Current Topics in Developmental Biology最新文献_第5页

Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula. 斑马鱼早期胃肠中 Wnt 和 Fgf 的运输和梯度形成。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2023-12-27 DOI: 10.1016/bs.ctdb.2023.12.003

Emma J Cooper, Steffen Scholpp

{"title":"Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula.","authors":"Emma J Cooper, Steffen Scholpp","doi":"10.1016/bs.ctdb.2023.12.003","DOIUrl":"10.1016/bs.ctdb.2023.12.003","url":null,"abstract":"Within embryonic development, the occurrence of gastrulation is critical in the formation of multiple germ layers with many differentiative abilities. These cells are instructed through exposure to signalling molecules called morphogens. The secretion of morphogens from a source tissue creates a concentration gradient that allows distinct pattern formation in the receiving tissue. This review focuses on the morphogens Wnt and Fgf in zebrafish development. Wnt has been shown to have critical roles throughout gastrulation, including in anteroposterior patterning and neural posterisation. Fgf is also a vital signal, contributing to involution and mesodermal specification. Both morphogens have also been found to work in finely balanced synergy for processes such as neural induction. Thus, the signalling range of Wnts and Fgfs must be strictly controlled to target the correct target cells. Fgf and Wnts signal to local cells as well as to cells in the distance in a highly regulated way, requiring specific dissemination mechanisms that allow efficient and precise signalling over short and long distances. Multiple transportation mechanisms have been discovered to aid in producing a stable morphogen gradient, including short-range diffusion, filopodia-like extensions called cytonemes and extracellular vesicles, mainly exosomes. These mechanisms are specific to the morphogen that they transport and the intended signalling range. This review article discusses how spreading mechanisms in these two morphogenetic systems differ and the consequences on paracrine signalling, hence tissue patterning.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"157 ","pages":"125-153"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skeletal muscle niche, at the crossroad of cell/cell communications. 处于细胞/细胞通讯十字路口的骨骼肌龛。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI: 10.1016/bs.ctdb.2024.01.012

Marine Theret, Bénédicte Chazaud

{"title":"Skeletal muscle niche, at the crossroad of cell/cell communications.","authors":"Marine Theret, Bénédicte Chazaud","doi":"10.1016/bs.ctdb.2024.01.012","DOIUrl":"10.1016/bs.ctdb.2024.01.012","url":null,"abstract":"Skeletal muscle is composed of a variety of tissue and non-tissue resident cells that participate in homeostasis. In particular, the muscle stem cell niche is a dynamic system, requiring direct and indirect communications between cells, involving local and remote cues. Interactions within the niche must happen in a timely manner for the maintenance or recovery of the homeostatic niche. For instance, after an injury, pro-myogenic cues delivered too early will impact on muscle stem cell proliferation, delaying the repair process. Within the niche, myofibers, endothelial cells, perivascular cells (pericytes, smooth muscle cells), fibro-adipogenic progenitors, fibroblasts, and immune cells are in close proximity with each other. Each cell behavior, membrane profile, and secretome can interfere with muscle stem cell fate and skeletal muscle regeneration. On top of that, the muscle stem cell niche can also be modified by extra-muscle (remote) cues, as other tissues may act on muscle regeneration via the production of circulating factors or the delivery of cells. In this review, we highlight recent publications evidencing both local and remote effectors of the muscle stem cell niche.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"158 ","pages":"203-220"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular development, remodeling and maturation. 血管发育、重塑和成熟。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-03-03 DOI: 10.1016/bs.ctdb.2024.02.001

Jessica Furtado, Anne Eichmann

引用次数: 0

The satellite cell in skeletal muscle: A story of heterogeneity. 骨骼肌中的卫星细胞：异质性的故事

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-02-19 DOI: 10.1016/bs.ctdb.2024.01.018

Corentin Guilhot, Marie Catenacci, Stephanie Lofaro, Michael A Rudnicki

{"title":"The satellite cell in skeletal muscle: A story of heterogeneity.","authors":"Corentin Guilhot, Marie Catenacci, Stephanie Lofaro, Michael A Rudnicki","doi":"10.1016/bs.ctdb.2024.01.018","DOIUrl":"10.1016/bs.ctdb.2024.01.018","url":null,"abstract":"Skeletal muscle is a highly represented tissue in mammals and is composed of fibers that are extremely adaptable and capable of regeneration. This characteristic of muscle fibers is made possible by a cell type called satellite cells. Adjacent to the fibers, satellite cells are found in a quiescent state and located between the muscle fibers membrane and the basal lamina. These cells are required for the growth and regeneration of skeletal muscle through myogenesis. This process is known to be tightly sequenced from the activation to the differentiation/fusion of myofibers. However, for the past fifteen years, researchers have been interested in examining satellite cell heterogeneity and have identified different subpopulations displaying distinct characteristics based on localization, quiescence state, stemness capacity, cell-cycle progression or gene expression. A small subset of satellite cells appears to represent multipotent long-term self-renewing muscle stem cells (MuSC). All these distinctions led us to the hypothesis that the characteristics of myogenesis might not be linear and therefore may be more permissive based on the evidence that satellite cells are a heterogeneous population. In this review, we discuss the different subpopulations that exist within the satellite cell pool to highlight the heterogeneity and to gain further understanding of the myogenesis progress. Finally, we discuss the long term self-renewing MuSC subpopulation that is capable of dividing asymmetrically and discuss the molecular mechanisms regulating MuSC polarization during health and disease.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"158 ","pages":"15-51"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The fusion of physics and biology in early mammalian embryogenesis. 早期哺乳动物胚胎发育过程中物理学和生物学的融合。

2区生物学

Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-06-21 DOI: 10.1016/bs.ctdb.2024.05.001

Walter Piszker, Mijo Simunovic

{"title":"The fusion of physics and biology in early mammalian embryogenesis.","authors":"Walter Piszker, Mijo Simunovic","doi":"10.1016/bs.ctdb.2024.05.001","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2024.05.001","url":null,"abstract":"Biomechanics in embryogenesis is a dynamic field intertwining the physical forces and biological processes that shape the first days of a mammalian embryo. From the first cell fate bifurcation during blastulation to the complex symmetry breaking and tissue remodeling in gastrulation, mechanical cues appear critical in cell fate decisions and tissue patterning. Recent strides in mouse and human embryo culture, stem cell modeling of mammalian embryos, and biomaterial design have shed light on the role of cellular forces, cell polarization, and the extracellular matrix in influencing cell differentiation and morphogenesis. This chapter highlights the essential functions of biophysical mechanisms in blastocyst formation, embryo implantation, and early gastrulation where the interplay between the cytoskeleton and extracellular matrix stiffness orchestrates the intricacies of embryogenesis and placenta specification. The advancement of in vitro models like blastoids, gastruloids, and other types of embryoids, has begun to faithfully recapitulate human development stages, offering new avenues for exploring the biophysical underpinnings of early development. The integration of synthetic biology and advanced biomaterials is enhancing the precision with which we can mimic and study these processes. Looking ahead, we emphasize the potential of CRISPR-mediated genomic perturbations coupled with live imaging to uncover new mechanosensitive pathways and the application of engineered biomaterials to fine-tune the mechanical conditions conducive to embryonic development. This synthesis not only bridges the gap between experimental models and in vivo conditions to advancing fundamental developmental biology of mammalian embryogenesis, but also sets the stage for leveraging biomechanical insights to inform regenerative medicine.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"160 ","pages":"31-64"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Got WNTS? Insight into bone health from a WNT perspective. 实际上wnt ?从WNT角度洞察骨骼健康。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2023.01.004

Sonya E L Craig, Megan N Michalski, Bart O Williams

引用次数: 2

Visualizing WNT signaling in mammalian systems. 哺乳动物系统中WNT信号的可视化。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ctdb.2023.02.001

Tanne van der Wal, Renée van Amerongen

{"title":"Visualizing WNT signaling in mammalian systems.","authors":"Tanne van der Wal, Renée van Amerongen","doi":"10.1016/bs.ctdb.2023.02.001","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2023.02.001","url":null,"abstract":"WNT/CTNNB1 signaling plays a critical role in the development of all multicellular animals. Here, we include both the embryonic stages, during which tissue morphogenesis takes place, and the postnatal stages of development, during which tissue homeostasis occurs. Thus, embryonic development concerns lineage development and cell fate specification, while postnatal development involves tissue maintenance and regeneration. Multiple tools are available to researchers who want to investigate, and ideally visualize, the dynamic and pleiotropic involvement of WNT/CTNNB1 signaling in these processes. Here, we discuss and evaluate the decisions that researchers need to make in identifying the experimental system and appropriate tools for the specific question they want to address, covering different types of WNT/CTNNB1 reporters in cells and mice. At a molecular level, advanced quantitative imaging techniques can provide spatio-temporal information that cannot be provided by traditional biochemical assays. We therefore also highlight some recent studies to show their potential in deciphering the complex and dynamic mechanisms that drive WNT/CTNNB1 signaling.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"153 ","pages":"61-93"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9256030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wnt regulation of hematopoietic stem cell development and disease. Wnt 对造血干细胞发育和疾病的调控。

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2023-01-09 DOI: 10.1016/bs.ctdb.2022.12.001

Kelsey A Carpenter, Kate E Thurlow, Sonya E L Craig, Stephanie Grainger

{"title":"Wnt regulation of hematopoietic stem cell development and disease.","authors":"Kelsey A Carpenter, Kate E Thurlow, Sonya E L Craig, Stephanie Grainger","doi":"10.1016/bs.ctdb.2022.12.001","DOIUrl":"10.1016/bs.ctdb.2022.12.001","url":null,"abstract":"Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all cells of the blood and most immune cells. Due to their capacity for unlimited self-renewal, long-term HSCs replenish the blood and immune cells of an organism throughout its life. HSC development, maintenance, and differentiation are all tightly regulated by cell signaling pathways, including the Wnt pathway. Wnt signaling is initiated extracellularly by secreted ligands which bind to cell surface receptors and give rise to several different downstream signaling cascades. These are classically categorized either β-catenin dependent (BCD) or β-catenin independent (BCI) signaling, depending on their reliance on the β-catenin transcriptional activator. HSC development, homeostasis, and differentiation is influenced by both BCD and BCI, with a high degree of sensitivity to the timing and dosage of Wnt signaling. Importantly, dysregulated Wnt signals can result in hematological malignancies such as leukemia, lymphoma, and myeloma. Here, we review how Wnt signaling impacts HSCs during development and in disease.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"153 ","pages":"255-279"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9256028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orchestrating recombination initiation in mice and men. 协调小鼠和人类的重组启动

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2022-08-08 DOI: 10.1016/bs.ctdb.2022.05.001

Elena Damm, Linda Odenthal-Hesse

引用次数: 0

Cancer and meiotic gene expression: Two sides of the same coin? 癌症与减数分裂基因表达：一枚硬币的两面？

2区生物学

Current Topics in Developmental Biology Pub Date : 2023-01-01 Epub Date: 2022-07-29 DOI: 10.1016/bs.ctdb.2022.06.002

Ieng Fong Sou, Geert Hamer, Wee-Wei Tee, Gerben Vader, Urszula Lucja McClurg

引用次数: 0