Current Topics in Developmental Biology最新文献_第3页

Fertilization mechanisms in hermaphroditic ascidians and nematodes: Common mechanisms with mammals and plants. 雌雄同体海鞘和线虫的受精机制：哺乳动物和植物的共同机制。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-03-05 DOI: 10.1016/bs.ctdb.2025.01.010

Hitoshi Sawada, Takako Saito, Yoshihiro Shimada, Hitoshi Nishimura

引用次数: 0

Cell migration during development: Is it always collective and never as a single cell? 细胞在发育过程中的迁移：是否总是集体迁移，而不是单个细胞迁移？

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-02-20 DOI: 10.1016/bs.ctdb.2024.10.004

Jorge Diaz, Amrutha Patkunarajah, Roberto Mayor

{"title":"Cell migration during development: Is it always collective and never as a single cell?","authors":"Jorge Diaz, Amrutha Patkunarajah, Roberto Mayor","doi":"10.1016/bs.ctdb.2024.10.004","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2024.10.004","url":null,"abstract":"Cell migration is a fundamental process essential for homeostasis, disease progression, and developmental biology. This review explores the mechanisms of cell migration, focusing on both single-cell and collective migration modes, and highlights their roles in early development. We examine the characteristics of amoeboid and mesenchymal migration, emphasizing their regulation and implications across various classical developmental models. By analyzing examples of single-cell migration, such as primordial germ cell migration in zebrafish and Drosophila melanogaster, and examples of collective cell migration in the lateral line of zebrafish, border cells, and testis myotubes in Drosophila, we illustrate the complexity and significance of cell-cell interactions, cell-matrix interactions, and the chemical and mechanical cues that drive migration. The review also highlights the \"supracellular organization\" observed in many systems where supracellular actomyosin cables are present, which allow for coordinated and cooperative movement. This cooperativity is crucial for effective positioning and function, ensuring proper tissue formation and responsive adaptation to environmental cues. This review provides insights and raises questions about the mechanisms of cell migration during development, supporting the idea that cells never migrate entirely alone. We propose that even in those cases normally described as single cell migration, some degree of collectiveness or cooperation is involved, suggesting that during development, cells always migrate in collective coordination when forming complex tissue and organ structures.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"164 ","pages":"153-185"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collective migration in complex environments: The case of the trunk neural crest. 复杂环境下的集体迁移：以主干神经嵴为例。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.ctdb.2025.01.004

Hanna-Maria Häkkinen, Soraya Villaseca, Marie De La Burgade, Zainalabdeen Alhashem, Elena Scarpa

{"title":"Collective migration in complex environments: The case of the trunk neural crest.","authors":"Hanna-Maria Häkkinen, Soraya Villaseca, Marie De La Burgade, Zainalabdeen Alhashem, Elena Scarpa","doi":"10.1016/bs.ctdb.2025.01.004","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2025.01.004","url":null,"abstract":"The neural crest is a highly invasive, multipotent embryonic cell population common to all vertebrates. Neural crest cells migrate all along the anteroposterior axis of the vertebrate embryos, crossing complex microenvironments during their journey and eventually halting their migration to give rise to a variety of derivatives. At cranial levels, neural crest cells originate cartilage and bone of the skull and face, cranial ganglia and glia and pigment cells. In contrast, neural crest of the trunk is unable to form ectomesenchymal tissues such as cartilage and bone, but instead contributes to the cardiac outflow tract, enteric neurons, sensory and sympathetic neurons, Schwann cells and pigment across the vertebrate trunk. Defects in neural crest formation and migration can result in an array of birth defects and childhood malignancies collectively known as neurocristopathies, and investigation of the mechanisms underlying neural crest migration has significant clinical relevance. Considerable progress has been made in recent years in our understanding of the principles underlying collective cell migration of cranial neural crest cells. However, the extracellular environment trunk neural crest traverse in vivo is radically different from that experienced by cranial neural crest cells. Here, we review collective cell migration, fate specification and current in vivo and in vitro models of trunk neural crest migration under the lens of the complex interaction of this extraordinary cell population with its complex tissue environment.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"164 ","pages":"109-151"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinoids and retinoid-binding proteins: Unexpected roles in metabolic disease. 维甲酸和维甲酸结合蛋白：代谢性疾病中的意外作用

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1016/bs.ctdb.2024.10.001

William S Blaner, Jisun Paik, Pierre-Jacques Brun, Marcin Golczak

{"title":"Retinoids and retinoid-binding proteins: Unexpected roles in metabolic disease.","authors":"William S Blaner, Jisun Paik, Pierre-Jacques Brun, Marcin Golczak","doi":"10.1016/bs.ctdb.2024.10.001","DOIUrl":"10.1016/bs.ctdb.2024.10.001","url":null,"abstract":"Alterations in tissue expression levels of both retinol-binding protein 2 (RBP2) and retinol-binding protein 4 (RBP4) have been associated with metabolic disease, specifically with obesity, glucose intolerance and hepatic steatosis. Our laboratories have shown that this involves novel pathways not previously considered as possible linkages between impaired retinoid metabolism and metabolic disease development. We have established both biochemically and structurally that RBP2 binds with very high affinity to very long-chain unsaturated 2-monoacylglycerols like the canonical endocannabinoid 2-arachidonoyl glycerol (2-AG) and other endocannabinoid-like substances. Binding of retinol or 2-MAGs involves the same binding pocket and 2-MAGs are able to displace retinol binding. Consequently, RBP2 is a physiologically relevant binding protein for endocannabinoids and endocannabinoid-like substances and is a nexus where the very potent retinoid and endocannabinoid signaling pathways converge. When Rbp2-null mice are challenged orally with fat, this gives rise to elevated levels in the proximal small intestine of both 2-AG and the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) in the proximal small intestine. We propose that elevation of GIP concentrations upon high fat diet feeding gives rise to obesity and the other elements of metabolic disease seen in Rbp2-null mice. Unexpectedly, we observed that RBP4 is present in secretory granules of the GIP-secreting intestinal K-cells and is co-secreted with GIP in response to a stimulus that provokes GIP secretion. Moreover, RBP4 is co-secreted along with glucagon from pancreatic alpha-cells in response to a secretory stimulus. The association during the secretory process of RBP4 with potent hormones that regulate metabolism (GIP and glucagon) accounts for at least some of the metabolic disease seen upon overexpression of Rbp4.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"89-111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifelong dynamic maintenance of stereocilia bundles in mammalian auditory hair cells. 哺乳动物听觉毛细胞中立体纤毛束的终身动态维持。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-04-09 DOI: 10.1016/bs.ctdb.2025.03.003

A Catalina Vélez-Ortega, Gregory I Frolenkov

引用次数: 0

Genetic and epigenetic control of photoreceptor development. 光感受器发育的遗传和表观遗传控制。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-04-10 DOI: 10.1016/bs.ctdb.2025.03.007

Zepeng Qu, Anand Swaroop, Carolina Beltrame Del Debbio

引用次数: 0

The action of retinoic acid on spermatogonia in the testis. 维甲酸对睾丸精原细胞的作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.1016/bs.ctdb.2024.10.005

Shelby L Havel, Michael D Griswold

{"title":"The action of retinoic acid on spermatogonia in the testis.","authors":"Shelby L Havel, Michael D Griswold","doi":"10.1016/bs.ctdb.2024.10.005","DOIUrl":"10.1016/bs.ctdb.2024.10.005","url":null,"abstract":"For mammalian spermatogenesis to proceed normally, it is essential that the population of testicular progenitor cells, A undifferentiated spermatogonia (Aundiff), undergoes differentiation during the A to A1 transition that occurs at the onset of spermatogenesis. The commitment of the Aundiff population to differentiation and leaving a quiescent, stem-like state gives rise to all the spermatozoa produced across the lifespan of an individual, and ultimately determines male fertility. The action of all-trans retinoic acid (atRA) on the Aundiff population is the determining factor that induces this change. Sertoli cells, omnipresent, nurse cells within the mammalian testis are responsible for synthesizing the atRA that prompts this change in the neonatal testicular environment. The mechanism of atRA synthesis and signaling has been robustly explored and, in this review, we have summarized what is currently known about the action of testicular atRA at the onset of spermatogenesis. We have combined this with evidence gained from prominent genetic studies that have further elucidated the function of genes critical to atRA synthesis. We have additionally described the effects of the first pulse of atRA delivered to the germ cells of the testis, which has been investigated using WIN 18,446 treatment which prevents atRA synthesis and induces spermatogenic synchrony. This method provides unparalleled resolution into cell and stage specific testicular changes, and combined with transgenic animal models, has allowed researchers to elucidate much regarding the onset of spermatogenesis.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"143-166"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of chromatin-related epigenetic modulations in CAKUT. 染色质相关表观遗传调控在CAKUT中的作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.ctdb.2024.11.006

Luise König, Miriam Schmidts

引用次数: 0

Understanding developing kidneys and Wilms tumors one cell at a time. 了解肾脏和肾母细胞肿瘤的一次一个细胞的发展。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-02-03 DOI: 10.1016/bs.ctdb.2024.11.005

Nine Solee Pop, Karamjit Singh Dolt, Peter Hohenstein

引用次数: 0

The multifaceted roles of retinoids in eye development, vision, and retinal degenerative diseases. 类维甲酸在眼睛发育、视力和视网膜退行性疾病中的多方面作用。