Current Topics in Developmental Biology最新文献_第7页

Biophysics of morphogenesis in the vertebrate lung. 脊椎动物肺部形态发生的生物物理学。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-06-04 DOI: 10.1016/bs.ctdb.2024.05.003

Samhita P Banavar, Eric W Fowler, Celeste M Nelson

引用次数: 0

The organizer and neural induction in birds and mammals. 鸟类和哺乳动物的组织器和神经诱导。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-21 DOI: 10.1016/bs.ctdb.2024.02.004

Claudio D Stern

{"title":"The organizer and neural induction in birds and mammals.","authors":"Claudio D Stern","doi":"10.1016/bs.ctdb.2024.02.004","DOIUrl":"10.1016/bs.ctdb.2024.02.004","url":null,"abstract":"In avian and mammalian embryos the \"organizer\" property associated with neural induction of competent ectoderm into a neural plate and its subsequent patterning into rostro-caudal domains resides at the tip of the primitive streak before neurulation begins, and before a morphological Hensen's node is discernible. The same region and its later derivatives (like the notochord) also have the ability to \"dorsalize\" the adjacent mesoderm, for example by converting lateral plate mesoderm into paraxial (pre-somitic) mesoderm. Both neural induction and dorsalization of the mesoderm involve inhibition of BMP, and the former also requires other signals. This review surveys the key experiments done to elucidate the functions of the organizer and the mechanisms of neural induction in amniotes. We conclude that the mechanisms of neural induction in amniotes and anamniotes are likely to be largely the same; apparent differences are likely to be due to differences in experimental approaches dictated by embryo topology and other practical constraints. We also discuss the relationships between \"neural induction\" assessed by grafts of the organizer and normal neural plate development, as well as how neural induction relates to the generation of neuronal cells from embryonic and other stem cells in vitro.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"157 ","pages":"43-65"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The organizer: What it meant, and still means, to developmental biology. 组织者：它对发育生物学意味着什么，现在仍然意味着什么。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2023-12-20 DOI: 10.1016/bs.ctdb.2023.12.001

Jonathan Slack

{"title":"The organizer: What it meant, and still means, to developmental biology.","authors":"Jonathan Slack","doi":"10.1016/bs.ctdb.2023.12.001","DOIUrl":"10.1016/bs.ctdb.2023.12.001","url":null,"abstract":"This article is about how the famous organizer experiment has been perceived since it was first published in 1924. The experiment involves the production of a secondary embryo under the influence of a graft of a dorsal lip from an amphibian gastrula to a host embryo. The early experiments of Spemann and his school gave rise to a view that the whole early amphibian embryo was \"indifferent\" in terms of determination, except for a special region called \"the organizer\". This was viewed mainly as an agent of neural induction, also having the ability to generate an anteroposterior body pattern. Early biochemical efforts to isolate a factor emitted by the organizer were not successful but culminated in the definition of \"neuralizing (N)\" and \"mesodermalizing (M)\" factors present in a wide variety of animal tissues. By the 1950s this view became crystallized as a \"two gradient\" model involving the N and M factors, which explained the anteroposterior patterning effect. In the 1970s, the phenomenon of mesoderm induction was characterized as a process occurring before the commencement of gastrulation. Reinvestigation of the organizer effect using lineage labels gave rise to a more precise definition of the sequence of events. Since the 1980s, modern research using the tools of molecular biology, combined with microsurgery, has explained most of the processes involved. The organizer graft should now be seen as an experiment which involves multiple interactions: dorsoventral polarization following fertilization, mesoderm induction, the dorsalizing signal responsible for neuralization and dorsoventral patterning of the mesoderm, and additional factors responsible for anteroposterior patterning.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"157 ","pages":"1-42"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissues and signals with true organizer properties in craniofacial development. 颅面发育过程中具有真正组织者特性的组织和信号。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2023-12-30 DOI: 10.1016/bs.ctdb.2023.12.002

Shruti S Tophkhane, Joy M Richman

{"title":"Tissues and signals with true organizer properties in craniofacial development.","authors":"Shruti S Tophkhane, Joy M Richman","doi":"10.1016/bs.ctdb.2023.12.002","DOIUrl":"10.1016/bs.ctdb.2023.12.002","url":null,"abstract":"Transplantation experiments have shown that a true organizer provides instructive signals that induce and pattern ectopic structures in the responding tissue. Here, we review craniofacial experiments to identify tissues with organizer properties and signals with organizer properties. In particular, we evaluate whether transformation of identity took place in the mesenchyme. Using these stringent criteria, we find the strongest evidence for the avian foregut ectoderm. Transplanting a piece of quail foregut endoderm to a host chicken embryo caused ectopic beaks to form derived from chicken mesenchyme. The beak identity, whether upper or lower as well as orientation, was controlled by the original anterior-posterior position of the donor endoderm. There is also good evidence that the nasal pit is necessary and sufficient for lateral nasal patterning. Finally, we review signals that have organizer properties on their own without the need for tissue transplants. Mouse germline knockouts of the endothelin pathway result in transformation of identity of the mandible into a maxilla. Application of noggin-soaked beads to post-migratory neural crest cells transforms maxillary identity. This suggests that endothelin or noggin rich ectoderm could be organizers (not tested). In conclusion, craniofacial, neural crest-derived mesenchyme is competent to respond to tissues with organizer properties, also originating in the head. In future, we can exploit such well defined systems to dissect the molecular changes that ultimately lead to patterning of the upper and lower jaw.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"157 ","pages":"67-82"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula. 斑马鱼早期胃肠中 Wnt 和 Fgf 的运输和梯度形成。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2023-12-27 DOI: 10.1016/bs.ctdb.2023.12.003

Emma J Cooper, Steffen Scholpp

{"title":"Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula.","authors":"Emma J Cooper, Steffen Scholpp","doi":"10.1016/bs.ctdb.2023.12.003","DOIUrl":"10.1016/bs.ctdb.2023.12.003","url":null,"abstract":"Within embryonic development, the occurrence of gastrulation is critical in the formation of multiple germ layers with many differentiative abilities. These cells are instructed through exposure to signalling molecules called morphogens. The secretion of morphogens from a source tissue creates a concentration gradient that allows distinct pattern formation in the receiving tissue. This review focuses on the morphogens Wnt and Fgf in zebrafish development. Wnt has been shown to have critical roles throughout gastrulation, including in anteroposterior patterning and neural posterisation. Fgf is also a vital signal, contributing to involution and mesodermal specification. Both morphogens have also been found to work in finely balanced synergy for processes such as neural induction. Thus, the signalling range of Wnts and Fgfs must be strictly controlled to target the correct target cells. Fgf and Wnts signal to local cells as well as to cells in the distance in a highly regulated way, requiring specific dissemination mechanisms that allow efficient and precise signalling over short and long distances. Multiple transportation mechanisms have been discovered to aid in producing a stable morphogen gradient, including short-range diffusion, filopodia-like extensions called cytonemes and extracellular vesicles, mainly exosomes. These mechanisms are specific to the morphogen that they transport and the intended signalling range. This review article discusses how spreading mechanisms in these two morphogenetic systems differ and the consequences on paracrine signalling, hence tissue patterning.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"157 ","pages":"125-153"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skeletal muscle niche, at the crossroad of cell/cell communications. 处于细胞/细胞通讯十字路口的骨骼肌龛。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI: 10.1016/bs.ctdb.2024.01.012

Marine Theret, Bénédicte Chazaud

{"title":"Skeletal muscle niche, at the crossroad of cell/cell communications.","authors":"Marine Theret, Bénédicte Chazaud","doi":"10.1016/bs.ctdb.2024.01.012","DOIUrl":"10.1016/bs.ctdb.2024.01.012","url":null,"abstract":"Skeletal muscle is composed of a variety of tissue and non-tissue resident cells that participate in homeostasis. In particular, the muscle stem cell niche is a dynamic system, requiring direct and indirect communications between cells, involving local and remote cues. Interactions within the niche must happen in a timely manner for the maintenance or recovery of the homeostatic niche. For instance, after an injury, pro-myogenic cues delivered too early will impact on muscle stem cell proliferation, delaying the repair process. Within the niche, myofibers, endothelial cells, perivascular cells (pericytes, smooth muscle cells), fibro-adipogenic progenitors, fibroblasts, and immune cells are in close proximity with each other. Each cell behavior, membrane profile, and secretome can interfere with muscle stem cell fate and skeletal muscle regeneration. On top of that, the muscle stem cell niche can also be modified by extra-muscle (remote) cues, as other tissues may act on muscle regeneration via the production of circulating factors or the delivery of cells. In this review, we highlight recent publications evidencing both local and remote effectors of the muscle stem cell niche.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"158 ","pages":"203-220"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular development, remodeling and maturation. 血管发育、重塑和成熟。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-03-03 DOI: 10.1016/bs.ctdb.2024.02.001

Jessica Furtado, Anne Eichmann

引用次数: 0

The satellite cell in skeletal muscle: A story of heterogeneity. 骨骼肌中的卫星细胞：异质性的故事

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-19 DOI: 10.1016/bs.ctdb.2024.01.018

Corentin Guilhot, Marie Catenacci, Stephanie Lofaro, Michael A Rudnicki

{"title":"The satellite cell in skeletal muscle: A story of heterogeneity.","authors":"Corentin Guilhot, Marie Catenacci, Stephanie Lofaro, Michael A Rudnicki","doi":"10.1016/bs.ctdb.2024.01.018","DOIUrl":"10.1016/bs.ctdb.2024.01.018","url":null,"abstract":"Skeletal muscle is a highly represented tissue in mammals and is composed of fibers that are extremely adaptable and capable of regeneration. This characteristic of muscle fibers is made possible by a cell type called satellite cells. Adjacent to the fibers, satellite cells are found in a quiescent state and located between the muscle fibers membrane and the basal lamina. These cells are required for the growth and regeneration of skeletal muscle through myogenesis. This process is known to be tightly sequenced from the activation to the differentiation/fusion of myofibers. However, for the past fifteen years, researchers have been interested in examining satellite cell heterogeneity and have identified different subpopulations displaying distinct characteristics based on localization, quiescence state, stemness capacity, cell-cycle progression or gene expression. A small subset of satellite cells appears to represent multipotent long-term self-renewing muscle stem cells (MuSC). All these distinctions led us to the hypothesis that the characteristics of myogenesis might not be linear and therefore may be more permissive based on the evidence that satellite cells are a heterogeneous population. In this review, we discuss the different subpopulations that exist within the satellite cell pool to highlight the heterogeneity and to gain further understanding of the myogenesis progress. Finally, we discuss the long term self-renewing MuSC subpopulation that is capable of dividing asymmetrically and discuss the molecular mechanisms regulating MuSC polarization during health and disease.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"158 ","pages":"15-51"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The fusion of physics and biology in early mammalian embryogenesis. 早期哺乳动物胚胎发育过程中物理学和生物学的融合。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-06-21 DOI: 10.1016/bs.ctdb.2024.05.001

Walter Piszker, Mijo Simunovic

{"title":"The fusion of physics and biology in early mammalian embryogenesis.","authors":"Walter Piszker, Mijo Simunovic","doi":"10.1016/bs.ctdb.2024.05.001","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2024.05.001","url":null,"abstract":"Biomechanics in embryogenesis is a dynamic field intertwining the physical forces and biological processes that shape the first days of a mammalian embryo. From the first cell fate bifurcation during blastulation to the complex symmetry breaking and tissue remodeling in gastrulation, mechanical cues appear critical in cell fate decisions and tissue patterning. Recent strides in mouse and human embryo culture, stem cell modeling of mammalian embryos, and biomaterial design have shed light on the role of cellular forces, cell polarization, and the extracellular matrix in influencing cell differentiation and morphogenesis. This chapter highlights the essential functions of biophysical mechanisms in blastocyst formation, embryo implantation, and early gastrulation where the interplay between the cytoskeleton and extracellular matrix stiffness orchestrates the intricacies of embryogenesis and placenta specification. The advancement of in vitro models like blastoids, gastruloids, and other types of embryoids, has begun to faithfully recapitulate human development stages, offering new avenues for exploring the biophysical underpinnings of early development. The integration of synthetic biology and advanced biomaterials is enhancing the precision with which we can mimic and study these processes. Looking ahead, we emphasize the potential of CRISPR-mediated genomic perturbations coupled with live imaging to uncover new mechanosensitive pathways and the application of engineered biomaterials to fine-tune the mechanical conditions conducive to embryonic development. This synthesis not only bridges the gap between experimental models and in vivo conditions to advancing fundamental developmental biology of mammalian embryogenesis, but also sets the stage for leveraging biomechanical insights to inform regenerative medicine.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"160 ","pages":"31-64"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Got WNTS? Insight into bone health from a WNT perspective. 实际上wnt ?从WNT角度洞察骨骼健康。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2023.01.004

Sonya E L Craig, Megan N Michalski, Bart O Williams

引用次数: 2