Current Topics in Developmental Biology最新文献_第3页

Paternal contributions to mammalian zygote - Beyond sperm-oocyte fusion. 父亲对哺乳动物受精卵的贡献——超越精卵融合。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI: 10.1016/bs.ctdb.2025.02.002

Peter Sutovsky, Michal Zigo, Filip Tirpak, Richard Oko

{"title":"Paternal contributions to mammalian zygote - Beyond sperm-oocyte fusion.","authors":"Peter Sutovsky, Michal Zigo, Filip Tirpak, Richard Oko","doi":"10.1016/bs.ctdb.2025.02.002","DOIUrl":"10.1016/bs.ctdb.2025.02.002","url":null,"abstract":"Contrary to a common misconception that the fertilizing spermatozoon acts solely as a vehicle for paternal genome delivery to the zygote, this chapter aims to illustrate how the male gamete makes other essential contributions , including the sperm borne-oocyte activation factors, centrosome components, and components of the sperm proteome and transcriptome that help to lay the foundation for pregnancy establishment and maintenance to term, and the newborn and adult health. Our inquiry starts immediately after sperm plasma membrane fusion with its oocyte counterpart, the oolemma. Parallel to and following sperm incorporation in the egg cytoplasm, some of the sperm structures (perinuclear theca) are dissolved and spent to induce development, others (nucleus, centriole) are transformed into zygotic structures enabling it, and yet others (mitochondrial and fibrous sheath, axonemal microtubules and outer dense fibers) are recycled as to not stand in its way. Noteworthy advances in this research include the identification of several sperm-borne oocyte activating factor candidates, the role of autophagy in the post-fertilization sperm mitochondrion degradation, new insight into zygotic centrosome origins and function, and the contributions of sperm-delivered RNA cargos to early embryo development. In concluding remarks, the unresolved issues, and clinical and biotechnological implications of sperm-vectored paternal inheritance are discussed.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"162 ","pages":"387-446"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activating the C. elegans egg: Molecular players, current knowledge, and unanswered questions. 激活秀丽隐杆线虫卵：分子玩家，当前的知识，和悬而未决的问题。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1016/bs.ctdb.2025.01.007

Aimee Jaramillo-Lambert, Amber R Krauchunas

引用次数: 0

Rethinking retinoic acid self-regulation: A signaling robustness network approach. 重新思考维甲酸的自我调节：信号稳健性网络方法

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1016/bs.ctdb.2024.11.002

Abraham Fainsod, Rajanikanth Vadigepalli

{"title":"Rethinking retinoic acid self-regulation: A signaling robustness network approach.","authors":"Abraham Fainsod, Rajanikanth Vadigepalli","doi":"10.1016/bs.ctdb.2024.11.002","DOIUrl":"10.1016/bs.ctdb.2024.11.002","url":null,"abstract":"All-trans retinoic acid (ATRA) signaling is a major pathway regulating numerous differentiation, proliferation, and patterning processes throughout life. ATRA biosynthesis depends on the nutritional availability of vitamin A and other retinoids and carotenoids, while it is sensitive to dietary and environmental toxicants. This nutritional and environmental influence requires a robustness response that constantly fine-tunes the ATRA metabolism to maintain a context-specific, physiological range of signaling levels. The ATRA metabolic and signaling network is characterized by the existence of multiple enzymes, transcription factors, and binding proteins capable of performing the same activity. The partial spatiotemporal expression overlap of these enzymes and proteins yields different network compositions in the cells and tissues where this pathway is active. Genetic polymorphisms affecting the activity of individual network components further impact the network composition variability and the self-regulatory feedback response to ATRA fluctuations. Experiments directly challenging the robustness response uncovered a Pareto optimality in the ATRA network, such that some genetic backgrounds efficiently deal with excess ATRA but are very limited in their robustness response to reduced ATRA and vice versa. We discuss a network-focused framework to describe the robustness response and the Pareto optimality of the ATRA metabolic and signaling network.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"113-141"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-organization, error-correction and homeorhesis in renal development. 肾脏发育中的自组织、错误纠正和同源性。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/bs.ctdb.2024.11.004

Jamie A Davies, Rhiannon Beadman

{"title":"Self-organization, error-correction and homeorhesis in renal development.","authors":"Jamie A Davies, Rhiannon Beadman","doi":"10.1016/bs.ctdb.2024.11.004","DOIUrl":"https://doi.org/10.1016/bs.ctdb.2024.11.004","url":null,"abstract":"Development is often described as following a 'genetic programme', yet perturbations to normal development, whether applied by an experimenter, the environment, or a mutation affecting development of a nearby part of the body, show developmental biology to be remarkably adaptable. This paper examines the evidence for adaptability in kidney development, focusing specifically on error-correction, self-organization, and homeorhesis (the dynamic equivalent to homeostasis: return of a perturbed system to a standard developmental trajectory, rather than a return to a fixed state that is seen in homeostasis). We present evidence for self-organization of renal tissue from randomly-aggregated progenitor cells, and also for the limitations of this self-organization and how they can be transcended by experimentally-applied symmetry-breaking cues. We provide evidence for error-correcting systems, and some evidence in the literature, generally in papers devoted to other problems, for genuine homeorhesis in aspects of kidney development. This review is not intended to be a 'last word' on any of these topics, and certainly not on the last-mentioned, for which data are very scant. It is instead intended to stimulate research in these areas, particularly homeorhesis, partly to increase understanding of natural development and partly as an aid to renal tissue engineering.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"163 ","pages":"105-128"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 DOI: 10.1016/S0070-2153(25)00056-0

引用次数: 0

The characteristics of the calcium signals that activate mammalian eggs at fertilization. 哺乳动物卵子受精时激活钙信号的特征。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-20 DOI: 10.1016/bs.ctdb.2024.12.002

Karl Swann

{"title":"The characteristics of the calcium signals that activate mammalian eggs at fertilization.","authors":"Karl Swann","doi":"10.1016/bs.ctdb.2024.12.002","DOIUrl":"10.1016/bs.ctdb.2024.12.002","url":null,"abstract":"Gamete membrane fusion in mammals brings the paternal genome into the cytoplasm of the egg. It also enables signals to pass from the sperm into the egg to trigger the completion of meiosis and the start of embryo development. The essential signal to activate development in all mammals studied, consists of a series of transient increases in the cytosolic Ca2+ concentration driven by cycles of InsP3 production. This review focusses on the characteristics of these sperm-induced Ca2+ signals. I consider how some specific features of sperm-derived phospholipase C-zeta (PLCζ), along with the known properties of the type 1 InsP3 receptor, provide a basis for understanding the mechanisms of the dynamic changes in Ca2+ observed in fertilizing eggs. I describe how the PLCζ targeting of cytoplasmic vesicles in the egg cytoplasm, that contain PI(4,5)P2, is necessary to explain the rapid waves associated with the rising phase of each Ca2+ transient. I also discuss the importance of the repetitive Ca2+ rises for egg activation and the way mitochondrial ATP production may modulate Ca2+ release in eggs. Finally, I consider the role that a sperm-induced ATP increase may play in the egg activation process.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"162 ","pages":"317-350"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular and molecular regulations of oocyte selection and activation in mammals. 哺乳动物卵母细胞选择和激活的细胞和分子调控。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1016/bs.ctdb.2024.11.003

Xuebing Yang, Yan Zhang, Hua Zhang

{"title":"Cellular and molecular regulations of oocyte selection and activation in mammals.","authors":"Xuebing Yang, Yan Zhang, Hua Zhang","doi":"10.1016/bs.ctdb.2024.11.003","DOIUrl":"10.1016/bs.ctdb.2024.11.003","url":null,"abstract":"Oocytes, a uniquely pivotal cell population, play a central role in species continuity. In mammals, oogenesis involves distinct processes characterized by sequential rounds of selection, arrest, and activation to produce a limited number of mature eggs, fitting their high-survival yet high-cost fertility. During the embryonic phase, oocytes undergo intensive selection via cytoplasmic and organelle enrichment, accompanied by the onset and arrest of meiosis, thereby establishing primordial follicles (PFs) as a finite reproductive reserve. Subsequently, the majority of primary oocytes enter a dormant state and are gradually recruited through a process termed follicle activation, essential for maintaining orderly fertility. Following activation, oocytes undergo rapid growth, experiencing cycles of arrest and activation regulated by endocrine and paracrine signals, ultimately forming fertilizable eggs. Over the past two decades, advancements in genetically modified animal models, high-resolution imaging, and omics technologies have significantly enhanced our understanding of the cellular and molecular mechanisms that govern mammalian oogenesis. These advances offer profound insights into the regulatory mechanisms of mammalian reproduction and associated female infertility disorders. In this chapter, we provide an overview of current knowledge in mammalian oogenesis, with a particular emphasis on oocyte selection and activation in vivo.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"162 ","pages":"283-315"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between retinoic acid binding proteins and retinoic acid degrading enzymes in modulating retinoic acid concentrations. 视黄酸结合蛋白和视黄酸降解酶在调节视黄酸浓度方面的相互作用。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1016/bs.ctdb.2024.09.001

Nina Isoherranen, Yue Winnie Wen

{"title":"The interplay between retinoic acid binding proteins and retinoic acid degrading enzymes in modulating retinoic acid concentrations.","authors":"Nina Isoherranen, Yue Winnie Wen","doi":"10.1016/bs.ctdb.2024.09.001","DOIUrl":"10.1016/bs.ctdb.2024.09.001","url":null,"abstract":"The active metabolite of vitamin A, all-trans-retinoic acid (atRA), is critical for maintenance of many cellular processes. Although the enzymes that can synthesize and clear atRA in mammals have been identified, their tissue and cell-type specific roles are still not fully established. Based on the plasma protein binding, tissue distribution and lipophilicity of atRA, atRA partitions extensively to lipid membranes and other neutral lipids in cells. As a consequence, free atRA concentrations in cells are expected to be exceedingly low. As such mechanisms must exist that allow sufficiently high atRA concentrations to occur for binding to retinoic acid receptor (RARs) and for RAR mediated signaling. Kinetic simulations suggest that cellular retinoic acid binding proteins (CRABPs) provide a cytosolic reservoir for atRA to allow high enough cytosolic concentrations that enable RAR signaling. Yet, the different CRABP family members CRABP1 and CRABP2 may serve different functions in this context. CRABP1 may reside in the cytosol as a member of a cytosolic signalosome and CRABP2 may bind atRA in the cytosol and localize to the nucleus. Both CRABPs appear to interact with the atRA-degrading cytochrome P450 (CYP) family 26 enzymes in the endoplasmic reticulum. These interactions, together with the expression levels of the CRABPs and CYP26s, likely modulate cellular atRA concentration gradients and tissue atRA concentrations in a tightly coordinated manner. This review provides a summary of the current knowledge of atRA distribution, metabolism and protein binding and how these characteristics may alter tissue atRA concentrations.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"167-200"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin A supply in the eye and establishment of the visual cycle. 维生素A在眼睛的供应和视觉周期的建立。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-10-02 DOI: 10.1016/bs.ctdb.2024.09.003

Sepalika Bandara, Johannes von Lintig

引用次数: 0

Early retinoic acid signaling organizes the body axis and defines domains for the forelimb and eye. 早期维甲酸信号组织身体轴并定义前肢和眼睛的区域。

2区生物学

Current Topics in Developmental Biology Pub Date : 2025-01-01 Epub Date: 2024-11-08 DOI: 10.1016/bs.ctdb.2024.10.002

Gregg Duester

{"title":"Early retinoic acid signaling organizes the body axis and defines domains for the forelimb and eye.","authors":"Gregg Duester","doi":"10.1016/bs.ctdb.2024.10.002","DOIUrl":"10.1016/bs.ctdb.2024.10.002","url":null,"abstract":"All-trans RA (ATRA) is a small molecule derived from retinol (vitamin A) that directly controls gene expression at the transcriptional level by serving as a ligand for nuclear ATRA receptors. ATRA is produced by ATRA-generating enzymes that convert retinol to retinaldehyde (retinol dehydrogenase; RDH10) followed by conversion of retinaldehyde to ATRA (retinaldehyde dehydrogenase; ALDH1A1, ALDH1A2, or ALDH1A3). Determining what ATRA normally does during vertebrate development has been challenging as studies employing ATRA gain-of-function (RA treatment) often do not agree with genetic loss-of-function studies that remove ATRA via knockouts of ATRA-generating enzymes. In mouse embryos, ATRA is first generated at stage E7.5 by ATRA-generating enzymes whose genes are first expressed at that stage. This article focuses upon what ATRA normally does at early stages based upon these knockout studies. It has been observed that early-generated ATRA performs three essential functions: (1) activation of genes that control hindbrain and spinal cord patterning; (2) repression of Fgf8 in the heart field and caudal progenitors to provide an FGF8-free region in the trunk essential for somitogenesis, heart morphogenesis, and initiation of forelimb fields; and (3) actions that stimulate invagination of the optic vesicle to form the optic cup.","PeriodicalId":55191,"journal":{"name":"Current Topics in Developmental Biology","volume":"161 ","pages":"1-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0