Salivary gland developmental mechanics.

2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Current Topics in Developmental Biology Pub Date : 2024-01-01 Epub Date: 2024-05-31 DOI:10.1016/bs.ctdb.2024.05.002
E Angelo Morales, Shaohe Wang
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引用次数: 0

Abstract

The salivary gland undergoes branching morphogenesis to elaborate into a tree-like structure with numerous saliva-secreting acinar units, all joined by a hierarchical ductal system. The expansive epithelial surface generated by branching morphogenesis serves as the structural basis for the efficient production and delivery of saliva. Here, we elucidate the process of salivary gland morphogenesis, emphasizing the role of mechanics. Structurally, the developing salivary gland is characterized by a stratified epithelium tightly encased by the basement membrane, which is in turn surrounded by a mesenchyme consisting of a dense network of interstitial matrix and mesenchymal cells. Diverse cell types and extracellular matrices bestow this developing organ with organized, yet spatially varied mechanical properties. For instance, the surface epithelial sheet of the bud is highly fluidic due to its high cell motility and weak cell-cell adhesion, rendering it highly pliable. In contrast, the inner core of the bud is more rigid, characterized by reduced cell motility and strong cell-cell adhesion, which likely provide structural support for the tissue. The interactions between the surface epithelial sheet and the inner core give rise to budding morphogenesis. Furthermore, the basement membrane and the mesenchyme offer mechanical constraints that could play a pivotal role in determining the higher-order architecture of a fully mature salivary gland.

唾液腺发育机制
唾液腺经过分枝形态发生,发育成一个树状结构,由无数个分泌唾液的尖腺单位组成,所有尖腺单位都由一个分层的导管系统连接。分支形态发生所产生的扩张性上皮表面是有效分泌和输送唾液的结构基础。在这里,我们阐明了唾液腺形态发生的过程,强调了力学的作用。从结构上看,发育中的唾液腺由基底膜紧紧包裹的分层上皮细胞构成,而基底膜又被由间质基质和间质细胞组成的致密网络所包围。不同类型的细胞和细胞外基质使这个发育中的器官具有有组织、但在空间上各不相同的机械特性。例如,由于细胞运动性强,细胞与细胞之间的粘附性弱,胚芽表面的上皮细胞片具有很强的流动性,因此非常柔韧。相比之下,芽的内核更为坚硬,其特点是细胞运动性降低,细胞间粘附性强,这可能为组织提供了结构支撑。表面上皮片和内核之间的相互作用促成了芽的形态发生。此外,基底膜和间质提供了机械约束,可能在决定完全成熟的唾液腺的高阶结构方面发挥关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.00
自引率
0.00%
发文量
91
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