Current Topics in Developmental Biology最新文献_第6页

Muscle stem cell niche dynamics during muscle homeostasis and regeneration. 肌肉稳态和再生过程中的肌肉干细胞生态位动态。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-03-23 DOI: 10.1016/bs.ctdb.2024.02.008

Yishu Yin, Gary J He, Shenyuan Hu, Erin H Y Tse, Tom H Cheung

引用次数: 0

Hox genes and patterning the vertebrate body. Hox基因与脊椎动物的身体形态。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-04-08 DOI: 10.1016/bs.ctdb.2024.02.011

Deneen M Wellik

{"title":"Hox genes and patterning the vertebrate body.","authors":"Deneen M Wellik","doi":"10.1016/bs.ctdb.2024.02.011","DOIUrl":"10.1016/bs.ctdb.2024.02.011","url":null,"abstract":"The diversity of vertebrate body plans is dizzying, yet stunning for the many things they have in common. Vertebrates have inhabited virtually every part of the earth from its coldest to warmest climates. They locomote by swimming, flying, walking, slithering, or climbing, or combinations of these behaviors. And they exist in many different sizes, from the smallest of frogs, fish and lizards to giraffes, elephants, and blue whales. Despite these differences, vertebrates follow a remarkably similar blueprint for the establishment of their body plan. Within the relatively small amount of time required to complete gastrulation, the process through which the three germ layers, ectoderm, mesoderm, and endoderm are created, the embryo also generates its body axis and is simultaneously patterned. For the length of this axis, the genes that distinguish the neck from the rib cage or the trunk from the sacrum are the Hox genes. In vertebrates, there was evolutionary pressure to maintain this set of genes in the organism. Over the past decades, much has been learned regarding the regulatory mechanisms that ensure the appropriate expression of these genes along the main body axes. Genetic functions continue to be explored though much has been learned. Much less has been discerned on the identity of co-factors used by Hox proteins for the specificity of transcriptional regulation or what downstream targets and pathways are critical for patterning events, though there are notable exceptions. Current work in the field is demonstrating that Hox genes continue to function in many organs long after directing early patterning events. It is hopeful continued research will shed light on remaining questions regarding mechanisms used by this important and conserved set of transcriptional regulators.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"159 ","pages":"1-27"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular regulation of myocyte fusion. 肌细胞融合的分子调控

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-03-16 DOI: 10.1016/bs.ctdb.2024.01.016

Tanner J Wherley, Serena Thomas, Douglas P Millay, Timothy Saunders, Sudipto Roy

{"title":"Molecular regulation of myocyte fusion.","authors":"Tanner J Wherley, Serena Thomas, Douglas P Millay, Timothy Saunders, Sudipto Roy","doi":"10.1016/bs.ctdb.2024.01.016","DOIUrl":"10.1016/bs.ctdb.2024.01.016","url":null,"abstract":"Myocyte fusion is a pivotal process in the development and regeneration of skeletal muscle. Failure during fusion can lead to a range of developmental as well as pathological consequences. This review aims to comprehensively explore the intricate processes underlying myocyte fusion, from the molecular to tissue scale. We shed light on key players, such as the muscle-specific fusogens - Myomaker and Myomixer, in addition to some lesser studied molecules contributing to myocyte fusion. Conserved across vertebrates, Myomaker and Myomixer play a crucial role in driving the merger of plasma membranes of fusing myocytes, ensuring the formation of functional muscle syncytia. Our multiscale approach also delves into broader cell and tissue dynamics that orchestrate the timing and positioning of fusion events. In addition, we explore the relevance of muscle fusogens to human health and disease. Mutations in fusogen genes have been linked to congenital myopathies, providing unique insights into the molecular basis of muscle diseases. We conclude with a discussion on potential therapeutic avenues that may emerge from manipulating the myocyte fusion process to remediate skeletal muscle disorders.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"158 ","pages":"53-82"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac construction-Recent advances in morphological and transcriptional modeling of early heart development. 心脏构造--早期心脏发育的形态和转录建模的最新进展。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-24 DOI: 10.1016/bs.ctdb.2024.02.005

Emily S Noël

{"title":"Cardiac construction-Recent advances in morphological and transcriptional modeling of early heart development.","authors":"Emily S Noël","doi":"10.1016/bs.ctdb.2024.02.005","DOIUrl":"10.1016/bs.ctdb.2024.02.005","url":null,"abstract":"During human embryonic development the early establishment of a functional heart is vital to support the growing fetus. However, forming the embryonic heart is an extremely complex process, requiring spatiotemporally controlled cell specification and differentiation, tissue organization, and coordination of cardiac function. These complexities, in concert with the early and rapid development of the embryonic heart, mean that understanding the intricate interplay between these processes that help shape the early heart remains highly challenging. In this review I focus on recent insights from animal models that have shed new light on the earliest stages of heart development. This includes specification and organization of cardiac progenitors, cell and tissue movements that make and shape the early heart tube, and the initiation of the first beat in the developing heart. In addition I highlight relevant in vitro models that could support translation of findings from animal models to human heart development. Finally I discuss challenges that are being addressed in the field, along with future considerations that together may help move us towards a deeper understanding of how our hearts are made.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"156 ","pages":"121-156"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromatin organization of muscle stem cell. 肌肉干细胞的染色质组织

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-16 DOI: 10.1016/bs.ctdb.2024.01.014

Philina Santarelli, Valentina Rosti, Maria Vivo, Chiara Lanzuolo

引用次数: 0

Effects of the immune system on muscle regeneration. 免疫系统对肌肉再生的影响

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-04-08 DOI: 10.1016/bs.ctdb.2024.01.013

Ping Hu

引用次数: 0

Navigating translational control of gene expression in satellite cells. 卫星细胞基因表达的翻译控制导航

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-03-19 DOI: 10.1016/bs.ctdb.2024.02.013

Holly Jiogo, Colin Crist

{"title":"Navigating translational control of gene expression in satellite cells.","authors":"Holly Jiogo, Colin Crist","doi":"10.1016/bs.ctdb.2024.02.013","DOIUrl":"10.1016/bs.ctdb.2024.02.013","url":null,"abstract":"Satellite cells, named for their satellite position around the sarcolemma of the myofibre, are responsible for skeletal muscle regeneration. Satellite cells normally reside in a quiescent state, but rapidly activate the myogenic program and the cell cycle in response to injury. Translational control of gene expression has emerged as an important regulator of satellite cell activity. Quiescent satellite cells maintain low levels of protein synthesis and selectively translate specific mRNAs to conserve limited energy. Activated satellite cells rapidly restore global protein synthesis to meet the demands of proliferating myogenic progenitors that participate in muscle repair. We propose a model by which translational control enables rapid protein level changes in response to injury-induced environmental shifts, serving as both a brake mechanism during quiescence and an accelerator for injury response. In this Chapter, we navigate the processing, translation and metabolism of newly transcribed mRNAs. We review the modifications of mRNA that occur during mRNA processing in the nucleus of satellite cells, and illustrate how these modifications impact the translation and stability of mRNAs. In the cytoplasm, we review how pathways work in concert to regulate protein synthesis globally, while trans acting microRNAs and RNA binding proteins modify specific mRNA translation within a context of tightly regulated protein synthesis. While navigating translational control of gene expression in satellite cells, this chapter reveals that despite significant progress, the field remains nascent in the broader scope of translational control in cell biology. We propose that future investigations will benefit from incorporating emerging global analyses to study translational control of gene expression in rare satellite cells, and we pose unanswered questions that warrant future exploration.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"158 ","pages":"253-277"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the forces that shape muscle stem cell function. 解码塑造肌肉干细胞功能的力量

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-03-05 DOI: 10.1016/bs.ctdb.2024.02.009

Jo Nguyen, Penney M Gilbert

引用次数: 0

Making developmental sense of the senses, their origin and function. 从发展的角度认识感官、感官的起源和功能。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1016/bs.ctdb.2024.01.015

Brittany M Edens, Marianne E Bronner

引用次数: 0

Shaping gene expression and its evolution by chromatin architecture and enhancer activity. 通过染色质结构和增强子活性塑造基因表达及其进化。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-01 DOI: 10.1016/bs.ctdb.2024.01.001

Jorge Mañes-García, Raquel Marco-Ferreres, Leonardo Beccari

{"title":"Shaping gene expression and its evolution by chromatin architecture and enhancer activity.","authors":"Jorge Mañes-García, Raquel Marco-Ferreres, Leonardo Beccari","doi":"10.1016/bs.ctdb.2024.01.001","DOIUrl":"10.1016/bs.ctdb.2024.01.001","url":null,"abstract":"Transcriptional regulation plays a pivotal role in orchestrating the intricate genetic programs governing embryonic development. The expression of developmental genes relies on the combined activity of several cis-regulatory elements (CREs), such as enhancers and silencers, which can be located at long linear distances from the genes that they regulate and that interact with them through establishment of chromatin loops. Mutations affecting their activity or interaction with their target genes can lead to developmental disorders and are thought to have importantly contributed to the evolution of the animal body plan. The income of next-generation-sequencing approaches has allowed identifying over a million of sequences with putative regulatory potential in the human genome. Characterizing their function and establishing gene-CREs maps is essential to decode the logic governing developmental gene expression and is one of the major challenges of the post-genomic era. Chromatin 3D organization plays an essential role in determining how CREs specifically contact their target genes while avoiding deleterious off-target interactions. Our understanding of these aspects has greatly advanced with the income of chromatin conformation capture techniques and fluorescence microscopy approaches to visualize the organization of DNA elements in the nucleus. Here we will summarize relevant aspects of how the interplay between CRE activity and chromatin 3D organization regulates developmental gene expression and how it relates to pathological conditions and the evolution of animal body plan.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"159 ","pages":"406-437"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140905032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0