Current Topics in Developmental Biology最新文献_第5页

Organizing chromosomes in oocytes and embryos. 在卵母细胞和胚胎中组织染色体。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-02-20 DOI: 10.1016/bs.ctdb.2026.01.015

Blake Hernandez, Nicolas Plachta

引用次数: 0

Building a resilient ovarian reserve: Early soma-oocyte interactions. 建立一个有弹性的卵巢储备：早期体细胞与卵母细胞的相互作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-05-16 DOI: 10.1016/bs.ctdb.2026.04.007

Cora Thompson, Alaina Houghton-Chamberlain, Joan S Jorgensen

引用次数: 0

Cyst-ained connections in the mammalian germline. 哺乳动物生殖系的囊肿性连接。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-04-09 DOI: 10.1016/bs.ctdb.2026.03.004

Isabella Leite, Tiffany V Roach, Katherine W Boer, Francesca T deFaria, Georgia Post, Eszter Posfai

{"title":"Cyst-ained connections in the mammalian germline.","authors":"Isabella Leite, Tiffany V Roach, Katherine W Boer, Francesca T deFaria, Georgia Post, Eszter Posfai","doi":"10.1016/bs.ctdb.2026.03.004","DOIUrl":"10.1016/bs.ctdb.2026.03.004","url":null,"abstract":"The germline cyst is a highly conserved structure that supports the proliferation and differentiation of gametes across many species. Germline cysts form when germ cells divide with incomplete cytokinesis, resulting in stable intercellular bridges that act as cytoplasmic channels between sister cells. In mammals, both male and female germ cells develop and enter meiosis within cysts, and disruption of intercellular bridges leads to defects in meiotic progression and gamete formation. However, we are only beginning to understand the biological mechanisms uniquely needed in the germline that are enabled by this structure. In this review, we provide an overview of germ cell development in cysts, from cyst formation through gamete individualization, culminating in the production of mature spermatozoa and oocytes. We highlight studies that examine the functional roles of intercellular bridges and discuss the potential advantages of gamete development within a syncytium, including intercellular communication, resource sharing, and coordinated cell fate decisions. Understanding the formation and breakdown of the cyst as well as the functions it supports will be essential for advancing our understanding of mammalian gametogenesis and for leveraging this knowledge to improve in vitro approaches for gamete generation.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"168 ","pages":"81-135"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the erythroid niche: From single-cell programs to spatially resolved architecture in mouse and human hematopoiesis. 解码红系生态位：从单细胞程序到小鼠和人类造血的空间分解结构。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-09-05 DOI: 10.1016/bs.ctdb.2026.06.009

Pan Wang, Kehan Ren, Peng Ji

{"title":"Decoding the erythroid niche: From single-cell programs to spatially resolved architecture in mouse and human hematopoiesis.","authors":"Pan Wang, Kehan Ren, Peng Ji","doi":"10.1016/bs.ctdb.2026.06.009","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2026.06.009","url":null,"abstract":"Erythropoiesis is a complex, spatially constrained morphogenetic process that transforms hematopoietic progenitors into specialized, enucleated red blood cells. While decades of research have defined the cell-intrinsic transcriptional and epigenetic circuits, governed by master regulators such as GATA1 and KLF1, the critical role of the microenvironmental niche remains less understood. Recent advances in single-cell omics have revealed a multi-layered landscape in which transcriptional potential is often uncoupled from proteomic and metabolic output. The transition from dissociative single-cell sequencing to spatially resolved omics further shaped our understanding of how these molecular programs are executed in situ. This chapter summarizes the broader landscape of omics profiling while focusing on how spatial transcriptomics and proteomics are uncovering the anatomical locations of erythropoiesis within the hematopoietic organs. We highlight a significant evolutionary divergence in niche architecture: while murine terminal erythropoiesis is organized with C1q + macrophage-centered erythroblastic islands, human erythropoiesis exhibits a unique, self-sustaining capacity characterized by autonomous erythroblast clustering independent of macrophages. We further discuss the technical hurdles of spatial profiling in mineralized bone and the potential for multimodal spatial omics to link chromatin accessibility, RNA, and protein abundance within intact tissues. By integrating molecular trajectories with microanatomical context, these technologies provide a new framework for understanding ineffective erythropoiesis and identifying therapeutic targets in hematologic diseases.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"170 ","pages":"325-344"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hijacking the host: Red blood cell remodeling and extracellular vesicle release during Babesia infection. 劫持宿主：巴贝斯虫感染期间红细胞重塑和细胞外囊泡释放。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-07-16 DOI: 10.1016/bs.ctdb.2026.06.003

Divya Beri, Yi-Tian Dai, Pratap Vydyam, Marilis Rodriguez, Cheryl A Lobo

{"title":"Hijacking the host: Red blood cell remodeling and extracellular vesicle release during Babesia infection.","authors":"Divya Beri, Yi-Tian Dai, Pratap Vydyam, Marilis Rodriguez, Cheryl A Lobo","doi":"10.1016/bs.ctdb.2026.06.003","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2026.06.003","url":null,"abstract":"The red blood cells (RBC) of various species serve as the host cells for the asexual stage of Babesia causing hemolysis and anemia, hallmark symptoms of parasitic infections that target RBCs. After Babesia invasion, RBCs are progressively modified by the parasite to suit their requirements of rapid proliferation and egress, while avoiding host immune consequences. This involves a complete morphological, biochemical and rheological overhaul of the RBC whereby the parasite confers on the host RBC, a new set of properties. Babesia infected RBCs exhibit increased membrane rigidity, reduced deformability, increased osmotic resistance, high vesiculation rates and in some species increased adhesiveness to the vascular endothelium. In this chapter we describe our current understanding of these changes in the Babesia-infected RBC that contribute to the modified RBC architecture. Further work must be directed to elucidate the structural and functional relationships of the pathogen-RBC networks at play in the infected cell, as these interactions may present targets for the development of novel therapeutics.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"170 ","pages":"157-198"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of cancer immunotherapies on oocyte health and ovarian function. 癌症免疫治疗对卵母细胞健康和卵巢功能的影响。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-04-30 DOI: 10.1016/bs.ctdb.2026.04.006

Yasmin Lewis, Yujie Cao, Jordan Higgins, Lauren R Alesi, Amy L Winship, Karla J Hutt

{"title":"Impact of cancer immunotherapies on oocyte health and ovarian function.","authors":"Yasmin Lewis, Yujie Cao, Jordan Higgins, Lauren R Alesi, Amy L Winship, Karla J Hutt","doi":"10.1016/bs.ctdb.2026.04.006","DOIUrl":"10.1016/bs.ctdb.2026.04.006","url":null,"abstract":"The ovary is an immunologically active organ in which tightly regulated interactions between immune cells, cytokines, and reproductive hormones are essential for follicle and oocyte development, ovulation, luteal function, and maintenance of the ovarian reserve. Immune checkpoints such as PD-1, PD-L1, and CTLA-4 are increasingly recognized as key regulators of immune tolerance beyond classical lymphoid tissues, yet their roles within the ovary remain poorly defined. Immune checkpoint inhibitors (ICIs), which target these pathways to enhance anti-tumor immunity, have transformed cancer treatment and are increasingly administered to women of reproductive age. While traditional cancer therapies are well known to compromise ovarian function and fertility, the reproductive consequences of ICIs are only beginning to emerge. Here we synthesize current knowledge of ovarian immune biology, with a focus on T cells and immune checkpoint signaling, and integrate clinical, preclinical, and mechanistic evidence linking immune checkpoint blockade to ovarian dysfunction. We discuss immune-related adverse events (irAEs), their management, and emerging evidence that the ovary may be uniquely sensitive to immune checkpoint perturbation. Collectively, this review highlights emerging knowledge of T cells and immune checkpoints in the ovary, highlights critical gaps in our understanding of immune - ovarian crosstalk, and discusses the urgent need to define the reproductive risks of ICIs to inform fertility preservation strategies and clinical decision-making for women with cancer.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"169 ","pages":"273-305"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Sertoli valve niche at the terminal end of seminiferous tubules for mammalian spermatogenic stem cells. 哺乳动物生精干细胞精小管末端的支持阀龛。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2025-12-17 DOI: 10.1016/bs.ctdb.2025.11.004

Xiao Han, Seohyeon Lee, Yoshiakira Kanai

{"title":"A Sertoli valve niche at the terminal end of seminiferous tubules for mammalian spermatogenic stem cells.","authors":"Xiao Han, Seohyeon Lee, Yoshiakira Kanai","doi":"10.1016/bs.ctdb.2025.11.004","DOIUrl":"10.1016/bs.ctdb.2025.11.004","url":null,"abstract":"In mammalian testes, GFRα1-positive spermatogonia, including spermatogonial stem cells (SSCs), are maintained in the basal compartment of seminiferous tubules. These cells actively migrate along the tubules within an 'open' niche, under the regulation of temporally fluctuating GDNF and retinoic acid (RA) signals, as well as constitutive FGF. In contrast, a newly discovered SSC niche exists in the Sertoli valve (SV) region at the terminal end of the seminiferous tubules, influenced by adjacent SOX17-positive rete testis. The SV epithelium, composed of specialized Sertoli cells, constitutively expresses GDNF and CYP26A1, an RA-degrading enzyme, supporting stable maintenance of GFRα1-positive spermatogonia in a region-specific manner. Unlike those in convoluted seminiferous tubules, SV Sertoli cells in rats and hamsters retain proliferative capacity in adulthood. In hamsters, these Sertoli cells relocate distally to support spermatogenesis, suggesting the presence of Sertoli cell progenitors in the SV region. This review discusses SV formation and its role as a 'closed' niche in mammalian spermatogenesis.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"168 ","pages":"137-162"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-transcriptional regulation of erythropoiesis. 红细胞生成的转录后调控。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-08-19 DOI: 10.1016/bs.ctdb.2026.06.006

Merlin Nithya Gnanapragasam, Raja Sundari Meenakshi Sundaram, Sarah E Adams, Rachael A White, Anita R Dhara, Parina N Patel, Sumayea B Mahmood Meem, Mahesh Ramamoorthy

引用次数: 0

Transcription elongation mechanisms that control gene expression in erythropoiesis. 调控红细胞生成过程中基因表达的转录延伸机制。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-06-23 DOI: 10.1016/bs.ctdb.2026.06.004

Kaustav Mukherjee, James J Bieker

引用次数: 0

Meiosis and retinoic acid in the mouse fetal gonads: An unforeseen twist. 小鼠胎儿性腺的减数分裂和维甲酸：一个意想不到的转折。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.1016/bs.ctdb.2024.10.006

Giulia Perrotta, Diana Condrea, Norbert B Ghyselinck

{"title":"Meiosis and retinoic acid in the mouse fetal gonads: An unforeseen twist.","authors":"Giulia Perrotta, Diana Condrea, Norbert B Ghyselinck","doi":"10.1016/bs.ctdb.2024.10.006","DOIUrl":"10.1016/bs.ctdb.2024.10.006","url":null,"abstract":"In mammals, differentiation of germ cells is crucial for sexual reproduction, involving complex signaling pathways and environmental cues defined by the somatic cells of the gonads. This review examines the long-standing model positing that all-trans retinoic acid (ATRA) acts as a meiosis-inducing substance (MIS) in the fetal ovary by inducing expression of STRA8 in female germ cells, while CYP26B1 serves as a meiosis-preventing substance (MPS) in the fetal testis by degrading ATRA and preventing STRA8 expression in the male germ cells until postnatal development. Recent genetic studies in the mouse challenge this paradigm, revealing that meiosis initiation in female germ cells can occur independently of ATRA signaling, with key roles played by other intrinsic factors like DAZL and DMRT1, and extrinsic signals such as BMPs and vitamin C. Thus, ATRA can no longer be considered as 'the' long-searched MIS. Furthermore, evidence indicates that CYP26B1 does not prevent meiosis by degrading ATRA in the fetal testis, but acts by degrading an unidentified MIS or synthesizing an equally unknown MPS. By emphasizing the necessity of genetic loss-of-function approaches to accurately delineate the roles of signaling molecules such ATRA in vivo, this chapter calls for a reevaluation of the mechanisms instructing and preventing meiosis initiation in the fetal ovary and testis, respectively. It highlights the need for further research into the molecular identities of the signals involved in these processes.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"59-88"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0