to severe developmental and health consequences. Furthermore, the associations are discussed between ATRA dysregulation and several diseases, including various genetic disorders, cancer, endometriosis, and heart failure, underscoring the role of retinoid-binding proteins like RBP1 in these conditions. The potential for gene-environment interactions in retinoid metabolism is also examined, suggesting that dietary factors may exacerbate genetic predispositions to ATRA-related pathologies. Methodological advancements in quantifying ATRA and its metabolites are reviewed, alongside the challenges inherent in studying retinoid dynamics. Future research directions are proposed to further elucidate the role of ATRA in health and disease, with the aim of identifying therapeutic targets for conditions linked to retinoid signaling dysregulation.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"201-233"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kidney development at a glance: metabolic regulation of renal progenitor cells. 肾脏发育概览：肾祖细胞的代谢调节。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/bs.ctdb.2024.11.009

K Kurtzeborn, S S El-Dahr, N Pakkasjärvi, G G Tortelote, S Kuure

{"title":"Kidney development at a glance: metabolic regulation of renal progenitor cells.","authors":"K Kurtzeborn, S S El-Dahr, N Pakkasjärvi, G G Tortelote, S Kuure","doi":"10.1016/bs.ctdb.2024.11.009","DOIUrl":"10.1016/bs.ctdb.2024.11.009","url":null,"abstract":"The aberrant regulation of renal progenitor cells during kidney development leads to congenital kidney anomalies and dysplasia. Recently, significant progress has been made in understanding the metabolic needs of renal progenitor cells during mammalian kidney development, with evidence indicating that multiple metabolic pathways play essential roles in determining the cell fates of distinct renal progenitor populations. This review summarizes recent findings and explores the prospects of integrating this novel information into current diagnostic and treatment strategies for renal diseases. Reciprocal interactions between various embryonic kidney progenitor populations establish the foundation for normal kidney organogenesis, with the three principal kidney structures-the nephrons, the collecting duct network, and the stroma-being generated by nephron progenitor cells, ureteric bud/collecting duct progenitor cells, and interstitial progenitor cells. While energy metabolism is well recognized for its importance in organism development, physiological function regulation, and responses to environmental stimuli, research has primarily focused on nephron progenitor metabolism, highlighting its role in maintaining self-renewal. In contrast, studies on the metabolic requirements of ureteric bud/collecting duct and stromal progenitors remain limited. Given the importance of interactions between progenitor populations during kidney development, further research into the metabolic regulation of self-renewal and differentiation in ureteric bud and stromal progenitor cells will be critical.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"163 ","pages":"15-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of vertebrate cutaneous end-organ complexes. 脊椎动物皮肤末端器官复合物的发育。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-04-03 DOI: 10.1016/bs.ctdb.2025.03.001

José A Vega, Yolanda García-Mesa, Patricia Cuendias, José Martín-Cruces, Ramón Cobo, Jorge García-Piqueras, Iván Suazo, Olivia García-Suárez

{"title":"Development of vertebrate cutaneous end-organ complexes.","authors":"José A Vega, Yolanda García-Mesa, Patricia Cuendias, José Martín-Cruces, Ramón Cobo, Jorge García-Piqueras, Iván Suazo, Olivia García-Suárez","doi":"10.1016/bs.ctdb.2025.03.001","DOIUrl":"10.1016/bs.ctdb.2025.03.001","url":null,"abstract":"The glabrous skin of vertebrates is populated by cutaneous end-organ complexes, sensory corpuscles that are the sites at which the qualities of contacting objects (form, sharpness, pressure, hardness or vibration) are transduced into electrical signals. Structurally, these mechanotransducers are comprised of an axon, glial cells, and connective tissue sheaths. The axon is the peripheral prolongation of an Aβ low-threshold mechanoreceptor neuron; the glial cells are represented by non-myelinating terminal glial cells; and the connective sheaths are specializations of the endoneurium and/or perineurium. The variable arrangement of these three elements gives rise to the morphotypes of the cutaneous end-organ complexes typical of mammals: Meissner, Pacini and Ruffini corpuscles, and those of birds: the Grandry and Herbst corpuscles. In this review, an update is made on the development of the individual cellular components of cutaneous sensory corpuscles, and of the cutaneous endo-organ complexes as a whole. In general, cutaneous endo-organ complexes develop through complex multidirectional interactions between the Aβ-axons of mechanoreceptors and the terminal glial cells (both of which are neural crest derivatives) and the surrounding mesenchyme. The development of cutaneous endo-organ complexes in birds, rodents and humans, and the molecular mechanisms that regulate them are detailed.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"165 ","pages":"555-594"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordination of nephrogenesis with branching of the urinary collecting system, the vasculature and the nervous system. 肾形成与泌尿系统、脉管系统和神经系统分支的协调。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.ctdb.2024.11.008

Dagmar Iber, Malte Mederacke, Roman Vetter

引用次数: 0

Multiple roles for retinoid signaling in craniofacial development. 类视黄醛信号在颅面发育中的多重作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-07 DOI: 10.1016/bs.ctdb.2024.09.002

Masahiro Nakamura, Lisa L Sandell

{"title":"Multiple roles for retinoid signaling in craniofacial development.","authors":"Masahiro Nakamura, Lisa L Sandell","doi":"10.1016/bs.ctdb.2024.09.002","DOIUrl":"10.1016/bs.ctdb.2024.09.002","url":null,"abstract":"Retinoic acid (RA) signaling plays multiple essential roles in development of the head and face. Animal models with mutations in genes involved in RA signaling have enabled understanding of craniofacial morphogenic processes that are regulated by the retinoid pathway. During craniofacial morphogenesis RA signaling is active in spatially restricted domains defined by the expression of genes involved in RA production and RA breakdown. The spatial distribution of RA signaling changes with progressive development, corresponding to a multiplicity of craniofacial developmental processes that are regulated by RA. One important role of RA signaling occurs in the hindbrain. There RA contributes to specification of the anterior-posterior (AP) axis of the developing CNS and to the neural crest cells (NCC) which form the bones and nerves of the face and pharyngeal region. In the optic vesicles and frontonasal process RA orchestrates development of the midface, eyes, and nasal airway. Additional roles for RA in craniofacial development include regulation of submandibular salivary gland development and maintaining patency in the sutures of the cranial vault.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"33-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinoids and retinoid-binding proteins: Unexpected roles in metabolic disease. 维甲酸和维甲酸结合蛋白：代谢性疾病中的意外作用

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1016/bs.ctdb.2024.10.001

William S Blaner, Jisun Paik, Pierre-Jacques Brun, Marcin Golczak

{"title":"Retinoids and retinoid-binding proteins: Unexpected roles in metabolic disease.","authors":"William S Blaner, Jisun Paik, Pierre-Jacques Brun, Marcin Golczak","doi":"10.1016/bs.ctdb.2024.10.001","DOIUrl":"10.1016/bs.ctdb.2024.10.001","url":null,"abstract":"Alterations in tissue expression levels of both retinol-binding protein 2 (RBP2) and retinol-binding protein 4 (RBP4) have been associated with metabolic disease, specifically with obesity, glucose intolerance and hepatic steatosis. Our laboratories have shown that this involves novel pathways not previously considered as possible linkages between impaired retinoid metabolism and metabolic disease development. We have established both biochemically and structurally that RBP2 binds with very high affinity to very long-chain unsaturated 2-monoacylglycerols like the canonical endocannabinoid 2-arachidonoyl glycerol (2-AG) and other endocannabinoid-like substances. Binding of retinol or 2-MAGs involves the same binding pocket and 2-MAGs are able to displace retinol binding. Consequently, RBP2 is a physiologically relevant binding protein for endocannabinoids and endocannabinoid-like substances and is a nexus where the very potent retinoid and endocannabinoid signaling pathways converge. When Rbp2-null mice are challenged orally with fat, this gives rise to elevated levels in the proximal small intestine of both 2-AG and the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) in the proximal small intestine. We propose that elevation of GIP concentrations upon high fat diet feeding gives rise to obesity and the other elements of metabolic disease seen in Rbp2-null mice. Unexpectedly, we observed that RBP4 is present in secretory granules of the GIP-secreting intestinal K-cells and is co-secreted with GIP in response to a stimulus that provokes GIP secretion. Moreover, RBP4 is co-secreted along with glucagon from pancreatic alpha-cells in response to a secretory stimulus. The association during the secretory process of RBP4 with potent hormones that regulate metabolism (GIP and glucagon) accounts for at least some of the metabolic disease seen upon overexpression of Rbp4.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"89-111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0