Current Topics in Developmental Biology最新文献_第3页

Mechanisms of germ-soma communication during follicular growth. 卵泡生长过程中胚体通讯机制。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-05-22 DOI: 10.1016/bs.ctdb.2026.04.009

Claude Robert, Ricardo Perecin Nociti

{"title":"Mechanisms of germ-soma communication during follicular growth.","authors":"Claude Robert, Ricardo Perecin Nociti","doi":"10.1016/bs.ctdb.2026.04.009","DOIUrl":"10.1016/bs.ctdb.2026.04.009","url":null,"abstract":"Communication between cells is essential for orchestrating tissue, organ, and whole-body cohesion. The communication can occur within the same cell (autocrine signaling), between neighboring cells (paracrine signaling), from distant cells (endocrine signaling), and between adjacent cells (juxtacrine signaling). Extracellular vesicle secretions, where messaging molecules like proteins, RNAs, and lipids are embedded in a membrane-enclosed particle released by the signaling cell, allow signaling to occur upon uptake and release of the cargo. Intercellular communications in synchrony between folliculogenesis and oogenesis involve both long-distance and short-distance messaging within the ovarian follicle, which is segmented into different cell types, with the oocyte lying at the center. Cells can generate extensions to increase the range of messaging by reaching out to more distant cells the so-called protrusion-based intercellular communication exemplified by tunneling nanotubes (TNTs), MT-nanotubes (MTNTs), microvilli, filopodia, and cytonemes. In mammalian oocytes, the filopodia from follicular cells that grow towards the oocyte is known as transzonal projections (TZPs). They accumulate large cargos, such as EVs, proteins and RNAs, at the tip creating the gametic synapses. These projections keep the oocyte and follicular cells connected and exchanging cytoplasmic content despite the apparent physical separation caused by the oocyte's zona pellucida. The protective and nurturing nature of follicular cells towards the oocyte, due to the presence of cellular interconnectivity within follicular cells and the oocyte, is conserved between species and is essential for communication, playing a crucial role in the development of a high-quality oocyte.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"169 ","pages":"169-191"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymmetry and the cytoskeleton: Mechanisms of asymmetric neural stem cell division in Drosophila melanogaster. 不对称与细胞骨架：黑腹果蝇神经干细胞不对称分裂的机制。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2025-12-16 DOI: 10.1016/bs.ctdb.2025.11.002

Clemens Cabernard

引用次数: 0

Purkinje cell diversification: A blueprint for cerebellar development, patterning, and evolution. 浦肯野细胞多样化：小脑发育、模式和进化的蓝图。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/bs.ctdb.2025.11.001

James Y H Li, Nagham Khouri-Farah, Martina Ysabel Mendoza Miranda

{"title":"Purkinje cell diversification: A blueprint for cerebellar development, patterning, and evolution.","authors":"James Y H Li, Nagham Khouri-Farah, Martina Ysabel Mendoza Miranda","doi":"10.1016/bs.ctdb.2025.11.001","DOIUrl":"10.1016/bs.ctdb.2025.11.001","url":null,"abstract":"Purkinje cells (PCs) are the linchpins of cerebellar development and function. As the sole output neurons of the cerebellar cortex, PCs play a key role in integrating input and transmitting cerebellar output. In addition, PCs influence the development of other cell populations through the secretion of morphogens and region-specific activity. PCs emerge as a molecularly heterogeneous population early in development, and their migration, spatial reorganization, and subtype-dependent roles sculpt the cerebellar architecture. In this review, we synthesize the current knowledge of PC ontogenesis and diversification, including recent single-cell transcriptomic findings that reveal embryonic subtype diversity and its spatial logic. We examine how combinatorial expression of key transcription factors, notably the FOXP family, drives PC subtype identity, and how their loss disrupts cerebellar regionalization. We also discuss how PC subtype diversification integrates developmental timing, circuit formation, and evolutionary expansion of the cerebellar hemisphere, highlighting its importance in both cerebellar morphogenesis and the emergence of higher cognitive functions.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"167 ","pages":"33-65"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymmetric male meiosis and its implications in heredity. 雄性不对称减数分裂及其遗传意义。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-02-09 DOI: 10.1016/bs.ctdb.2026.01.005

Xuefeng Meng, Robert B Baird, Yukiko M Yamashita

{"title":"Asymmetric male meiosis and its implications in heredity.","authors":"Xuefeng Meng, Robert B Baird, Yukiko M Yamashita","doi":"10.1016/bs.ctdb.2026.01.005","DOIUrl":"10.1016/bs.ctdb.2026.01.005","url":null,"abstract":"Meiosis is the process where diploid cells reduce the ploidy to generate haploid gametes. Meiosis in males and females is often regarded as polar opposites: female meiosis produces a large cell (oocyte/egg) with all essential ingredients to start a new life in it, whereas male meiosis produces tiny sperm cells that have stripped down all cytoplasm and only contribute nuclear DNA to the next generation. Female meiosis is inherently asymmetric, producing one oocyte and three polar bodies, the latter of which do not participate in fertilization. In contrast, male meiosis is generally regarded as a symmetric process, where one diploid cell generates four sperm cells. This assumed dichotomy has influenced the framework of how we view the process of inheritance. However, interestingly, a considerable number of species exhibit asymmetric male meiosis, in which spermatogenesis generates fewer than four sperm from a single diploid germ cell, akin to oogenesis, where each germ cell produces only one oocyte. This review attempts to examine the possibility that male meiosis can be asymmetric, even outside the species that exhibit constitutive asymmetric male meiosis. We discuss the possibility that asymmetric male meiosis may provide a foundation for meiotic drive, the phenomenon that causes biased inheritance of alleles and violates Mendel's Law of Equal Segregation.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"168 ","pages":"211-243"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ovarian stroma as a key regulator of follicular development and gamete quality across the reproductive lifespan. 卵巢间质是卵泡发育和配子质量的关键调节因子。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-05-08 DOI: 10.1016/bs.ctdb.2026.04.005

Shweta S Dipali, Francesca E Duncan

引用次数: 0

Evolutionary perspectives on the development of the mammalian cerebellum: From cellular diversity to gene regulatory programs. 哺乳动物小脑发育的进化观点：从细胞多样性到基因调控程序。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-02-07 DOI: 10.1016/bs.ctdb.2026.01.010

Tetsuya Yamada, Ioannis Sarropoulos, Mari Sepp

引用次数: 0

Developmental roots of cerebellar degeneration in spinocerebellar ataxia. 脊髓小脑共济失调小脑变性的发育根源。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-02-06 DOI: 10.1016/bs.ctdb.2026.01.011

Élyse Zadigue-Dubé, Alanna J Watt

{"title":"Developmental roots of cerebellar degeneration in spinocerebellar ataxia.","authors":"Élyse Zadigue-Dubé, Alanna J Watt","doi":"10.1016/bs.ctdb.2026.01.011","DOIUrl":"10.1016/bs.ctdb.2026.01.011","url":null,"abstract":"Late-onset neurodegenerative diseases have long been conceptualized as disorders arising from cumulative cellular stress and age-related decline, with pathology emerging at the time of symptom onset. However, emerging evidence challenges this view, suggesting that developmental perturbations may establish early vulnerabilities that predispose specific neuronal populations to degeneration later in life. In the cerebellum, mutations causing spinocerebellar ataxias (SCAs) such as SCA1 and SCA6 affect genes involved in normal circuit formation, resulting in subtle early abnormalities in Purkinje cell activity and connectivity. These alterations seem to be initially buffered by compensatory mechanisms, and the eventual breakdown of homeostatic resilience during midlife may thus be the trigger for disease onset and progression. This developmental perspective reframes late-onset neurodegeneration as a lifelong process shaped by the interplay between early developmental wiring, adaptive compensation, and age-dependent vulnerability. Understanding these early developmental alterations provides critical insight into disease mechanisms and opens new avenues for pre-symptomatic intervention and prevention.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"167 ","pages":"413-428"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of the spinocerebellar system within the precerebellar network. 小脑前网络中脊髓小脑系统的发育。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-03-02 DOI: 10.1016/bs.ctdb.2026.01.013

Helen C Lai

引用次数: 0

Lessons from human neuroimaging on the developing cerebellum in health and disease. 人类神经影像学对健康和疾病中小脑发育的启示。

2区生物学

Current Topics in Developmental Biology Pub Date : 2026-01-01 Epub Date: 2026-04-11 DOI: 10.1016/bs.ctdb.2026.02.002

A J Jain, A M D'Mello

引用次数: 0

Ontogenesis and diversification of cerebellar glia: A developmental perspective. 小脑胶质细胞的个体发生和分化：一个发育的观点。